Цисплатин (цис-диаминдихлорплатина), представляет собой прот... Инструкция
Показания к применению
Цисплатин, обычно в составе комбинированной химиотерапии, широко применяется при лечении следующих солидных опухолей: герминогенные опухоли женщин и мужчин, рак яичников и яичка, мелкоклеточный и немелкоклеточный рак легкого, плоскоклеточный рак головы и шеи, рак мочевого пузыря. Кроме того, цисплатин обладает противоопухолевой активностью при следующих ...
Концентрат для приготовления раствора для инфузий Кемоплат - прозрачный раствор от бесцветного до бледно-желтого цвета с активным веществом цисплатином обладает иммуносупрессивными и радиосенсибилизирующими свойствами.
Фармакологические свойства
Цисплатин (цис-диаминдихлорплатина), представляет собой противоопухолевый препарат, содержащий тяжелый металл платину. Цисплатин обладает свойствами, сходными со свойствами бифункциональных алкилирующих агентов, образующих межтяжевые и внутритяжевые сшивки в ДНК тем самым нарушая ее функции, что приводит к гибели клеток, при этом препарат не обладает циклической и фазовой специфичностью. Обладает иммуносупрессивными и радиосенсибилизирующими свойствами.
Показания к применению
Цисплатин, обычно в составе комбинированной химиотерапии, широко применяется при лечении следующих солидных опухолей: герминогенные опухоли женщин и мужчин, рак яичников и яичка, мелкоклеточный и немелкоклеточный рак легкого, плоскоклеточный рак головы и шеи, рак мочевого пузыря. Кроме того, цисплатин обладает противоопухолевой активностью при следующих видах опухолей: рак шейки матки, остеосаркома, меланома, нейробластома, рак пищевода.
Способ применения и дозы
Кемоплат может применяться как в качестве монотерапии, так и в комбинации с другими цитостатиками в различных дозах в зависимости от схемы терапии. При индивидуальном подборе дозы следует руководствоваться данными специальной литературы. Кемоплат вводится внутривенно или при показаниях (интраперитонеальные опухоли) в брюшную полость. Кемоплат в монотерапии и в сочетании с другими химиопрепаратами обычно вводится в дозе 50-100 мг/м2 в виде внутривенной инфузии каждые 3-4 недели или 15-20 мг/м2 внутривенно капельно ежедневно в течение 5 дней каждые 3-4 недели.
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