Сухой кашель любой этиологии (при простудных заболеваниях, гриппе, коклюше и других состояниях). Подавление кашля в предоперационном и послеоперационном периоде, во время проведения хирургических вмешательств, бронхоскопии.
Противопоказания
Повышенная чувствительность к компонентам препарата, беременность (I триместр), период грудного вскармливания, детский возраст до 6 лет — таблетки 20 мг, детский возраст до 18 лет — таблетки 50 мг.
Непереносимость лактозы, дефицит лактазы, глюкозо-галактозная мальабсорбция (препарат содержит лактозу)....
Дозировка 20 мг: круглые двояковыпуклые таблетки, покрытые пленочной оболочкой от желтого до оранжевого цвета. На поперечном разрезе ядро белого или почти белого цвета.
Дозировка 50 мг: круглые двояковыпуклые таблетки, покрытые пленочной оболочкой темно-красного цвета. На поперечном разрезе ядро белого или почти белого цвета.
Фармакотерапевтическая группа
Противокашлевое средство центрального действия
Фармакологические свойства
Бутамират, активное вещество препарата Омнитус, является противокашлевым средством центрального действия. Ни химически, ни фaрмaкологически не относится к aлкaлоидaм опия. Не формирует зависимости или привыкания.
Подавляет кашель, обладая прямым влиянием на кашлевой центр. Оказывает бронходилатирующий эффект (расширяет бронхи). Способствует облегчению дыхания, улучшая показатели спирометрии (снижает сопротивление дыхательных путей) и оксигенации крови (насыщает кровь кислородом).
Абсорбция — высокая. После приема внутрь таблетки с модифицированным высвобождением (50 мг) максимальная концентрация в плазме основного метаболита (2-фенилмасляной кислоты) наблюдается через 9 ч и составляет 1,4 мкг/мл.
Бутамират гидролизуется в плазме крови до 2-фенилмaсляной кислоты и диэтилaминоэтоксиэтaнола. Эти метaболиты тaкже обладают противокашлевой активностью, и, подобно бутамирату, в значительной степени (около 95 %) связываются с белками плазмы, что обуславливает их длительный период полувыведения. 2-фенилмaслянaя кислотa частично метаболизируется путем гидроксилирования в пара-положении. При повторном приеме препарата кумуляции не наблюдается.
Период полувыведения — 13 ч. Выведение трех метaболитов происходит в основном через почки; после конъюгации в печени метаболиты с кислой реакцией в значительной степени связываются с глюкуроновой кислотой.
Показания к применению
Сухой кашель любой этиологии (при простудных заболеваниях, гриппе, коклюше и других состояниях). Подавление кашля в предоперационном и послеоперационном периоде, во время проведения хирургических вмешательств, бронхоскопии.
Противопоказания
Повышенная чувствительность к компонентам препарата, беременность (I триместр), период грудного вскармливания, детский возраст до 6 лет — таблетки 20 мг, детский возраст до 18 лет — таблетки 50 мг.
Непереносимость лактозы, дефицит лактазы, глюкозо-галактозная мальабсорбция (препарат содержит лактозу).
Применение при беременности и в период грудного вскармливания
Нет данных о безопасности применения препарата при беременности и прохождении его через плацентарный барьер.
Применение препарата в I триместре беременности противопоказано.
Во II и III триместрах беременности применение препарата возможно в случае, если ожидаемая польза для матери превосходит потенциальный риск для плода.
Неизвестно, проникает ли действующее вещество препарата или его метаболиты в грудное молоко, поэтому применение препарата в период грудного вскармливания не рекомендуется.
Способ применения и дозы
Внутрь. Таблетки принимают перед едой, не разжевывая.
Таблетки, 50 мг
Взрослые — 2 табл. 2–3 раза в день.
Побочное действие
Классификация частоты развития побочных реакций: очень часто (≥1/10), часто (≥1/100, <1/10), нечасто (≥1/1000, <1/100), редко (≥1/10000, <1/1000), очень редко (<1/10000), включая отдельные случаи.
Со стороны центральной нервной системы: редко - головокружение, сонливость.
Со стороны пищеварительной системы: редко - тошнота, диарея.
Аллергические реакции: редко - кожная сыпь, зуд, крапивница.
Передозировка
Симптомы: головокружение, сонливость, тошнота, рвота, диарея, нарушение координации движений, снижение артериального давления.
Взаимодействие с другими лекарственными средствами
Какие-либо лекарственные взаимодействия для бутамирата не описаны.
В период лечения препаратом, не рекомендуется употреблять алкогольные напитки, а также лекарственные средства, угнетающие центральную нервную систему (снотворные препараты, нейролептики, транквилизаторы и пр.).
Особые указания
Таблетки Омнитус 20 мг противопоказаны детям до 6 лет.
В связи с тем, что бутамират подавляет кашлевой рефлекс, следует избегать одновременного применения отхаркивающих средств во избежание скопления мокроты в дыхательных путях с риском развития бронхоспазма и инфекции дыхательных путей.
Влияние на способность управлять автомобилем и движущимися механизмами
Омнитус может вызывать головокружение и сонливость, поэтому в период лечения необходимо соблюдать осторожность при управлении транспортными средствами и выполнении других потенциально опасных видов деятельности, требующих повышенной концентрации внимания и быстроты психомоторных реакций.
Форма выпуска
Таблетки c модифицированным высвобождением, покрытые пленочной оболочкой 20 мг или 50 мг.
10 таблеток в блистер из алюминиевой фольги и поливинилхлоридной пленки.
1 блистер вместе с инструкцией по медицинскому применению лекарственного препарата в пачку из картона.
Условия хранения
Таблетки: При температуре не выше 25 °C в потребительской упаковке. Хранить в недоступном для детей месте.
Срок годности
Таблетки: 2 года. Не применять по истечении срока годности, указанного на упаковке.
Условия отпуска
Отпускают без рецепта.
Производитель
Хемофарм А.Д., Сербия
26300 г. Вршац, Београдский путь бб
тел.: 13/803100, факс: 13/803424
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110]."}},{"type":"paragraph","data":{"text":"1 таблетка c модифицированным высвобождением, покрытая пленочной оболочкой 50 мг содержит:"}},{"type":"paragraph","data":{"text":"\u003ci\u003eдействующее вещество:\u003c/i\u003e бутамирата цитрат — 50 мг; \u003ci\u003eвспомогательные вещества: \u003c/i\u003eлактозы моногидрат, гипромеллоза, тальк, магния стеарат, кремния диоксид коллоидный, повидон; \u003ci\u003eсостав оболочки: \u003c/i\u003eгипромеллоза, тальк, этилцеллюлоза, макрогол, титана диоксид, краситель пунцовый [Понсо 4R] [Е 124], коричневый лак (краситель солнечный закат желтый [Е110], краситель азорубин [Е122], краситель бриллиантовый черный [Е151])."}}]},{"id":5,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eДозировка 20 мг: \u003c/i\u003eкруглые двояковыпуклые таблетки, покрытые пленочной оболочкой от желтого до оранжевого цвета. На поперечном разрезе ядро белого или почти белого цвета."}},{"type":"paragraph","data":{"text":"\u003ci\u003eДозировка 50 мг:\u003c/i\u003e круглые двояковыпуклые таблетки, покрытые пленочной оболочкой темно-красного цвета. На поперечном разрезе ядро белого или почти белого цвета."}}]},{"id":6,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"Противокашлевое средство центрального действия"}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"Бутамират, активное вещество препарата Омнитус, является противокашлевым средством центрального действия. Ни химически, ни фaрмaкологически не относится к aлкaлоидaм опия. Не формирует зависимости или привыкания."}},{"type":"paragraph","data":{"text":"Подавляет кашель, обладая прямым влиянием на кашлевой центр. Оказывает бронходилатирующий эффект (расширяет бронхи). Способствует облегчению дыхания, улучшая показатели спирометрии (снижает сопротивление дыхательных путей) и оксигенации крови (насыщает кровь кислородом)."}},{"type":"paragraph","data":{"text":"Абсорбция — высокая. После приема внутрь таблетки с модифицированным высвобождением (50 мг) максимальная концентрация в плазме основного метаболита (2-фенилмасляной кислоты) наблюдается через 9 ч и составляет 1,4 мкг/мл."}},{"type":"paragraph","data":{"text":"Бутамират гидролизуется в плазме крови до 2-фенилмaсляной кислоты и диэтилaминоэтоксиэтaнола. Эти метaболиты тaкже обладают противокашлевой активностью, и, подобно бутамирату, в значительной степени (около 95 %) связываются с белками плазмы, что обуславливает их длительный период полувыведения. 2-фенилмaслянaя кислотa частично метаболизируется путем гидроксилирования в пара-положении. При повторном приеме препарата кумуляции не наблюдается."}},{"type":"paragraph","data":{"text":"Период полувыведения — 13 ч. Выведение трех метaболитов происходит в основном через почки; после конъюгации в печени метаболиты с кислой реакцией в значительной степени связываются с глюкуроновой кислотой."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Сухой кашель любой этиологии (при простудных заболеваниях, гриппе, коклюше и других состояниях). Подавление кашля в предоперационном и послеоперационном периоде, во время проведения хирургических вмешательств, бронхоскопии."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к компонентам препарата, беременность (I триместр), период грудного вскармливания, детский возраст до 6 лет — таблетки 20 мг, детский возраст до 18 лет — таблетки 50 мг."}},{"type":"paragraph","data":{"text":"Непереносимость лактозы, дефицит лактазы, глюкозо-галактозная мальабсорбция (препарат содержит лактозу)."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Нет данных о безопасности применения препарата при беременности и прохождении его через плацентарный барьер."}},{"type":"paragraph","data":{"text":"Применение препарата в I триместре беременности противопоказано."}},{"type":"paragraph","data":{"text":"Во II и III триместрах беременности применение препарата возможно в случае, если ожидаемая польза для матери превосходит потенциальный риск для плода."}},{"type":"paragraph","data":{"text":"Неизвестно, проникает ли действующее вещество препарата или его метаболиты в грудное молоко, поэтому применение препарата в период грудного вскармливания не рекомендуется."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь. Таблетки принимают перед едой, не разжевывая."}},{"type":"paragraph","data":{"text":"Таблетки, 50 мг"}},{"type":"paragraph","data":{"text":"Взрослые — 2 табл. 2–3 раза в день."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Классификация частоты развития побочных реакций: очень часто (≥1/10), часто (≥1/100, <1/10), нечасто (≥1/1000, <1/100), редко (≥1/10000, <1/1000), очень редко (<1/10000), включая отдельные случаи."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны центральной нервной системы:\u003c/i\u003e редко - головокружение, сонливость."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны пищеварительной системы: \u003c/i\u003eредко - тошнота, диарея."}},{"type":"paragraph","data":{"text":"\u003ci\u003eАллергические реакции: \u003c/i\u003eредко - кожная сыпь, зуд, крапивница."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы: \u003c/i\u003eголовокружение, сонливость, тошнота, рвота, диарея, нарушение координации движений, снижение артериального давления."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение: \u003c/i\u003eпромывание желудка; активированный уголь, солевые слабительные средства, симптоматическая терапия (по показаниям)."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Какие-либо лекарственные взаимодействия для бутамирата не описаны."}},{"type":"paragraph","data":{"text":"В период лечения препаратом, не рекомендуется употреблять алкогольные напитки, а также лекарственные средства, угнетающие центральную нервную систему (снотворные препараты, нейролептики, транквилизаторы и пр.)."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки Омнитус 20 мг противопоказаны детям до 6 лет."}},{"type":"paragraph","data":{"text":"В связи с тем, что бутамират подавляет кашлевой рефлекс, следует избегать одновременного применения отхаркивающих средств во избежание скопления мокроты в дыхательных путях с риском развития бронхоспазма и инфекции дыхательных путей."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Омнитус может вызывать головокружение и сонливость, поэтому в период лечения необходимо соблюдать осторожность при управлении транспортными средствами и выполнении других потенциально опасных видов деятельности, требующих повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки c модифицированным высвобождением, покрытые пленочной оболочкой \u003ca href=\"https://www.stada.ru/products/omnitus-tabletki.html#\"\u003e20 мг\u003c/a\u003e или \u003ca href=\"https://www.stada.ru/products/omnitus-tabletki.html#\"\u003e50 мг\u003c/a\u003e."}},{"type":"paragraph","data":{"text":"10 таблеток в блистер из алюминиевой фольги и поливинилхлоридной пленки."}},{"type":"paragraph","data":{"text":"1 блистер вместе с инструкцией по медицинскому применению лекарственного препарата в пачку из картона."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Таблетки: При температуре не выше 25 °C в потребительской упаковке. Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"Таблетки: 2 года. Не применять по истечении срока годности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nХемофарм А.Д., Сербия"}},{"type":"paragraph","data":{"text":"26300 г. Вршац, Београдский путь бб"}},{"type":"paragraph","data":{"text":"тел.: 13/803100, факс: 13/803424\n\n"}}]}],"source":null},"description_toggle":false,"short_description":"Бутамират, активное вещество препарата Омнитус, является противокашлевым средством центрального действия. Ни химически, ни фaрмaкологически не относится к aлкaлоидaм опия. Не формирует зависимости или привыкания. Подавляет кашель, обладая прямым влиянием на кашлевой центр. Оказывает бронходилатирующий эффект (расширяет бронхи). Способствует облегчению дыхания, улучшая показатели спирометрии (снижает сопротивление дыхательных путей) и оксигенации крови (насыщает кровь кислородом). Абсорбция — высокая. После приема внутрь таблетки с модифицированным высвобождением (50 мг) максимальная концентрация в плазме основного метаболита (2-фенилмасляной кислоты) наблюдается через 9 ч и составляет 1,4 мкг/мл. Бутамират гидролизуется в плазме крови до 2-фенилмaсляной кислоты и диэтилaминоэтоксиэтaнола. Эти метaболиты тaкже обладают противокашлевой активностью, и, подобно бутамирату, в значительной степени (около 95 %) связываются с белками плазмы, что обуславливает их длительный период полувыведения. 2-фенилмaслянaя кислотa частично метаболизируется путем гидроксилирования в пара-положении. При повторном приеме препарата кумуляции не наблюдается. Период полувыведения — 13 ч. 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