Креон Капсулы, 20 шт, 10000 ед, 150 мг

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"}}]},{"id":7,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Заместительная терапия экзокринной (ферментной) недостаточности поджелудочной железы у детей и взрослых, обусловленной снижением ферментной активности поджелудочной железы вследствие нарушения продукции, регуляции секреции, доставки панкреатических ферментов или повышенного их разрушения в просвете кишечника, что вызвано разнообразными заболеваниями желудочно-кишечного тракта, и наиболее часто встречающейся при:"}},{"type":"list","data":{"style":"unordered","items":["муковисцидозе;"]}},{"type":"list","data":{"style":"unordered","items":["хроническом панкреатите;"]}},{"type":"list","data":{"style":"unordered","items":["после операции на поджелудочной железе;"]}},{"type":"list","data":{"style":"unordered","items":["после гастрэктомии;"]}},{"type":"list","data":{"style":"unordered","items":["раке поджелудочной железы;"]}},{"type":"list","data":{"style":"unordered","items":["частичной резекции желудка (например, Бильрот II);"]}},{"type":"list","data":{"style":"unordered","items":["обструкции протоков поджелудочной железы или общего желчного протока (например, вследствие новообразования);"]}},{"type":"list","data":{"style":"unordered","items":["синдроме Швахмана–Даймонда;"]}},{"type":"list","data":{"style":"unordered","items":["состоянии после приступа острого панкреатита и возобновлении питания."]}},{"type":"paragraph","data":{"text":"Для улучшения переваривания пищи у пациентов с нормальной функцией ЖКТ в случаях погрешностей в питании (употребление жирной пищи, переедание, нерегулярное питание и т.д.). "}}]},{"id":8,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к любому из компонентов препарата. "}}]},{"id":10,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"header","data":{"text":"Беременность","level":4}},{"type":"paragraph","data":{"text":"Клинические данные о лечении беременных женщин препаратами, содержащими ферменты поджелудочной железы, отсутствуют. В ходе исследований на животных не выявлено абсорбции ферментов поджелудочной железы свиного происхождения, поэтому токсического воздействия на репродуктивную функцию и развитие плода не предполагается. "}},{"type":"paragraph","data":{"text":"Назначать препарат беременным женщинам следует с осторожностью, если предполагаемая польза для матери превышает потенциальный риск для плода."}},{"type":"header","data":{"text":"Период грудного вскармливания","level":4}},{"type":"paragraph","data":{"text":"Исходя из исследований на животных, во время которых не выявлено систематического негативного влияния ферментов поджелудочной железы, не ожидается никакого вредного влияния препарата на грудного ребенка через грудное молоко."}},{"type":"paragraph","data":{"text":"Во время кормления грудью можно принимать ферменты поджелудочной железы."}},{"type":"paragraph","data":{"text":"При необходимости приема во время беременности или кормления грудью препарат следует принимать в дозах, достаточных для поддержания адекватного нутритивного статуса. "}}]},{"id":11,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь."}},{"type":"paragraph","data":{"text":"Дозы препарата подбирают индивидуально в зависимости от тяжести заболевания и состава диеты."}},{"type":"paragraph","data":{"text":"Капсулы следует принимать во время или сразу после каждого приема пищи (в т.ч. легкой закуски), проглатывать целиком, не разламывать и не разжевывать, запивая достаточным количеством жидкости."}},{"type":"paragraph","data":{"text":"При затрудненном глотании (например, у маленьких детей или пациентов пожилого возраста) капсулы осторожно вскрывают, а минимикросферы добавляют к мягкой пище, не требующей пережевывания и имеющей кислый вкус (pH < 5,5), или принимают с жидкостью, также имеющей кислый вкус (pH < 5,5). Например, минимикросферы можно добавлять к яблочному пюре, йогурту или фруктовому соку (яблочному, апельсиновому или ананасовому) с pH менее 5,5. Не рекомендуется добавлять содержимое капсул в горячую пищу. Любая смесь минимикросфер с пищей или жидкостью не подлежит хранению, и ее следует принимать сразу же после приготовления."}},{"type":"paragraph","data":{"text":"Размельчение или разжевывание минимикросфер, а также смешивание их с пищей или жидкостью с pH более 5,5 может разрушить их защитную кишечнорастворимую оболочку. Это может привести к раннему высвобождению ферментов в полости рта, снижению эффективности и раздражению слизистых оболочек. Необходимо убедиться, что во рту не осталось минимикросфер."}},{"type":"paragraph","data":{"text":"Важно обеспечить достаточный постоянный прием жидкости пациентом, особенно при повышенной потере жидкости. Неадекватное потребление жидкости может приводить к возникновению или усилению запора."}},{"type":"header","data":{"text":"Доза для взрослых и детей при муковисцидозе","level":4}},{"type":"list","data":{"style":"unordered","items":["Доза зависит от массы тела и должна составлять в начале лечения 1000 липазных единиц/кг на каждый прием пищи для детей младше четырех лет и 500 липазных единиц/кг во время приема пищи для детей старше четырех лет и взрослых."]}},{"type":"list","data":{"style":"unordered","items":["Дозу следует определять в зависимости от выраженности симптомов заболевания, результатов контроля за стеатореей и поддержания адекватного нутритивного статуса."]}},{"type":"list","data":{"style":"unordered","items":["У большинства пациентов доза должна оставаться меньше или не превышать 10000 липазных единиц/кг массы тела в сутки или 4000 липазных единиц/г потребленного жира."]}},{"type":"header","data":{"text":"Доза при других состояниях, сопровождающихся экзокринной недостаточностью поджелудочной железы","level":4}},{"type":"paragraph","data":{"text":"Дозу следует устанавливать с учетом индивидуальных особенностей пациента, к которым относятся степень недостаточности пищеварения и содержание жира в пище. Доза, которая требуется пациенту вместе с основным приемом пищи, варьируется от 25000 до 80000 ЕД липазы, а во время приема легкой закуски – половина индивидуальной дозы. "}},{"type":"paragraph","data":{"text":"\u003cb\u003eДоза для улучшения переваривания пищи у пациентов с нормальной функцией ЖКТ в случаях погрешностей в питании\u003c/b\u003e зависит от массы тела и содержания жира в пище, варьирует от 10 000 до 20 000 ЕД липазы на один прием."}},{"type":"paragraph","data":{"text":"У детей препарат должен применяться в соответствии с назначением врача. "}}]},{"id":12,"name":"Побочное действие","slug":"side_effects","body":[{"type":"header","data":{"text":"Нарушения со стороны желудочно-кишечного тракта","level":4}},{"type":"paragraph","data":{"text":"Очень часто (≥ 1 / 10): боль в области живота."}},{"type":"paragraph","data":{"text":"Часто (≥ 1 / 100, < 1 / 10): тошнота, рвота, запор, вздутие живота, диарея."}},{"type":"paragraph","data":{"text":"Частота неизвестна: стриктуры подвздошной, слепой и толстой кишки (фиброзирующая колонопатия)."}},{"type":"header","data":{"text":"Желудочно-кишечные расстройства связаны главным образом с основным заболеванием.","level":4}},{"type":"paragraph","data":{"text":"Частота возникновения таких нежелательных реакций как боль в области живота и диарея была ниже или схожей с таковой при применении плацебо."}},{"type":"paragraph","data":{"text":"Стриктуры подвздошной, слепой и толстой кишки (фиброзирующая колонопатия) наблюдались у пациентов с муковисцидозом, получавших высокие дозы препаратов панкреатина (см. раздел «Особые указания»)."}},{"type":"header","data":{"text":"Нарушения со стороны кожи и подкожных тканей","level":4}},{"type":"paragraph","data":{"text":"Нечасто ( ≥ 1 / 1000, <1  / 100): сыпь."}},{"type":"paragraph","data":{"text":"Частота неизвестна: зуд, крапивница."}},{"type":"header","data":{"text":"Нарушения со стороны иммунной системы","level":4}},{"type":"paragraph","data":{"text":"Частота неизвестна: гиперчувствительность (анафилактические реакции)."}},{"type":"paragraph","data":{"text":"Аллергические реакции наблюдались преимущественно со стороны кожных покровов, но отмечались также и другие проявления аллергии. Сообщения о данных побочных эффектах были получены в период постмаркетингового применения и носили спонтанный характер. Для точной оценки частоты случаев имеющихся данных недостаточно."}},{"type":"paragraph","data":{"text":"При применении у детей не было отмечено каких-либо специфических нежелательных реакций. Частота, тип и степень тяжести нежелательных реакций у детей с муковисцидозом были сходны с таковыми у взрослых. "}}]},{"id":13,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: гиперурикозурия и гиперурикемия."}},{"type":"paragraph","data":{"text":"Лечение: отмена препарата, симптоматическая терапия. "}}]},{"id":14,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Исследований по взаимодействию не проводилось."}}]},{"id":15,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"У пациентов с муковисцидозом, получавших высокие дозы препаратов панкреатина, описаны стриктуры подвздошной, слепой и толстой кишки (фиброзирующая колонопатия). В качестве меры предосторожности, при появлении необычных симптомов или изменений в брюшной полости необходимо медицинское обследование для исключения фиброзирующей колонопатии, особенно у пациентов, которые принимают препарат в дозе более 10000 липазных единиц/кг в сутки."}},{"type":"paragraph","data":{"text":"Во избежание осложнений применять только после консультации с врачом. "}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Применение препарата Креон® 10000 не влияет или оказывает незначительное влияние на способность к управлению автомобилем и механизмами. "}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Капсулы кишечнорастворимые 10000 ЕД. По 20, 50 или 100 капсул во флакон из полиэтилена высокой плотности белого цвета с навинчивающейся крышкой из полипропилена с контролем первого вскрытия. На флакон наклеивают этикетку. По 1 флакону вместе с инструкцией по применению в пачку из картона. "}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 25 ºС в плотно закрытой упаковке."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте! "}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года."}},{"type":"paragraph","data":{"text":"Срок годности после первого вскрытия флакона – 3 месяца."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности, указанного на упаковке. "}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта. "}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Эбботт Лэбораториз ГмбХ"}},{"type":"paragraph","data":{"text":"Юстус-фон-Либиг-Штрассе 33,"}},{"type":"paragraph","data":{"text":"31535 Нойштадт, Германия"}},{"type":"paragraph","data":{"text":"или"}},{"type":"paragraph","data":{"text":"АО \"ВЕРОФАРМ\","}},{"type":"paragraph","data":{"text":"308013, Россия, г. Белгород,"}},{"type":"paragraph","data":{"text":"ул. Рабочая, д. 14 "}},{"type":"header","data":{"text":"Упаковщик, выпускающий контроль качества","level":4}},{"type":"paragraph","data":{"text":"Эбботт Лэбораториз ГмбХ"}},{"type":"paragraph","data":{"text":"Юстус-фон-Либиг-Штрассе 33,"}},{"type":"paragraph","data":{"text":"31535 Нойштадт, Германия"}},{"type":"paragraph","data":{"text":"или"}},{"type":"paragraph","data":{"text":"ОАО \"Фармстандарт-Лексредства\""}},{"type":"paragraph","data":{"text":"305022, Россия, г. Курск,"}},{"type":"paragraph","data":{"text":"ул. 2-я Агрегатная, д. 1а/18"}},{"type":"paragraph","data":{"text":"или"}},{"type":"paragraph","data":{"text":"АО \"ВЕРОФАРМ\","}},{"type":"paragraph","data":{"text":"308013, Россия, г. Белгород,"}},{"type":"paragraph","data":{"text":"ул. Рабочая, д. 14 "}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО «Эбботт Лэбораториз»"}},{"type":"paragraph","data":{"text":"125171, г. Москва,"}},{"type":"paragraph","data":{"text":"Ленинградское шоссе, дом 16 А, стр. 1"}},{"type":"paragraph","data":{"text":"Тел.: +7 (495) 258 42 80"}},{"type":"paragraph","data":{"text":"Факс: +7 (495) 258 42 81"}},{"type":"paragraph","data":{"text":"abbott-russia@abbott.com"}}]}],"source":null},"description_toggle":false,"short_description":"твердые желатиновые капсулы №2, состоящие из коричневой непрозрачной крышечки и прозрачного бесцветного корпуса. Содержимое капсул – минимикросферы светло-коричневого цвета.","substance":[{"id":119,"title":"Панкреатин","title_latin":"Pancreatinum","slug":"pankreatin_119"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":true,"comments":null,"image_alt":"Креон - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/70086/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/70086/share_default/"}},"diseases":[{"id":"221","title":"Злокачественное новообразование поджелудочной железы","slug":"221-zlokachestvennoe_novoobrazovanie_podzheludochnoy_zhelezy"},{"id":"454","title":"Кистозный фиброз","slug":"454-kistoznyy_fibroz"},{"id":"896","title":"Фиброз и цирроз печени","slug":"896-fibroz_i_tsirroz_pecheni"},{"id":"909","title":"Закупорка желчного протока","slug":"909-zakuporka_zhelchnogo_protoka"},{"id":"912","title":"Другие хронические 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