Повышенная чувствительность к активному веществу или к любому из компонентов препарата. Острая циркуляторная недостаточность, тяжелая артериальная гипотензия (систолическое давление ниже 90 мм рт.ст.) или гиповолемия, коллапс. кардиогенный шок, если не обеспечено достаточно высокий конечный диастолическое давление в левом желудочке путем применения ...
Антиангинальный препарат. Периферический вазодилататор с преимущественным влиянием на венозные сосуды. Стимулирует образование оксида азота (эндотелиального релаксирующего фактора) в эндотелии сосудов, вызывающего активацию внутриклеточной гуанилатциклазы, следствием этого является повышение уровня цГМФ (медиатора вазодилатации). Уменьшает потребность миокарда в кислороде за счет снижения преднагрузки и постнагрузки. Обладает коронарорасширяющим действием. Снижает приток крови к правому предсердию, способствует снижению давления в малом круге кровообращения и регрессии симптомов при отеке легких. Способствует перераспределению коронарного кровотока в области со сниженным кровоснабжением. Повышает толерантность к физической нагрузке у пациентов с ИБС, стенокардией. Расширяет сосуды головного мозга, твердой мозговой оболочки, что может сопровождаться головной болью. Как и к другим нитратам, к препарату развивается перекрестная толерантность. После отмены (перерыва в лечении) чувствительность к препарату быстро восстанавливается. Антиангинальный эффект развивается через 30-45 мин после приема препарата и продолжается до 8-10 ч.
Повышенная чувствительность к активному веществу или к любому из компонентов препарата. Острая циркуляторная недостаточность, тяжелая артериальная гипотензия (систолическое давление ниже 90 мм рт.ст.) или гиповолемия, коллапс. кардиогенный шок, если не обеспечено достаточно высокий конечный диастолическое давление в левом желудочке путем применения интрааортальнои контрпульсации или препаратов с положительным инотропным эффектом. Острый инфаркт миокарда с низким давлением наполнения левого желудочка. Выраженная анемия. Токсический отек легких. Недавно перенесенная черепно-мозговая травма или кровоизлияние в мозг, повышенное внутричерепное давление. Глаукома. Повышенная чувствительность к нитратам. Одновременное применение силденафила и другими ингибиторами фосфодиэстеразы.
Применение при беременности и в период грудного вскармливания
Применение при беременности возможно только в случаях, когда предполагаемая польза для матери превышает потенциальный риск для плода.
Способ применения и дозы
Препарат применять внутрь перед приемом пищи, не разжевывая, запивая достаточным количеством жидкости. Дозу и кратность приема устанавливает врач индивидуально. Для достижения максимального терапевтического эффекта рекомендуется индивидуальное дозирование препарата в зависимости от состояния пациента, его реакции на препарат и переносимости. Начинать лечение с низких доз, которые в процессе лечения при необходимости повышать. Рекомендуемая доза - 40 мг 2 раза в сутки. В большинстве случаев назначать по 20 мг 2 раза в сутки или по 40 мг 2 раза в сутки утром и после обеда. С целью предотвращения развития толерантности к нитратам (при любом режиме дозирования) вторую таблетку рекомендуется принимать не ранее, чем через 8: 00 после приема первой. При лечении стенокардии с частыми ночными приступами препарат следует применять утром и непосредственно перед сном. Для определения индивидуального дозирования важное значение имеет мониторинг гемодинамики. Суточная доза, в зависимости от тяжести течения заболевания, может достигать 120 мг (максимальная суточная доза), разделенная на 3 приема. Дети. Препарат не применять детям.
Побочное действие
Со стороны нервной системы головная боль, которая постепенно уменьшается в течение нескольких суток, но может быть сильным и устойчивым. рассеянность, головокружение, сонливость и слабость, двигательное беспокойство, обмороки. Со стороны сердечно-сосудистой системы артериальная (в т.ч. ортостатическая) гипотензия, коллапс с нарушением сердечного ритма и брадикардией, усиление симптомов стенокардии, брадиаритмия, рефлекторная тахикардия, переходящая гипоксемия с гипоксии миокарда у пациентов с ишемической болезнью сердца. Со стороны пищеварительного тракта тошнота, рвота, диарея, диспепсия. Со стороны кожи и подкожной клетчатки кожные аллергические реакции (в т.ч. сыпь, зуд, эксфолиативный дерматит), дилатация сосудов кожи с покраснением, бледность и повышенное потоотделение. Со стороны иммунной системы у пациентов с индивидуальной непереносимостью к компонентам препарата возможны реакции гиперчувствительности. Другие гиперемия лица, шум в ушах, астения. Наблюдались случаи возникновения толерантности к препарату, в т.ч. перекрестной толерантности к другим органическим нитратам. Чтобы предотвратить ослабление эффекта от применения или полной неэффективности лекарственного средства, рекомендуется избегать непрерывного применения высоких доз в течение длительного времени.
Передозировка
Симптомы: головная боль, головокружение, сердцебиение, гипертермия, гиперемия кожи, потливость, тошнота, рвота, диарея, метгемоглобинемия (цианоз, аноксия), гиперпноэ, диспноэ, брадикардия, судороги, зрительные расстройства, повышение внутричерепного давления, коллапс, обморок, паралич, кома. Лечение: промывание желудка; при метгемоглобинемии – внутрь или в/в аскорбиновая кислота 1 г, в/в - 1% раствор метилтиониния хлорида (метиленового синего) в дозе 1-2 мг/кг массы тела. Симптоматическая терапия при тяжелой артериальной гипотензии - в/в фенилэфрин (эпинефрин и родственные ему соединения малоэффективны).
Особые указания
Моносан не применяют для купирования приступов стенокардии. В период терапии необходимо осуществлять контроль АД, ЧСС. При необходимости применения препарата на фоне артериальной гипотензии следует одновременно принимать препараты, обладающие положительным инотропным эффектом. Частый прием и применение в высоких дозах могут вызвать развитие толерантности; в этом случае после 3-6 недель регулярного приема рекомендуется отмена Моносана на 24-48 ч или перерыв в терапии на 3-5 дней с заменой препарата на это время другими антиангинальными препаратами. Необходимо избегать резкой отмены препарата и снижать дозу постепенно. Влияние на способность к вождению автотранспорта и управлению механизмами В период применения препарата возможно снижение психомоторных реакций пациента, поэтому следует с осторожностью управлять транспортными средствами и заниматься потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций.
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