Противогельминтное средство широкого спектра действия . производное бензимидазола карбамата. Противогельминтное и противопротозойное средство. Избирательно подавляет полимеризацию бета-тубулина, что приводит к деструкции цитоплазматических микроканальцев клеток кишечного тракта гельминтов . вызывает необратимое нарушение утилизации глюкозы в организме гельминта и тормозит синтез АТФ . блокирует передвижение секреторных гранул и других органелл в мышечных клетках круглых червей, обусловливая их гибель. Наиболее эффективен в отношении личиночных форм цестод - Echinococcus granulosus и Taenia solium . нематод - Strongyloides stercolatis.
Показания к применению
Эхинококкоз, нейроцистицеркоз, нематодозы (аскаридоз, трихоцефалез, анкилостомидоз, энтеробиоз, стронгилоидоз), трематодозы (описторхоз), лямблиоз, микроспоридиоз, смешанные гельминтозы. В качестве вспомогательного средства при хирургическом лечении эхинококкозных кист.
Противопоказания
Беременность, лактация (грудное вскармливание), детский возраст до 3 лет, повышенная чувствительность к албендазолу.
Применение при беременности и в период грудного вскармливания
Албендазол противопоказан к применению при беременности и в период лактации (грудного вскармливания). Женщинам детородного возраста в период лечения рекомендуется использовать негормональные методы контрацепции. Неизвестно, выделяется ли албендазол и его активный метаболит с грудным молоком. В экспериментальных исследованиях на животных показана тератогенность албендазола.
Побочное действие
Со стороны пищеварительной системы: абдоминальная боль, тошнота, рвота, повышение активности печеночных трансаминаз. Со стороны ЦНС: головная боль, головокружение, менингеальные симптомы. Со стороны системы кроветворения: лейкопения, гранулоцитопения, агранулоцитоз, тромбоцитопения, панцитопения. Аллергические реакции: кожная сыпь, зуд. Со стороны мочевыделительной системы: нарушение функции почек, острая почечная недостаточность. Прочие: гипертермия, повышение АД, алопеция.
Особые указания
Со стороны пищеварительной системы: абдоминальная боль, тошнота, рвота, повышение активности печеночных трансаминаз. Со стороны ЦНС: головная боль, головокружение, менингеальные симптомы. Со стороны системы кроветворения: лейкопения, гранулоцитопения, агранулоцитоз, тромбоцитопения, панцитопения. Аллергические реакции: кожная сыпь, зуд. Со стороны мочевыделительной системы: нарушение функции почек, острая почечная недостаточность. Прочие: гипертермия, повышение АД, алопеция.
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