Лечение и профилактика гриппа А и В и других острых респираторных вирусных
инфекций (аденовирусная инфекция, парагрипп, респираторно-синцитиальная
инфекция, риновирусная инфекция) у взрослых и детей от 3 лет.
Противопоказания
Повышенная чувствительность к действующему веществу или любому другому
компоненту препарата.
для дозировки 30 мг - титана диоксид Е 171,
краситель бриллиантовый черный Е 151, краситель синий патентованный Е 131,
краситель пунцовый [Понсо 4 R] Е 124, краситель азорубин Е 122, желатин;
для дозировки 90 мг - титана диоксид Е 171, краситель пунцовый [Понсо 4 R]
Е 124,краситель азорубин Е 122, краситель хинолиновый желтый Е 104,
желатин;
состав чернил для логотипа: шеллак, пропиленгликоль Е 1520,
титана диоксид Е 171.
Описание
Капсулы № 2 или № 4 синего цвета (для дозировки 30 мг), капсулы № 2 или № 3
красного цвета (для дозировки 90 мг). На крышечке капсулы нанесен логотип
белого цвета в виде кольца и буквы И внутри кольца. Содержимое капсул —гранулы и порошок белого или почти
белого цвета; допускается образование конгломератов, легко рассыпающихся при
легком надавливании.
В доклинических и клинических исследованиях показана эффективность
препарата Ингавирин® в отношении вирусов гриппа типа A (A(H1N1), в т.ч. пандемический штамм A(H1N1)pdm09 («свиной»), A(H3N2), A(H5N1)) и типа В, аденовируса, вируса парагриппа, респираторно-синцитиального
вируса; в доклинических исследованиях: коронавируса, метапневмовируса,
энтеровирусов, в том числе вируса Коксаки и риновируса. В клиническом
исследовании у амбулаторных пациентов с COVID-19 легкого течения препарат Ингавирин® сокращал время до клинического
выздоровления.
Механизм действия реализуется на уровне инфицированных клеток за счет
активации факторов врожденного иммунитета,
подавля-емых вирусными белками. В экспериментальных исследованиях, в частности, показа-но, что
препарат Ингавирин® повышает экс-прессию рецептора интерферона
первого типа IFNAR на поверхности эпителиальных и иммунокомпетентных клеток. Увеличение
плотности интерфероновых рецепторов приводит к повышению чувствительности
клеток к сигналам эндогенного интерферона. Процесс сопровождается активацией
(фосфорилированием) белка-трансмиттера STAT1, передающего сигнал в ядро клетки для индукции синтеза противовирусных
генов. Показано, что в условиях инфекции препарат активирует синтез
антивирусного эффекторного белка МхА (ранний фактор противовирусного ответа,
ингибирующий внутриклеточный транспорт рибонуклеопротеиновых комплексов
различных вирусов) и фосфорилированной формы PКR, подавляющей трансляцию вирусных белков, таким образом замедляя и
останавливая процесс вирусной репродукции.
Действие препарата Ингавирин® заключается в значительном
уменьшении признаков цитопатического и цитодеструктивного действия вируса,
снижении количества инфицированных клеток, ограничении патоло-гического
процесса, нормализации состава и структуры клеток и морфологической картины
тканей в зоне инфекционного процесса, как на ранних, так и на поздних его
стадиях.
Противовоспалительное действие обусловлено подавлением продукции ключевых
провоспалительных цитокинов (фактора некроза опухоли (TNF-α), интерлейкинов (IL-1β и IL-6)), снижением
активности миелопероксидазы.
В экспериментальных исследованиях показано, что совместное использование
препарата Ингавирин® с антибиотиками повышает эффективность терапии
на модели бактериального сепсиса, в том числе вызванного
пенициллин-резистентными штаммами стафилококка.
Проведенные экспериментальные токсикологические исследования
свидетельствуют о низком уровне токсичности и высоком профиле безопасности
препарата.
По параметрам острой токсичности препарат Ингавирин® относится к
4 классу токсичности - «Малотоксичные вещества» (при определении LD50 в экспериментах по острой токсичности летальные дозы
препарата определить не удалось).
Препарат не обладает мутагенными, иммунотоксическими, аллергизирующими и
канцерогенными свойствами, не оказывает местнораздражающего действия. Препарат
Ингавирин® не влияет на репродуктивную функцию, не оказывает
эмбриотоксического и тератогенного действия.
Отсутствует влияние препарата Ингавирин® на систему
кроветворения при приеме соответствующей возрасту дозы рекомендованными схемой
и курсом.
Фармакокинетика
Всасывание и распределение.
В эксперименте с использованием радиоактивной метки установлено: препарат быстро поступает в кровь из
желудочно-кишечного тракта, распределяясь по внутренним органам. Максимальные
концентрации в крови, плазме крови и большинстве органов достигаются через 30
минут после введения препарата. Величины AUC (площадь под фармакокинетической кривой «концентрация - время»)
почек, печени и легких незначительно превышают
AUC крови (43,77 мкг.ч/г). Величины AUC для селезенки, надпочечников, лимфатических узлов и тимуса ниже AUC крови. MRT (среднее время удержания препарата) в
крови - 37,2 часа.
При курсовом приеме препарата один раз в сутки происходит его накопление во
внутренних органах и тканях. При этом качественные характеристики фармакокинетических
кривых после каждого введения препарата тождественны: быстрое повышение
концентрации препарата после каждого введения через 0,5-1 час после приема и
затем медленное снижение к 24 часам.
Метаболизм.
Препарат не метаболизируется в организме и выводится в неизмененном виде.
Выведение.
Основной процесс выведения происходит в течение 24 часов. За этот период
выводится 80 % принятой дозы: 34,8 % выводится во временном интервале от 0 до 5
часов и 45,2 % во временном интервале от 5 до 24 часов. Из них 77 % выводится
через кишечник и 23 % - через почки.
Метаболизм.
Препарат не метаболизируется в организме и выводится в
неизмененном виде.
Выведение.
Основной процесс выведения происходит в течение 24 часов.
За этот период выводится 80 % принятой дозы: 34,8 % выводится во временном
интервале от 0 до 5 часов и 45,2 % во временном интервале от 5 до 24 часов. Из
них 77 % выводится через кишечник и 23 % - через почки.
Показания к применению
Лечение и профилактика гриппа А и В и других острых респираторных вирусных
инфекций (аденовирусная инфекция, парагрипп, респираторно-синцитиальная
инфекция, риновирусная инфекция) у взрослых и детей от 3 лет.
Противопоказания
Повышенная чувствительность к действующему веществу или любому другому
компоненту препарата.
Применение при беременности и в период грудного вскармливания
Применение препарата во время беременности не изучалось.
Применение препарата во время лактации не изучалось, поэтому при
необходимости применения препарата в период лактации следует прекратить грудное
вскармливание.
Способ применения и дозы
Внутрь. Независимо от приема пищи.
У детей от 3 до 6 лет, которые испытывают трудности с
проглатыванием капсулы, допускается разведение содержимого капсулы в воде или
яблочном соке. Для этого необходимо аккуратно открыть капсулу над емкостью с
небольшим количеством (50-70 мл) кипяченой воды или яблочного сока комнатной
температуры, высыпать содержимое капсулы в воду или сок, перемешать смесь в
течение 20 секунд и выпить ее целиком. Допускается добавление сахара. Смесь
следует готовить непосредственно перед приемом; готовая смесь хранению не
подлежит.
Для лечения и профилактики гриппа и острых респираторных
вирусных инфекций взрослым назначают по 90 мг 1 раз в день, детям от 7 лет - по
60 мг 1 раз в день, детям от 3 до 6 лет - по 30 мг 1 раз в день.
Длительность лечения гриппа и острых респираторных
вирусных инфекций у взрослых и детей от 7 лет - 5-7 дней (в зависимости
от тяжести состояния). Длительность лечения гриппа и острых респираторных
вирусных инфекций у детей от 3 до 6 лет -
5 дней. Прием препарата начинают с момента появления первых симптомов
заболевания, желательно не позднее 2 суток от начала болезни.
Взрослым и детям при выраженных симптомах, а также при
наличии сопутствующих заболеваний (болезни дыхательной и сердечно-сосудистой
систем, сахарный диабет, ожирение) следует принимать двойную дозу препарата в
первые три дня заболевания, далее продолжить приём в обычной дозировке в
течение 2-4 дней.
Для профилактики гриппа и острых респираторных вирусных
инфекций после контакта с больными лицами взрослым и детям от 7 лет препарат
назначают в течение 7 дней, детям от 3 до 6 лет - в течение 5 дней.
Если через 5 дней лечения улучшения не наступает или
симптомы усугубляются, или появляются новые симптомы, необходимо
проконсультироваться с врачом. Применяйте препарат только согласно тем
показаниям, тому способу применения и в тех дозах, которые указаны в
инструкции.
Побочное действие
Аллергические реакции (редко).
Если любые из указанных в инструкции побочных эффектов усугубляются или Вы
заметили любые другие побочные эффекты, не указанные в инструкции, сообщите об
этом врачу.
Передозировка
О случаях
передозировки препарата Ингавирин® до настоящего времени не
сообщалось.
Взаимодействие с другими лекарственными средствами
Лекарственное взаимодействие препарата Ингавирин® не описано.
Особые указания
Не рекомендуется одновременный прием других
противовирусных препаратов без предварительной консультации врача.
Сохраняйте инструкцию. Она может понадобиться вновь. Если
у Вас возникли вопросы, обратитесь к врачу.
Влияние на способность управлять автомобилем и движущимися механизмами
Не изучалось, однако, учитывая механизм действия и профиль побочных
реакций, можно предположить, что препарат не оказывает влияния на способность
управлять транспортными средствами, механизмами.
Форма выпуска
Капсулы 30 мг и 90 мг.
По 7 или 10 капсул в контурную ячейковую упаковку или в контурную ячейковую
упаковку с перфорацией из пленки поливинилхлоридной и фольги алюминиевой
печатной лакированной.
1 или 2 контурные упаковки (для дозировки 30 мг), или 1 контурную упаковку
(для дозировки 90 мг) вместе с инструкцией по применению помещают в пачку.
Условия хранения
В оригинальной упаковке при температуре не выше 25 °С.
Хранить в недоступном для детей месте.
Срок годности
3 года.
Не применять по истечении срока годности, указанного на упаковке.
Условия отпуска
Отпускают без рецепта.
Производитель
АО «Валента Фарм»
141101, Россия, Московская область, г. Щелково, ул. Фабричная, д. 2.
Тел. +7 (495) 933 48 62,
факс +7 (495) 933 48 63.
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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препарата","slug":"","body":[{"type":"paragraph","data":{"text":"Ингaвиpин"}}]},{"id":16,"name":"Лекарственная форма","slug":"","body":[{"type":"paragraph","data":{"text":"капсулы"}}]},{"id":1,"name":"Состав","slug":"ingredients","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Одна капсула содержит:"}},{"type":"paragraph","data":{"text":"\u003ci\u003eдействующее вещество: \u003c/i\u003eимидазолилэтанамид пентандиовой\nкислоты (витаглутам) в пересчете на 100 % вещество - 30,00 мг или 90,00 мг;"}},{"type":"paragraph","data":{"text":"\u003ci\u003eвспомогательные вещества: лактозы моногидрат, крахмал картофельный, кремния\nдиоксид коллоидный (аэросил), магния стеарат;\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eкапсулы твердые желатиновые: \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eдля дозировки 30 мг\u003c/i\u003e - титана диоксид Е 171,\nкраситель бриллиантовый черный Е 151, краситель синий патентованный Е 131,\nкраситель пунцовый [Понсо 4 R] Е 124, краситель азорубин Е 122, желатин;"}},{"type":"paragraph","data":{"text":"\u003ci\u003eдля дозировки 90 мг - титана диоксид Е 171, краситель пунцовый [Понсо 4 R]\nЕ 124,\u003cb\u003e \u003c/b\u003eкраситель азорубин Е 122, краситель хинолиновый желтый Е 104,\nжелатин;\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eсостав чернил для логотипа: шеллак, пропиленгликоль \u003cb\u003e \u003c/b\u003eЕ 1520, \nтитана диоксид Е 171.\u003c/i\u003e"}}]},{"id":2,"name":"Описание","slug":"common_description","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Капсулы № 2 или № 4 синего цвета (для дозировки 30 мг), капсулы № 2 или № 3\nкрасного цвета (для дозировки 90 мг). На крышечке капсулы нанесен логотип\nбелого цвета в виде кольца и буквы И внутри кольца. Содержимое капсул —гранулы и порошок белого или почти\nбелого цвета; допускается образование конгломератов, легко рассыпающихся при\nлегком надавливании."}}]},{"id":17,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"Противовирусное средство. Противовоспалительное средство."}},{"type":"paragraph","data":{"text":"\u003cb\u003eКод АТХ\u003c/b\u003e: [J05AX]."}}]},{"id":3,"name":"Фармакологические свойства","slug":"pharmacologic_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"\u003cb\u003eФармакодинамика\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Противовирусный препарат."}},{"type":"paragraph","data":{"text":"В доклинических и клинических исследованиях показана эффективность\nпрепарата Ингавирин\u003csup\u003e®\u003c/sup\u003e в отношении вирусов гриппа типа A (A(H1N1), в т.ч. пандемический штамм A(H1N1)pdm09 («свиной»), A(H3N2), A(H5N1)) и типа В, аденовируса, вируса парагриппа, респираторно-синцитиального\nвируса; в доклинических исследованиях: коронавируса, метапневмовируса,\nэнтеровирусов, в том числе вируса Коксаки и риновируса. В клиническом\nисследовании у амбулаторных пациентов с COVID-19 легкого течения препарат Ингавирин® сокращал время до клинического\nвыздоровления."}},{"type":"paragraph","data":{"text":"Механизм действия реализуется на уровне инфицированных клеток за счет\nактивации факторов врожденного иммунитета,\nподавля-емых вирусными белками. В экспериментальных исследованиях, в частности, показа-но, что\nпрепарат Ингавирин\u003csup\u003e®\u003c/sup\u003e повышает экс-прессию рецептора интерферона\nпервого типа IFNAR на поверхности эпителиальных и иммунокомпетентных клеток. Увеличение\nплотности интерфероновых рецепторов приводит к повышению чувствительности\nклеток к сигналам эндогенного интерферона. Процесс сопровождается активацией\n(фосфорилированием) белка-трансмиттера STAT1, передающего сигнал в ядро клетки для индукции синтеза противовирусных\nгенов. Показано, что в условиях инфекции препарат активирует синтез\nантивирусного эффекторного белка МхА (ранний фактор противовирусного ответа,\nингибирующий внутриклеточный транспорт рибонуклеопротеиновых комплексов\nразличных вирусов) и фосфорилированной формы PКR, подавляющей трансляцию вирусных белков, таким образом замедляя и\nостанавливая процесс вирусной репродукции. "}},{"type":"paragraph","data":{"text":"Действие препарата Ингавирин\u003csup\u003e®\u003c/sup\u003e заключается в значительном\nуменьшении признаков цитопатического и цитодеструктивного действия вируса,\nснижении количества инфицированных клеток, ограничении патоло-гического\nпроцесса, нормализации состава и структуры клеток и морфологической картины\nтканей в зоне инфекционного процесса, как на ранних, так и на поздних его\nстадиях."}},{"type":"paragraph","data":{"text":"Противовоспалительное действие обусловлено подавлением продукции ключевых\nпровоспалительных цитокинов (фактора некроза опухоли (TNF-α), интерлейкинов (IL-1β и IL-6)), снижением\nактивности миелопероксидазы."}},{"type":"paragraph","data":{"text":"В экспериментальных исследованиях показано, что совместное использование\nпрепарата Ингавирин\u003csup\u003e®\u003c/sup\u003e с антибиотиками повышает эффективность терапии\nна модели бактериального сепсиса, в том числе вызванного\nпенициллин-резистентными штаммами стафилококка."}},{"type":"paragraph","data":{"text":"Проведенные экспериментальные токсикологические исследования\nсвидетельствуют о низком уровне токсичности и высоком профиле безопасности\nпрепарата."}},{"type":"paragraph","data":{"text":"По параметрам острой токсичности препарат Ингавирин\u003csup\u003e®\u003c/sup\u003e относится к\n4 классу токсичности - «Малотоксичные вещества» (при определении LD\u003csub\u003e50\u003c/sub\u003e в экспериментах по острой токсичности летальные дозы\nпрепарата определить не удалось)."}},{"type":"paragraph","data":{"text":"Препарат не обладает мутагенными, иммунотоксическими, аллергизирующими и\nканцерогенными свойствами, не оказывает местнораздражающего действия. Препарат\nИнгавирин\u003csup\u003e®\u003c/sup\u003e не влияет на репродуктивную функцию, не оказывает\nэмбриотоксического и тератогенного действия."}},{"type":"paragraph","data":{"text":"Отсутствует влияние препарата Ингавирин\u003csup\u003e®\u003c/sup\u003e на систему\nкроветворения при приеме соответствующей возрасту дозы рекомендованными схемой\nи курсом."}},{"type":"paragraph","data":{"text":"\u003cb\u003eФармакокинетика\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Всасывание и распределение."}},{"type":"paragraph","data":{"text":"В эксперименте с использованием радиоактивной метки установлено: препарат быстро поступает в кровь из\nжелудочно-кишечного тракта, распределяясь по внутренним органам. Максимальные\nконцентрации в крови, плазме крови и большинстве органов достигаются через 30\nминут после введения препарата. Величины AUC (площадь под фармакокинетической кривой «концентрация \u003cb\u003e-\u003c/b\u003e время»)\nпочек, печени и легких незначительно превышают\nAUC крови (43,77 мкг.ч/г). Величины AUC для селезенки, надпочечников, лимфатических узлов и тимуса ниже AUC крови. MRT (среднее время удержания препарата) в\nкрови \u003cb\u003e-\u003c/b\u003e 37,2 часа."}},{"type":"paragraph","data":{"text":"При курсовом приеме препарата один раз в сутки происходит его накопление во\nвнутренних органах и тканях. При этом качественные характеристики фармакокинетических\nкривых после каждого введения препарата тождественны: быстрое повышение\nконцентрации препарата после каждого введения через 0,5-1 час после приема и\nзатем медленное снижение к 24 часам."}},{"type":"paragraph","data":{"text":"Метаболизм."}},{"type":"paragraph","data":{"text":"Препарат не метаболизируется в организме и выводится в неизмененном виде."}},{"type":"paragraph","data":{"text":"Выведение."}},{"type":"paragraph","data":{"text":"Основной процесс выведения происходит в течение 24 часов. За этот период\nвыводится 80 % принятой дозы: 34,8 % выводится во временном интервале от 0 до 5\nчасов и 45,2 % во временном интервале от 5 до 24 часов. Из них 77 % выводится\nчерез кишечник и 23 % - через почки."}},{"type":"paragraph","data":{"text":"Метаболизм."}},{"type":"paragraph","data":{"text":"Препарат не метаболизируется в организме и выводится в\nнеизмененном виде."}},{"type":"paragraph","data":{"text":"Выведение."}},{"type":"paragraph","data":{"text":"Основной процесс выведения происходит в течение 24 часов.\nЗа этот период выводится 80 % принятой дозы: 34,8 % выводится во временном\nинтервале от 0 до 5 часов и 45,2 % во временном интервале от 5 до 24 часов. Из\nних 77 % выводится через кишечник и 23 % - через почки."}}]},{"id":4,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Лечение и профилактика гриппа А и В и других острых респираторных вирусных\nинфекций (аденовирусная инфекция, парагрипп, респираторно-синцитиальная\nинфекция, риновирусная инфекция) у взрослых и детей от 3 лет."}}]},{"id":5,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к действующему веществу или любому другому\nкомпоненту препарата."}},{"type":"paragraph","data":{"text":"Дефицит лактазы, непереносимость лактозы, глюкозо-галактозная\nмальабсорбция."}},{"type":"paragraph","data":{"text":"Беременность."}},{"type":"paragraph","data":{"text":"Период грудного вскармливания."}},{"type":"paragraph","data":{"text":"Детский возраст до 3 лет."}}]},{"id":6,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Применение препарата во время беременности не изучалось."}},{"type":"paragraph","data":{"text":"Применение препарата во время лактации не изучалось, поэтому при\nнеобходимости применения препарата в период лактации следует прекратить грудное\nвскармливание."}}]},{"id":7,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Внутрь. Независимо от приема пищи."}},{"type":"paragraph","data":{"text":"У детей от 3 до 6 лет, которые испытывают трудности с\nпроглатыванием капсулы, допускается разведение содержимого капсулы в воде или\nяблочном соке. Для этого необходимо аккуратно открыть капсулу над емкостью с\nнебольшим количеством (50-70 мл) кипяченой воды или яблочного сока комнатной\nтемпературы, высыпать содержимое капсулы в воду или сок, перемешать смесь в\nтечение 20 секунд и выпить ее целиком. Допускается добавление сахара. Смесь\nследует готовить непосредственно перед приемом; готовая смесь хранению не\nподлежит."}},{"type":"paragraph","data":{"text":"Для лечения и профилактики гриппа и острых респираторных\nвирусных инфекций взрослым назначают по 90 мг 1 раз в день, детям от 7 лет - по\n60 мг 1 раз в день, детям от 3 до 6 лет - по 30 мг 1 раз в день."}},{"type":"paragraph","data":{"text":"Длительность лечения гриппа и острых респираторных\nвирусных инфекций у взрослых и детей от 7 лет \u003cb\u003e-\u003c/b\u003e 5-7 дней (в зависимости\nот тяжести состояния). Длительность лечения гриппа и острых респираторных\nвирусных инфекций у детей от 3 до 6 лет - \n5 дней. Прием препарата начинают с момента появления первых симптомов\nзаболевания, желательно не позднее 2 суток от начала болезни."}},{"type":"paragraph","data":{"text":"Взрослым и детям при выраженных симптомах, а также при\nналичии сопутствующих заболеваний (болезни дыхательной и сердечно-сосудистой\nсистем, сахарный диабет, ожирение) следует принимать двойную дозу препарата в\nпервые три дня заболевания, далее продолжить приём в обычной дозировке в\nтечение 2-4 дней."}},{"type":"paragraph","data":{"text":"Для профилактики гриппа и острых респираторных вирусных\nинфекций после контакта с больными лицами взрослым и детям от 7 лет препарат\nназначают в течение 7 дней, детям от 3 до 6 лет \u003cb\u003e-\u003c/b\u003e в течение 5 дней."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЕсли через 5 дней лечения улучшения не наступает или\nсимптомы усугубляются, или появляются новые симптомы, необходимо\nпроконсультироваться с врачом. Применяйте препарат только согласно тем\nпоказаниям, тому способу применения и в тех дозах, которые указаны в\nинструкции.\u003c/i\u003e"}}]},{"id":8,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Аллергические реакции (редко)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЕсли любые из указанных в инструкции побочных эффектов усугубляются или Вы\nзаметили любые другие побочные эффекты, не указанные в инструкции, сообщите об\nэтом врачу.\u003c/i\u003e"}}]},{"id":9,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"О случаях\nпередозировки препарата Ингавирин\u003csup\u003e®\u003c/sup\u003e до настоящего времени не\nсообщалось. "}}]},{"id":10,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Лекарственное взаимодействие препарата Ингавирин\u003csup\u003e®\u003c/sup\u003e не описано."}}]},{"id":11,"name":"Особые указания","slug":"","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Не рекомендуется одновременный прием других\nпротивовирусных препаратов без предварительной консультации врача."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСохраняйте инструкцию. Она может понадобиться вновь. Если\nу Вас возникли вопросы, обратитесь к врачу.\u003c/i\u003e"}}]},{"id":19,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Не изучалось, однако, учитывая механизм действия и профиль побочных\nреакций, можно предположить, что препарат не оказывает влияния на способность\nуправлять транспортными средствами, механизмами."}}]},{"id":20,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Капсулы 30 мг и 90 мг."}},{"type":"paragraph","data":{"text":"По 7 или 10 капсул в контурную ячейковую упаковку или в контурную ячейковую\nупаковку с перфорацией из пленки поливинилхлоридной и фольги алюминиевой\nпечатной лакированной."}},{"type":"paragraph","data":{"text":"1 или 2 контурные упаковки (для дозировки 30 мг), или 1 контурную упаковку\n(для дозировки 90 мг) вместе с инструкцией по применению помещают в пачку."}}]},{"id":12,"name":"Условия хранения","slug":"storage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"В оригинальной упаковке при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":13,"name":"Срок годности","slug":"expiry_date","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности, указанного на упаковке."}}]},{"id":14,"name":"Условия отпуска","slug":"release_condition","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"АО «Валента Фарм»"}},{"type":"paragraph","data":{"text":"141101, Россия, Московская область, г. Щелково, ул. Фабричная, д. 2."}},{"type":"paragraph","data":{"text":"Тел. +7 (495) 933 48 62,"}},{"type":"paragraph","data":{"text":"факс +7 (495) 933 48 63."}}]}],"source":null},"description_toggle":false,"short_description":"ФармакодинамикаПротивовирусный препарат. В доклинических и клинических исследованиях показана эффективность препарата Ингавирин®в отношении вирусов гриппа типа A (A(H1N1), в т.ч. пандемический штамм A(H1N1)pdm09 («свиной»), A(H3N2), A(H5N1)) и типа В, аденовируса, вируса парагриппа, респираторно-синцитиального вируса; в доклинических исследованиях: коронавируса, метапневмовируса, энтеровирусов, в том числе вируса Коксаки и риновируса. В клиническом исследовании у амбулаторных пациентов с COVID-19 легкого течения препарат Ингавирин® сокращал время до клинического выздоровления. Механизм действия реализуется на уровне инфицированных клеток за счет активации факторов врожденного иммунитета, подавля-емых вирусными белками. В экспериментальных исследованиях, в частности, показа-но, что препарат Ингавирин®повышает экс-прессию рецептора интерферона первого типа IFNAR на поверхности эпителиальных и иммунокомпетентных клеток. Увеличение плотности интерфероновых рецепторов приводит к повышению чувствительности клеток к сигналам эндогенного интерферона. Процесс сопровождается активацией (фосфорилированием) белка-трансмиттера STAT1, передающего сигнал в ядро клетки для индукции синтеза противовирусных генов. Показано, что в условиях инфекции препарат активирует синтез антивирусного эффекторного белка МхА (ранний фактор противовирусного ответа, ингибирующий внутриклеточный транспорт рибонуклеопротеиновых комплексов различных вирусов) и фосфорилированной формы PКR, подавляющей трансляцию вирусных белков, таким образом замедляя и останавливая процесс вирусной репродукции. Действие препарата Ингавирин®заключается в значительном уменьшении признаков цитопатического и цитодеструктивного действия вируса, снижении количества инфицированных клеток, ограничении патоло-гического процесса, нормализации состава и структуры клеток и морфологической картины тканей в зоне инфекционного процесса, как на ранних, так и на поздних его стадиях. Противовоспалительное действие обусловлено подавлением продукции ключевых провоспалительных цитокинов (фактора некроза опухоли (TNF-α), интерлейкинов (IL-1β и IL-6)), снижением активности миелопероксидазы. В экспериментальных исследованиях показано, что совместное использование препарата Ингавирин®с антибиотиками повышает эффективность терапии на модели бактериального сепсиса, в том числе вызванного пенициллин-резистентными штаммами стафилококка. Проведенные экспериментальные токсикологические исследования свидетельствуют о низком уровне токсичности и высоком профиле безопасности препарата. По параметрам острой токсичности препарат Ингавирин®относится к 4 классу токсичности - «Малотоксичные вещества» (при определении LD50в экспериментах по острой токсичности летальные дозы препарата определить не удалось). Препарат не обладает мутагенными, иммунотоксическими, аллергизирующими и канцерогенными свойствами, не оказывает местнораздражающего действия. Препарат Ингавирин®не влияет на репродуктивную функцию, не оказывает эмбриотоксического и тератогенного действия. Отсутствует влияние препарата Ингавирин®на систему кроветворения при приеме соответствующей возрасту дозы рекомендованными схемой и курсом.ФармакокинетикаВсасывание и распределение. В эксперименте с использованием радиоактивной метки установлено: препарат быстро поступает в кровь из желудочно-кишечного тракта, распределяясь по внутренним органам. Максимальные концентрации в крови, плазме крови и большинстве органов достигаются через 30 минут после введения препарата. Величины AUC (площадь под фармакокинетической кривой «концентрация-время») почек, печени и легких незначительно превышают AUC крови (43,77 мкг.ч/г). Величины AUC для селезенки, надпочечников, лимфатических узлов и тимуса ниже AUC крови. MRT (среднее время удержания препарата) в крови-37,2 часа. При курсовом приеме препарата один раз в сутки происходит его накопление во внутренних органах и тканях. При этом качественные характеристики фармакокинетических кривых после каждого введения препарата тождественны: быстрое повышение концентрации препарата после каждого введения через 0,5-1 час после приема и затем медленное снижение к 24 часам. Метаболизм. Препарат не метаболизируется в организме и выводится в неизмененном виде. Выведение. Основной процесс выведения происходит в течение 24 часов. За этот период выводится 80 % принятой дозы: 34,8 % выводится во временном интервале от 0 до 5 часов и 45,2 % во временном интервале от 5 до 24 часов. Из них 77 % выводится через кишечник и 23 % - через почки. Метаболизм. Препарат не метаболизируется в организме и выводится в неизмененном виде. Выведение. Основной процесс выведения происходит в течение 24 часов. За этот период выводится 80 % принятой дозы: 34,8 % выводится во временном интервале от 0 до 5 часов и 45,2 % во временном интервале от 5 до 24 часов. 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