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Со стороны опорно-двигательного аппарата: обратимый гиперостоз длинных трубчатых костей (при длительном непрерывном введении от 4 недель). Местные реакции: боль, отек, эритема, нарушение чувствительности, флебит (проксимальнее места внутривенного введения). Лабораторные показатели: лейкоцитоз, лейкопения, увеличение титра С-реактивного белка, повышение активности трансаминаз. Прочие: повышенное потоотделение, гипертермия, отечность конечности, в вену которой проводится инфузия. Редко: боли в суставах, спутанность сознания, судороги центрального генеза, лихорадка, озноб, брадипноэ, артралгии, психоз, почечная недостаточность, анурия. Сообщалось о нескольких случаях развития отека легких и острой левожелудочковой недостаточности. Аллергические реакции: кожная сыпь, зуд. 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