Эквамер показан в качестве заместительной терапии у взрослых пациентов, состояние которых адекватно контролируется применением амлодипина, лизиноприла и розувастатина в тех же дозах, что и в препарате Эквамер, при лечении артериальной гипертензии и сопутствующей дислипидемии:
Первичная гиперхолестеринемия (тип IIa по классификации Фредриксона, за исключением семейной гетерозиготной гиперхолестеринемии) или смешанная гиперхолестеринемия (тип IIb по классификации Фредриксона), когда диета и другие немедикаментозные методы (например, физические упражнения, снижение массы тела) оказываются недостаточными,
Семейная гомозиготная гиперхолестеринемия, когда диета или другая липидснижающая терапия (например, ЛПНП-аферез) недостаточно эффективна,
Гипертриглицеридемия (тип IV по классификации Фредриксона)
Капсулы Эквамер 5мг+10мг+20мг - комбинированный антигипертензивный и гиполипидемический препарат (блокатор «медленных» кальциевых каналов + ингибитор ангиотензинпревращающего фермента + ингибитор ГМГ-Ко-А-редуктазы). В состав препарата Эквамер входят три действующих вещества - амлодипин, лизиноприл и розувастатин. Механизм действия препарата Эквамер основан на фармакологических свойствах действующих веществ.
Показания к применению
Эквамер показан в качестве заместительной терапии у взрослых пациентов, состояние которых адекватно контролируется применением амлодипина, лизиноприла и розувастатина в тех же дозах, что и в препарате Эквамер, при лечении артериальной гипертензии и сопутствующей дислипидемии:
Первичная гиперхолестеринемия (тип IIa по классификации Фредриксона, за исключением семейной гетерозиготной гиперхолестеринемии) или смешанная гиперхолестеринемия (тип IIb по классификации Фредриксона), когда диета и другие немедикаментозные методы (например, физические упражнения, снижение массы тела) оказываются недостаточными,
Семейная гомозиготная гиперхолестеринемия, когда диета или другая липидснижающая терапия (например, ЛПНП-аферез) недостаточно эффективна,
Гипертриглицеридемия (тип IV по классификации Фредриксона)
Применение при беременности и в период грудного вскармливания
Противопоказано при беременности и кормлении грудью.
Способ применения и дозы
Препарат принимают внутрь, независимо от времени приема пищи. Рекомендуемая доза препарата составляет 1 капс./сут. Максимальная суточная доза - 1 капс. В случае если необходима коррекция дозы препарата, титрование доз следует проводить, применяя отдельно амлодипин, лизиноприл и розувастатин.
Побочное действие
Смотреть инструкцию
Особые указания
Противопоказания к применению— ангионевротический отек в анамнезе, в т.ч. при применении ингибиторов АПФ,— наследственный или идиопатический ангионевротический отек,— тяжелая артериальная гипотензия (систолическое АД менее 90 мм рт. ст.),— обструкция выводного тракта левого желудочка (включая тяжелый аортальный стеноз),— гемодинамически нестабильная сердечная недостаточность после острого инфаркта миокарда,— заболевание печени в активной фазе, включая стойкое повышение активности трансаминаз в сыворотке крови, а также любое повышение активности трансаминаз (более чем в 3 раза по сравнению с ВГН),— тяжелые нарушения функции почек (КК менее 30 мл/мин),— миопатия,— предрасположенность к развитию миотоксических осложнений,— одновременное применение с алискиренсодержащими препаратами у пациентов с сахарным диабетом или почечной недостаточностью (СКФ менее 60 мл/мин/1.73 м2),— одновременное применение циклоспорина,— беременность,— период лактации (грудного вскармливания),— применение у женщин, не пользующихся адекватными методами контрацепции,— детский и подростковый возраст до 18 лет (эффективность и безопасность не установлены),— непереносимость лактозы, дефицит лактазы или синдром мальабсорбции глюкозы/галактозы,— повышенная чувствительность к амлодипину или другим производным дигидропиридина,— повышенная чувствительность к лизиноприлу или другим ингибиторам АПФ,— повышенная чувствительность к розувастатину,— повышенная чувствительность к любому из вспомогательных компонентов препарата.
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