Экстренная (посткоитальная) контрацепция (после незащищённого полового акта или если применённый способ контрацепции не может считаться надёжным).
Противопоказания
Наличие в анамнезе повышенной чувствительности к мифепристону, надпочечниковая недостаточность и длительная глюкокортикостероидная терапия, острая и хроническая почечная и/или печеночная недостаточность, наличие тяжелой экстрагенитальной патологии.
Круглые плоскоцилиндрические таблетки от светло-желтого до светло-желтого с зеленоватым оттенком цвета с фаской с двух сторон.
Фармакотерапевтическая группа
Антигестаген
Фармакологические свойства
Фармакодинамика: Гинепристон — синтетическое стероидное антигестагенное средство (блокирует действие прогестерона на уровне рецепторов), гестагенной активностью не обладает. Отмечен антагонизм с глюкокортикостероидами (ГКС) (за счет конкуренции на уровне связи с рецепторами).
Повышает сократительную способность миометрия, стимулируя высвобождение интерлейкина-8 в хориодецидуальных клетках, повышая чувствительность миометрия к простагландинам. В зависимости от фазы менструального цикла вызывает торможение овуляции, изменение эндометрия и препятствует имплантации оплодотворенной яйцеклетки.
Фармакокинетика: После однократного приема в дозе 600 мг максимальная концентрация в сыворотке крови 1,98 мг/л достигается через 1.30 часа. Абсолютная биодоступность составляет 69%.
Связь с белками плазмы крови (альбумином и кислым альфа1-гликопротеином) составляет 98%.
После фазы распределения выведение сначала происходит медленно, концентрация уменьшается в 2 раза между 12-72 часами, затем более быстро.
Период полувыведения составляет 18 час.
Показания к применению
Экстренная (посткоитальная) контрацепция (после незащищённого полового акта или если применённый способ контрацепции не может считаться надёжным).
Противопоказания
Наличие в анамнезе повышенной чувствительности к мифепристону, надпочечниковая недостаточность и длительная глюкокортикостероидная терапия, острая и хроническая почечная и/или печеночная недостаточность, наличие тяжелой экстрагенитальной патологии.
С осторожностью
Нарушение гемостаза (в том числе предшествующее лечение антикоагулянтами), хронические обструктивные заболевания легких (в том числе бронхиальная астма), тяжелая артериальная гипертензия, нарушения ритма сердца, сердечная недостаточность.
Применение при беременности и в период грудного вскармливания
Препарат нельзя применять в период беременности. Грудное вскармливание следует прекратить на 14 дней после приема Гинепристон.
Способ применения и дозы
Внутрь, в течение 72 часов после незащищенного контрацепцией полового сношения, по 1 таблетке Гинепристона 10 мг. Для сохранения контрацептивного эффекта следует воздержаться от приема пищи за 2 часа до применения препарата и 2 часа после него. Гинепристон может применяться в любую фазу менструального цикла.
Побочное действие
Чувство дискомфорта внизу живота, слабость, головная боль, тошнота, рвота, головокружение, крапивница, гипертермия, кровянистые выделения из половых путей, нарушение менструального цикла.
Передозировка
Прием Гинепристона в дозах до 2 г не вызывает нежелательных реакций. В случаях передозировки препарата может наблюдаться надпочечниковая недостаточность.
Взаимодействие с другими лекарственными средствами
Следует избегать применения нестероидных противовоспалительных препаратов.
Особые указания
Гинепристон не рекомендуется для регулярного применения в качестве плановой, постоянной контрацепции. Гинепристон не защищает от заболеваний, передаваемых половым путём и СПИДа.
Влияние на способность управлять автомобилем и другими механизмами
В настоящее время отсутствуют данные о том, что препарат может оказывать влияние на способность управлять автомобилем и другими механизмами.
Влияние на способность управлять автомобилем и движущимися механизмами
В настоящее время отсутствуют данные о том, что препарат может оказывать влияние на способность управлять автомобилем и другими механизмами.
Форма выпуска
Таблетки, 10 мг. По 1 или 2 таблетки в контурную ячейковую упаковку из пленки поливинилхлоридной и фольги алюминиевой печатной лакированной.
1 контурную ячейковую упаковку вместе с инструкцией по медицинскому применению лекарственного препарата в пачку из картона.
Условия хранения
В сухом, защищенном от света месте. При температуре не выше 30 °С.
Хранить в недоступном для детей месте.
Срок годности
5 лет. Не использовать после окончания срока, указанного на упаковке.
Условия отпуска
По рецепту
Производитель
Россия, Калужская область,
г. Обнинск, Киевское шоссе, зд. 103, зд. 107
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
Начните сравнивать цены и заказывать лекарства прямо в приложении
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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