Амоксициллин Таблетки, 20 шт, 500 мг, для приема внутрь

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Для применения в комбинации с клавулановой кислотой: указания в анамнезе на нарушения функции печени и желтуху, связанные с приемом амоксициллина в комбинации с клавулановой кислотой."}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Амоксициллин проникает через плацентарный барьер, в небольших количествах выделяется с грудным молоком. При необходимости применения амоксициллина при беременности следует тщательно взвесить ожидаемую пользу терапии для матери и потенциальный риск для плода. С осторожностью применять амоксициллин в период лактации (грудного вскармливания)."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Индивидуальный. 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Пациентам с нарушением функции почек, дозу и интервал между введениями необходимо корректировать в соответствии со значениями КК."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Аллергические реакции: крапивница, эритема, отек Квинке, ринит, конъюнктивит; редко - лихорадка, боли в суставах, эозинофилия; в единичных случаях - анафилактический шок. Эффекты, связанные с химиотерапевтическим действием: возможно развитие суперинфекций (особенно у пациентов с хроническими заболеваниями или пониженной резистентностью организма). При длительном применении в высоких дозах: головокружение, атаксия, спутанность сознания, депрессия, периферические невропатии, судороги. Преимущественно при применении в комбинации с метронидазолом: тошнота, рвота, анорексия, диарея, запор, боли в эпигастрии, глоссит, стоматит; редко - гепатит, псевдомембранозный колит, аллергические реакции (крапивница, ангионевротический отек), интерстициальный нефрит, нарушения гемопоэза. Преимущественно при применении в комбинации с клавулановой кислотой: холестатическая желтуха, гепатит; редко - многоформная эритема, токсический эпидермальный некролиз, эксфолиативный дерматит."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: тошнота, рвота, диарея, нарушение водно-электролитного баланса (как следствие рвоты и диареи). Лечение: промывание желудка, активированный уголь, солевые слабительные, лекарственные средства для поддержания водно-электролитного баланса; гемодиализ."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Возможно увеличение времени абсорбции дигоксина на фоне терапии Амоксициллин. Пробенецид снижает выведение амоксициллина почками и увеличивает концентрацию амоксициллина в желчи и крови. Следует избегать одновременного применения амоксициллина и других бактериостатических препаратов (макролиды, тетрациклины, сульфаниламиды, хлорамфениколы) из-за возможности развития антагонизма. При одновременном применении аминогликозидов и амоксициллина возможно развитие синнергического эффекта. Не рекомендуется одновременное применение амоксициллина и дисульфирама. При одновременном применении метотрексата и амоксициллина возможно увеличение токсичности первого, вероятно, из-за конкурентного ингибирования канальцевой почечной секреции метотрексата амоксициллином. Антациды, глюкозамин, слабительные лекарственные препараты, пища, аминогликозиды замедляют и снижают абсорбцию, аскорбиновая кислота повышает абсорбцию амоксициллина. Повышает эффективность непрямых антикоагулянтов (подавляя кишечную микрофлору, снижает синтез витамина К и протромбиновый индекс); уменьшает эффективность эстрогенсодержащих пероральных контрацептивов; лекарственные препараты, в процессе метаболизма которых образуется парааминобензойная кислота (ПАБК), препараты этинилэстрадиола — риск развития кровотечений «прорыва». Диуретики, аллопуринол, оксифенбутазон, фенилбутазон, нестероидные противовоспалительные препараты и другие лекарственные препараты, блокирующие канальцевую секрецию, повышают концентрацию амоксициллина в крови. Аллопуринол повышает риск развития кожной сыпи."}}]},{"id":8,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"С осторожностью применяют у пациентов, склонных к аллергическим реакциям. 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Активен в отношении аэробных грамположительных бактерий: Staphylococcus spp. (за исключением штаммов, продуцирующих пенициллиназу), Streptococcus spp.; аэробных грамотрицательных бактерий: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Klebsiella spp. К амоксициллину устойчивы микроорганизмы, продуцирующие пенициллиназу. В комбинации с метронидазолом проявляет активность в отношении Helicobacter pylori. Полагают, что амоксициллин ингибирует развитие резистентности Helicobacter pylori к метронидазолу. Между амоксициллином и ампициллином существует перекрестная резистентность. Спектр антибактериального действия расширяется при одновременном применении амоксициллина и ингибитора бета-лактамаз клавулановой кислоты. В этой комбинации повышается активность амоксициллина в отношении Bacteroides spp., Legionella spp., Nocardia spp., Pseudomonas (Burkholderia) pseudomallei. 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