Кишечный амебиаз у взрослых:-как дополнительное средство к терапии тканевыми амебицидами; -как монотерапия при бессимптомном носительстве амебиаза.
Противопоказания
повышенная индивидуальная чувствительность к компонентам препарата.
Применение при беременности и в период грудного вскармливания
Ввиду отсутствия клинического опыта применение препарата в период беременности и кормления грудью противопоказано.
Способ применения и дозы
Внутрь, при острых кишечных инфекциях 4-6 капсул в сутки в течение 3-5 дней; при хроническом амебиозе -4 капсулы в сутки в течение 10 суток (максимальная длительность лечения 4 нед.). Для профилактики кишечных инфекций и поноса во время путешествий - 2 капсулы в день в течение путешествия и 3-х дней по возвращении.
Побочное действие
в единичных случаях отмечали повышение уровня печеночных трансаминаз; большинство из них были бессимптомными и заканчивались снижением уровня после прекращения лечения. Сообщалось о развитии гепатита. Сообщалось о некоторых редких кожных реакциях гиперсенситивного (крапивница, отек Квинке) или буллезного типа (постоянная пигментная эритема). В исключительных случаях при длительном применении сообщалось о периферической нейропатии или поражении зрительного нерва.
Передозировка
при случайном применении препарата в высокой дозе необходим тщательный контроль уровня печеночных трансаминаз в плазме крови, а также уровня протромбина.
Особые указания
результаты клинических исследований подтвердили, что у здоровых добровольцев Интетрикс часто приводит к умеренному асимптоматическому и обратимому повышению уровня печеночных трансаминаз. Поэтому в случае повышения уровня трансаминаз и особенно при развитии желтухи применение лекарственного средства следует прекратить. Продолжительное применение Интетрикса не рекомендуется ввиду риска возникновения периферической нейропатии (см. ПОБОЧНЫЕ ЭФФЕКТЫ). Интетрикс нельзя назначать одновременно с другими препаратами, содержащими гидроксихинолины. Лекарственное средство содержит краситель азорубин (E122) и может вызвать аллергические реакции. Не применять Интетрикс длительное время из-за риска возникновения периферической или оптической нейропатии. Препарат содержит лактозу, поэтому его применение не рекомендуется пациентам с непереносимостью галактозы, недостаточностью лактазы или синдромом глюкозо-галактозной мальабсорбции (редкое наследственное заболевание). У женщин репродуктивного возраста препарат применяют только при условии использования надежных методов контрацепции. Применение в период беременности и кормления грудью. Надежные данные о потенциальных тератогенных эффектах Интетрикс у животных отсутствуют. В настоящее время отсутствуют необходимые данные в достаточном количестве, чтобы оценить потенциальный мальформационный или фетотоксический эффект этого лекарственного средства при применении его в период беременности. Лекарственное средство можно применять женщинам репродуктивного возраста только при условии использования надежных методов контрацепции. Не применять препарат в период беременности и кормления грудью. Следует обратиться за советом к врачу, прежде чем применять какие-либо лекарственные средства. Дети. Не применяют у детей. Способность влиять на скорость реакции при управлении транспортными средствами или работе с другими механизмами. Данные отсутствуют.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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