Негормональный ингибитор костной резорбции из группы бифосфо... Инструкция
Показания к применению
Постменопаузальный остеопороз у женщин (предупреждение развития переломов, в частности бедренной кости, компрессионных переломов позвоночника); профилактика развития остеопороза при риске его возникновения у женщин в период менопаузы (снижение вероятности возникновения переломов); терапия остеопороза у мужчин (предупреждение развития переломов); лечение ...
Состав на один флакон: Активное вещество: Октреотида ацетат в пересчете на октреотид 10,0 вспомогательные вещества: DL-молочной и гликолевой кислот сополимер 270,0 мг, D-Маннитол 85,0 мг, кармеллоза натрия 30,0 м, полисорбат-80 2,0 Растворитель для приготовления суспензии - Маннит, раствор 0,8 % Состав на 1 мл: D-Маннитол 8,0 мг Вода для инъекций до 1,0 мл
Фармакологические свойства
Негормональный ингибитор костной резорбции из группы бифосфонатов - аналогов пирофосфатов. Локализуется под остеокластами в зонах резорбции кости и ингибирует этот процесс. В его химической структуре есть Р-О-Р-связь, при помощи которой он включается в ткань и подавляет остеокласты. Резорбция и образование новой костной ткани происходят параллельно, поэтому процесс образования кости тоже снижается, однако меньше, чем резорбция и в результате происходит увеличение костной ткани. Фосамакс стимулирует остеогенез, увеличивает минеральную плотность кости (МПК), благотворно влияет на формирование нормальной костной ткани, уменьшает риск переломов при остеопорозе. В терапевтических дозах не вызывает остеомаляцию. Доказана его эффективность при остеопорозе у мужчин и женщин, вызванном приемом глюкокортикоидов, а также при остеопорозе у мужчин Обратное развитие остеопороза при приеме этого препарата доказано исследованиями - кость приобретает нормальную структуру и минерализацию, снижаются показатели распада коллагена кости и кальция в моче. Эффективность препарата не зависит от возраста, функции почек и исходной скорости процессов обмена в костной ткани
Показания к применению
Постменопаузальный остеопороз у женщин (предупреждение развития переломов, в частности бедренной кости, компрессионных переломов позвоночника); профилактика развития остеопороза при риске его возникновения у женщин в период менопаузы (снижение вероятности возникновения переломов); терапия остеопороза у мужчин (предупреждение развития переломов); лечение индуцированного глюкокортикоидами остеопороза; терапия костной болезни Педжета
Противопоказания
Заболевания верхних отделов ЖКТ (ахалазия, дисфагия, стриктуры пищевода, дуоденит, язвенная болезнь); гипокальциемия (гипопаратиреоидизм, мальабсорбция кальция, дефицит витамина D); беременность, кормление грудью; детский возраст; выраженное нарушение функции почек; повышенная чувствительность к препарату
Применение при беременности и в период грудного вскармливания
Противопоказано
Способ применения и дозы
Принимается внутрь, раз в сут. желательно утром, не разжевывая, за 2 ч до приема пищи. Запивать таблетку необходимо только водой, поскольку прочие напитки снижают абсорбцию. При болезни Педжета- 40 мг не менее 6 мес. Для профилактики остеопороза назначают 5 мг/сут. При остеопорозе в постменопаузе - 10 мг/сут. Имеется форма выпуска в таблетках по 70 мг, которые принимают 1 раз в неделю. Для еженедельного приема также есть комбинированный препарат с витамином D. Прием 10 мг препарата по результативности и появлению побочных реакций эквивалентен еженедельному приему по 70 мг. Инструкция по применению Фосамакса содержит предупреждение о том, что с целью уменьшения раздражающего действия препарата на пищевод необходимо принять таблетку утром, запивая стаканом воды, после чего нельзя ложиться в течение 30 мин. Если принять таблетку перед сном, увеличивается риск появления эзофагита и прочих заболеваний пищевода. Лечение необходимо сочетать с диетой, богатой солями Ca2+.
Проявляется симптомами: гипокальциемия, гипофосфатемия, осложнения со стороны ЖКТ (диспепсия, изжога, гастрит, эзофагит, язвы желудка и пищевода). Специфической терапии не существует. Для связывания алендроната принять молоко или антациды. Не следует вызывать рвоту
Особые указания
При применении Фосамакса и аналогов существует риск поражения верхних отделов ЖКТ. Пациенты должны быть предупреждены о таком риске. При появлении характерной симптоматики необходима медицинская помощь. Риск развития тяжелого поражения ЖКТ существенно выше у пациентов, нарушающих рекомендации по применению Фосамакса или продолжающих его прием после появления первых симптомов поражения слизистой ЖКТ. При случайном пропуске очередного приема Фосамакса (в режиме 1 таблетка в неделю) следующую таблетку рекомендуется принять ближайшим утром. В последующем рекомендовано вернуться к выбранному графику приема препарата. Нельзя принимать 2 таблетки в один день. Фосамакс используется исключительно по назначению врача и под строгим врачебным контролем.
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