Милдронат Капсулы, 60 шт, 500 мг

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Содержимое – белый кристаллический порошок со слабым запахом. Порошок\nгигроскопичен."}}]},{"id":13,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"метаболическое средство"}},{"type":"paragraph","data":{"text":"\u003cb\u003eКод АТХ:\u003c/b\u003e C01EB"}}]},{"id":2,"name":"Фармакологические свойства","slug":"pharmacologic_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eФармакодинамика\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Мельдоний – синтетический аналог гамма-бутиробетаина – вещества, которое\nнаходится в каждой клетке организма человека. Ингибирует гамма\nбутиробетаингидрооксиназу, снижает синтез карнитина и транспорт\nдлинноцепочечных жирных кислот через оболочки клеток, препятствует накоплению в\nклетках активированных форм неокисленных жирных\nкислот – производных ацилкарнитина и ацилкофермента А."}},{"type":"paragraph","data":{"text":"Кардиопротекторное средство,\nнормализующее метаболизм миокарда. В условиях ишемии мельдоний восстанавливает\nравновесие между процессами доставки кислорода и его потребления в клетках,\nпредупреждает нарушение транспорта аденозинтрифосфата (АТФ); одновременно с\nэтим активирует гликолиз, который протекает без дополнительного потребления\nкислорода. В результате снижения\nконцентрации карнитина усиленно синтезируется гамма-бутиробетаин, обладающий\nвазодилатирующими свойствами. Механизм действия определяет многообразие его\nфармакологических эффектов: повышение работоспособности,\nуменьшение симптомов психического и физического перенапряжения, активация тканевого и\nгуморального иммунитета, кардиопротекторное действие."}},{"type":"paragraph","data":{"text":"В случае острого\nишемического повреждения миокарда мельдоний замедляет образование некротической\nзоны, укорачивает реабилитационный период."}},{"type":"paragraph","data":{"text":"При  сердечной недостаточности повышает сократимость миокарда, увеличивает\nтолерантность к физической нагрузке, снижает частоту приступов стенокардии.\nПри острых и хронических ишемических нарушениях мозгового кровообращения\nулучшает циркуляцию крови в очаге ишемии, способствует перераспределению крови\nв пользу ишемизированного участка."}},{"type":"paragraph","data":{"text":"Эффективен в случае васкулярной и дистрофической\nпатологии сосудов глазного дна."}},{"type":"paragraph","data":{"text":"Характерно также\nтонизирующее действие на центральную нервную систему, устранение функциональных\nнарушений соматической и вегетативной нервных систем у больных хроническим\nалкоголизмом при синдроме абстиненции."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eФармакокинетика\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"После приема внутрь мельдоний быстро всасывается, биодоступность – 78 %.\nВремя достижения максимальной концентрации в плазме крови –\n1 - 2 часа после приема внутрь. Метаболизируется главным образом\nв печени с образованием двух основных метаболитов, которые выводятся\nпочками. 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Чтобы избежать возможного неблагоприятного\nвоздействия на плод, во время беременности применение препарата МИЛДРОНАТ не рекомендуется."}},{"type":"paragraph","data":{"text":"Неизвестно, выделяется ли мельдоний в грудное\nмолоко. Если лечение препаратом МИЛДРОНАТ для матери необходимо, то\nкормление ребенка грудью прекращают."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Ввиду возможного развития возбуждающего эффекта,\nрекомендуется применять в первой половине дня и не позже 17.00 при приеме несколько\nраз в сутки."}},{"type":"paragraph","data":{"text":"\u003cb\u003e1\u003ci\u003e. \u003c/i\u003eИшемическая\nболезнь сердца (стенокардия, инфаркт миокарда), хроническая сердечная\nнедостаточность и дисгормональная кардиомиопатия \u003ci\u003e\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"В составе комплексной терапии по 500 мг - 1 г в день внутрь,\nприменяя всю дозу сразу или разделив ее на 2 раза. Курс лечения – 4 - 6 недель."}},{"type":"paragraph","data":{"text":"Дисгормональная кардиомиопатия – в составе комплексной терапии по 500 мг внутрь в день.\nКурс лечения – 12 дней."}},{"type":"paragraph","data":{"text":"\u003cb\u003e2. Подострые и хронические нарушения кровоснабжения мозга\n(после инсульта, цереброваскулярная недостаточность)\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"В составе комплексной терапии после\nокончания курса инъекционной терапии препаратом МИЛДРОНАТ, препарат\nпродолжают принимать внутрь по 500 мг - 1 г в день,\nприменяя всю дозу сразу или разделив ее на 2 раза.\u003cb\u003e \u003c/b\u003eКурс лечения – 4 - 6  недель."}},{"type":"paragraph","data":{"text":"При хронических нарушениях – в составе комплексной терапии по 500 мг внутрь в день. Общий курс лечения – 4 ‑ 6 недель."}},{"type":"paragraph","data":{"text":"Повторные курсы (обычно 2 - 3 раза в год) возможны после консультации с\nврачом."}},{"type":"paragraph","data":{"text":"\u003cb\u003e3. Сниженная работоспособность; умственные и физические\nперегрузки (в том числе у спортсменов)\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Взрослым – внутрь по 500 мг 2  раза в день.\nКурс лечения – 10 - 14 дней. При необходимости лечение\nповторяют через 2 - 3 недели."}},{"type":"paragraph","data":{"text":"Спортсменам по 500 мг - 1 г внутрь 2  раза в\nдень перед тренировками. Продолжительность\nкурса в подготовительном тренировочном периоде\n– 14 - 21 день, в период соревнований –10 - 14 дней."}},{"type":"paragraph","data":{"text":"\u003cb\u003e4. Синдром абстиненции\nпри хроническом алкоголизме (в комбинации со специфической терапией)\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Внутрь по 500 мг 4 раза в день. Курс лечения – 7 - 10 дней."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Редко – аллергические реакции (покраснение и зуд кожи, кожная сыпь,\nкрапивница, ангионевротический отек), а также – диспептические явления, тахикардия, снижение или\nповышение артериального давления, повышенная возбудимость.\u003cb\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Очень редко –\nэозинофилия, общая слабость.\u003cb\u003e\u003c/b\u003e"}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы\u003c/i\u003e:\nснижение артериального давления, сопровождающееся головной болью, тахикардией,\nголовокружением и общей слабостью."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение\u003c/i\u003e:\nсимптоматическое."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Усиливает\u003cb\u003e \u003c/b\u003eдействие\u003cb\u003e \u003c/b\u003eкоронародилатирующих\nсредств, некоторых гипотензивных средств, сердечных гликозидов.\u003cb\u003e \u003c/b\u003eМожно сочетать с пролонгированными формами нитратов, другими антиангинальными средствами, антикоагулянтами, антиагрегантами,\nантиаритмическими средствами, диуретиками, бронхолитиками."}},{"type":"paragraph","data":{"text":"Ввиду возможного развития тахикардии и артериальной\nгипотензии, следует соблюдать осторожность при комбинации с нитроглицерином (для\nподъязычного применения) и гипотензивными средствами (особенно альфа-адреноблокаторами и короткодействующими формами нифедипина)."}}]},{"id":9,"name":"Особые указания","slug":"","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Пациентам с хроническими заболеваниями печени и\nпочек следует соблюдать осторожность при длительном применении препарата."}},{"type":"paragraph","data":{"text":"Нет достаточных данных о применении препарата\nМИЛДРОНАТ у детей до 18 лет."}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Нет данных о неблагоприятном влиянии препарата МИЛДРОНАТ на способность управлять транспортными средствами и механизмами. "}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Капсулы 500 мг. По 10 капсул в контурной ячейковой упаковке из пленки\nполивинилхлоридной с поливинилиденхлоридным\nпокрытием и алюминиевой фольги. По 2, 3, 6, 9 или 12 контурных ячейковых упаковок вместе с инструкцией по\nприменению помещают в картонную пачку. "}},{"type":"paragraph","data":{"text":"На пачке может быть нанесен стикер для контроля\nпервого вскрытия."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте!"}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"4 года."}},{"type":"paragraph","data":{"text":"Не применять по\nистечении срока годности, указанного на упаковке. "}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"АО «Гриндекс». Ул. Крустпилс,\n53, Рига, LV-1057, Латвия"}},{"type":"paragraph","data":{"text":"Телефон: +371 67083205"}},{"type":"paragraph","data":{"text":"Факс: +371 67083505"}},{"type":"paragraph","data":{"text":"Электронная почта: grindeks@grindeks.lv"}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО «Гриндекс Рус»."}},{"type":"paragraph","data":{"text":"Россия, 117556, г. Москва, Варшавское\nшоссе, д. 74, корп. 3, 5 этаж"}},{"type":"paragraph","data":{"text":"Телефон:+7 (495) 7716505*"}},{"type":"paragraph","data":{"text":"Факс: +7 (499) 6103963"}},{"type":"paragraph","data":{"text":"Электронная почта: office@grindeks.ru"}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"ФармакодинамикаМельдоний – синтетический аналог гамма-бутиробетаина – вещества, которое находится в каждой клетке организма человека. Ингибирует гамма бутиробетаингидрооксиназу, снижает синтез карнитина и транспорт длинноцепочечных жирных кислот через оболочки клеток, препятствует накоплению в клетках активированных форм неокисленных жирных кислот – производных ацилкарнитина и ацилкофермента А. Кардиопротекторное средство, нормализующее метаболизм миокарда. В условиях ишемии мельдоний восстанавливает равновесие между процессами доставки кислорода и его потребления в клетках, предупреждает нарушение транспорта аденозинтрифосфата (АТФ); одновременно с этим активирует гликолиз, который протекает без дополнительного потребления кислорода. В результате снижения концентрации карнитина усиленно синтезируется гамма-бутиробетаин, обладающий вазодилатирующими свойствами. Механизм действия определяет многообразие его фармакологических эффектов: повышение работоспособности, уменьшение симптомов психического и физического перенапряжения, активация тканевого и гуморального иммунитета, кардиопротекторное действие. В случае острого ишемического повреждения миокарда мельдоний замедляет образование некротической зоны, укорачивает реабилитационный период. При сердечной недостаточности повышает сократимость миокарда, увеличивает толерантность к физической нагрузке, снижает частоту приступов стенокардии. При острых и хронических ишемических нарушениях мозгового кровообращения улучшает циркуляцию крови в очаге ишемии, способствует перераспределению крови в пользу ишемизированного участка. Эффективен в случае васкулярной и дистрофической патологии сосудов глазного дна. Характерно также тонизирующее действие на центральную нервную систему, устранение функциональных нарушений соматической и вегетативной нервных систем у больных хроническим алкоголизмом при синдроме абстиненции.ФармакокинетикаПосле приема внутрь мельдоний быстро всасывается, биодоступность – 78 %. Время достижения максимальной концентрации в плазме крови – 1 - 2 часа после приема внутрь. Метаболизируется главным образом в печени с образованием двух основных метаболитов, которые выводятся почками. Период полувыведения (T1/2) при приеме внутрь зависит от дозы, составляет 3 - 6 часов.","substance":[{"id":726,"title":"Мельдоний","title_latin":"Meldonium","slug":"meldoniy_726"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":{"count":90,"url":"/review/535-mildronate/"},"image_alt":"Милдронат - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/89859/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/89859/share_default/"}},"diseases":[{"id":"425","title":"Другие виды недостаточности питания","slug":"425-drugie_vidy_nedostatochnosti_pitaniya"},{"id":"475","title":"Абстинентное состояние","slug":"475-abstinentnoe_sostoyf103"},{"id":"557","title":"Преходящие транзиторные церебральные ишемические приступы [атаки] и родственные 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