Действующее вещество: гидрокортизона бутират -1 мг. Вспомогательное вещество: вазелин белый до 1 г.
Фармакотерапевтическая группа
Глюкокортикостероид для местного применения.
Фармакологические свойства
Фармакодинамика
Гидрокортизон является синтетическим негалогенизированным глюкокортикостероидным препаратом для наружного применения. Тормозит высвобождение цитокинов (интерлейкинов и интерферона) из лимфоцитов и макрофагов, угнетает высвобождение эозинофилами медиаторов воспаления, нарушает метаболизм арахидоновой кислоты и синтез простагландинов. Уменьшает воспалительные клеточные инфильтраты, снижает миграцию лейкоцитов, в том числе лимфоцитов, в область воспаления. Оказывает противовоспалительное, противоотечное или сосудосуживающее и противозудное действие. Вследствие местного сосудосуживающего действия уменьшает экссудативные реакции. Применение мази в рекомендуемых дозах не вызывает подавления гипоталамо-гипофизарно-адреналовой системы.
Фармакокинетика
Всасывание
После аппликации происходит накопление гидрокортизона бутирата в эпидермисе, в основном в зернистом слое, системная абсорбция незначительна. Небольшое количество гидрокортизона бутирата всасывается в системный кровоток в неизмененном виде. Всасывание гидрокортизона бутирата усиливается при применении на тонкой коже в области складок или на лице, а также на участках с повреждённым эпидермисом или на коже, пораженной воспалительным процессом. Всасывание гидрокортизона бутирата также усиливается при применении окклюзионной повязки, частом нанесении лекарственного препарата или применении его на большом участке кожи. У детей всасывание гидрокортизона бутирата через кожу выражено в большей степени, чем у взрослых.
Метаболизм
Большая часть гидрокортизона бутирата метаболизируется до гидрокортизона и других метаболитов непосредственно в эпидермисе и в последующем в печени.
Выведение
Метаболиты и незначительная часть неизмененного гидрокортизона бутирата выводится в основном почками и через кишечник с желчью.
Показания к применению
Подострые и хронические поверхностные, неинфицированные, чувствительные к местным глюкокортикостероидам заболевания кожи:
Дерматиты, в том числе атопический, контактный, себорейный;
Экзема;
Псориаз.
Противопоказания
Повышенная чувствительность к гидрокортизону (или любому глюкокортикостероиду) и к вспомогательному веществу препарата.
Бактериальные, грибковые, и вирусные (в том числе, ветряная оспа, простой герпес) инфекции кожи.
Акне, розацеа.
Периоральный дерматит.
Поствакцинальный период.
Нарушение целостности кожных покровов (раны, язвы)
Опухоли кожи.
Туберкулезные или сифилитические поражения кожи.
Детский возраст до 2-х лет.
I триместр беременности.
С осторожностью
Нанесение на большие участки кожи, повреждённую кожу, применения больших доз, а также длительная терапия препаратом (особенно у детей старше 2-х лет).
Нанесение на кожу лица и интертригинозную кожу (складки кожи, подмышечные впадины, паховая область, сгибы рук и ног).
Применение окклюзивных повязок.
Нанесение на кожу вокруг глаз или веки (риск развития глаукомы, катаракты), в том числе у пациентов с глаукомой или катарактой.
Период грудного вскармливания
Атрофические изменения подкожной клетчатки, особенно у лиц пожилого возраста.
Применение при беременности и в период грудного вскармливания
Противопоказан в I триместр беременности, с осторожностью в период лактации.
Способ применения и дозы
Наружно. Препарат Латикорт наносят тонким слоем на пораженные участки кожи массирующими движениями для улучшения проникновения. В случаях резистентного течения заболеваний, например, при локализации плотных псориатических бляшек на локтях, коленях, препарат необходимо применять под окклюзионными повязками, которые меняют каждые 24 часа.
Взрослые пациенты
Применять не чаще 2 раз в сутки. Курс лечения препаратом у взрослых – не более 2-х недель; в частности, на коже лица - не более 5 дней. В течение недели доза препарата не должна превышать 30-60 г мази.
Дети и подростки
Препарат Латикорт противопоказан детям младше 2-х лет.
У детей из-за более высокого отношения площади поверхности тела к массе тела, чем у взрослых, легче может развиться нарушение функции гипоталамо-гипофизарно-надпочечниковой системы и возникнуть нежелательные реакции, характерные для кортикостероидов, в том числе задержка роста и развития.
У детей старше 2-х лет препарат Латикорт следует применять с большой осторожностью, только один раз в сутки на небольших участках кожи под контролем врача, короткими курсами (не более 7 дней); не следует применять на коже лица.
Если после терапии препаратом Латикорт улучшение не наступает или появляются новые симптомы, необходимо проконсультироваться с врачом. Применяете препарат только согласно тому способу применения и в тех дозах, которые указаны в инструкции. В случае необходимости, пожалуйста, проконсультируйтесь с врачом перед применением препарата.
Побочное действие
Частота возникновения побочных реакций классифицирована в соответствии с рекомендациями Всемирной Организацией Здравоохранения (ВОЗ), побочные эффекты классифицированы по частоте: очень часто (≥ 1/10), часто (≥ 1/100 и ˂ 1/10), нечасто (≥ 1/1000 и ˂ 1/100), редко (≥ 1/10000 и ˂ 1/1000), очень редко (˂ 1/10000), частота неизвестна (невозможно оценить по доступным данным).
Побочные эффекты развиваются редко и носят обратимый характер.
Со стороны кожи и подкожной клетчатки
Частота неизвестна: могут возникнуть акнеподобные симптомы, постстероидная пурпура, атрофия эпидермиса и подкожной клетчатки, сухость кожи, гипертрихоз или алопеция, депигментация или гиперпигментация кожи, стрии, телеангиэктазии, периоральный дерматит, воспаление волосяных фолликулов, вторичные инфекции, раздражение кожи. Иногда может возникнуть крапивница или пятнисто-папулёзная сыпь, возможно обострение текущих заболеваний кожи.
Со стороны органа зрения
Частота неизвестна: снижение остроты зрения. В случае применения лекарственного препарата на коже век иногда может развиться глаукома или катаракта, а в редких случаях - центральная серозная хориоретинопатия (ЦСХ).
Передозировка
При длительном применении препарата или с использованием окклюзивной повязки, а также в случае применения на больших участках пораженной кожи с повышенной способностью к резорбции, возможна передозировка, сопровождающаяся признаками гиперкортицизма.
Лечение: симптоматическое, отмена препарата (при длительной терапии – постепенная отмена или назначение препаратов с меньшей активностью).
Взаимодействие с другими лекарственными средствами
Взаимодействия лекарственного препарата Латикорт при наружном применении с другими лекарственными средствами не выявлено.
Особые указания
Следует избегать попадания мази Латикорт в глаза и на слизистые оболочки.
Если при наружном применении мази Латикорт отмечаются признаки повышенной чувствительности или раздражения кожи, а также усиление побочных эффектов или эффектов, не указанных в инструкции, следует прекратить лечение и обратиться к врачу.
При длительном применении и/или нанесении на большие поверхности кожи, при использовании окклюзионных повязок и при терапии у детей мази Латикорт возможна системная абсорбция глюкокортикостероида; возможно подавление функции гипоталамо-гипофизарно-надпочечниковой системы и развитие симптомов гиперкортицизма.
Во время терапии препаратом необходим периодический контроль функции коры надпочечников, с помощью определения уровня кортизола в крови и моче после стимуляции надпочечников адренокортикотропным гормоном (АКТГ).В случае развития вторичной бактериальной или грибковой инфекции необходимо назначить наружное применение антибактериального или противогрибкового препарата. Если симптомы инфекции сохраняются, следует прекратить применение лекарственного препарата Латикорт до излечения инфекции.
Форма выпуска
Мазь для наружного применения.
Условия хранения
Хранить при температуре не выше 25°C. Хранить в недоступном для детей месте.
Срок годности
3 года. Не применять по истечении срока годности.
Условия отпуска
Без рецепта.
Производитель
JELFA. Страна производитель: Польша.
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Вспомогательное вещество: вазелин белый до 1 г."}}]},{"name":"Фармакотерапевтическая группа","slug":"","id":13,"body":[{"type":"paragraph","data":{"text":"Глюкокортикостероид для местного применения."}}]},{"id":2,"name":"Фармакологические свойства","slug":"pharmacologic_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Фармакодинамика"}},{"type":"paragraph","data":{"text":"Гидрокортизон является синтетическим негалогенизированным глюкокортикостероидным препаратом для наружного применения. Тормозит высвобождение цитокинов (интерлейкинов и интерферона) из лимфоцитов и макрофагов, угнетает высвобождение эозинофилами медиаторов воспаления, нарушает метаболизм арахидоновой кислоты и синтез простагландинов. Уменьшает воспалительные клеточные инфильтраты, снижает миграцию лейкоцитов, в том числе лимфоцитов, в область воспаления. Оказывает противовоспалительное, противоотечное или сосудосуживающее и противозудное действие. Вследствие местного сосудосуживающего действия уменьшает экссудативные реакции. Применение мази в рекомендуемых дозах не вызывает подавления гипоталамо-гипофизарно-адреналовой системы."}},{"type":"paragraph","data":{"text":"Фармакокинетика"}},{"type":"paragraph","data":{"text":"Всасывание"}},{"type":"paragraph","data":{"text":"После аппликации происходит накопление гидрокортизона бутирата в эпидермисе, в основном в зернистом слое, системная абсорбция незначительна. Небольшое количество гидрокортизона бутирата всасывается в системный кровоток в неизмененном виде. Всасывание гидрокортизона бутирата усиливается при применении на тонкой коже в области складок или на лице, а также на участках с повреждённым эпидермисом или на коже, пораженной воспалительным процессом. Всасывание гидрокортизона бутирата также усиливается при применении окклюзионной повязки, частом нанесении лекарственного препарата или применении его на большом участке кожи. У детей всасывание гидрокортизона бутирата через кожу выражено в большей степени, чем у взрослых."}},{"type":"paragraph","data":{"text":"Метаболизм"}},{"type":"paragraph","data":{"text":"Большая часть гидрокортизона бутирата метаболизируется до гидрокортизона и других метаболитов непосредственно в эпидермисе и в последующем в печени."}},{"type":"paragraph","data":{"text":"Выведение"}},{"type":"paragraph","data":{"text":"Метаболиты и незначительная часть неизмененного гидрокортизона бутирата выводится в основном почками и через кишечник с желчью."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Подострые и хронические поверхностные, неинфицированные, чувствительные к местным глюкокортикостероидам заболевания кожи:"}},{"type":"paragraph","data":{"text":"Дерматиты, в том числе атопический, контактный, себорейный;"}},{"type":"paragraph","data":{"text":"Экзема;"}},{"type":"paragraph","data":{"text":"Псориаз."}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к гидрокортизону (или любому глюкокортикостероиду) и к вспомогательному веществу препарата."}},{"type":"paragraph","data":{"text":"Бактериальные, грибковые, и вирусные (в том числе, ветряная оспа, простой герпес) инфекции кожи."}},{"type":"paragraph","data":{"text":"Акне, розацеа."}},{"type":"paragraph","data":{"text":"Периоральный дерматит."}},{"type":"paragraph","data":{"text":"Поствакцинальный период."}},{"type":"paragraph","data":{"text":"Нарушение целостности кожных покровов (раны, язвы)"}},{"type":"paragraph","data":{"text":"Опухоли кожи."}},{"type":"paragraph","data":{"text":"Туберкулезные или сифилитические поражения кожи."}},{"type":"paragraph","data":{"text":"Детский возраст до 2-х лет."}},{"type":"paragraph","data":{"text":"I триместр беременности."}}]},{"name":"С осторожностью","slug":"cautions","id":14,"body":[{"type":"paragraph","data":{"text":"Нанесение на большие участки кожи, повреждённую кожу, применения больших доз, а также длительная терапия препаратом (особенно у детей старше 2-х лет)."}},{"type":"paragraph","data":{"text":"Нанесение на кожу лица и интертригинозную кожу (складки кожи, подмышечные впадины, паховая область, сгибы рук и ног)."}},{"type":"paragraph","data":{"text":"Применение окклюзивных повязок."}},{"type":"paragraph","data":{"text":"Нанесение на кожу вокруг глаз или веки (риск развития глаукомы, катаракты), в том числе у пациентов с глаукомой или катарактой."}},{"type":"paragraph","data":{"text":"Период грудного вскармливания"}},{"type":"paragraph","data":{"text":"Атрофические изменения подкожной клетчатки, особенно у лиц пожилого возраста."}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Противопоказан в I триместр беременности, с осторожностью в период лактации."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Наружно. Препарат Латикорт наносят тонким слоем на пораженные участки кожи массирующими движениями для улучшения проникновения. В случаях резистентного течения заболеваний, например, при локализации плотных псориатических бляшек на локтях, коленях, препарат необходимо применять под окклюзионными повязками, которые меняют каждые 24 часа."}},{"type":"paragraph","data":{"text":"Взрослые пациенты"}},{"type":"paragraph","data":{"text":"Применять не чаще 2 раз в сутки. Курс лечения препаратом у взрослых – не более 2-х недель; в частности, на коже лица - не более 5 дней. В течение недели доза препарата не должна превышать 30-60 г мази."}},{"type":"paragraph","data":{"text":"Дети и подростки"}},{"type":"paragraph","data":{"text":"Препарат Латикорт противопоказан детям младше 2-х лет."}},{"type":"paragraph","data":{"text":"У детей из-за более высокого отношения площади поверхности тела к массе тела, чем у взрослых, легче может развиться нарушение функции гипоталамо-гипофизарно-надпочечниковой системы и возникнуть нежелательные реакции, характерные для кортикостероидов, в том числе задержка роста и развития."}},{"type":"paragraph","data":{"text":"У детей старше 2-х лет препарат Латикорт следует применять с большой осторожностью, только один раз в сутки на небольших участках кожи под контролем врача, короткими курсами (не более 7 дней); не следует применять на коже лица."}},{"type":"paragraph","data":{"text":"Если после терапии препаратом Латикорт улучшение не наступает или появляются новые симптомы, необходимо проконсультироваться с врачом. Применяете препарат только согласно тому способу применения и в тех дозах, которые указаны в инструкции. В случае необходимости, пожалуйста, проконсультируйтесь с врачом перед применением препарата."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Частота возникновения побочных реакций классифицирована в соответствии с рекомендациями Всемирной Организацией Здравоохранения (ВОЗ), побочные эффекты классифицированы по частоте: очень часто (≥ 1/10), часто (≥ 1/100 и ˂ 1/10), нечасто (≥ 1/1000 и ˂ 1/100), редко (≥ 1/10000 и ˂ 1/1000), очень редко (˂ 1/10000), частота неизвестна (невозможно оценить по доступным данным)."}},{"type":"paragraph","data":{"text":"Побочные эффекты развиваются редко и носят обратимый характер."}},{"type":"paragraph","data":{"text":"Со стороны кожи и подкожной клетчатки"}},{"type":"paragraph","data":{"text":"Частота неизвестна: могут возникнуть акнеподобные симптомы, постстероидная пурпура, атрофия эпидермиса и подкожной клетчатки, сухость кожи, гипертрихоз или алопеция, депигментация или гиперпигментация кожи, стрии, телеангиэктазии, периоральный дерматит, воспаление волосяных фолликулов, вторичные инфекции, раздражение кожи. Иногда может возникнуть крапивница или пятнисто-папулёзная сыпь, возможно обострение текущих заболеваний кожи."}},{"type":"paragraph","data":{"text":"Со стороны органа зрения"}},{"type":"paragraph","data":{"text":"Частота неизвестна: снижение остроты зрения. В случае применения лекарственного препарата на коже век иногда может развиться глаукома или катаракта, а в редких случаях - центральная серозная хориоретинопатия (ЦСХ)."}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"При длительном применении препарата или с использованием окклюзивной повязки, а также в случае применения на больших участках пораженной кожи с повышенной способностью к резорбции, возможна передозировка, сопровождающаяся признаками гиперкортицизма."}},{"type":"paragraph","data":{"text":"Лечение: симптоматическое, отмена препарата (при длительной терапии – постепенная отмена или назначение препаратов с меньшей активностью)."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Взаимодействия лекарственного препарата Латикорт при наружном применении с другими лекарственными средствами не выявлено."}}]},{"id":9,"name":"Особые указания","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Следует избегать попадания мази Латикорт в глаза и на слизистые оболочки."}},{"type":"paragraph","data":{"text":"Если при наружном применении мази Латикорт отмечаются признаки повышенной чувствительности или раздражения кожи, а также усиление побочных эффектов или эффектов, не указанных в инструкции, следует прекратить лечение и обратиться к врачу."}},{"type":"paragraph","data":{"text":"При длительном применении и/или нанесении на большие поверхности кожи, при использовании окклюзионных повязок и при терапии у детей мази Латикорт возможна системная абсорбция глюкокортикостероида; возможно подавление функции гипоталамо-гипофизарно-надпочечниковой системы и развитие симптомов гиперкортицизма."}},{"type":"paragraph","data":{"text":"Во время терапии препаратом необходим периодический контроль функции коры надпочечников, с помощью определения уровня кортизола в крови и моче после стимуляции надпочечников адренокортикотропным гормоном (АКТГ).В случае развития вторичной бактериальной или грибковой инфекции необходимо назначить наружное применение антибактериального или противогрибкового препарата. Если симптомы инфекции сохраняются, следует прекратить применение лекарственного препарата Латикорт до излечения инфекции."}}],"slug":""},{"name":"Форма выпуска","slug":"","id":17,"body":[{"type":"paragraph","data":{"text":"Мазь для наружного применения."}}]},{"name":"Условия хранения","slug":"storage","id":18,"body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 25°C. Хранить в недоступном для детей месте."}}]},{"name":"Срок годности","slug":"expiry_date","id":19,"body":[{"type":"paragraph","data":{"text":"3 года. Не применять по истечении срока годности."}}]},{"name":"Условия отпуска","slug":"release_condition","id":20,"body":[{"type":"paragraph","data":{"text":"Без рецепта."}}]},{"name":"Производитель","slug":"","id":21,"body":[{"type":"paragraph","data":{"text":"JELFA. Страна производитель: Польша."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Фармакодинамика Гидрокортизон является синтетическим негалогенизированным глюкокортикостероидным препаратом для наружного применения. Тормозит высвобождение цитокинов (интерлейкинов и интерферона) из лимфоцитов и макрофагов, угнетает высвобождение эозинофилами медиаторов воспаления, нарушает метаболизм арахидоновой кислоты и синтез простагландинов. Уменьшает воспалительные клеточные инфильтраты, снижает миграцию лейкоцитов, в том числе лимфоцитов, в область воспаления. Оказывает противовоспалительное, противоотечное или сосудосуживающее и противозудное действие. Вследствие местного сосудосуживающего действия уменьшает экссудативные реакции. Применение мази в рекомендуемых дозах не вызывает подавления гипоталамо-гипофизарно-адреналовой системы. Фармакокинетика Всасывание После аппликации происходит накопление гидрокортизона бутирата в эпидермисе, в основном в зернистом слое, системная абсорбция незначительна. Небольшое количество гидрокортизона бутирата всасывается в системный кровоток в неизмененном виде. Всасывание гидрокортизона бутирата усиливается при применении на тонкой коже в области складок или на лице, а также на участках с повреждённым эпидермисом или на коже, пораженной воспалительным процессом. Всасывание гидрокортизона бутирата также усиливается при применении окклюзионной повязки, частом нанесении лекарственного препарата или применении его на большом участке кожи. У детей всасывание гидрокортизона бутирата через кожу выражено в большей степени, чем у взрослых. Метаболизм Большая часть гидрокортизона бутирата метаболизируется до гидрокортизона и других метаболитов непосредственно в эпидермисе и в последующем в печени. 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