Эффективность определяется комбинированным антагонистическим... Инструкция
Показания к применению
Шизофрения, биполярное аффективное расстройство.
Противопоказания
Повышенная чувствительность к азенапину или любому другому компоненту препарата.
Инструкция
Состав
Азенапина малеат, желатин, маннитол.
Описание
Таблетки Сафрис показаны для купирующего и поддерживающего лечения взрослых пациентов с шизофренией и биполярным аффективным расстройством.
Фармакологические свойства
Эффективность определяется комбинированным антагонистическим воздействием на D2 и 5-HT2 A рецепторы. Азенапин проявляет высокое сродство к серотониновым рецепторам 5-HT1 A, 5-HT1 B, 5-HT2 A, 5-HT2 B, 5-HT2 C, 5-HT5, 5-HT6, 5-HT7, дофаминовым рецепторам D2, D3, D4 и D1, адренорецепторам α1 и α2, гистаминовому рецептору H1 и умеренное сродство к гистаминовому рецептору H2.
Показания к применению
Шизофрения, биполярное аффективное расстройство.
Противопоказания
Повышенная чувствительность к азенапину или любому другому компоненту препарата.
Применение при беременности и в период грудного вскармливания
Препарат Сафрис не рекомендуется применять при беременности, за исключением тех случаев, когда потенциальная польза для пациентки значительно превышает возможный риск для плода. Женщинам, принимающим Сафрис, не рекомендуется кормление грудью.
Способ применения и дозы
Рекомендуемая доза препарата Сафрис при шизофрении составляет 5-10 мг два раза в сутки (суточная доза 10-20 мг). Пациентов следует периодически обследовать с целью определения необходимости поддерживающей терапии. При биполярном аффективном расстройстве рекомендуемая начальная доза при монотерапии составляет 10 мг два раза в сутки (суточная доза 20 мг). При комбинированной терапии рекомендуемая начальная доза составляет 5 мг два раза в сутки (суточная доза 10 мг). Способ применения: таблетку следует извлечь из блистера непосредственно перед приемом. Руки должны быть сухими. Не выдавливайте таблетку через блистер. Блистер не следует разрезать или рвать. Необходимо потянуть за цветной кончик фольги и осторожно вынуть таблетку. Таблетку не ломать. Для оптимального всасывания положить таблетку под язык до её полного растворения. Таблетка растворяется в слюне в течение нескольких секунд. Таблетку не разжевывать и не глотать. После приема таблетки не есть и не пить в течение 10 минут. При комбинированном лечении с другими препаратами препарат Сафрис следует принимать последним.
Побочное действие
Сонливость
Передозировка
Симптомы: ажитация и спутанность сознания. Лечение: поддерживающая терапия, обеспечение проходимости дыхательных путей, адекватной оксигенации и вентиляции. В случае гипотензии и сосудистого коллапса — в/в введение жидкости и/или симпатомиметиков (эпинефрин и дофамин не должны использоваться, т.к. бета-стимуляция может усугубить гипотензию в условиях вызванной азенапином альфа-блокады). В случае тяжелых экстрапирамидных симптомов следует назначить антихолинергические препараты. Специфический антидот неизвестен.
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