на 1 мл: Активные вещества: гидроксиметилхиноксалиндиоксид 5 мгВспомогательные вещества: вода для инъекций - до 1 мл.
Фармакотерапевтическая группа
Противомикробное средство - хиноксалин. При местном применении частично всасывается с раневой или ожоговой поверхности, выводится почками.
Фармакологические свойства
2, 3-бис-(оксиметил) хиноксалина 1,4-ди-N-оксид. Антибактериальный бактерицидный препарат широкого спектра действия. Активен в отношении Proteus vulgaris, Pseudomonas aeruginosa, палочки Фридлендера, Escherichia coli, Shigella dysenteria, Shigella flexneri, Shigella boydii, Shigella sonnei, Salmonella spp., Staphylococcus spp., Streptococcus spp., патогенных анаэробов (Clostridium perfringens). Действует на штаммы бактерий, устойчивых к другим противомикробным лекарственным средствам, включая антибиотики. Не оказывает местнораздражающего действия. Возможно развитие лекарственной устойчивости бактерий. При в/в введении характеризуется малой терапевтической широтой, в связи с чем необходимо строгое соблюдение рекомендуемых доз. Обработка ожоговых и гнойно-некротических ран способствует более быстрому очищению раневой поверхности, стимулирует репаративную регенерацию и краевую эпителизацию и благоприятно влияет на течение раневого процесса. В экспериментальных исследованиях продемонстрировано наличие тератогенного, эмбриотоксического и мутагенного действия.
Показания к применению
Для в/в введения:
Септические состояния (в т.ч. у больных ожоговой болезнью)
Гнойный менингит
Гнойно-воспалительные процессы с симптомами генерализации. Для внутриполостного введения - гнойные процессы в грудной и брюшной полости, в т.ч.:
Гнойный плеврит
Эмпиема плевры
Перитонит
Цистит
Эмпиема желчного пузыря
Профилактика инфекционных осложнений после катетеризации мочевого пузыря. Для наружного, местного применения:
Раневая и ожоговая инфекция (поверхностные и глубокие гнойные раны различной локализации, длительно не заживающие раны и трофические язвы, флегмоны мягких тканей, инфицированные ожоги, гнойные раны при остеомиелитах)
Надпочечниковая недостаточность (в т.ч. в анамнезе)
Беременность
Период лактации (грудное вскармливание)
Детский возраст (до 18 лет).C осторожностью: почечная недостаточность
С осторожностью
Почечная недостаточность.
Применение при беременности и в период грудного вскармливания
При ХПН дозу уменьшают. Назначают только при неэффективности других противомикробных лекарственных средств.
Способ применения и дозы
В/в капельно. При тяжелых септических состояниях вводят 0.5% раствор для инъекций, предварительно разведя в 5% растворе декстрозы или в 0.9% растворе натрия хлорида до концентрации 0.1-0.2%. Высшая разовая доза - 300 мг, суточная - 600 мг. Внутриполостно. В полости раствор вводят через дренажную трубку, катетер или шприц, 10-50 мл 1% раствора. Наружно, на раневую поверхность, предварительно очищенную от гнойно-некротических масс, накладывают салфетки, смоченные 1% раствором ежедневно или через день, в зависимости от состояния ожоговой раны и течения раневого процесса. Глубокие раны тампонируют или проводят орошение 0.5% раствором. Максимальная суточная доза - 2.5 г. Длительность лечения - до 3 нед.
Побочное действие
Аллергические реакции. После в/в и внутриполостного введения - головная боль, озноб, гипертермия, тошнота, рвота, диарея, подергивание мышц. Местные реакции: околораневой дерматит.
Передозировка
При передозировке Диоксидина возможно развитие острой надпочечниковой недостаточности, что требует немедленной отмены препарата и соответствующей заместительной гормонотерапии.
Взаимодействие с другими лекарственными средствами
При повышенной чувствительности к препарату, Диоксидин применяют одновременно с антигистаминными препаратами или препаратами кальция.
Особые указания
Диоксидин назначают только при тяжелых формах инфекционных заболеваний или при неэффективности других антибактериальных препаратов, в том числе цефалоспоринов II-IV поколений, фторхинолонов, карбапенемов. При хронической почечной недостаточности дозу уменьшают. В случае выпадения кристаллов в процессе хранения (при температуре ниже 15 °С) их растворяют, нагревая ампулы в кипящей водяной бане при встряхивании до полного растворения кристаллов (прозрачный раствор). Если при охлаждении до 36 - 38 °С кристаллы не выпадут вновь, препарат годен к применению. Влияние на способность управлять транспортными средствами и другими механизмами: В период лечения необходимо соблюдать осторожность при управлении транспортными средствами и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций.
Форма выпуска
Раствор.
Условия хранения
от 15℃ до 25℃.
Условия отпуска
По рецепту.
Производитель
Валента Фармацевтика.
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