Тиоктовая кислота (α-липоевая кислота) - эндогенный антиоксидант (связывает свободные радикалы), в организме образуется при окислительном декарбоксилировании α-кетокислот. В качестве коэнзима митохондриальных мультиферментных комплексов участвует в окислительном декарбоксилировании пировиноградной кислоты и α-кетокислот. Способствует снижению содержания глюкозы в крови и увеличению содержания гликогена в печени, а также преодолению инсулинорезистентности. По характеру биохимического действия тиоктовая кислота близка к витаминам группы В. Участвует в регулировании липидного и углеводного обмена, стимулирует обмен холестерина, улучшает функцию печени. Оказывает гепатопротекторное, гиполипидемическое, гипохолестеринемическое, гипогликемическое действие. Улучшает трофику нейронов и аксональную проводимость, уменьшает проявления диабетической и алкогольной полиневропатии.
Показания к применению
Диабетическая полиневропатия
Алкогольная полиневропатия
Противопоказания
Беременность (отсутствует достаточный опыт применения препарата)
Период грудного вскармливания (отсутствует достаточный опыт применения препарата)
Детский и подростковый возраст до 18 лет (эффективность и безопасность применения не установлены)
Гиперчувствительность к тиоктовой кислоте и компонентам препарата
Применение при беременности и в период грудного вскармливания
Применение препарата во время беременности противопоказано в связи с отсутствием достаточного клинического опыта применения тиоктовой кислоты при беременности. Исследования репродуктивной токсичности не выявили рисков в отношении фертильности, влияния на развитие плода и каких-либо эмбриотоксических свойств препарата. Применение препарата Октолипен в период лактации противопоказано ввиду отсутствия данных о проникновении тиоктовой кислоты в грудное молоко.
Способ применения и дозы
Препарат принимают внутрь, натощак, за 30 мин до первого приема пищи, не разжевывая и запивая достаточным количеством воды. Рекомендуемая доза - по 600 мг (2 капсулы) 1 раз/сут. Длительность курса лечения определяет врач.
Побочное действие
Аллергические реакции: возможно - крапивница, системные аллергические реакции (вплоть до развития анафилактического шока). Со стороны обмена веществ: возможно развитие симптомов гипогликемии (в связи с улучшением усвоения глюкозы). Со стороны пищеварительной системы: возможны диспептические явления, в т.ч. тошнота, рвота, изжога.
Передозировка
Симптомы: головная боль, тошнота, рвота. Лечение: проведение симптоматической терапии. Специфического антидота нет.
Особые указания
У больных сахарным диабетом необходим частый контроль содержания глюкозы в крови (особенно в начале лечения). В отдельных случаях требуется снижение дозы гипогликемических средств. Во время лечения необходимо строго воздерживаться от употребления алкоголя, т.к. при воздействии этанола терапевтический эффект тиоктовой кислоты ослабляется. Влияние на способность к вождению автотранспорта и управлению механизмами Влияние на способность к вождению транспортных средств и управлению механизмами специально не изучалось. Необходимо соблюдать осторожность при вождении транспортных средств и занятиях потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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