Эпилепсия. Поражения сухожилий при ранее проводившемся лечении хинолонами. Детский и подростковый возраст до 18 лет. Беременность. Период лактации. Повышенная чувствительность к левофлоксацину или к другим хинолонам. С осторожностью следует применять препарат у пациентов пожилого возраста, в связи с высокой вероятностью наличия сопутствующего снижения ...
Синтетический противомикробный препарат широкого спектра действия из группы фторхинолонов. Левофлоксацин - левовращающий изомер офлоксацина. Блокирует ДНК-гиразу, нарушает суперспирализацию и сшивку разрывов ДНК, ингибирует синтез ДНК, вызывает глубокие морфологические изменения в цитоплазме, клеточной стенке и мембранах. К левофлоксацину чувствительны большинство штаммов микроорганизмов как в условиях in vitro, так и in vivo. Препарат активен в отношении аэробных грамположительных микроорганизмов: Corynebacterium diphtheriae, Enterococcus spp. (в т.ч. Enterococcus faecalis), Listeria monocytogenes, Staphylococcus spp. (коагулазонегативные метициллин-чувствительные/метициллин-умеренно чувствительные штаммы), Staphylococcus aureus (метициллин-чувствительные штаммы), Staphylococcus epidermidis (метициллин-чувствительные штаммы), Staphylococcus spp. (коагулазонегативные штаммы), Streptococcus spp. группы С и G, Streptococcus agalactiae, Streptococcus pneumoniae (пенициллин-чувствительные/умеренно чувствительные/резистентные штаммы), Streptococcus pyogenes, Streptococcus viridans (пенициллин-чувствительные/резистентные штаммы) . аэробных грамотрицательных микроорганизмов: Acinetobacter baumannil, Acinetobacter spp, Actinobacillus actinimycetemcomitans, Citrobacter freundii, Eikenella corrodens, Enterobacter spp. (в т.ч. Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter cloacae), Escherichia coli, Gardnerella vaginalis, Haemophilus ducreyi, Haemophilus influenzae (ампициллин-чувствительные/резистентные штаммы), Haemophilus parainfluenzae, Helicobacter pylori, Klebsiella spp. (в т.ч. Klebsiella oxytoca, Klebsiella pneumoniae), Moraxella catarrhalis (штаммы, продуцирующие и непродуцирующие β .-лактамазы), Morganella morganii, Neisseria gonorrhoeae (штаммы, продуцирующие и непродуцирующие пенициллиназу), Neisseria meningitidis, Pasteurella spp. (Pasteurella conis, Pasteurella dagmatis, Pasteurella multocida), Proteus mirabilis, Proteus vulgaris, Providencia spp. (в т.ч. Providencia rettgeri, Providencia stuartii), Pseudomonas spp. (в т.ч. Pseudomonas aeruginosa), Salmonella spp, Serratia spp. (в т.ч. Serratia marcescens) . анаэробных микроорганизмов: Bacteroides fragilis, Bifidobacterium spp, Clostridium perfringens, Fusobacterium spp., Peptostreptococcus spp., Propionibacterum spp., Veilonella spp. . других микроорганизмов: Bartonella spp, Chlamydia pneumoniae, Chlamydia psittaci, Chlamydia trachomatis, Legionella spp. (в т.ч. Legionella pneumophila), Mycobacterium spp. (в т.ч. Mycobacterium leprae, Mycobacterium tuberculosis), Mycoplasma hominis, Mycoplasma pneumoniae, Rickettsia spp., Ureaplasma urealyticum.
Показания к применению
Инфекционно-воспалительные заболевания, вызванные чувствительными к препарату микроорганизмами: Острый синусит. Обострение хронического бронхита. Внебольничная пневмония. Осложненные инфекции мочевыводящих путей (включая пиелонефрит). Неосложненные инфекции мочевыводящих путей. Простатит. Инфекции кожи и мягких тканей. Септицемия/бактериемия, связанные с указанными выше Показания к применениюми. Интраабдоминальная инфекция.
Противопоказания
Эпилепсия. Поражения сухожилий при ранее проводившемся лечении хинолонами. Детский и подростковый возраст до 18 лет. Беременность. Период лактации. Повышенная чувствительность к левофлоксацину или к другим хинолонам. С осторожностью следует применять препарат у пациентов пожилого возраста, в связи с высокой вероятностью наличия сопутствующего снижения функции почек, при дефиците глюкозо-6-фосфатдегидрогеназы.
Применение при беременности и в период грудного вскармливания
Препарат противопоказан при беременности и в период лактации.
Способ применения и дозы
Препарат принимают внутрь 1 или 2 раза/сут. Таблетки не разжевывают и запивают достаточным количеством жидкости (1/2-1 стакана). Препарат можно принимать перед или между приемами пищи. Доза определяется в зависимости от характера и тяжести инфекции, а также чувствительности предполагаемого возбудителя. Пациентам с нормальной или умеренно сниженной функцией почек (КК>50 мл/мин) рекомендуется следующий режим дозирования препарата. Синусит: по 500 мг 1 раз/сут в течение 10-14 дней. Обострение хронического бронхита: по 250-500 мг 1 раз/сут в течение 7-10 дней. Внебольничная пневмония: по 500 мг 1-2 раза/сут в течение 7-14 дней. Неосложненные инфекции мочевыводящих путей: по 250 мг 1 раз/сут в течение 3 дней. Простатит: по 500 мг 1 раз/сут в течение 28 дней. Осложненные инфекции мочевыводящих путей, включая пиелонефрит: по 250 мг 1 раз/сут в течение 7-10 дней. Инфекции кожи и мягких тканей: по 250 мг 1 раз/сут или по 500 мг 1-2 раза/сут в течение 7-14 дней. Септицемия/бактериемия: по 250-500 мг 1-2 раза/сут в течение10-14 дней (после в/в введения для продолжения терапии). Интраабдоминальная инфекция: по 250-500 мг 1 раз/сут в течение 7-14 дней (в комбинации с антибактериальными препаратами, действующими на анаэробную флору, после в/в введения для продолжения терапии).
Побочное действие
Со стороны пищеварительной системы часто - тошнота, диарея, повышение активности печеночных ферментов (АЛТ, АСТ). иногда - потеря аппетита, рвота, боли в животе, нарушения пищеварения. редко - диарея с кровью (может являться признаком колита и даже псевдомембранозного колита), повышение уровня билирубина в сыворотке крови. очень редко - печеночные реакции (гепатит). Со стороны обмена веществ очень редко - гипогликемия (особое значение имеет для пациентов с сахарным диабетом). возможные признаки гипогликемии значительно повышенный аппетит, нервозность, испарина, дрожь. При применении хинолонов имеется риск обострения порфирии, что нельзя исключить при лечении препаратом Лефокцин. Со стороны ЦНС и периферической нервной системы иногда - головная боль, головокружение и/или оцепенение, сонливость, нарушения сна. редко - депрессия, беспокойство, психотические реакции (например, с галлюцинациями), парестезии в кистях рук, тремор, психомоторное возбуждение, спутанность сознания, судорожный синдром, тревога. Со стороны органов чувств очень редко - нарушения зрения и слуха, нарушения вкусовой чувствительности и обоняния, понижение тактильной чувствительности. Со стороны сердечно-сосудистой системы редко - усиление сердцебиения, снижение АД. очень редко - сосудистый (шокоподобный) коллапс. в отдельных случаях - удлинение интервала QT. Со стороны костно-мышечной системы редко - поражения сухожилий (включая тендинит), суставные и мышечные боли. очень редко - разрыв сухожилий (например, ахиллова сухожилия), мышечная слабость (имеющая особое значение для больных с бульбарным синдромом). в отдельных случаях - поражения мышц (рабдомиолиз). Со стороны мочевыделительной системы редко - повышение уровня креатинина в сыворотке крови. очень редко - ухудшение функции почек вплоть до острой почечной недостаточности, например, вследствие аллергических реакций (интерстициальный нефрит). Со стороны системы кроветворения иногда - повышение количества эозинофилов, уменьшение количества лейкоцитов. редко - нейтропения. тромбоцитопения, что может сопровождаться усилением кровоточивости. очень редко - агранулоцитоз и развитие тяжелых инфекций (стойкое или рецидивирующее повышение температуры тела, ухудшение самочувствия). в отдельных случаях - гемолитическая анемия, панцитопения. Аллергические реакции иногда - зуд и покраснение кожи. редко - анафилактические и анафилактоидные реакции с такими симптомами, как крапивница, бронхоспазм и возможно - тяжелое удушье. очень редко - ангионевротический отек (например, в области лица и глотки), внезапное падение АД и шок, фотосенсибилизация, аллергический пневмонит. васкулит. в отдельных случаях - синдром Стивенса-Джонсона, токсический эпидермальный некролиз (синдром Лайелла) и экссудативная многоформная эритема. Общим реакциям повышенной чувствительности могут иногда предшествовать более легкие кожные реакции. Названные выше реакции могут развиться уже после первой дозы через несколько минут или часов после введения препарата. Прочие иногда - общая слабость (астения). очень редко - лихорадка. Любая антибиотикотерапия может вызывать изменения микрофлоры (бактерии и грибы), которая в норме присутствует у человека. По этой причине может произойти усиленное размножение бактерий и грибов, устойчивых к применяемому антибиотику (вторичная инфекция и суперинфекция), которое в редких случаях может потребовать дополнительного лечения.
Особые указания
Со стороны пищеварительной системы часто - тошнота, диарея, повышение активности печеночных ферментов (АЛТ, АСТ). иногда - потеря аппетита, рвота, боли в животе, нарушения пищеварения. редко - диарея с кровью (может являться признаком колита и даже псевдомембранозного колита), повышение уровня билирубина в сыворотке крови. очень редко - печеночные реакции (гепатит). Со стороны обмена веществ очень редко - гипогликемия (особое значение имеет для пациентов с сахарным диабетом). возможные признаки гипогликемии значительно повышенный аппетит, нервозность, испарина, дрожь. При применении хинолонов имеется риск обострения порфирии, что нельзя исключить при лечении препаратом Лефокцин. Со стороны ЦНС и периферической нервной системы иногда - головная боль, головокружение и/или оцепенение, сонливость, нарушения сна. редко - депрессия, беспокойство, психотические реакции (например, с галлюцинациями), парестезии в кистях рук, тремор, психомоторное возбуждение, спутанность сознания, судорожный синдром, тревога. Со стороны органов чувств очень редко - нарушения зрения и слуха, нарушения вкусовой чувствительности и обоняния, понижение тактильной чувствительности. Со стороны сердечно-сосудистой системы редко - усиление сердцебиения, снижение АД. очень редко - сосудистый (шокоподобный) коллапс. в отдельных случаях - удлинение интервала QT. Со стороны костно-мышечной системы редко - поражения сухожилий (включая тендинит), суставные и мышечные боли. очень редко - разрыв сухожилий (например, ахиллова сухожилия), мышечная слабость (имеющая особое значение для больных с бульбарным синдромом). в отдельных случаях - поражения мышц (рабдомиолиз). Со стороны мочевыделительной системы редко - повышение уровня креатинина в сыворотке крови. очень редко - ухудшение функции почек вплоть до острой почечной недостаточности, например, вследствие аллергических реакций (интерстициальный нефрит). Со стороны системы кроветворения иногда - повышение количества эозинофилов, уменьшение количества лейкоцитов. редко - нейтропения. тромбоцитопения, что может сопровождаться усилением кровоточивости. очень редко - агранулоцитоз и развитие тяжелых инфекций (стойкое или рецидивирующее повышение температуры тела, ухудшение самочувствия). в отдельных случаях - гемолитическая анемия, панцитопения. Аллергические реакции иногда - зуд и покраснение кожи. редко - анафилактические и анафилактоидные реакции с такими симптомами, как крапивница, бронхоспазм и возможно - тяжелое удушье. очень редко - ангионевротический отек (например, в области лица и глотки), внезапное падение АД и шок, фотосенсибилизация, аллергический пневмонит. васкулит. в отдельных случаях - синдром Стивенса-Джонсона, токсический эпидермальный некролиз (синдром Лайелла) и экссудативная многоформная эритема. Общим реакциям повышенной чувствительности могут иногда предшествовать более легкие кожные реакции. Названные выше реакции могут развиться уже после первой дозы через несколько минут или часов после введения препарата. Прочие иногда - общая слабость (астения). очень редко - лихорадка. Любая антибиотикотерапия может вызывать изменения микрофлоры (бактерии и грибы), которая в норме присутствует у человека. По этой причине может произойти усиленное размножение бактерий и грибов, устойчивых к применяемому антибиотику (вторичная инфекция и суперинфекция), которое в редких случаях может потребовать дополнительного лечения.
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Левофлоксацин - левовращающий изомер офлоксацина. Блокирует ДНК-гиразу, нарушает суперспирализацию и сшивку разрывов ДНК, ингибирует синтез ДНК, вызывает глубокие морфологические изменения в цитоплазме, клеточной стенке и мембранах. К левофлоксацину чувствительны большинство штаммов микроорганизмов как в условиях in vitro, так и in vivo. Препарат активен в отношении аэробных грамположительных микроорганизмов: Corynebacterium diphtheriae, Enterococcus spp. (в т.ч. Enterococcus faecalis), Listeria monocytogenes, Staphylococcus spp. (коагулазонегативные метициллин-чувствительные/метициллин-умеренно чувствительные штаммы), Staphylococcus aureus (метициллин-чувствительные штаммы), Staphylococcus epidermidis (метициллин-чувствительные штаммы), Staphylococcus spp. (коагулазонегативные штаммы), Streptococcus spp. группы С и G, Streptococcus agalactiae, Streptococcus pneumoniae (пенициллин-чувствительные/умеренно чувствительные/резистентные штаммы), Streptococcus pyogenes, Streptococcus viridans (пенициллин-чувствительные/резистентные штаммы) . аэробных грамотрицательных микроорганизмов: Acinetobacter baumannil, Acinetobacter spp, Actinobacillus actinimycetemcomitans, Citrobacter freundii, Eikenella corrodens, Enterobacter spp. (в т.ч. Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter cloacae), Escherichia coli, Gardnerella vaginalis, Haemophilus ducreyi, Haemophilus influenzae (ампициллин-чувствительные/резистентные штаммы), Haemophilus parainfluenzae, Helicobacter pylori, Klebsiella spp. (в т.ч. Klebsiella oxytoca, Klebsiella pneumoniae), Moraxella catarrhalis (штаммы, продуцирующие и непродуцирующие β .-лактамазы), Morganella morganii, Neisseria gonorrhoeae (штаммы, продуцирующие и непродуцирующие пенициллиназу), Neisseria meningitidis, Pasteurella spp. (Pasteurella conis, Pasteurella dagmatis, Pasteurella multocida), Proteus mirabilis, Proteus vulgaris, Providencia spp. (в т.ч. Providencia rettgeri, Providencia stuartii), Pseudomonas spp. (в т.ч. Pseudomonas aeruginosa), Salmonella spp, Serratia spp. (в т.ч. Serratia marcescens) . анаэробных микроорганизмов: Bacteroides fragilis, Bifidobacterium spp, Clostridium perfringens, Fusobacterium spp., Peptostreptococcus spp., Propionibacterum spp., Veilonella spp. . других микроорганизмов: Bartonella spp, Chlamydia pneumoniae, Chlamydia psittaci, Chlamydia trachomatis, Legionella spp. (в т.ч. Legionella pneumophila), Mycobacterium spp. (в т.ч. Mycobacterium leprae, Mycobacterium tuberculosis), Mycoplasma hominis, Mycoplasma pneumoniae, Rickettsia spp., Ureaplasma urealyticum."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Инфекционно-воспалительные заболевания, вызванные чувствительными к препарату микроорганизмами: Острый синусит. Обострение хронического бронхита. Внебольничная пневмония. Осложненные инфекции мочевыводящих путей (включая пиелонефрит). Неосложненные инфекции мочевыводящих путей. Простатит. Инфекции кожи и мягких тканей. Септицемия/бактериемия, связанные с указанными выше Показания к применениюми. Интраабдоминальная инфекция."}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Эпилепсия. Поражения сухожилий при ранее проводившемся лечении хинолонами. Детский и подростковый возраст до 18 лет. Беременность. Период лактации. Повышенная чувствительность к левофлоксацину или к другим хинолонам. С осторожностью следует применять препарат у пациентов пожилого возраста, в связи с высокой вероятностью наличия сопутствующего снижения функции почек, при дефиците глюкозо-6-фосфатдегидрогеназы."}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Препарат противопоказан при беременности и в период лактации."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Препарат принимают внутрь 1 или 2 раза/сут. Таблетки не разжевывают и запивают достаточным количеством жидкости (1/2-1 стакана). Препарат можно принимать перед или между приемами пищи. Доза определяется в зависимости от характера и тяжести инфекции, а также чувствительности предполагаемого возбудителя. Пациентам с нормальной или умеренно сниженной функцией почек (КК\u003e50 мл/мин) рекомендуется следующий режим дозирования препарата. Синусит: по 500 мг 1 раз/сут в течение 10-14 дней. Обострение хронического бронхита: по 250-500 мг 1 раз/сут в течение 7-10 дней. Внебольничная пневмония: по 500 мг 1-2 раза/сут в течение 7-14 дней. Неосложненные инфекции мочевыводящих путей: по 250 мг 1 раз/сут в течение 3 дней. Простатит: по 500 мг 1 раз/сут в течение 28 дней. Осложненные инфекции мочевыводящих путей, включая пиелонефрит: по 250 мг 1 раз/сут в течение 7-10 дней. Инфекции кожи и мягких тканей: по 250 мг 1 раз/сут или по 500 мг 1-2 раза/сут в течение 7-14 дней. Септицемия/бактериемия: по 250-500 мг 1-2 раза/сут в течение10-14 дней (после в/в введения для продолжения терапии). Интраабдоминальная инфекция: по 250-500 мг 1 раз/сут в течение 7-14 дней (в комбинации с антибактериальными препаратами, действующими на анаэробную флору, после в/в введения для продолжения терапии)."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы часто - тошнота, диарея, повышение активности печеночных ферментов (АЛТ, АСТ). иногда - потеря аппетита, рвота, боли в животе, нарушения пищеварения. редко - диарея с кровью (может являться признаком колита и даже псевдомембранозного колита), повышение уровня билирубина в сыворотке крови. очень редко - печеночные реакции (гепатит). Со стороны обмена веществ очень редко - гипогликемия (особое значение имеет для пациентов с сахарным диабетом). возможные признаки гипогликемии значительно повышенный аппетит, нервозность, испарина, дрожь. При применении хинолонов имеется риск обострения порфирии, что нельзя исключить при лечении препаратом Лефокцин. Со стороны ЦНС и периферической нервной системы иногда - головная боль, головокружение и/или оцепенение, сонливость, нарушения сна. редко - депрессия, беспокойство, психотические реакции (например, с галлюцинациями), парестезии в кистях рук, тремор, психомоторное возбуждение, спутанность сознания, судорожный синдром, тревога. Со стороны органов чувств очень редко - нарушения зрения и слуха, нарушения вкусовой чувствительности и обоняния, понижение тактильной чувствительности. Со стороны сердечно-сосудистой системы редко - усиление сердцебиения, снижение АД. очень редко - сосудистый (шокоподобный) коллапс. в отдельных случаях - удлинение интервала QT. Со стороны костно-мышечной системы редко - поражения сухожилий (включая тендинит), суставные и мышечные боли. очень редко - разрыв сухожилий (например, ахиллова сухожилия), мышечная слабость (имеющая особое значение для больных с бульбарным синдромом). в отдельных случаях - поражения мышц (рабдомиолиз). Со стороны мочевыделительной системы редко - повышение уровня креатинина в сыворотке крови. очень редко - ухудшение функции почек вплоть до острой почечной недостаточности, например, вследствие аллергических реакций (интерстициальный нефрит). Со стороны системы кроветворения иногда - повышение количества эозинофилов, уменьшение количества лейкоцитов. редко - нейтропения. тромбоцитопения, что может сопровождаться усилением кровоточивости. очень редко - агранулоцитоз и развитие тяжелых инфекций (стойкое или рецидивирующее повышение температуры тела, ухудшение самочувствия). в отдельных случаях - гемолитическая анемия, панцитопения. Аллергические реакции иногда - зуд и покраснение кожи. редко - анафилактические и анафилактоидные реакции с такими симптомами, как крапивница, бронхоспазм и возможно - тяжелое удушье. очень редко - ангионевротический отек (например, в области лица и глотки), внезапное падение АД и шок, фотосенсибилизация, аллергический пневмонит. васкулит. в отдельных случаях - синдром Стивенса-Джонсона, токсический эпидермальный некролиз (синдром Лайелла) и экссудативная многоформная эритема. Общим реакциям повышенной чувствительности могут иногда предшествовать более легкие кожные реакции. Названные выше реакции могут развиться уже после первой дозы через несколько минут или часов после введения препарата. Прочие иногда - общая слабость (астения). очень редко - лихорадка. Любая антибиотикотерапия может вызывать изменения микрофлоры (бактерии и грибы), которая в норме присутствует у человека. По этой причине может произойти усиленное размножение бактерий и грибов, устойчивых к применяемому антибиотику (вторичная инфекция и суперинфекция), которое в редких случаях может потребовать дополнительного лечения."}}]},{"id":8,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы часто - тошнота, диарея, повышение активности печеночных ферментов (АЛТ, АСТ). иногда - потеря аппетита, рвота, боли в животе, нарушения пищеварения. редко - диарея с кровью (может являться признаком колита и даже псевдомембранозного колита), повышение уровня билирубина в сыворотке крови. очень редко - печеночные реакции (гепатит). Со стороны обмена веществ очень редко - гипогликемия (особое значение имеет для пациентов с сахарным диабетом). возможные признаки гипогликемии значительно повышенный аппетит, нервозность, испарина, дрожь. При применении хинолонов имеется риск обострения порфирии, что нельзя исключить при лечении препаратом Лефокцин. Со стороны ЦНС и периферической нервной системы иногда - головная боль, головокружение и/или оцепенение, сонливость, нарушения сна. редко - депрессия, беспокойство, психотические реакции (например, с галлюцинациями), парестезии в кистях рук, тремор, психомоторное возбуждение, спутанность сознания, судорожный синдром, тревога. Со стороны органов чувств очень редко - нарушения зрения и слуха, нарушения вкусовой чувствительности и обоняния, понижение тактильной чувствительности. Со стороны сердечно-сосудистой системы редко - усиление сердцебиения, снижение АД. очень редко - сосудистый (шокоподобный) коллапс. в отдельных случаях - удлинение интервала QT. Со стороны костно-мышечной системы редко - поражения сухожилий (включая тендинит), суставные и мышечные боли. очень редко - разрыв сухожилий (например, ахиллова сухожилия), мышечная слабость (имеющая особое значение для больных с бульбарным синдромом). в отдельных случаях - поражения мышц (рабдомиолиз). Со стороны мочевыделительной системы редко - повышение уровня креатинина в сыворотке крови. очень редко - ухудшение функции почек вплоть до острой почечной недостаточности, например, вследствие аллергических реакций (интерстициальный нефрит). Со стороны системы кроветворения иногда - повышение количества эозинофилов, уменьшение количества лейкоцитов. редко - нейтропения. тромбоцитопения, что может сопровождаться усилением кровоточивости. очень редко - агранулоцитоз и развитие тяжелых инфекций (стойкое или рецидивирующее повышение температуры тела, ухудшение самочувствия). в отдельных случаях - гемолитическая анемия, панцитопения. Аллергические реакции иногда - зуд и покраснение кожи. редко - анафилактические и анафилактоидные реакции с такими симптомами, как крапивница, бронхоспазм и возможно - тяжелое удушье. очень редко - ангионевротический отек (например, в области лица и глотки), внезапное падение АД и шок, фотосенсибилизация, аллергический пневмонит. васкулит. в отдельных случаях - синдром Стивенса-Джонсона, токсический эпидермальный некролиз (синдром Лайелла) и экссудативная многоформная эритема. Общим реакциям повышенной чувствительности могут иногда предшествовать более легкие кожные реакции. Названные выше реакции могут развиться уже после первой дозы через несколько минут или часов после введения препарата. Прочие иногда - общая слабость (астения). очень редко - лихорадка. Любая антибиотикотерапия может вызывать изменения микрофлоры (бактерии и грибы), которая в норме присутствует у человека. По этой причине может произойти усиленное размножение бактерий и грибов, устойчивых к применяемому антибиотику (вторичная инфекция и суперинфекция), которое в редких случаях может потребовать дополнительного лечения."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"Синтетический противомикробный препарат широкого спектра действия из группы фторхинолонов. Левофлоксацин - левовращающий изомер офлоксацина. Блокирует ДНК-гиразу, нарушает суперспирализацию и сшивку разрывов ДНК, ингибирует синтез ДНК, вызывает глубокие морфологические изменения в цитоплазме, клеточной стенке и мембранах. К левофлоксацину чувствительны большинство штаммов микроорганизмов как в условиях in vitro, так и in vivo. Препарат активен в отношении аэробных грамположительных микроорганизмов: Corynebacterium diphtheriae, Enterococcus spp. (в т.ч. Enterococcus faecalis), Listeria monocytogenes, Staphylococcus spp. (коагулазонегативные метициллин-чувствительные/метициллин-умеренно чувствительные штаммы), Staphylococcus aureus (метициллин-чувствительные штаммы), Staphylococcus epidermidis (метициллин-чувствительные штаммы), Staphylococcus spp. (коагулазонегативные штаммы), Streptococcus spp. группы С и G, Streptococcus agalactiae, Streptococcus pneumoniae (пенициллин-чувствительные/умеренно чувствительные/резистентные штаммы), Streptococcus pyogenes, Streptococcus viridans (пенициллин-чувствительные/резистентные штаммы) . аэробных грамотрицательных микроорганизмов: Acinetobacter baumannil, Acinetobacter spp, Actinobacillus actinimycetemcomitans, Citrobacter freundii, Eikenella corrodens, Enterobacter spp. (в т.ч. Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter cloacae), Escherichia coli, Gardnerella vaginalis, Haemophilus ducreyi, Haemophilus influenzae (ампициллин-чувствительные/резистентные штаммы), Haemophilus parainfluenzae, Helicobacter pylori, Klebsiella spp. (в т.ч. Klebsiella oxytoca, Klebsiella pneumoniae), Moraxella catarrhalis (штаммы, продуцирующие и непродуцирующие β .-лактамазы), Morganella morganii, Neisseria gonorrhoeae (штаммы, продуцирующие и непродуцирующие пенициллиназу), Neisseria meningitidis, Pasteurella spp. (Pasteurella conis, Pasteurella dagmatis, Pasteurella multocida), Proteus mirabilis, Proteus vulgaris, Providencia spp. (в т.ч. Providencia rettgeri, Providencia stuartii), Pseudomonas spp. (в т.ч. Pseudomonas aeruginosa), Salmonella spp, Serratia spp. (в т.ч. Serratia marcescens) . анаэробных микроорганизмов: Bacteroides fragilis, Bifidobacterium spp, Clostridium perfringens, Fusobacterium spp., Peptostreptococcus spp., Propionibacterum spp., Veilonella spp. . других микроорганизмов: Bartonella spp, Chlamydia pneumoniae, Chlamydia psittaci, Chlamydia trachomatis, Legionella spp. (в т.ч. Legionella pneumophila), Mycobacterium spp. (в т.ч. Mycobacterium leprae, Mycobacterium tuberculosis), Mycoplasma hominis, Mycoplasma pneumoniae, Rickettsia spp., Ureaplasma urealyticum.","substance":[{"id":263,"title":"Левофлоксацин","title_latin":"Levofloxacinum","slug":"levofloksatsin_263"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Лефокцин - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/399/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/399/share_default/"}},"diseases":[{"id":"42","title":"Стрептококковая септицемия","slug":"42-streptokokkovaya_septitsemiya"},{"id":"43","title":"Другая септицемия","slug":"43-drugaya_septitsemiya"},{"id":"790","title":"Острый синусит","slug":"790-ostryy_sinusit"},{"id":"802","title":"Бактериальная пневмония, не классифицированная в других 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