Артрит, ревматическая боль в суставах и мышцах, спортивные травмы, ушибы и повреждения связочного аппарата, мышечная боль, вызванная чрезмерной физической нагрузкой, люмбаго, неврит, ишиалгия, бурсит и тендовагинит. Для предварительного «разогрева» мышц перед физическими упражнениями, спортивными соревнованиями. В составе комплексной сосудорасширяющей ...
Повышенная чувствительность к никобоксилу, нонивамиду или вспомогательным веществам препарата. Не следует наносить мазь на чувствительную кожу, открытые раны, воспаленные участки кожи, участки кожи с повышенной проницаемостью: шея, низ живота, внутренняя сторона бедер. Детский возраст до 12 лет.
Нонивамид является синтетическим аналогом капсаицина и обладает анальгезирующими свойствами, которые проявляются в результате постепенного проникновения активного вещества в периферические ноцицептивные C-волокна и А-дельта нервные волокна при повторном нанесении препарата на кожу. Нонивамид оказывает сосудорасширяющее действие, которое сопровождается интенсивным, длительным ощущением тепла, за счет стимуляции афферентных нервных окончаний в коже. Никобоксил является производным никотиновой кислоты, обладающей сосудорасширяющими свойствами при участии простагландинов I2 и Е2. Гиперемический эффект никобоксила (бутоксиэтиловый эфир никотиновой кислоты) развивается быстрее и имеет большую интенсивность, чем гиперемический эффект нонивамида. Комбинированное действиеНонивамид и никобоксил обладают дополняющими друг друга сосудорасширяющими свойствами, вызывают гиперемию кожи, увеличивают скорость ферментативных реакций, активизируют обмен веществ. Появление гиперемии и повышение температуры кожи в течение нескольких минут после нанесения свидетельствуют о быстром проникновении активных компонентов препарата в кожу. Действие Финалгона проявляется локально, развивается через несколько минут и достигает максимума через 20-30 мин. Анальгезирующее действие комбинации 0.4% нонивамида и 2.5% никобоксила было продемонстрировано в исследовании эффективности у пациентов с острой неспецифической болью в нижней части спины. Установлено, что у пациентов, применявших препарат Финалгон (2 см мази на одно нанесение до 3 раз/сут в течение 4 дней), наблюдалось клинически значимое уменьшение интенсивности болей в нижней части спины уже через 4 ч после первого применения; в последний день лечения, определявшийся индивидуально, также наблюдалось клинически значимое уменьшение боли. В клиническом исследовании установлено, что уменьшение боли начиналось через 1-2 ч.
Показания к применению
Артрит, ревматическая боль в суставах и мышцах, спортивные травмы, ушибы и повреждения связочного аппарата, мышечная боль, вызванная чрезмерной физической нагрузкой, люмбаго, неврит, ишиалгия, бурсит и тендовагинит. Для предварительного «разогрева» мышц перед физическими упражнениями, спортивными соревнованиями. В составе комплексной сосудорасширяющей терапии при нарушениях периферического кровообращения.
Противопоказания
Повышенная чувствительность к никобоксилу, нонивамиду или вспомогательным веществам препарата. Не следует наносить мазь на чувствительную кожу, открытые раны, воспаленные участки кожи, участки кожи с повышенной проницаемостью: шея, низ живота, внутренняя сторона бедер. Детский возраст до 12 лет.
Применение при беременности и в период грудного вскармливания
Препарат вызывает гиперемию кожи, вследствие чего появляется покраснение, ощущение тепла, зуда и жжения в месте применения. Данные симптомы могут быть более выражены при нанесении избыточного количества препарата или в случае интенсивного растирания по поверхности кожи. Использование чрезмерных количеств препарата или интенсивное растирание по поверхности кожи может привести к возникновению везикул или пустул в месте нанесения мази. После использования препарата Финалгон следует немедленно вымыть руки с мылом. Необходимо соблюдать осторожность и избегать случайного попадания препарата на другие участки кожи или попадания препарата на другого человека. Избегать случайного попадания препарата на лицо, в глаза, нос или рот. Это может привести к временному отеку лица, боли в области лица, воспалению конъюнктивы, гиперемии глаз, жжению в глазах, нарушению зрения, дискомфорту в полости рта и стоматиту. До или после нанесения препарата на кожу не следует принимать горячую ванну или душ. Выделение пота или приложение тепла к месту нанесения препарата может вызвать покраснение кожи и интенсивное ощущение тепла даже через несколько часов после нанесения Финалгона. В составе препарата содержится сорбиновая кислота, которая может вызвать местное раздражение кожи (например, контактный дерматит). Влияние на способность к вождению автотранспорта и управлению механизмамиСпециальных клинических исследований влияния препарата на способность управлять автомобилем и механизмами не проводилось. Однако во время применения препарата при управлении автомобилем и работе с механизмами следует проявлять осторожность.
Способ применения и дозы
Лечение необходимо начинать с нанесения небольшого количества препарата на небольшой участок кожи для оценки индивидуальной реакции. Индивидуальная реакция на препарат может значительно отличаться: некоторым людям будет достаточно нанести небольшое количество мази, для того, чтобы вызвать необходимый разогревающий эффект. При помощи прилагаемого аппликатора столбик препарата размером не более 0,5 см, наносится на соответствующий участок кожи размером с ладонь легкими втирающими движениями. Для усиления лечебного действия участок кожи, на который нанесен препарат, можно накрыть шерстяной тканью. При многократном применении реакция на мазь может уменьшаться, что требует увеличения дозы, которая подбирается индивидуально. При необходимости мазь используют 2-3 раза в день. Для предварительного разогревания мышц перед физическими упражнениями, спортивными соревнованиями рекомендуется втирать примерно за 30 минут до их начала. При отсутствии желаемого эффекта в течение 10 дней следует обратиться к специалисту. После нанесения препарата на кожу следует тщательно вымыть руки с мылом.
Передозировка
Побочное действиеВ ходе длительного опыта применения препарата были выявлены следующие побочные эффекты: Со стороны иммунной системы: анафилактические реакции, повышенная чувствительность. Со стороны нервной системы: парестезия, ощущение жжения кожи. Со стороны органов дыхания: кашель, одышка. Со стороны кожи и подкожных тканей: везикулы или пустулы в месте нанесения, местная кожная реакция (например контактный дерматит), зуд, сыпь, отек лица, крапивница, ощущение жара в месте нанесения.
Особые указания
Симптомы: эффект гиперемии кожи и тяжесть дозозависимых побочных эффектов может усугубляться после применения избыточного количества мази Финалгон. Использование чрезмерных количеств препарата может привести к возникновению везикул или пустул в месте нанесения мази. Передозировка препаратом может вызвать системные реакции (покраснение верхней части тела, повышение температуры тела, приливы крови, болезненная гиперемия, снижение АД), т.к. эфиры никотиновой кислоты обладают хорошей трансдермальной абсорбцией. Лечение: при использовании избыточного количества препарата эффект может быть уменьшен, если удалить мазь с поверхности кожи при помощи растительного масла или косметического крема на жирной основе, со слизистой оболочки глаза (при случайном попадании) - с помощью медицинского вазелина. При необходимости, должно быть проведено симптоматическое лечение.
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вещество: Нонивамид + Никобоксил* (Nonivamidum+ Nicoboxilum)Концентрация действующего вещества (мг ): Нонивамид (ваниллиламид нониловой кислоты) (PSVA) 4 мг, никобоксил (бутоксиэтиловый эфир никотиновой кислоты) (NSBE) 25 мг"}}]},{"id":2,"name":"Фармакологические свойства","slug":"pharmacologic_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Нонивамид является синтетическим аналогом капсаицина и обладает анальгезирующими свойствами, которые проявляются в результате постепенного проникновения активного вещества в периферические ноцицептивные C-волокна и А-дельта нервные волокна при повторном нанесении препарата на кожу. Нонивамид оказывает сосудорасширяющее действие, которое сопровождается интенсивным, длительным ощущением тепла, за счет стимуляции афферентных нервных окончаний в коже. Никобоксил является производным никотиновой кислоты, обладающей сосудорасширяющими свойствами при участии простагландинов I2 и Е2. Гиперемический эффект никобоксила (бутоксиэтиловый эфир никотиновой кислоты) развивается быстрее и имеет большую интенсивность, чем гиперемический эффект нонивамида. Комбинированное действиеНонивамид и никобоксил обладают дополняющими друг друга сосудорасширяющими свойствами, вызывают гиперемию кожи, увеличивают скорость ферментативных реакций, активизируют обмен веществ. Появление гиперемии и повышение температуры кожи в течение нескольких минут после нанесения свидетельствуют о быстром проникновении активных компонентов препарата в кожу. Действие Финалгона проявляется локально, развивается через несколько минут и достигает максимума через 20-30 мин. Анальгезирующее действие комбинации 0.4% нонивамида и 2.5% никобоксила было продемонстрировано в исследовании эффективности у пациентов с острой неспецифической болью в нижней части спины. Установлено, что у пациентов, применявших препарат Финалгон (2 см мази на одно нанесение до 3 раз/сут в течение 4 дней), наблюдалось клинически значимое уменьшение интенсивности болей в нижней части спины уже через 4 ч после первого применения; в последний день лечения, определявшийся индивидуально, также наблюдалось клинически значимое уменьшение боли. В клиническом исследовании установлено, что уменьшение боли начиналось через 1-2 ч."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Артрит, ревматическая боль в суставах и мышцах, спортивные травмы, ушибы и повреждения связочного аппарата, мышечная боль, вызванная чрезмерной физической нагрузкой, люмбаго, неврит, ишиалгия, бурсит и тендовагинит. Для предварительного «разогрева» мышц перед физическими упражнениями, спортивными соревнованиями. В составе комплексной сосудорасширяющей терапии при нарушениях периферического кровообращения."}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к никобоксилу, нонивамиду или вспомогательным веществам препарата. Не следует наносить мазь на чувствительную кожу, открытые раны, воспаленные участки кожи, участки кожи с повышенной проницаемостью: шея, низ живота, внутренняя сторона бедер. Детский возраст до 12 лет."}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Препарат вызывает гиперемию кожи, вследствие чего появляется покраснение, ощущение тепла, зуда и жжения в месте применения. Данные симптомы могут быть более выражены при нанесении избыточного количества препарата или в случае интенсивного растирания по поверхности кожи. Использование чрезмерных количеств препарата или интенсивное растирание по поверхности кожи может привести к возникновению везикул или пустул в месте нанесения мази. После использования препарата Финалгон следует немедленно вымыть руки с мылом. Необходимо соблюдать осторожность и избегать случайного попадания препарата на другие участки кожи или попадания препарата на другого человека. Избегать случайного попадания препарата на лицо, в глаза, нос или рот. Это может привести к временному отеку лица, боли в области лица, воспалению конъюнктивы, гиперемии глаз, жжению в глазах, нарушению зрения, дискомфорту в полости рта и стоматиту. До или после нанесения препарата на кожу не следует принимать горячую ванну или душ. Выделение пота или приложение тепла к месту нанесения препарата может вызвать покраснение кожи и интенсивное ощущение тепла даже через несколько часов после нанесения Финалгона. В составе препарата содержится сорбиновая кислота, которая может вызвать местное раздражение кожи (например, контактный дерматит). Влияние на способность к вождению автотранспорта и управлению механизмамиСпециальных клинических исследований влияния препарата на способность управлять автомобилем и механизмами не проводилось. Однако во время применения препарата при управлении автомобилем и работе с механизмами следует проявлять осторожность."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Лечение необходимо начинать с нанесения небольшого количества препарата на небольшой участок кожи для оценки индивидуальной реакции. Индивидуальная реакция на препарат может значительно отличаться: некоторым людям будет достаточно нанести небольшое количество мази, для того, чтобы вызвать необходимый разогревающий эффект. При помощи прилагаемого аппликатора столбик препарата размером не более 0,5 см, наносится на соответствующий участок кожи размером с ладонь легкими втирающими движениями. Для усиления лечебного действия участок кожи, на который нанесен препарат, можно накрыть шерстяной тканью. При многократном применении реакция на мазь может уменьшаться, что требует увеличения дозы, которая подбирается индивидуально. При необходимости мазь используют 2-3 раза в день. Для предварительного разогревания мышц перед физическими упражнениями, спортивными соревнованиями рекомендуется втирать примерно за 30 минут до их начала. При отсутствии желаемого эффекта в течение 10 дней следует обратиться к специалисту. После нанесения препарата на кожу следует тщательно вымыть руки с мылом."}}]},{"id":7,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Побочное действиеВ ходе длительного опыта применения препарата были выявлены следующие побочные эффекты: Со стороны иммунной системы: анафилактические реакции, повышенная чувствительность. Со стороны нервной системы: парестезия, ощущение жжения кожи. Со стороны органов дыхания: кашель, одышка. Со стороны кожи и подкожных тканей: везикулы или пустулы в месте нанесения, местная кожная реакция (например контактный дерматит), зуд, сыпь, отек лица, крапивница, ощущение жара в месте нанесения."}}]},{"id":8,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Симптомы: эффект гиперемии кожи и тяжесть дозозависимых побочных эффектов может усугубляться после применения избыточного количества мази Финалгон. Использование чрезмерных количеств препарата может привести к возникновению везикул или пустул в месте нанесения мази. Передозировка препаратом может вызвать системные реакции (покраснение верхней части тела, повышение температуры тела, приливы крови, болезненная гиперемия, снижение АД), т.к. эфиры никотиновой кислоты обладают хорошей трансдермальной абсорбцией. Лечение: при использовании избыточного количества препарата эффект может быть уменьшен, если удалить мазь с поверхности кожи при помощи растительного масла или косметического крема на жирной основе, со слизистой оболочки глаза (при случайном попадании) - с помощью медицинского вазелина. При необходимости, должно быть проведено симптоматическое лечение."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Нонивамид является синтетическим аналогом капсаицина и обладает анальгезирующими свойствами, которые проявляются в результате постепенного проникновения активного вещества в периферические ноцицептивные C-волокна и А-дельта нервные волокна при повторном нанесении препарата на кожу. Нонивамид оказывает сосудорасширяющее действие, которое сопровождается интенсивным, длительным ощущением тепла, за счет стимуляции афферентных нервных окончаний в коже. Никобоксил является производным никотиновой кислоты, обладающей сосудорасширяющими свойствами при участии простагландинов I2 и Е2. Гиперемический эффект никобоксила (бутоксиэтиловый эфир никотиновой кислоты) развивается быстрее и имеет большую интенсивность, чем гиперемический эффект нонивамида. Комбинированное действиеНонивамид и никобоксил обладают дополняющими друг друга сосудорасширяющими свойствами, вызывают гиперемию кожи, увеличивают скорость ферментативных реакций, активизируют обмен веществ. Появление гиперемии и повышение температуры кожи в течение нескольких минут после нанесения свидетельствуют о быстром проникновении активных компонентов препарата в кожу. Действие Финалгона проявляется локально, развивается через несколько минут и достигает максимума через 20-30 мин. Анальгезирующее действие комбинации 0.4% нонивамида и 2.5% никобоксила было продемонстрировано в исследовании эффективности у пациентов с острой неспецифической болью в нижней части спины. Установлено, что у пациентов, применявших препарат Финалгон (2 см мази на одно нанесение до 3 раз/сут в течение 4 дней), наблюдалось клинически значимое уменьшение интенсивности болей в нижней части спины уже через 4 ч после первого применения; в последний день лечения, определявшийся индивидуально, также наблюдалось клинически значимое уменьшение боли. 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