Действующее вещество: Рилменидин (Rilmenidine); Концентрация действующего вещества (мг): 1
Фармакологические свойства
Антигипертензивный препарат, производное оксазолина. Избирательно взаимодействует с имидазолиновыми рецепторами (I1) корковых и периферических вазомоторных центров, в частности почечных центров. Связывание рилменидина с имидазолиновыми рецепторами ингибирует симпатомиметическую активность как корковых, так и периферических центров, что ведет к снижению АД.; Альбарел; оказывает зависимое от дозы гипотензивное действие на систолическое и диастолическое АД в положении лежа и стоя. Показано, что назначение препарата Альбарел; в терапевтических дозах (1 или 2 мг/сут) эффективно при лечении легкой и умеренной артериальной гипертензии. Действие препарата сохраняется в течение 24 ч, эффективен во время физических нагрузок. При длительном применении привыкание не развивается.; В терапевтических дозах Альбарел; не вызывает задержки электролитов и воды, не нарушает метаболическое равновесие.; Альбарел; снижает ОПСС без изменений сердечного выброса. Сократимость миокарда и электрофизиологические индексы остаются без изменения.; Альбарел; не вызывает ортостатической гипотензии (в т.ч. у лиц пожилого возраста); не нарушает компенсаторную физиологическую реакцию сердечного ритма на физическую нагрузку; не влияет на почечный кровоток, клубочковую фильтрацию или фильтрационную фракцию; не влияет на липидный и углеводный обмен (в т.ч. у больных сахарным диабетом 1 и 2 типа).
Показания к применению
Артериальная гипертензия.
Противопоказания
Выраженная депрессия.
Почечная недостаточность тяжелой степени ( клиренс креатинина < 15 мл/мин).
Беременность.
Лактация (грудное вскармливание).
Повышенная чувствительность к препарату.
Применение при беременности и в период грудного вскармливания
Из-за отсутствия достаточных клинических данных применение препарата Альбарел; противопоказано при беременности, хотя в экспериментальных исследованиях на животных не наблюдали тератогенных и эмбриотоксических эффектов.; Неизвестно, выделяется ли рилменидин или его метаболиты с грудным молоком. Имеющиеся данные экспериментальных и токсикологических исследований показали, что рилменидин и его метаболиты выделяются с грудным молоком у животных. Нельзя исключить риск для новорожденных и младенцев. Препарат Альбарел; не рекомендуется применять в период грудного вскармливания.; Исследования репродуктивной функции крыс не выявили влияние рилменидина на фертильность.
Способ применения и дозы
Рекомендуемая доза Альбарела составляет 1 мг/сут (1 таб. ) утром. ; Если АД снижается недостаточно после одного месяца лечения, дозу можно увеличить до 2 мг/сут в 2 приема (1 таб. утром и 1 таб. вечером во время приема пищи). ; У пациентов с почечной недостаточностью легкой и средней степени тяжести ( клиренс креатинина более 15 мл/мин) не требуется коррекции дозы препарата. ; Лечение проводится длительно. ;
Побочное действие
Побочные эффекты отмечаются редко, как правило, слабо выражены и имеют транзиторный характер. ; Со стороны ЦНС: возможны астения, бессонница, сонливость, повышенная усталость при физических нагрузках; в единичных случаях - тревожность, депрессия, судороги. ; Со стороны сердечно-сосудистой системы: возможно сердцебиение; в единичных случаях - похолодание конечностей, ортостатическая гипотензия. ; Со стороны пищеварительной системы: возможны боли в эпигастрии, сухость во рту, диарея; в единичных случаях - тошнота, запор. ; Дерматологические реакции: редко - кожная сыпь, зуд. ; Прочие: в единичных случаях - периферические отеки, приливы, расстройство половой функции. ;
Передозировка
Симптомы: выраженное снижение АД, нарушение способности к концентрации внимания.; Лечение: проведение симпатомиметической терапии; промывание желудка; при выраженном снижении АД - применение симпатомиметиков. Гемодиализ малоэффективен.
Особые указания
Не следует внезапно прекращать прием препарата. Дозу препарата следует снижать постепенно.; Как и при применении других антигипертензивных препаратов, при назначении препарата Альбарел; пациентам после недавно перенесенного инсульта или инфаркта миокарда требуется регулярный медицинский контроль.; Одновременное применение препарата Альбарел; с бета-адреноблокаторами, применяемыми для терапии сердечной недостаточности (бисопролол, метопролол, карведилол) не рекомендуется.; Одновременное применение препарата Альбарел; с ингибиторами МАО не рекомендуется.; Во время курса лечения не рекомендуется употреблять алкоголь.; В связи с возможностью развития ортостатической гипотензии пациентов пожилого возраста следует предупреждать о возможности падений.; Препарат содержит лактозу, поэтому его не следует назначать пациентам с редкими наследственными заболеваниями, такими как непереносимость галактозы, наследственный дефицит лактазы или синдром мальабсорбции глюкозы-галактозы.; Влияние на способность к вождению автотранспорта и управлению механизмами; Не проводилось специфических исследований влияния рилменидина на способность к управлению автотранспортом и работе с механизмами. Необходимо соблюдать осторожность при управлении автотранспортом и работе с механизмами (риск развития сонливости).
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Имеющиеся данные экспериментальных и токсикологических исследований показали, что рилменидин и его метаболиты выделяются с грудным молоком у животных. Нельзя исключить риск для новорожденных и младенцев. 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