Эрекция полового члена представляет собой гемодинамический п... Инструкция
Показания к применению
Лечение эректильной дисфункции, характеризующейся неспособностью к достижению или сохранению эрекции полового члена, достаточной для удовлетворительного полового акта. Эффективен только при сексуальной стимуляции.
Противопоказания
Гиперчувствительность к любому из компонентов препарата, тяжелые нарушения функции печени, заболевания почек в терминальной стадии, требующие гемодиализа, артериальная гипотензия (систолическое АД в покое менее 90 мм рт. ст.), недавно перенесенный инсульт или инфаркт миокарда (в течение последних 6 месяцев), нестабильная стенокардия, наследственные ...
Диспергирующие таблетки Левитра - средство лечения эректильной дисфункции. Применяется для лечения эректильной дисфункции, восстанавливает в условиях сексуальной стимуляции нарушенную эректильную функцию путем увеличения кровотока в половом члене.
Фармакологические свойства
Эрекция полового члена представляет собой гемодинамический процесс, в основе которого лежит расслабление гладких мышц пещеристых тел и расположенных в нем артериол. Во время сексуальной стимуляции из нервных окончаний пещеристых тел выделяется оксид азота (NO), активирующий фермент гуанилатциклазу, что приводит к повышению содержания в пещеристых телах циклического гуанозинмонофосфата (цГМФ). В результате происходит расслабление гладких мышц пещеристых тел, что способствует увеличению притока крови в половой член. Уровень цГМФ регулируется, с одной стороны, синтезом гуанилатциклазы, а с другой стороны - деградацией (расщеплением) цГМФ путем гидролиза фосфодиэстеразами (ФДЭ). Самой известной ФДЭ является цГМФ специфическая фосфодиэстераза типа 5 (ФДЭ5). Блокируя ФДЭ5, участвующую в расщеплении цГМФ, варденафил тем самым способствует усилению местного действия эндогенного оксида азота (NО) в пещеристых телах во время сексуальной стимуляции. Повышение уровня цГМФ за счет ингибирования ФДЭ5 приводит к расслаблению гладких мышц пещеристых тел и увеличению притока крови в них. Этот эффект обуславливает способность варденафила усиливать естественную реакцию на сексуальную стимуляцию. Варденафил является мощным и высокоселективным ингибитором ФДЭ5 (средняя ингибирующая концентрация по отношению к ФДЭ5 - 0,7 нМ). Ингибирующая активность варденафила на ФДЭ5 более выражена, чем на другие известные ФДЭ (в 15 раз больше, чем на ФДЭ6, в 130 раз больше, чем на ФДЭ1, в 300 раз больше, чем на ФДЭ11 и в 1000 раз больше, чем на ФДЭ-2, 3, 4, 7, 8, 9, 10). Варденафил повышал цГМФ в изолированном пещеристом теле, что приводило к расслаблению гладких мышц. Варденафил вызывает эрекцию полового члена, которая зависит от эндогенного оксида азота и стимулируется донаторами оксида азота. Прием варденафила в дозе 20 мг у некоторых мужчин вызывал эрекцию (достаточную для проникновения) уже через 15 мин. Полный ответ достигался через 25 мин (статистически достоверный и сравнимый с плацебо).
Показания к применению
Лечение эректильной дисфункции, характеризующейся неспособностью к достижению или сохранению эрекции полового члена, достаточной для удовлетворительного полового акта. Эффективен только при сексуальной стимуляции.
Противопоказания
Гиперчувствительность к любому из компонентов препарата, тяжелые нарушения функции печени, заболевания почек в терминальной стадии, требующие гемодиализа, артериальная гипотензия (систолическое АД в покое менее 90 мм рт. ст.), недавно перенесенный инсульт или инфаркт миокарда (в течение последних 6 месяцев), нестабильная стенокардия, наследственные дегенеративные заболевания сетчатки, например, пигментный ретинит, детский возраст (до 18 лет).
Способ применения и дозы
Таблетку принимают сразу же после ее извлечения из упаковки. Таблетку следует держать на языке до ее полного растворения и затем проглотить, не запивая жидкостью. В начале лечения рекомендуемая доза составляет 10 мг (приблизительно за 25-60 мин до сексуального контакта). Максимальная рекомендованная доза составляет 10 мг 1 раз в сутки.
Побочное действие
Инфекционные и паразитарные заболевания: редко - конъюнктивит. Нарушения со стороны иммунной системы: нечасто - аллергический отек и ангионевротический отек, редко - аллергическая реакция. Нарушения со стороны нервной системы: очень часто - головная боль, часто - головокружение, нечасто - нарушение чувствительности, сонливость, нарушения сна, редко - обморок, амнезия, судороги. Нарушения со стороны органа зрения: нечасто - нарушения зрения, гиперемия конъюнктивы глазного яблока, нарушения цветовосприятия, боль в глазных яблоках и дискомфорт в глазах, фотофобия, редко - повышение внутриглазного давления. Нарушения со стороны органа слуха и лабиринтные нарушения: нечасто - звон в ушах, вертиго. Нарушения со стороны сердца: нечасто - сердцебиение, тахикардия, редко - стенокардия, инфаркт миокарда, желудочковые тахиаритмии. Нарушения со стороны сосудов: часто - вазодилатация, редко - гипотензия. Нарушения со стороны дыхательной системы, органов грудной клетки и средостения: часто - заложенность носа, нечасто- одышка, заложенность околоносовых пазух. Нарушения со стороны желудочно-кишечного тракта: часто - диспепсия, нечасто - тошнота, боли в животе, сухость во рту, диарея, гастроэзофагеальная, рефлюксная болезнь, гастрит, рвота. Нарушения со стороны печени и желчевыводящих путей: нечасто - повышение уровня трансаминаз. Нарушения со стороны кожи и подкожных тканей: нечасто - эритема, сыпь. Нарушения со стороны скелетно-мышечной и соединительной ткани: нечасто - боль в спине, повышение уровня креатинфосфокиназы (КФК), повышенный мышечный тонус и судороги, миалгия. Нарушения со стороны половых органов и молочной железы: нечасто - усиление эрекции, редко - приапизм. Общие расстройства и нарушения в месте введения: нечасто - плохое самочувствие, редко - боль в груди.
Передозировка
Оценка побочных эффектов проводилась при назначении варденафила в дозе до 120 мг в сутки. При назначении варденафила в дозе до 80 мг 1 раз в сутки и в дозе до 40 мг несколько раз в сутки в течение 4 недель не наблюдалось развития серьезных побочных реакций. При применении доз варденафила от 80 до 120 мг увеличивается риск развития побочных эффектов. При применении варденафила в дозе 40 мг 2 раза в сутки, отмечались выраженные боли в пояснице без признаков токсического действия на мышечную и нервную системы. В случаях передозировки следует проводить стандартную поддерживающую терапию. Поскольку варденафил в высокой степени связывается с белками плазмы, и лишь незначительное количество препарата выводится почками, эффективность гемодиализа маловероятна.
Особые указания
До назначения препаратов, применяемых для лечения эректильной дисфункции, врач должен оценить состояние сердечно-сосудистой системы, поскольку существует риск развития осложнений со стороны сердца во время сексуальной активности.
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аспартам, ароматизатор, стеарат магния, кросповидон, маннитол, коллоидный диоксид кремния, сорбитол."}}]},{"id":2,"name":"Описание","slug":"common_description","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Диспергирующие таблетки Левитра - средство лечения эректильной дисфункции. Применяется для лечения эректильной дисфункции, восстанавливает в условиях сексуальной стимуляции нарушенную эректильную функцию путем увеличения кровотока в половом члене."}}]},{"id":3,"name":"Фармакологические свойства","slug":"pharmacologic_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Эрекция полового члена представляет собой гемодинамический процесс, в основе которого лежит расслабление гладких мышц пещеристых тел и расположенных в нем артериол. Во время сексуальной стимуляции из нервных окончаний пещеристых тел выделяется оксид азота (NO), активирующий фермент гуанилатциклазу, что приводит к повышению содержания в пещеристых телах циклического гуанозинмонофосфата (цГМФ). В результате происходит расслабление гладких мышц пещеристых тел, что способствует увеличению притока крови в половой член. Уровень цГМФ регулируется, с одной стороны, синтезом гуанилатциклазы, а с другой стороны - деградацией (расщеплением) цГМФ путем гидролиза фосфодиэстеразами (ФДЭ). Самой известной ФДЭ является цГМФ специфическая фосфодиэстераза типа 5 (ФДЭ5). Блокируя ФДЭ5, участвующую в расщеплении цГМФ, варденафил тем самым способствует усилению местного действия эндогенного оксида азота (NО) в пещеристых телах во время сексуальной стимуляции. Повышение уровня цГМФ за счет ингибирования ФДЭ5 приводит к расслаблению гладких мышц пещеристых тел и увеличению притока крови в них. Этот эффект обуславливает способность варденафила усиливать естественную реакцию на сексуальную стимуляцию. Варденафил является мощным и высокоселективным ингибитором ФДЭ5 (средняя ингибирующая концентрация по отношению к ФДЭ5 - 0,7 нМ). Ингибирующая активность варденафила на ФДЭ5 более выражена, чем на другие известные ФДЭ (в 15 раз больше, чем на ФДЭ6, в 130 раз больше, чем на ФДЭ1, в 300 раз больше, чем на ФДЭ11 и в 1000 раз больше, чем на ФДЭ-2, 3, 4, 7, 8, 9, 10). Варденафил повышал цГМФ в изолированном пещеристом теле, что приводило к расслаблению гладких мышц. Варденафил вызывает эрекцию полового члена, которая зависит от эндогенного оксида азота и стимулируется донаторами оксида азота. Прием варденафила в дозе 20 мг у некоторых мужчин вызывал эрекцию (достаточную для проникновения) уже через 15 мин. Полный ответ достигался через 25 мин (статистически достоверный и сравнимый с плацебо)."}}]},{"id":4,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Лечение эректильной дисфункции, характеризующейся неспособностью к достижению или сохранению эрекции полового члена, достаточной для удовлетворительного полового акта. Эффективен только при сексуальной стимуляции."}}]},{"id":5,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Гиперчувствительность к любому из компонентов препарата, тяжелые нарушения функции печени, заболевания почек в терминальной стадии, требующие гемодиализа, артериальная гипотензия (систолическое АД в покое менее 90 мм рт. ст.), недавно перенесенный инсульт или инфаркт миокарда (в течение последних 6 месяцев), нестабильная стенокардия, наследственные дегенеративные заболевания сетчатки, например, пигментный ретинит, детский возраст (до 18 лет)."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Таблетку принимают сразу же после ее извлечения из упаковки. Таблетку следует держать на языке до ее полного растворения и затем проглотить, не запивая жидкостью. В начале лечения рекомендуемая доза составляет 10 мг (приблизительно за 25-60 мин до сексуального контакта). Максимальная рекомендованная доза составляет 10 мг 1 раз в сутки."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Инфекционные и паразитарные заболевания: редко - конъюнктивит. Нарушения со стороны иммунной системы: нечасто - аллергический отек и ангионевротический отек, редко - аллергическая реакция. Нарушения со стороны нервной системы: очень часто - головная боль, часто - головокружение, нечасто - нарушение чувствительности, сонливость, нарушения сна, редко - обморок, амнезия, судороги. Нарушения со стороны органа зрения: нечасто - нарушения зрения, гиперемия конъюнктивы глазного яблока, нарушения цветовосприятия, боль в глазных яблоках и дискомфорт в глазах, фотофобия, редко - повышение внутриглазного давления. Нарушения со стороны органа слуха и лабиринтные нарушения: нечасто - звон в ушах, вертиго. Нарушения со стороны сердца: нечасто - сердцебиение, тахикардия, редко - стенокардия, инфаркт миокарда, желудочковые тахиаритмии. Нарушения со стороны сосудов: часто - вазодилатация, редко - гипотензия. Нарушения со стороны дыхательной системы, органов грудной клетки и средостения: часто - заложенность носа, нечасто- одышка, заложенность околоносовых пазух. Нарушения со стороны желудочно-кишечного тракта: часто - диспепсия, нечасто - тошнота, боли в животе, сухость во рту, диарея, гастроэзофагеальная, рефлюксная болезнь, гастрит, рвота. Нарушения со стороны печени и желчевыводящих путей: нечасто - повышение уровня трансаминаз. Нарушения со стороны кожи и подкожных тканей: нечасто - эритема, сыпь. Нарушения со стороны скелетно-мышечной и соединительной ткани: нечасто - боль в спине, повышение уровня креатинфосфокиназы (КФК), повышенный мышечный тонус и судороги, миалгия. Нарушения со стороны половых органов и молочной железы: нечасто - усиление эрекции, редко - приапизм. Общие расстройства и нарушения в месте введения: нечасто - плохое самочувствие, редко - боль в груди."}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Оценка побочных эффектов проводилась при назначении варденафила в дозе до 120 мг в сутки. При назначении варденафила в дозе до 80 мг 1 раз в сутки и в дозе до 40 мг несколько раз в сутки в течение 4 недель не наблюдалось развития серьезных побочных реакций. При применении доз варденафила от 80 до 120 мг увеличивается риск развития побочных эффектов. При применении варденафила в дозе 40 мг 2 раза в сутки, отмечались выраженные боли в пояснице без признаков токсического действия на мышечную и нервную системы. В случаях передозировки следует проводить стандартную поддерживающую терапию. Поскольку варденафил в высокой степени связывается с белками плазмы, и лишь незначительное количество препарата выводится почками, эффективность гемодиализа маловероятна."}}]},{"id":9,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"До назначения препаратов, применяемых для лечения эректильной дисфункции, врач должен оценить состояние сердечно-сосудистой системы, поскольку существует риск развития осложнений со стороны сердца во время сексуальной активности."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Эрекция полового члена представляет собой гемодинамический процесс, в основе которого лежит расслабление гладких мышц пещеристых тел и расположенных в нем артериол. Во время сексуальной стимуляции из нервных окончаний пещеристых тел выделяется оксид азота (NO), активирующий фермент гуанилатциклазу, что приводит к повышению содержания в пещеристых телах циклического гуанозинмонофосфата (цГМФ). В результате происходит расслабление гладких мышц пещеристых тел, что способствует увеличению притока крови в половой член. Уровень цГМФ регулируется, с одной стороны, синтезом гуанилатциклазы, а с другой стороны - деградацией (расщеплением) цГМФ путем гидролиза фосфодиэстеразами (ФДЭ). Самой известной ФДЭ является цГМФ специфическая фосфодиэстераза типа 5 (ФДЭ5). Блокируя ФДЭ5, участвующую в расщеплении цГМФ, варденафил тем самым способствует усилению местного действия эндогенного оксида азота (NО) в пещеристых телах во время сексуальной стимуляции. Повышение уровня цГМФ за счет ингибирования ФДЭ5 приводит к расслаблению гладких мышц пещеристых тел и увеличению притока крови в них. Этот эффект обуславливает способность варденафила усиливать естественную реакцию на сексуальную стимуляцию. Варденафил является мощным и высокоселективным ингибитором ФДЭ5 (средняя ингибирующая концентрация по отношению к ФДЭ5 - 0,7 нМ). Ингибирующая активность варденафила на ФДЭ5 более выражена, чем на другие известные ФДЭ (в 15 раз больше, чем на ФДЭ6, в 130 раз больше, чем на ФДЭ1, в 300 раз больше, чем на ФДЭ11 и в 1000 раз больше, чем на ФДЭ-2, 3, 4, 7, 8, 9, 10). Варденафил повышал цГМФ в изолированном пещеристом теле, что приводило к расслаблению гладких мышц. Варденафил вызывает эрекцию полового члена, которая зависит от эндогенного оксида азота и стимулируется донаторами оксида азота. Прием варденафила в дозе 20 мг у некоторых мужчин вызывал эрекцию (достаточную для проникновения) уже через 15 мин. 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