Ликопид Таблетки, 10 шт, 10 мг, для приема внутрь

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ГМДП является активатором врожденного и"}},{"type":"paragraph","data":{"text":"приобретенного иммунитета, усиливает защиту организма от вирусных,\nбактериальных и грибковых инфекций; оказывает адъювантный эффект в развитии\nиммунологических реакций."}},{"type":"paragraph","data":{"text":"Биологическая активность препарата реализуется посредством связывания\nГМДП с внутриклеточным рецепторным белком NOD2, локализованным в цитоплазме\nфагоцитов (нейтрофилов, макрофагов, дендритных клеток). Препарат стимулирует\nфункциональную (бактерицидную, цитотоксическую) активность фагоцитов, усиливает\nпрезентацию ими антигенов, пролиферацию Т- и В-лимфоцитов, повышает синтез\nспецифических антител, способствует нормализации баланса Th1/Th2-лимфоцитов в\nсторону преобладания Th1. Фармакологическое действие осуществляется посредством\nусиления выработки ключевых интерлейкинов (интерлейкина-1, интерлейкина-6,\nинтерлейкина-12), фактора некроза опухолей альфа, гамма-интерферона,\nколониестимулирующих факторов. Препарат повышает активность естественных\nкиллерных клеток."}},{"type":"paragraph","data":{"text":"Ликопид обладает\nнизкой токсичностью (ЛД50 превышает терапевтическую дозу более чем в 49 000\nраз). В эксперименте при пероральном способе введения в дозах, в 100 раз\nпревышающих терапевтическую, препарат не оказывает токсического действия на\nцентральную нервную и сердечно-сосудистую системы, не вызывает патологических\nизменений со стороны внутренних органов. Ликопид не оказывает эмбриотоксического и тератогенного\nдействия, не вызывает хромосомных, генных мутаций. В экспериментальных\nисследованиях, проведенных на животных, получены данные о противоопухолевой\nактивности Ликопида (ГМДП)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eФармакокинетика\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Биодоступность препарата при пероральном приёме составляет 7-13 %.\nСтепень связывания с альбуминами крови слабая. Время достижения максимальной\nконцентрации (tmax) – 1,5 часа после\nприёма. Период полувыведения (t1/2)– 4,29 часа. Активных метаболитов не образует,\nвыводится в основном через почки в неизмененном виде."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Препарат применяется у взрослых в комплексной терапии заболеваний,\nсопровождающихся вторичными иммунодефицитными состояниями:"}},{"type":"paragraph","data":{"text":"–     \nострые и хронические гнойно-воспалительные заболевания\nкожи и мягких тканей, включая гнойно-септические послеоперационные осложнения;"}},{"type":"paragraph","data":{"text":"–     \nинфекции, передающиеся половым путем\n(папилломавирусная инфекция, хронический трихомониаз);"}},{"type":"paragraph","data":{"text":"–      герпетическая инфекция\n(включая офтальмогерпес);"}},{"type":"paragraph","data":{"text":"–      псориаз (включая\nпсориатический артрит);"}},{"type":"paragraph","data":{"text":"–      туберкулез легких."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"повышенная чувствительность к глюкозаминилмурамилдипептиду и другим\nкомпонентам препарата;"}},{"type":"paragraph","data":{"text":"беременность\nи грудное вскармливание; дети в возрасте до 18-ти лет;"}},{"type":"paragraph","data":{"text":"аутоиммунный тиреоидит в фазе обострения;"}},{"type":"paragraph","data":{"text":"состояния, сопровождающиеся фебрильной температурой (>38°С) на момент\nприема препарата;"}},{"type":"paragraph","data":{"text":"редко встречающиеся врожденные нарушения обмена веществ: алактазия,\nгалактоземия, дефицит лактазы, непереносимость лактозы, дефицит\nсахаразы/изомальтазы, непереносимость фруктозы, глюкозо-галактозная\nмальабсорбция;"}},{"type":"paragraph","data":{"text":"применение при аутоиммунных заболеваниях не рекомендуется вследствие\nотсутствия клинических данных."}}]},{"id":1,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Ликопид 10 мг\nприменяется с осторожностью у лиц пожилого возраста, строго под контролем\nврача. "}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Прием препарата Ликопид 10\nмг \u003cb\u003eпротивопоказан \u003c/b\u003eженщинам в период\nбеременности и грудного вскармливания."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Ликопид применяют внутрь натощак, за 30 минут до еды."}},{"type":"header","data":{"text":"Пациентам\nпожилого возраста рекомендуется начинать лечение с половинных доз (1/2 от\nтерапевтической), при отсутствии побочных эффектов повышая дозу препарата до\nнеобходимой терапевтической.","level":4}},{"type":"paragraph","data":{"text":"\u003ci\u003eПри пропуске приема препарата, если\nпрошло не более 12 часов от запланированного времени, Вы можете принять\nпропущенную дозу; в случае, если прошло более 12 часов от запланированного\nвремени приема, необходимо принять только следующую по схеме дозу и не\nпринимать пропущенную.\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003cb\u003eГнойно-воспалительные заболевания\nкожи и мягких тканей острые и хронические, тяжелое течение, включая\nгнойно-септические послеоперационные осложнения\u003c/b\u003e: по 10 мг\n1 раз в сутки в течение 10 дней;"}},{"type":"paragraph","data":{"text":"\u003cb\u003eГерпетическая инфекция (рецидивирующее течение,\nтяжелые формы): \u003c/b\u003eпо 10 мг 1 раз в сутки в течение 6 дней;"}},{"type":"paragraph","data":{"text":"- \u003cb\u003eпри офтальмогерпесе:\n\u003c/b\u003eпо 10 мг 2 раза в сутки в течение 3-х дней. После перерыва в 3 дня курс\nлечения повторяют."}},{"type":"header","data":{"text":"Инфекции,     передающиеся     половым     путем                         (папилломавирусная инфекция, хронический трихомониаз):","level":4}},{"type":"paragraph","data":{"text":"–        \nпри папилломавирусной инфекции: по 10 мг 1 раз в сутки в течение 10 дней,"}},{"type":"paragraph","data":{"text":"–        \nпри хроническом трихомониазе: по 10 мг 1 раз в сутки в течение 10 дней."}},{"type":"paragraph","data":{"text":"\u003cb\u003eПсориаз: \u003c/b\u003eпо 10-20 мг 1 раз в сутки в\nтечение 10 дней и далее пять приемов через день по 10-20 мг 1 раз в сутки."}},{"type":"paragraph","data":{"text":"При \u003ci\u003eтяжелом течении \u003c/i\u003eпсориаза и обширном\nпоражении (включая псориатический артрит): по 10 мг 2 раза в сутки в течение 20\nдней."}},{"type":"paragraph","data":{"text":"\u003cb\u003eТуберкулез\nлегких: \u003c/b\u003eпо\n10 мг 1 раз в сутки в течение 10 дней."}},{"type":"header","data":{"text":"Меры предосторожности при применении","level":4}},{"type":"paragraph","data":{"text":"Каждая таблетка\nЛикопид 10 мг содержит\nсахарозу в количестве 0,001 х.е. (хлебных единиц), что следует учитывать\nпациентам с сахарным диабетом."}},{"type":"paragraph","data":{"text":"Каждая\nтаблетка Ликопид 10 мг содержит\n0,184 грамма лактозы, что следует учитывать"}},{"type":"paragraph","data":{"text":"больным, страдающим гиполактазией (непереносимость лактозы, при котором в\nорганизме наблюдается снижение уровня лактазы – фермента, необходимого для\nпереваривания лактозы)."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eЧасто (1-10%) \u003c/i\u003e– артралгии (боли\nв суставах), миалгии (боли в мышцах); в начале лечения может отмечаться\nкратковременное повышение температуры тела до субфебрильных значений (до\n37,9°С), что не является показанием к отмене препарата. Чаще всего"}},{"type":"paragraph","data":{"text":"вышеописанные побочные эффекты наблюдается при приеме таблеток Ликопид в высоких дозах (20 мг)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eРедко (0,01-0,1%) – \u003c/i\u003eповышение\nтемпературы тела до фебрильных значений (>38,0°С). При повышении температуры\nтела больше 38,0°С возможен прием жаропонижающих средств, что не снижает\nфармакологических эффектов таблеток Ликопид."}},{"type":"paragraph","data":{"text":"\u003ci\u003eОчень редко (меньше 0,01%) \u003c/i\u003e– диарея."}},{"type":"paragraph","data":{"text":"Если любые из указанных в инструкции побочных эффектов усугубляются, или\nВы заметили любые другие побочные эффекты, не указанные в инструкции, \u003cb\u003eсообщите об этом лечащему врачу.\u003c/b\u003e"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Случаи передозировки препарата\nнеизвестны.Исходя из фармакологических свойств препарата, в случае его передозировки\nможет наблюдаться подъем температуры тела до субфебрильных (до 37,9°С)\nзначений. При необходимости проводится симптоматическая терапия (жаропонижающие\nсредства), назначаются сорбенты. Специфический антидот неизвестен."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Препарат повышает эффективность противомикробных препаратов, отмечается\nсинергизм в отношении противовирусных и противогрибковых препаратов. Антациды и\nсорбенты значительно снижают биодоступность препарата. Глюкокортикостероиды\nснижают биологический эффект Ликопида."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"В начале приема Ликопида 10\nмг возможно обострение симптомов хронических и латентно-протекающих\nзаболеваний, связанное с основными фармакологическими эффектами препарата."}},{"type":"paragraph","data":{"text":"У лиц пожилого возраста Ликопид 10\nмг применяется с осторожностью, строго под контролем врача. Пациентам пожилого\nвозраста рекомендуется начинать лечение с половинных доз (1/2 от\nтерапевтической), при отсутствии побочных эффектов повышая дозу препарата до\nнеобходимой терапевтической."}},{"type":"paragraph","data":{"text":"Решение о назначение препарата Ликопид таблетки 10 мг пациентам с сочетанием диагнозов\n«псориаз» и «подагра» должен принимать \u003cb\u003eврач\n\u003c/b\u003eпри оценке соотношения риск/польза, вследствие наличия потенциального риска\nобострения подагрического артрита и отека сустава. В случае принятия \u003cb\u003eврачом \u003c/b\u003eрешения о назначении Ликопид таблетки 10 мг в ситуации\nсочетания у пациента диагнозов «псориаз» и «подагра»,"}},{"type":"paragraph","data":{"text":"лечение\nследует начинать с низких доз, при отсутствии побочных эффектов, повышая дозу\nдо терапевтической."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Не влияет на\nспособность управлять транспортными средствами и сложными механизмами. "}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки по 10 мг."}},{"type":"paragraph","data":{"text":"По 10 таблеток в контурную ячейковую упаковку из\nполивинилхлоридной плёнки и фольги алюминиевой печатной лакированной."}},{"type":"paragraph","data":{"text":"По 1 контурной ячейковой упаковке вместе с инструкцией\nпо медицинскому применению помещают в пачку из картона."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В оригинальной\nупаковке, защищённом от света месте, при температуре не выше                25 °С.  Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"5 лет. "}},{"type":"paragraph","data":{"text":"Не применять после\nистечения срока годности. "}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают по\nрецепту. "}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"1. АО «Пептек», Россия"}},{"type":"paragraph","data":{"text":"117997, Москва, ул. Миклухо-Маклая, дом\n16/10,  тел./факс:  + 7 (495) 330-74-56"}},{"type":"paragraph","data":{"text":"2. ООО «СКОПИНФАРМ», Россия"}},{"type":"paragraph","data":{"text":"391800, Рязанская обл., Скопинский район,\nПромышленная зона № 1 тер., здание 1."}},{"type":"paragraph","data":{"text":"тел./факс: \n+7(49156)2-28-44"}},{"type":"paragraph","data":{"text":"\u003cb\u003eАдрес производства\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"1. АО «Пептек», Россия."}},{"type":"paragraph","data":{"text":"117997, Москва, ул. Миклухо-Маклая, дом 16/10,\nкорпуса 2, 7, 9, 10, 14, 20."}},{"type":"paragraph","data":{"text":"тел./факс: (495) 330-74-56"}},{"type":"paragraph","data":{"text":"2. ООО «СКОПИНФАРМ», Россия"}},{"type":"paragraph","data":{"text":"391800, Рязанская обл., Скопинский район,\nПромышленная зона № 1 тер., здание 1,"}},{"type":"paragraph","data":{"text":"тел./факс: \n+7(49156)2-28-44"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"АО «Пептек», Россия"}},{"type":"paragraph","data":{"text":"117997, г. Москва, ул. Миклухо-Маклая, дом 16/10"}},{"type":"paragraph","data":{"text":" \u003cb\u003e\u003ci\u003eПо адресу, электронному адресу и\nтелефону АО «Пептек» можно, при необходимости, получить дополнительные данные о\nпрепарате, сообщить о нежелательных побочных реакциях при приеме препарата (побочных\nэффектах) или направить рекламацию на его качество.\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003cb\u003ewww.peptek.ru,\nwww.licopid.ru\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003cb\u003ee-mail: peptek@peptek.ru, med_dir@peptek.ru\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003cb\u003eТел./факс: +7\n(495) 776-00-40\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003cb\u003e                    +7 (495)330-74-56\u003c/b\u003e"}}]}],"source":null},"description_toggle":false,"short_description":"ФармакодинамикаДействующее вещество таблеток Ликопид – глюкозаминилмурамилдипептид (ГМДП) – представляет собой синтетический аналог структурного фрагмента оболочки (пептидогликана) бактериальных клеток. ГМДП является активатором врожденного и приобретенного иммунитета, усиливает защиту организма от вирусных, бактериальных и грибковых инфекций; оказывает адъювантный эффект в развитии иммунологических реакций. Биологическая активность препарата реализуется посредством связывания ГМДП с внутриклеточным рецепторным белком NOD2, локализованным в цитоплазме фагоцитов (нейтрофилов, макрофагов, дендритных клеток). Препарат стимулирует функциональную (бактерицидную, цитотоксическую) активность фагоцитов, усиливает презентацию ими антигенов, пролиферацию Т- и В-лимфоцитов, повышает синтез специфических антител, способствует нормализации баланса Th1/Th2-лимфоцитов в сторону преобладания Th1. Фармакологическое действие осуществляется посредством усиления выработки ключевых интерлейкинов (интерлейкина-1, интерлейкина-6, интерлейкина-12), фактора некроза опухолей альфа, гамма-интерферона, колониестимулирующих факторов. Препарат повышает активность естественных киллерных клеток. Ликопид обладает низкой токсичностью (ЛД50 превышает терапевтическую дозу более чем в 49 000 раз). В эксперименте при пероральном способе введения в дозах, в 100 раз превышающих терапевтическую, препарат не оказывает токсического действия на центральную нервную и сердечно-сосудистую системы, не вызывает патологических изменений со стороны внутренних органов. Ликопид не оказывает эмбриотоксического и тератогенного действия, не вызывает хромосомных, генных мутаций. В экспериментальных исследованиях, проведенных на животных, получены данные о противоопухолевой активности Ликопида (ГМДП).ФармакокинетикаБиодоступность препарата при пероральном приёме составляет 7-13 %. Степень связывания с альбуминами крови слабая. Время достижения максимальной концентрации (tmax) – 1,5 часа после приёма. Период полувыведения (t1/2)– 4,29 часа. Активных метаболитов не образует, выводится в основном через почки в неизмененном виде.","substance":[{"id":108,"title":"Глюкозаминилмурамилдипептид","title_latin":"Glucoseminylmuramildipeptidum","slug":"glyukozaminilmuramildipeptid_108"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":{"count":42,"url":"/review/1353-licopid/"},"image_alt":"Ликопид - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/70027/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/70027/share_default/"}},"diseases":[{"id":"63","title":"Трихомоноз","slug":"63-trihomonoz"},{"id":"64","title":"Аногенитальная герпетическая вирусная инфекция [herpes simplex]","slug":"64-anogenitalnaya_gerpeticheskaya_virusnaya_infektsiya_herpes_simplex"},{"id":"92","title":"Инфекции, вызванные вирусом простого герпеса [herpes 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