1 мл раствора для внутривенного введения содержит: действующее вещество: урапидила гидрохлорид 5,47 мг (соответствует 5 мг урапидила).
Вспомогательные вещества: пропиленгликоль; натрия гидрофосфата дигидрат; натрия дигидрофосфата дигидрат; вода для инъекций.
Фармакологические свойства
Препарат Эбрантил сбалансированно снижает сАД и дАД, уменьшая периферическое сопротивление.
Урапидил снижает пред- и постнагрузку на сердце, повышает эффективность сердечного сокращения, тем самым, при отсутствии аритмии, препарат увеличивает сниженный минутный объем сердца.
Механизм действия. Препарат Эбрантил имеет центральный и периферический механизмы действия.
Преимущественно блокирует периферические постсинаптические α1- адренорецепторы, т.о. препарат блокирует сосудосуживающее действие катехоламинов.
В ЦНС урапидил влияет на активность сосудодвигательного центра, что проявляется в предотвращении рефлекторного изменения тонуса симпатической нервной системы.
Урапидил не влияет на показатели углеводного обмена, обмен мочевой кислоты и не вызывает задержки жидкости в организме.
Показания к применению
рефрактерная гипертензия или тяжелая степень ее выраженности;
управляемая артериальная гипотензия во время и/или после хирургической операции.
гипертонический криз;
Противопоказания
открытый Боталлов проток;
беременность;
повышенная чувствительность к препарату Эбрантил;
аортальный стеноз;
период лактации (эффективность и безопасность не установлены);
возраст до 18 лет.
С осторожностью
С осторожностью: пожилой возраст, нарушение функции печени и/или почек, гиповолемия.
Способ применения и дозы
Вводят струйно или путем длительной инфузии в положении больного лежа.
Гипертонический криз, тяжелая степень артериальной гипертензии, рефрактерная гипертензия
1. Внутривенно: 10–50 мг препарата Эбрантил медленно вводят под контролем АД. Снижение АД ожидается в течение 5 мин после введения. В зависимости от терапевтического эффекта, возможно повторное введение препарата Эбрантил.
2. Внутривенная капельная или непрерывная инфузия с помощью перфузионного насоса. Поддерживающая доза — в среднем 9 мг/ч, т.е. 250 мг препарата Эбрантил (10 ампул по 5 мл или 5 ампул по 10 мл) в 500 мл раствора для инфузий (1 мг = 44 капли = 2,2 мл).
Максимальное допустимое соотношение — 4 мг препарата Эбрантил на 1 мл раствора для инфузий.
Рекомендуемая максимальная начальная скорость — 2 мг/мин.
Скорость капельного введения зависит от показателей АД пациента.
Раствор для капельной инфузий, предназначенный для поддержания АД, готовится следующим образом.
Обычно 250 мг препарата (10 ампул по 5 мл или 5 амп. по 10 мл) препарата Эбрантил добавляют к 500 мл раствора для инфузий, например физиологического раствора, 5 или 10% раствора декстрозы (глюкозы).
Если для введения поддерживающей дозы используется перфузионный насос, то 100 мг (4 ампулы по 5 мл или 2 ампулы по 10 мл) препарата Эбрантил вводят в шприц перфузионного насоса и разводят до 50 мл физиологическим раствором, 5 или 10% раствором декстрозы (глюкозы).
Управляемое (контролируемое) снижение АД при его повышении во время и/или после хирургической операции. Непрерывная инфузия с помощью перфузионного насоса или капельная инфузия используется для поддержания АД на уровне, достигнутом с помощью в/в введения.
Схема дозирования представлена на рисунке.
Примечания:
- если ранее использовались другие гипотензивные средства, то препарат Эбрантил, можно вводить только через промежуток времени, достаточный, чтобы подействовал(и) ранее введенный(е) препарат(ы); дозу препарата Эбрантил следует соответственно скорректировать;
- при использовании гипотензивных средств у пожилых пациентов необходимо соблюдать осторожность; начальная доза должна быть снижена по сравнению с рекомендуемой, поскольку чувствительность у пожилых пациентов к препаратам такого ряда часто изменена (Vd снижен, а T1/2 увеличен).
Введение препарата может быть однократным или многократным. Инъекционное введение препарата можно сочетать с последующей капельной инфузией. Парентеральную терапию можно повторить при новом повышении АД.
Побочное действие
Большинство из следующих побочных эффектов обусловлены резким падением АД, однако опыт клинического применения показывает, что они исчезают в течение нескольких минут даже после проведения капельной инфузии препарата Эбрантил. При тяжелых побочных эффектах может потребоваться прекращение лечения.
Лечение: при резком падении АД необходимо приподнять пациенту ноги и начать инфузионную терапию для увеличения ОЦК. При неэффективности этих мер можно начать инфузию вазоконстрикторов под контролем АД. В очень редких случаях необходимо в/в введение катехоламинов (0,5–1 мг эпинефрина (адреналина), разведенного в 10 мл физиологического раствора).
Взаимодействие с другими лекарственными средствами
Гипотензивное действие урапидила может усиливаться при совместном приеме с α-адреноблокаторами или другими гипотензивными средствами, а также при гиповолемии (тошнота, рвота) и при приеме этанола.
При одновременном приеме циметидина Cmax урапидила в плазме крови может увеличиваться на 15%.
Особые указания
Возможно одновременное применение с другими назначаемыми внутрь гипотензивными средствами.
Нет клинических данных о применении препарата у детей до 18 лет.
Форма выпуска
Раствор для внутривенного введения.
Условия хранения
При температуре не выше 30 °C
Срок годности
2 года.
Условия отпуска
По рецепту.
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Препарат Эбрантил имеет центральный и периферический механизмы действия."}},{"type":"paragraph","data":{"text":"Преимущественно блокирует периферические постсинаптические α\u003csub\u003e1\u003c/sub\u003e- адренорецепторы, т.о. препарат блокирует сосудосуживающее действие катехоламинов."}},{"type":"paragraph","data":{"text":"В ЦНС урапидил влияет на активность сосудодвигательного центра, что проявляется в предотвращении рефлекторного изменения тонуса симпатической нервной системы."}},{"type":"paragraph","data":{"text":"Урапидил не влияет на показатели углеводного обмена, обмен мочевой кислоты и не вызывает задержки жидкости в организме."}}]},{"id":7,"name":"Показания к применению","slug":"indications","body":[{"type":"list","data":{"style":"ordered","items":["рефрактерная гипертензия или тяжелая степень ее выраженности;","управляемая артериальная гипотензия во время и/или после хирургической операции.","гипертонический криз;"]}}]},{"id":8,"name":"Противопоказания","slug":"contraindications","body":[{"type":"list","data":{"style":"ordered","items":["открытый Боталлов проток;","беременность;","повышенная чувствительность к препарату Эбрантил;","аортальный стеноз;","период лактации (эффективность и безопасность не установлены);","возраст до 18 лет."]}}]},{"id":9,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"С осторожностью: пожилой возраст, нарушение функции печени и/или почек, гиповолемия."}}]},{"id":11,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Вводят струйно или путем длительной инфузии в положении больного лежа."}},{"type":"paragraph","data":{"text":"Гипертонический криз, тяжелая степень артериальной гипертензии, рефрактерная гипертензия"}},{"type":"paragraph","data":{"text":"1. Внутривенно: 10–50 мг препарата Эбрантил медленно вводят под контролем АД. Снижение АД ожидается в течение 5 мин после введения. В зависимости от терапевтического эффекта, возможно повторное введение препарата Эбрантил."}},{"type":"paragraph","data":{"text":"2. Внутривенная капельная или непрерывная инфузия с помощью перфузионного насоса. Поддерживающая доза — в среднем 9 мг/ч, т.е. 250 мг препарата Эбрантил (10 ампул по 5 мл или 5 ампул по 10 мл) в 500 мл раствора для инфузий (1 мг = 44 капли = 2,2 мл)."}},{"type":"paragraph","data":{"text":"Максимальное допустимое соотношение — 4 мг препарата Эбрантил на 1 мл раствора для инфузий."}},{"type":"paragraph","data":{"text":"Рекомендуемая максимальная начальная скорость — 2 мг/мин."}},{"type":"paragraph","data":{"text":"Скорость капельного введения зависит от показателей АД пациента."}},{"type":"paragraph","data":{"text":"Раствор для капельной инфузий, предназначенный для поддержания АД, готовится следующим образом."}},{"type":"paragraph","data":{"text":"Обычно 250 мг препарата (10 ампул по 5 мл или 5 амп. по 10 мл) препарата Эбрантил добавляют к 500 мл раствора для инфузий, например физиологического раствора, 5 или 10% раствора декстрозы (глюкозы)."}},{"type":"paragraph","data":{"text":"Если для введения поддерживающей дозы используется перфузионный насос, то 100 мг (4 ампулы по 5 мл или 2 ампулы по 10 мл) препарата Эбрантил вводят в шприц перфузионного насоса и разводят до 50 мл физиологическим раствором, 5 или 10% раствором декстрозы (глюкозы)."}},{"type":"paragraph","data":{"text":"Управляемое (контролируемое) снижение АД при его повышении во время и/или после хирургической операции. Непрерывная инфузия с помощью перфузионного насоса или капельная инфузия используется для поддержания АД на уровне, достигнутом с помощью в/в введения."}},{"type":"paragraph","data":{"text":"Схема дозирования представлена на рисунке."}},{"type":"paragraph","data":{"text":"Примечания:"}},{"type":"paragraph","data":{"text":"- если ранее использовались другие гипотензивные средства, то препарат Эбрантил, можно вводить только через промежуток времени, достаточный, чтобы подействовал(и) ранее введенный(е) препарат(ы); дозу препарата Эбрантил следует соответственно скорректировать;"}},{"type":"paragraph","data":{"text":"- при использовании гипотензивных средств у пожилых пациентов необходимо соблюдать осторожность; начальная доза должна быть снижена по сравнению с рекомендуемой, поскольку чувствительность у пожилых пациентов к препаратам такого ряда часто изменена (V\u003csub\u003ed\u003c/sub\u003e снижен, а T\u003csub\u003e1/2\u003c/sub\u003e увеличен)."}},{"type":"paragraph","data":{"text":"Введение препарата может быть однократным или многократным. Инъекционное введение препарата можно сочетать с последующей капельной инфузией. Парентеральную терапию можно повторить при новом повышении АД."}}]},{"id":12,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Большинство из следующих побочных эффектов обусловлены резким падением АД, однако опыт клинического применения показывает, что они исчезают в течение нескольких минут даже после проведения капельной инфузии препарата Эбрантил. При тяжелых побочных эффектах может потребоваться прекращение лечения."}}]},{"id":13,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: головокружение, ортостатический коллапс, утомляемость, заторможенность."}},{"type":"paragraph","data":{"text":"Лечение: при резком падении АД необходимо приподнять пациенту ноги и начать инфузионную терапию для увеличения ОЦК. При неэффективности этих мер можно начать инфузию вазоконстрикторов под контролем АД. В очень редких случаях необходимо в/в введение катехоламинов (0,5–1 мг эпинефрина (адреналина), разведенного в 10 мл физиологического раствора)."}}]},{"id":14,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Гипотензивное действие урапидила может усиливаться при совместном приеме с α-адреноблокаторами или другими гипотензивными средствами, а также при гиповолемии (тошнота, рвота) и при приеме этанола."}},{"type":"paragraph","data":{"text":"При одновременном приеме циметидина C\u003csub\u003emax\u003c/sub\u003e урапидила в плазме крови может увеличиваться на 15%."}}]},{"id":15,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Возможно одновременное применение с другими назначаемыми внутрь гипотензивными средствами."}},{"type":"paragraph","data":{"text":"Нет клинических данных о применении препарата у детей до 18 лет."}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для внутривенного введения."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре не выше 30 °C"}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту."}}]}],"source":{"title":"ЗдравСити","url":"https://zdravcity.ru"}},"description_toggle":false,"short_description":"Препарат Эбрантил сбалансированно снижает сАД и дАД, уменьшая периферическое сопротивление. 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Урапидил не влияет на показатели углеводного обмена, обмен мочевой кислоты и не вызывает задержки жидкости в организме.","substance":[{"id":477,"title":"Урапидил","title_latin":"Urapidilum","slug":"urapidil_477"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"Эбрантил - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/867/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/867/share_default/"}},"diseases":[{"id":"717","title":"Эссенциальная [первичная] гипертензия","slug":"717-essentsialnaya_pervichnaya_gipertenziya"}],"other_packages":[],"other_product_forms":[],"related_products":{"title":"Похожие товары","type":"nondrugs","products":[{"id":144099,"title":"Магния сульфат","subtitle":{"full":"Раствор, ампулы, 10 шт, 10 мл, 25 %, для внутривенного введения","short":"Раствор, 10 шт, 10 мл, 25 %","package":"10 шт, 10 мл, 25 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