Гестаген, гормон желтого тела. Связываясь с рецепторами на поверхности клеток органов - мишеней, проникает в ядро где, активируя ДНК, стимулирует синтез РНК.; Способствует переходу слизистой оболочки матки из фазы пролиферации, вызываемой фолликулярным гормоном в секреторную фазу, а после оплодотворения - в состояние, необходимое для развития оплодотворенной яйцеклетки.; Уменьшает возбудимость и сократимость мускулатуры матки и маточных труб, стимулирует развитие концевых,; элементов молочной железы.; Стимулируя протеинлипазу, увеличивает запасы жира, повышает утилизацию глюкозы, увеличивая концентрацию базального и стимулированного инсулина, способствует накоплению в печени гликогена, повышает выработку альдостерона; в малых дозах ускоряет, а в больших - подавляет продукцию гонадотропных гормонов гипофиза; уменьшает азотемию, увеличивает выведение азота с мочой. Активирует рост секреторного отдела ацинусов молочных желез и индуцирует лактацию. Способствует развитию нормального эндометрия.
Показания к применению
Для приема внутрь:
Предменструальный синдром
Фиброзно-кистозная мастопатия
Пременопауза
В качестве гестагенного компонента заместительной гормонотерапии в постменопаузе (в сочетании с эстрогенами)
Интравагинально:
Заместительная гормонотерапия с нефункционирующими (отсутствующими) яичниками в случае полного недостатка прогестерона (донорство яйцеклеток)
Поддержка лютеиновой фазы во время подготовки к ЭКО
Поддержка лютеиновой фазы в спонтанном или индуцированном менструальном цикле
Преждевременная менопауза, постменопауза (в сочетании с эстрогенами)
Профилактика привычного и угрожающего выкидыша, вследствие гестагенной недостаточности
Эндокринное бесплодие
Профилактика миомы матки
Эндометриоз
Противопоказания
Склонность к тромбозам
Острые формы флебита или тромбоэмболических заболеваний
Кровотечения из влагалища неясного генеза
Неполный аборт
Порфирия
Установленные или подозреваемые злокачественные новообразования молочных желез и половых органов
Повышенная чувствительность к любому из ингредиентов препарата
С осторожностью: заболевания сердечно-сосудистой системы, артериальная гипертензия, хроническая почечная недостаточность, сахарный диабет, бронхиальная астма, эпилепсия, мигрень, депрессия; гиперлипопротеинемия, период лактации.
Пероральный путь введения - при выраженных нарушениях функции печени.
Применение при беременности и в период грудного вскармливания
Следует с осторожностью применять при беременности из-за риска нарушения функции печени.; С осторожностью - в период лактации.
Способ применения и дозы
Строго следуйте рекомендуемой дозировке, если только не будет других указаний от врача.; Внутрь: вечером перед сном (не рекомендуется принимать до, после или во время еды).; При предменструальном синдроме, фиброзно-кистозной мастопатии, дисменорее, пременопаузе - 200-300 мг в течение 10 дней (с 17 по 26 день цикла); при заместительной гормонотерапии в постменопаузе на фоне приема эстрогенов - 200 мг/сут, в течение 10-12 дней.; Интравагинально: При донорстве яйцеклеток (на фоне эстрогенной терапии) - по 100 мг/сут на 13 и 14 дни цикла, затем по 100 мг 2 раза/сут, с 15 по 25 день цикла; с 26 дня и в случае определения беременности доза возрастает на 100 мг/сут каждую неделю, достигая максимума 600 мг в 3 приема (на протяжении 60 дней).; Для поддержки лютеиновой фазы во время проведения цикла ЭКО - по 400-600 мг/сут, начиная со дня инъекции XГ до 12 недели беременности.; Для поддержки лютеиновой фазы в спонтанном или индуцированном менструальном цикле, при бесплодии, связанном с нарушением функции желтого тела - по 200-300 мг/сут, начиная с 17 дня цикла в течение 10 дней; в случае задержки менструации и диагностики беременности лечение должно быть продолжено. При угрозе или профилактике аборта - 100-200 мг 2 раза/сут ежедневно, до 12 недели беременности. Продолжительность лечения определяется характером и особенностями состояния пациента.
Побочное действие
Аллергические реакции, сонливость, преходящее головокружение (через 1-3 ч после применения препарата), сокращение менструального цикла, межменструальное кровотечение.
Передозировка
Возможны нежелательные эффекты, перечисленные выше, которые исчезают при уменьшении дозы препарата.
Особые указания
Препарат нельзя применять с целью контрацепции.; Влияние на способность к вождению автотранспорта и управлению механизмами; При пероральном приеме необходимо соблюдать осторожность при вождении автотранспорта и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций.
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