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"}},{"type":"paragraph","data":{"text":"При необходимости назначения препарата в период лактации грудное\nвскармливание должно быть прекращено, так как метронидазол проникает в грудное\nмолоко. Грудное вскармливание можно возобновить через 24 - 48 ч после окончания\nлечения. "}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Интравагинально."}},{"type":"paragraph","data":{"text":"Предварительно освободив суппозиторий от контурной упаковки при помощи\nножниц (разрезать пленку по контуру суппозитория), ввести его глубоко во\nвлагалище."}},{"type":"paragraph","data":{"text":"По 1 суппозиторию утром и на ночь в течение 7 дней. При рецидивирующих\nвагинитах или вагинитах резистентных к другим видам лечения, применять в\nтечение 14 дней."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"\u003ci\u003eМестные реакции: \u003c/i\u003eжжение,\nзуд, раздражение слизистой оболочки влагалища и усиление отечности. Из-за\nвоспаления слизистой оболочки влагалища при вагините раздражение может\nусиливаться после введения первого суппозитория или к третьему дню лечения. Эти\nосложнения быстро исчезают после прекращения лечения."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны желудочно-кишечного тракта: \u003c/i\u003eболь или спазмы в животе, «металлический»\nпривкус, сухость во рту, запор, диарея, потеря аппетита, тошнота, рвота."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны нервной системы:\u003c/i\u003e головная боль, двигательные нарушения (атаксия), головокружение,\nпсихоэмоциональные нарушения (тревожность, лабильность настроения, повышенная\nутомляемость), судороги."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны системы кроветворения:\u003c/i\u003e лейкопения."}},{"type":"paragraph","data":{"text":"\u003ci\u003eАллергические реакции:\u003c/i\u003e кожные высыпания, в том числе крапивница.\u003cb\u003e\u003c/b\u003e"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"При соблюдении рекомендуемых доз, в связи с низкой абсорбцией препарата,\nслучаи передозировки не выявлены. "}},{"type":"paragraph","data":{"text":"Возможные \u003ci\u003eсимптомы:\u003c/i\u003e тошнота, рвота, боль в животе, диарея, зуд,\nметаллический привкус во рту, атаксия, головокружение, парестезии,\nпериферическая невропатия (при продолжительном применении в высоких дозах),\nсудороги, лейкопения, темное окрашивание мочи (обусловлено передозировкой\nметронидазола)."}},{"type":"paragraph","data":{"text":"Симптомы передозировки миконазола не выявлены. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение:\u003c/i\u003e\nсимптоматическая и поддерживающая терапия, при случайном приеме внутрь -\nпромывание желудка. "}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"В связи с попаданием\nметронидазола в системный кровоток могут отмечать следующие реакции\nвзаимодействия при одновременном применении с некоторыми веществами: "}},{"type":"paragraph","data":{"text":"\u003ci\u003eПероральные антикоагулянты:\u003c/i\u003e усиливается действие\nнепрямых антикоагулянтов. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eДисульфирам:\u003c/i\u003e могут\nнаблюдаться нарушения со стороны ЦНС (психические реакции); не следует\nназначать метронидазол больным, которые принимали дисульфирам в течение\nпоследних 2 недель; "}},{"type":"paragraph","data":{"text":"\u003ci\u003eФенитоин:\u003c/i\u003e повышается\nконцентрация фенитоина в крови; а концентрация метронидазола в крови снижается.\n"}},{"type":"paragraph","data":{"text":"\u003ci\u003eПрепараты лития:\u003c/i\u003e может\nнаблюдаться повышение их токсичности. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eФенобарбитал:\u003c/i\u003e снижается\nконцентрация метронидазола в крови. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eЦиметидин:\u003c/i\u003e может\nповыситься концентрация метронидазола в крови. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eАстемизол и терфенадин\u003c/i\u003e: метронидазол и миконазол ингибируют метаболизм этих препаратов и\nповышают концентрацию в плазме крови. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eЭтанол:\u003c/i\u003e\nвзаимодействие метронидазола с этанолом вызывает дисульфирамоподобные реакции. "}}]},{"id":8,"name":"Особые указания","slug":"","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"При применении препарата следует воздерживаться от половых контактов. "}},{"type":"paragraph","data":{"text":"С целью избежания повторного инфицирования необходимо одновременное\nлечение полового партнера. В случае трихомонадного вагинита целесообразно\nодновременное лечение полового партнера метронидазолом для приема внутрь. "}},{"type":"paragraph","data":{"text":"Во время лечения и, по крайней мере, в течение 24-48 ч после окончания\nкурса лечения следует избегать приема этанола (возможна непереносимость\nэтанола)."}},{"type":"paragraph","data":{"text":"Не рекомендуется одновременное применение препарата с контрацептивными\nдиафрагмами и презервативами из каучука или латекса (возможно взаимодействие с\nосновой суппозиториев). "}},{"type":"paragraph","data":{"text":"При сильном раздражении влагалища лечение препаратом следует прекратить.\n"}},{"type":"paragraph","data":{"text":"Суппозитории следует применять только интравагинально, их нельзя\nпроглатывать или применять другим способом. "}},{"type":"paragraph","data":{"text":"В случае применения препарата совместно с метронидазолом для приема\nвнутрь, особенно при повторном курсе, необходим контроль картины периферической\nкрови (опасность лейкопении). "}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Применение препарата не влияет на способность\nуправлять транспортными средствами и заниматься другими потенциально опасными\nвидами деятельности, требующими повышенной концентрации внимания и быстроты\nпсихомоторных реакций, однако при появлении побочных эффектов со стороны\nцентральной нервной системы, следует воздержаться от управления транспортными\nсредствами и занятий другими потенциально опасными видами деятельности,\nтребующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Суппозитории вагинальные содержащие метронидазол 500 мг и миконазола\nнитрат 100 мг. "}},{"type":"paragraph","data":{"text":"По 7 суппозиториев в контурную ячейковую упаковку из ПВХ/ПЭ пленки. "}},{"type":"paragraph","data":{"text":"По 2 контурные ячейковые упаковки вместе с инструкцией по применению в\nпачку картонную. "}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года. "}},{"type":"paragraph","data":{"text":"Не использовать после истечения срока годности. "}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают по рецепту. "}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ООО «ФАРМАПРИМ»"}},{"type":"paragraph","data":{"text":"МD-4829, Республика Молдова, р-он Криулень,"}},{"type":"paragraph","data":{"text":"с. Порумбень, ул. Кринилор, д. 5."}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО «Авексима Сибирь»"}},{"type":"paragraph","data":{"text":"652473, Россия, Кемеровская обл., "}},{"type":"paragraph","data":{"text":"г. Анжеро-Судженск, ул. Герцена, д. 7."}},{"type":"paragraph","data":{"text":"Тел./факс: (38453)\n5-23-51."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Фармакодинамика.Метронидазол относится к 5-нитроимидазолам и является препаратом с бактерицидным типом действия, проявляющим тропность (способность взаимодействия) к дезоксирибонуклеиновой кислоте. Механизм действия заключается в биохимическом восстановлении 5-нитрогруппы метронидазола внутриклеточными транспортными протеинами анаэробных микроорганизмов и простейших. Восстановленная 5-нитрогруппа метронидазола взаимодействует с дезоксирибонуклеиновой кислотой клетки микроорганизмов, ингибируя синтез их нуклеиновых кислот, что ведет к гибели бактерий. Активен в отношении простейших:Trichomonas vaginalis, Entamoeba histolytica,а также облигатных анаэробных бактерий: грамотрицательных –Bacteroides spp.(в том числеBacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens),грамположительных –Clostridium spp., Eubacterium spp., Peptococcus spp., Peptostreptococcus spp., Mobiluncus spp.и факультативного анаэроба– Gardnerella vaginalis.К метронидазолу нечувствительны аэробные микроорганизмы, но в присутствии смешанной флоры (аэробы и анаэробы) метронидазол действует синергично с антибиотиками, эффективными против обычных аэробов. Миконазол является противогрибковым средством, производным азола. При интравагинальном применении активен в основном в отношенииCandida albicans.Фунгицидный и фунгистатический эффект миконазола обусловлен ингибированием биосинтеза эргостерола оболочки и плазматических мембран грибов, измене­нием липидного состава и проницаемости клеточной стенки, вызывая гибель клетки гриба.Фармакокинетика.По сравнению с приемом внутрь биодоступность метронидазола при интравагинальном введении составляет 20 %. Метронидазол метаболизи­руется в печени. Гидроксильные метаболиты активны. Период полувыведения метронидазола составляет 6 - 11 ч. Около 20 % дозы выводится в неизменном виде с мочой. 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