Круглые двояковыпуклые таблетки, покрытые пленочной оболочкой от белого до желтовато-белого цвета, с характерным запахом. На поперечном разрезе ядро от почти белого до белого с желтоватым оттенком цвета.
Фармакотерапевтическая группа
Средство понижающее секрецию желез желудка — Н2-гистаминовых рецепторов блокатор.
Фармакологические свойства
Фармакодинамика.
Ранитидин является блокатором Н2-гистаминовых рецепторов париетальных клеток слизистой оболочки желудка. Снижает базальную и стимулированную секрецию соляной кислоты, вызванную раздражением барорецепторов, пищевой нагрузкой, действием гормонов и биогенных стимуляторов (гастрин, гистамин, ацетилхолин, пентагастрин, кофеин). Ранитидин уменьшает объем желудочного сока и содержание соляной кислоты в нем, повышает рН содержимого желудка, что приводит к снижению активности пепсина. Продолжительность действия после однократного приема — до 12 часов.
Фармакокинетика.
Быстро всасывается из желудочно-кишечного тракта, прием пищи не влияет на степень абсорбции. При приеме внутрь биодоступность ранитидина составляет 50%. Связь с белками плазмы не превышает 15%. Частично метаболизируется в печени. Максимальная концентрация в плазме достигается через 2 часа после приема таблеток, покрытых оболочкой, и колеблется от 36 до 94 нг/мл. Период полувыведения составляет 2-3 часа. 35% принятой дозы выводится с мочой в неизмененном виде, незначительное количество — с калом.
Проникает через плаценту. Выделяется с грудным молоком (концентрация в грудном молоке у женщины в период лактации выше, чем в плазме.)
Показания к применению
Лечение и профилактика обострений язвенной болезни желудка и двенадцатиперстной кишки; язвы желудка и 12-перстной кишки, связанные с приемом нестероидных противовоспалительных препаратов (НПВП); рефлюкс-эзофагит, эрозивный эзофагит; синдром Золлингера-Эллисона; лечение и профилактика послеоперационных, «стрессовых» язв верхних отделов желудочно-кишечного тракта (ЖКТ); профилактика рецидивов кровотечений из верхних отделов ЖКТ; профилактика аспирации желудочного сока при операциях под наркозом (синдром Мендельсона).
Противопоказания
Повышенная чувствительность к ранитидину или другим компонентам препарата. Беременность, период лактации. Детский возраст до 14 лет.
С осторожностью
Почечная и/или печеночная недостаточность, цирроз печени с портосистемной энцефалопатией в анамнезе; острая порфирия (в том числе в анамнезе).
Способ применения и дозы
Внутрь, независимо от приема пищи, не разжевывая, запивая небольшим количеством жидкости
Язвенная болезнь желудка и 12-перстной кишки. Для лечения обострений назначают по 150 мг 2 раза в сутки (утром и вечером) или 300 мг на ночь. При необходимости — по 300 мг 2 раза в сутки. Продолжительность курса лечения — 4-8 недель. Для профилактики обострений назначают по 150 мг на ночь.
Язвы, связанные с приемом НПВП. Назначают по 150 мг 2 раза в сутки или 300 мг на ночь в течение 8-12 недель. Профилактика образования язв при приеме НПВП — по 150 мг 2 раза в сутки.
Послеоперационные и «стрессовые» язвы. Назначают по 150 мг 2 раза в сутки в течение 4-8 недель.
Гастроэзофагальная рефлюксная болезнь. Назначают по 150 мг 2 раза в сутки или 300 мг на ночь. При необходимости доза может быть увеличена до 150 мг 4 раза в сутки. Курс лечения 8-12 недель.
Синдром Золлингера-Эллисона. Начальная доза составляет 150 мг 3 раза в сутки, при необходимости доза может быть увеличена до 6 г/сутки.
Профилактика рецидивирующих кровотечений. По 150 мг 2 раза в сутки.
Профилактика развития синдрома Мендельсона. Назначают ранитидин в дозе 150 мг за 2 часа до наркоза, а также, желательно 150 мг накануне вечером. Больным с почечной недостаточностью при клиренсе креатинина менее 50 мл/мин рекомендуемая доза составляет 150 мг в сутки.
Побочное действие
Со стороны пищеварительной системы: тошнота, сухость во рту, запор, рвота, диарея, абдоминальные боли; редко — гепатит (гепатоцеллюлярный, холестатический, смешанный), острый панкреатит.
Со стороны органов кроветворения: лейкопения, тромбоцитопения, агранулоцитоз, панцитопения, гипо- и аплазия костного мозга, иммунная гемолитическая анемия.
Со стороны сердечно-сосудистой системы: снижение артериального давления, брадикардия, васкулит, аритмия, атрио-вентрикулярная блокада.
Со стороны нервной системы: повышенная утомляемость, головная боль, головокружение, сонливость, бессонница, эмоциональная лабильность, беспокойство, тревога, депрессия, гипертермия; редко — спутанность сознания, шум в ушах, раздражительность, галлюцинации (в основном у пожилых пациентов и тяжелых больных), непроизвольные движения.
Со стороны органов чувств: нечеткость зрительного восприятия, парез аккомодации.
Со стороны опорно-двигательного аппарата: артралгия, миалгия.
Со стороны эндокринной системы: гиперпролактинемия, гинекомастия, аменорея, снижение потенции и/или либидо.
Аллергические реакции: крапивница, кожная сыпь, зуд, ангионевротический отек, анафилактический шок, бронхоспазм, мультиформная экссудативная эритема (в том числе синдром Стивенса-Джонсона).
Прочие: алопеция, гиперкреатининемия, повышение активности глутаматтранспептидазы, острая порфирия.
Лечение: симптоматическое. При развитии судорог — диазепам внутривенно, при брадикардии или желудочковых аритмиях — атропин, лидокаин. Гемодиализ — эффективен.
Взаимодействие с другими лекарственными средствами
Вследствие повышения рН содержимого желудка при одновременном приеме может уменьшиться всасывание итраконазола и кетоконазола.
При одновременном применении с прокаинамидом возможно повышение его концентрации в плазме крови из-за снижения его выведения почками.
При одновременном применении с антацидами, сукральфатом в высоких дозах возможно нарушение абсорбции ранитидина, поэтому перерыв между приемом этих препаратов должен быть не менее 2 часов.
Лечение ранитидином может маскировать симптомы, связанные с карциномой желудка, поэтому перед началом лечения необходимо исключить наличие злокачественного новообразования. Ранитидин, как и все блокаторы Н2-гистаминовых рецепторов нежелательно отменять резко (во избежание синдрома «рикошета»).
При длительном лечении ослабленных больных в условиях стресса возможны бактериальные поражения желудка с последующим распространением инфекции. Имеются сведения о том, что ранитидин может вызвать острые приступы порфирии.
В период лечения необходимо воздерживаться от занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций.
Может повышать активность глутаматтранспептидазы.
Может быть причиной ложноположительной реакции при проведении пробы на белок в моче. Блокаторы Н2-гистаминовых рецепторов могут противодействовать влиянию пентагастрина и гистамина на кислотообразующую функцию желудка, поэтому в течение 24 часов, предшествующих тесту, их применение не рекомендуется.
Может подавлять кожную реакцию на гистамин, приводя таким образом к ложноположительным результатам (рекомендуется прекратить прием ранитидина перед проведением диагностических кожных проб для выявления аллергической кожной реакции немедленного типа).
Во время лечения следует избегать употребления продуктов питания, напитков и других лекарственных средств, которые могут вызвать раздражение слизистой оболочки желудка.
Форма выпуска
Таблетки, покрытые пленочной оболочкой, 150 мг.
По 6 или 10 таблеток в блистер из фольги алюминиевой и фольги алюминиевой, ламинированной поливинилхлоридной и полиамидной пленкой.
По 5 блистеров по 6 таблеток или по 3 блистера по 10 таблеток с инструкцией по медицинскому применению лекарственного препарата в пачку картонную.
Условия хранения
При температуре не выше 25 ºС в потребительской упаковке.
Хранить в недоступном для детей месте.
Срок годности
3 года.
Не использовать после истечения срока годности, указанного на упаковке.
Условия отпуска
Отпускают без рецепта.
Производитель
Хемофарм А.Д. Вршац, отделение Производственная площадка Шабац, Сербия
15000, г. Шабац, ул. Хайдук Велькова бб
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Мобильное приложение «Все аптеки»
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014316/01"}}]},{"id":2,"name":"Торговое название препарата","slug":"","body":[{"type":"paragraph","data":{"text":"РАНИТИДИН"}}]},{"id":3,"name":"Лекарственная форма","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки, покрытые пленочной оболочкой"}}]},{"id":4,"name":"Состав","slug":"ingredients","body":[{"type":"paragraph","data":{"text":"\u003cb\u003eСостав на одну таблетку:\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eдействующее вещество:\u003c/i\u003e ранитидин — 150,00 мг (в виде ранитидина гидрохлорида — 167,40 мг);"}},{"type":"paragraph","data":{"text":"\u003ci\u003eвспомогательные вещества:\u003c/i\u003e целлюлоза микрокристаллическая, кроскармеллоза натрия, кремния диоксид коллоидный, магния стеарат; оболочка: гипромеллоза, триацетин, титана диоксид Е 171, тальк."}}]},{"id":5,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"Круглые двояковыпуклые таблетки, покрытые пленочной оболочкой от белого до желтовато-белого цвета, с характерным запахом. На поперечном разрезе ядро от почти белого до белого с желтоватым оттенком цвета."}}]},{"id":6,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":" Средство понижающее секрецию желез желудка — Н\u003csub\u003e2\u003c/sub\u003e-гистаминовых рецепторов блокатор. "}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"\u003cb\u003eФармакодинамика.\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Ранитидин является блокатором Н\u003csub\u003e2\u003c/sub\u003e-гистаминовых рецепторов париетальных клеток слизистой оболочки желудка. Снижает базальную и стимулированную секрецию соляной кислоты, вызванную раздражением барорецепторов, пищевой нагрузкой, действием гормонов и биогенных стимуляторов (гастрин, гистамин, ацетилхолин, пентагастрин, кофеин). Ранитидин уменьшает объем желудочного сока и содержание соляной кислоты в нем, повышает рН содержимого желудка, что приводит к снижению активности пепсина. Продолжительность действия после однократного приема — до 12 часов."}},{"type":"paragraph","data":{"text":"\u003cb\u003eФармакокинетика.\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Быстро всасывается из желудочно-кишечного тракта, прием пищи не влияет на степень абсорбции. При приеме внутрь биодоступность ранитидина составляет 50%. Связь с белками плазмы не превышает 15%. Частично метаболизируется в печени. Максимальная концентрация в плазме достигается через 2 часа после приема таблеток, покрытых оболочкой, и колеблется от 36 до 94 нг/мл. Период полувыведения составляет 2-3 часа. 35% принятой дозы выводится с мочой в неизмененном виде, незначительное количество — с калом."}},{"type":"paragraph","data":{"text":"Проникает через плаценту. Выделяется с грудным молоком (концентрация в грудном молоке у женщины в период лактации выше, чем в плазме.)"}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Лечение и профилактика обострений язвенной болезни желудка и двенадцатиперстной кишки; язвы желудка и 12-перстной кишки, связанные с приемом нестероидных противовоспалительных препаратов (НПВП); рефлюкс-эзофагит, эрозивный эзофагит; синдром Золлингера-Эллисона; лечение и профилактика послеоперационных, «стрессовых» язв верхних отделов желудочно-кишечного тракта (ЖКТ); профилактика рецидивов кровотечений из верхних отделов ЖКТ; профилактика аспирации желудочного сока при операциях под наркозом (синдром Мендельсона)."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к ранитидину или другим компонентам препарата. Беременность, период лактации. Детский возраст до 14 лет."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Почечная и/или печеночная недостаточность, цирроз печени с портосистемной энцефалопатией в анамнезе; острая порфирия (в том числе в анамнезе)."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь, независимо от приема пищи, не разжевывая, запивая небольшим количеством жидкости"}},{"type":"paragraph","data":{"text":"\u003ci\u003eЯзвенная болезнь желудка и 12-перстной кишки.\u003c/i\u003e Для лечения обострений назначают по 150 мг 2 раза в сутки (утром и вечером) или 300 мг на ночь. При необходимости — по 300 мг 2 раза в сутки. Продолжительность курса лечения — 4-8 недель. Для профилактики обострений назначают по 150 мг на ночь."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЯзвы, связанные с приемом НПВП.\u003c/i\u003e Назначают по 150 мг 2 раза в сутки или 300 мг на ночь в течение 8-12 недель. Профилактика образования язв при приеме НПВП — по 150 мг 2 раза в сутки."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПослеоперационные и «стрессовые» язвы.\u003c/i\u003e Назначают по 150 мг 2 раза в сутки в течение 4-8 недель."}},{"type":"paragraph","data":{"text":"\u003ci\u003eГастроэзофагальная рефлюксная болезнь.\u003c/i\u003e Назначают по 150 мг 2 раза в сутки или 300 мг на ночь. При необходимости доза может быть увеличена до 150 мг 4 раза в сутки. Курс лечения 8-12 недель."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСиндром Золлингера-Эллисона.\u003c/i\u003e Начальная доза составляет 150 мг 3 раза в сутки, при необходимости доза может быть увеличена до 6 г/сутки."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПрофилактика рецидивирующих кровотечений. \u003c/i\u003eПо 150 мг 2 раза в сутки."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПрофилактика развития синдрома Мендельсона.\u003c/i\u003e Назначают ранитидин в дозе 150 мг за 2 часа до наркоза, а также, желательно 150 мг накануне вечером. Больным с почечной недостаточностью при клиренсе креатинина менее 50 мл/мин рекомендуемая доза составляет 150 мг в сутки."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны пищеварительной системы:\u003c/i\u003e тошнота, сухость во рту, запор, рвота, диарея, абдоминальные боли; редко — гепатит (гепатоцеллюлярный, холестатический, смешанный), острый панкреатит."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны органов кроветворения:\u003c/i\u003e лейкопения, тромбоцитопения, агранулоцитоз, панцитопения, гипо- и аплазия костного мозга, иммунная гемолитическая анемия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны сердечно-сосудистой системы:\u003c/i\u003e снижение артериального давления, брадикардия, васкулит, аритмия, атрио-вентрикулярная блокада."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны нервной системы:\u003c/i\u003e повышенная утомляемость, головная боль, головокружение, сонливость, бессонница, эмоциональная лабильность, беспокойство, тревога, депрессия, гипертермия; редко — спутанность сознания, шум в ушах, раздражительность, галлюцинации (в основном у пожилых пациентов и тяжелых больных), непроизвольные движения."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны органов чувств:\u003c/i\u003e нечеткость зрительного восприятия, парез аккомодации."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны опорно-двигательного аппарата:\u003c/i\u003e артралгия, миалгия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны эндокринной системы:\u003c/i\u003e гиперпролактинемия, гинекомастия, аменорея, снижение потенции и/или либидо."}},{"type":"paragraph","data":{"text":"\u003ci\u003eАллергические реакции:\u003c/i\u003e крапивница, кожная сыпь, зуд, ангионевротический отек, анафилактический шок, бронхоспазм, мультиформная экссудативная эритема (в том числе синдром Стивенса-Джонсона)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПрочие:\u003c/i\u003e алопеция, гиперкреатининемия, повышение активности глутаматтранспептидазы, острая порфирия."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: судороги, брадикардия, желудочковые аритмии."}},{"type":"paragraph","data":{"text":"Лечение: симптоматическое. При развитии судорог — диазепам внутривенно, при брадикардии или желудочковых аритмиях — атропин, лидокаин. Гемодиализ — эффективен."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Вследствие повышения рН содержимого желудка при одновременном приеме может уменьшиться всасывание итраконазола и кетоконазола."}},{"type":"paragraph","data":{"text":"Угнетает метаболизм в печени феназона, аминофеназона, диазепама, гексобарбитала, пропранолола, метопролола, нифедипина, варфарина, диазепама, лидокаина, лигнокаина, фенитоина, теофиллина, аминофиллина, непрямых антикоагулянтов, глипизида, буформина, метронидазола."}},{"type":"paragraph","data":{"text":"При одновременном применении с прокаинамидом возможно повышение его концентрации в плазме крови из-за снижения его выведения почками."}},{"type":"paragraph","data":{"text":"При одновременном применении с антацидами, сукральфатом в высоких дозах возможно нарушение абсорбции ранитидина, поэтому перерыв между приемом этих препаратов должен быть не менее 2 часов."}},{"type":"paragraph","data":{"text":"Лекарственные средства, угнетающие костный мозг, увеличивают риск нейтропении."}},{"type":"paragraph","data":{"text":"Курение снижает эффективность ранитидина."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Лечение ранитидином может маскировать симптомы, связанные с карциномой желудка, поэтому перед началом лечения необходимо исключить наличие злокачественного новообразования. Ранитидин, как и все блокаторы Н\u003csub\u003e2\u003c/sub\u003e-гистаминовых рецепторов нежелательно отменять резко (во избежание синдрома «рикошета»)."}},{"type":"paragraph","data":{"text":"При длительном лечении ослабленных больных в условиях стресса возможны бактериальные поражения желудка с последующим распространением инфекции. Имеются сведения о том, что ранитидин может вызвать острые приступы порфирии."}},{"type":"paragraph","data":{"text":"В период лечения необходимо воздерживаться от занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."}},{"type":"paragraph","data":{"text":"Может повышать активность глутаматтранспептидазы."}},{"type":"paragraph","data":{"text":"Может быть причиной ложноположительной реакции при проведении пробы на белок в моче. Блокаторы Н\u003csub\u003e2\u003c/sub\u003e-гистаминовых рецепторов могут противодействовать влиянию пентагастрина и гистамина на кислотообразующую функцию желудка, поэтому в течение 24 часов, предшествующих тесту, их применение не рекомендуется."}},{"type":"paragraph","data":{"text":"Может подавлять кожную реакцию на гистамин, приводя таким образом к ложноположительным результатам (рекомендуется прекратить прием ранитидина перед проведением диагностических кожных проб для выявления аллергической кожной реакции немедленного типа)."}},{"type":"paragraph","data":{"text":"Во время лечения следует избегать употребления продуктов питания, напитков и других лекарственных средств, которые могут вызвать раздражение слизистой оболочки желудка."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки, покрытые пленочной оболочкой, 150 мг."}},{"type":"paragraph","data":{"text":"По 6 или 10 таблеток в блистер из фольги алюминиевой и фольги алюминиевой, ламинированной поливинилхлоридной и полиамидной пленкой."}},{"type":"paragraph","data":{"text":"По 5 блистеров по 6 таблеток или по 3 блистера по 10 таблеток с инструкцией по медицинскому применению лекарственного препарата в пачку картонную."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре не выше 25 ºС в потребительской упаковке."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не использовать после истечения срока годности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nХемофарм А.Д. Вршац, отделение Производственная площадка Шабац, Сербия"}},{"type":"paragraph","data":{"text":"15000, г. Шабац, ул. Хайдук Велькова бб\n\n"}}]}],"source":null},"description_toggle":false,"short_description":"Фармакодинамика.Ранитидин является блокатором Н2-гистаминовых рецепторов париетальных клеток слизистой оболочки желудка. Снижает базальную и стимулированную секрецию соляной кислоты, вызванную раздражением барорецепторов, пищевой нагрузкой, действием гормонов и биогенных стимуляторов (гастрин, гистамин, ацетилхолин, пентагастрин, кофеин). Ранитидин уменьшает объем желудочного сока и содержание соляной кислоты в нем, повышает рН содержимого желудка, что приводит к снижению активности пепсина. Продолжительность действия после однократного приема — до 12 часов.Фармакокинетика.Быстро всасывается из желудочно-кишечного тракта, прием пищи не влияет на степень абсорбции. При приеме внутрь биодоступность ранитидина составляет 50%. Связь с белками плазмы не превышает 15%. Частично метаболизируется в печени. Максимальная концентрация в плазме достигается через 2 часа после приема таблеток, покрытых оболочкой, и колеблется от 36 до 94 нг/мл. Период полувыведения составляет 2-3 часа. 35% принятой дозы выводится с мочой в неизмененном виде, незначительное количество — с калом. Проникает через плаценту. Выделяется с грудным молоком (концентрация в грудном молоке у женщины в период лактации выше, чем в плазме.)","substance":[{"id":1105,"title":"Ранитидин","title_latin":"Ranitidinum","slug":"ranitidin_1105"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"Ранитидин хемофарм - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/71429/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/71429/share_default/"}},"diseases":[{"id":"858","title":"Гастроэзофагеальный рефлюкс","slug":"858-gastroezofagealnyy_reflyuks"},{"id":"860","title":"Язва желудка","slug":"860-yazva_zheludka"},{"id":"862","title":"Язва двенадцатиперстной кишки","slug":"862-yazva_dvenadtsatiperstnoy_kishki"},{"id":"3378","title":"Синдром Золлингера-Эллисона","slug":"3378-sindrom_zollingeraellisona"}],"other_packages":[],"other_product_forms":[],"related_products":{"title":"Похожие 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