Препарат железа. Железо - важнейший микроэлемент организма. Как коэнзим цитохромоксидазы, каталазы и пероксидазы, а также как составная часть гемоглобина, миоглобина и цитохромов он вовлечен во множество метаболических процессов, стимулирует эритропоэз.; Входящая в состав препарата -аминокислота серин способствует более эффективному всасыванию железа и его поступлению в системный кровоток, что приводит к быстрому восстановлению нормального содержания железа в организме. Это обеспечивает лучшую переносимость препарата и позволяет уменьшить необходимую дозу железа.; Суточная потребность в железе у взрослых составляет 1-2 мг, у беременных - 2-5 мг, у детей в возрасте до 7 лет - 0.5-1.5 мг. В среднем всасывается 10%, поэтому для восполнения потребности в железе, доза при приеме внутрь должна превышать суточную потребность в 10 раз.
Показания к применению
— лечение дефицита железа.
Противопоказания
Повышенная чувствительность к компонентам препарата
Нарушения всасывания железа (сидероахрестическая анемия, свинцовая анемия, талассемия)
Повышенное содержание железа в организме (гемохроматоз, гемолитическая анемия)
Анемия, не связанная с дефицитом железа
С осторожностью следует применять препараты железа с диетическими продуктами и добавками, содержащими соли железа (возможный риск передозировки). У пациентов с воспалением и язвенными поражениями слизистой оболочки ЖКТ следует оценивать соотношение пользы лечения и риска развития обострений гастроэнтерологических заболеваний на фоне терапии препаратами железа.
Не следует назначать препарат пациентам с наследственной непереносимостью фруктозы или галактозы, дефицитом лактазы, глюкозо-галактозной мальабсорбцией, дефицитом сахаразы-изомальтазы.
Применение при беременности и в период грудного вскармливания
Применение при беременности и в период лактации возможно, если потенциальная польза терапии для матери превышает возможный риск для плода или грудного ребенка.
Способ применения и дозы
Режим дозирования; Суточная доза устанавливается из расчета 5 капель на 1 кг массы тела, кратность приема - 2-3 раза/сут.; Грудные дети: средняя доза составляет по 10-15 капель 3 раза/сут.; Дети дошкольного возраста: средняя доза - 25-35 капель 3 раза/сут.; Дети школьного возраста: средняя доза - по 50 капель 3 раза/сут.; Чтобы открыть флакон, следует нажать на колпачок вниз и одновременно повернуть в направлении стрелки. После применения лекарства колпачок установить и туго завинтить (предотвращает доступ для детей).; Дефицит железа может быть приблизительно рассчитан по формуле: железо (мг) = масса тела (кг)×3.5×(16 - количество гемоглобина (г%)); Чтобы обеспечить усиление ответа, терапию железом следует проводить длительно и продолжать, по крайней мере, в течение 8 недель; затем, после нормализации содержания гемоглобина, лечение следует продолжать еще 6-8 недель для восполнения депо железа.; Контроль лабораторных показателей; При необходимости, степень дефицита железа и последующую потребность восполнения железа следует контролировать каждые 4 недели по следующим лабораторным показателям: гемоглобин, эритроциты, ретикулоциты, сывороточное железо, трансферрин, средний эритроцитарный гемоглобин, средний объем эритроцитов.
Побочное действие
Аллергические реакции: редко (>1/10 000 и <1/1000) - кожные проявления.; Со стороны пищеварительной системы: очень редко (< 1/10 000) - запор, диарея, боли в животе, тошнота, рвота. При приеме железосодержащих препаратов возможно окрашивание кала в темный (черный) цвет, что не имеет клинического значения.; Желудочно-кишечные расстройства можно предупредить путем постепенного увеличения дозы в начале лечения или снижением дозы в процессе лечения.
Передозировка
У детей имеется высокий риск интоксикации препаратами железа, жизнеугрожающие состояния могут возникать при приеме 1 г железа сульфата. Поэтому препараты железа должны храниться в недоступном для детей месте.; Симптомы: при случайном приеме препарата в очень высоких дозах возможны слабость, усталость, парестезии, бледность кожных покровов, холодный липкий пот, снижение АД, сердцебиение, акроцианоз, боли в животе, диарея с примесью крови, цианоз, спутанность сознания, слабый пульс, гипертермия, летаргия, судорожные припадки, симптомы гипервентиляции, кома. Признаки периферического сосудистого коллапса проявляются в течение 30 мин после приема; метаболический ацидоз, судороги, жар, лейкоцитоз, кома - в течение 12-24 ч; острый почечный и печеночный некроз - через 2-4 дня.; Лечение: до проведения специфической терапии следует принять меры по удалению из желудка еще не всосавшегося препарата (промывание желудка), дать пациенту выпить молоко, сырое яйцо. Специфическую терапию проводят назначением дефероксамина (десферала) внутрь и парентерально. При острых отравлениях для связывания железа, еще не абсорбировавшегося из ЖКТ, назначают внутрь 5-10 г дефероксамина (растворяют содержимое 10-20 ампул в питьевой воде). Для удаления абсорбировавшегося железа дефероксамин вводят в/м медленно, детям - 15 мг/ч, взрослым - 5 мг/кг/ч (до 80 мг/кг/сут); при легком отравлении - в/м детям по 1 г каждые 4-6 ч, взрослым - по 50 мг/кг (до 4 г/сут). В тяжелых случаях, сопровождающихся развитием шока, вводят в/в капельно в дозе 1 г и проводят симптоматическую терапию. Летальный исход главным образом возникает при несвоевременной противошоковой терапии.; Гемодиализ неэффективен для выведения железа, но может быть использован для ускорения выведения железо-дефероксаминового комплекса, а также может назначаться при олиго- и анурии. Возможно проведение перитонеального диализа.; При курсовом лечении препаратами железа необходим систематический контроль уровня сывороточного железа и других показателей сыворотки крови.; При тяжелых интоксикациях назначают унитиол (димеркаптопропансульфонат натрия) парентерально. Из-за возможности образования нейротоксичных комплексов унитиол следует применять с осторожностью.
Особые указания
Печеночная или почечная недостаточность увеличивают риск кумуляции железа.; Препарат может вызывать обострение язвенных и воспалительных заболеваний кишечника.; При применении препарата возможно стойкое потемнение зубов.; Влияние на способность к вождению автотранспорта и управлению механизмами; Не выявлено.
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Активные вещества: железа сульфата гептагидрат - 4.72 г, D,L-серин - 3.56 г; Вспомогательные вещества: аскорбиновая кислота - 0.8 г, калия сорбат - 0.1 г, сахарный сироп инвертный (72.7% TS) - 15.18 г, этанол 96% - 0.1563 г, ароматизатор сливочный - 0.0125 г, ароматизатор малиновый - 0.05 г, вода очищенная - 83.4 г."}}]},{"id":2,"name":"Фармакологические свойства","slug":"pharmacologic_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Препарат железа. Железо - важнейший микроэлемент организма. Как коэнзим цитохромоксидазы, каталазы и пероксидазы, а также как составная часть гемоглобина, миоглобина и цитохромов он вовлечен во множество метаболических процессов, стимулирует эритропоэз.; Входящая в состав препарата -аминокислота серин способствует более эффективному всасыванию железа и его поступлению в системный кровоток, что приводит к быстрому восстановлению нормального содержания железа в организме. Это обеспечивает лучшую переносимость препарата и позволяет уменьшить необходимую дозу железа.; Суточная потребность в железе у взрослых составляет 1-2 мг, у беременных - 2-5 мг, у детей в возрасте до 7 лет - 0.5-1.5 мг. В среднем всасывается 10%, поэтому для восполнения потребности в железе, доза при приеме внутрь должна превышать суточную потребность в 10 раз."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"— лечение дефицита железа."}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"list","data":{"style":"unordered","items":["Повышенная чувствительность к компонентам препарата","Нарушения всасывания железа (сидероахрестическая анемия, свинцовая анемия, талассемия)","Повышенное содержание железа в организме (гемохроматоз, гемолитическая анемия)","Анемия, не связанная с дефицитом железа"]}},{"type":"paragraph","data":{"text":"С осторожностью следует применять препараты железа с диетическими продуктами и добавками, содержащими соли железа (возможный риск передозировки). У пациентов с воспалением и язвенными поражениями слизистой оболочки ЖКТ следует оценивать соотношение пользы лечения и риска развития обострений гастроэнтерологических заболеваний на фоне терапии препаратами железа."}},{"type":"paragraph","data":{"text":"Не следует назначать препарат пациентам с наследственной непереносимостью фруктозы или галактозы, дефицитом лактазы, глюкозо-галактозной мальабсорбцией, дефицитом сахаразы-изомальтазы."}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Применение при беременности и в период лактации возможно, если потенциальная польза терапии для матери превышает возможный риск для плода или грудного ребенка."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Режим дозирования; Суточная доза устанавливается из расчета 5 капель на 1 кг массы тела, кратность приема - 2-3 раза/сут.; Грудные дети: средняя доза составляет по 10-15 капель 3 раза/сут.; Дети дошкольного возраста: средняя доза - 25-35 капель 3 раза/сут.; Дети школьного возраста: средняя доза - по 50 капель 3 раза/сут.; Чтобы открыть флакон, следует нажать на колпачок вниз и одновременно повернуть в направлении стрелки. После применения лекарства колпачок установить и туго завинтить (предотвращает доступ для детей).; Дефицит железа может быть приблизительно рассчитан по формуле: железо (мг) = масса тела (кг)×3.5×(16 - количество гемоглобина (г%)); Чтобы обеспечить усиление ответа, терапию железом следует проводить длительно и продолжать, по крайней мере, в течение 8 недель; затем, после нормализации содержания гемоглобина, лечение следует продолжать еще 6-8 недель для восполнения депо железа.; Контроль лабораторных показателей; При необходимости, степень дефицита железа и последующую потребность восполнения железа следует контролировать каждые 4 недели по следующим лабораторным показателям: гемоглобин, эритроциты, ретикулоциты, сывороточное железо, трансферрин, средний эритроцитарный гемоглобин, средний объем эритроцитов."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Аллергические реакции: редко (\u003e1/10 000 и \u003c1/1000) - кожные проявления.; Со стороны пищеварительной системы: очень редко (\u003c 1/10 000) - запор, диарея, боли в животе, тошнота, рвота. При приеме железосодержащих препаратов возможно окрашивание кала в темный (черный) цвет, что не имеет клинического значения.; Желудочно-кишечные расстройства можно предупредить путем постепенного увеличения дозы в начале лечения или снижением дозы в процессе лечения."}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"У детей имеется высокий риск интоксикации препаратами железа, жизнеугрожающие состояния могут возникать при приеме 1 г железа сульфата. Поэтому препараты железа должны храниться в недоступном для детей месте.; Симптомы: при случайном приеме препарата в очень высоких дозах возможны слабость, усталость, парестезии, бледность кожных покровов, холодный липкий пот, снижение АД, сердцебиение, акроцианоз, боли в животе, диарея с примесью крови, цианоз, спутанность сознания, слабый пульс, гипертермия, летаргия, судорожные припадки, симптомы гипервентиляции, кома. Признаки периферического сосудистого коллапса проявляются в течение 30 мин после приема; метаболический ацидоз, судороги, жар, лейкоцитоз, кома - в течение 12-24 ч; острый почечный и печеночный некроз - через 2-4 дня.; Лечение: до проведения специфической терапии следует принять меры по удалению из желудка еще не всосавшегося препарата (промывание желудка), дать пациенту выпить молоко, сырое яйцо. Специфическую терапию проводят назначением дефероксамина (десферала) внутрь и парентерально. При острых отравлениях для связывания железа, еще не абсорбировавшегося из ЖКТ, назначают внутрь 5-10 г дефероксамина (растворяют содержимое 10-20 ампул в питьевой воде). Для удаления абсорбировавшегося железа дефероксамин вводят в/м медленно, детям - 15 мг/ч, взрослым - 5 мг/кг/ч (до 80 мг/кг/сут); при легком отравлении - в/м детям по 1 г каждые 4-6 ч, взрослым - по 50 мг/кг (до 4 г/сут). В тяжелых случаях, сопровождающихся развитием шока, вводят в/в капельно в дозе 1 г и проводят симптоматическую терапию. Летальный исход главным образом возникает при несвоевременной противошоковой терапии.; Гемодиализ неэффективен для выведения железа, но может быть использован для ускорения выведения железо-дефероксаминового комплекса, а также может назначаться при олиго- и анурии. Возможно проведение перитонеального диализа.; При курсовом лечении препаратами железа необходим систематический контроль уровня сывороточного железа и других показателей сыворотки крови.; При тяжелых интоксикациях назначают унитиол (димеркаптопропансульфонат натрия) парентерально. Из-за возможности образования нейротоксичных комплексов унитиол следует применять с осторожностью."}}]},{"id":9,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Печеночная или почечная недостаточность увеличивают риск кумуляции железа.; Препарат может вызывать обострение язвенных и воспалительных заболеваний кишечника.; При применении препарата возможно стойкое потемнение зубов.; Влияние на способность к вождению автотранспорта и управлению механизмами; Не выявлено."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Препарат железа. Железо - важнейший микроэлемент организма. 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В среднем всасывается 10%, поэтому для восполнения потребности в железе, доза при приеме внутрь должна превышать суточную потребность в 10 раз.","substance":[{"id":5,"title":"Железа сульфат","title_latin":"Ferri sulfas","slug":"zheleza_sulfat_5"},{"id":2060,"title":"Серин","title_latin":"Serinum","slug":"serinum"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"Актиферрин - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/4476/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/4476/share_default/"}},"diseases":[{"id":"318","title":"Железодефицитная анемия","slug":"318-zhelezodefitsitnaya_anemiya"},{"id":"423","title":"Недостаточность железа","slug":"423-nedostatochnost_zheleza"}],"other_packages":[],"other_product_forms":[],"related_products":{"title":"Похожие товары","type":"similar","products":[{"id":95266,"title":"Сорбифер 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