Фармакологическое действиеКреон - ферментный препарат, улучшающий процессы пищеварения. Панкреатические ферменты, входящие в состав препарата, облегчают расщепление белков, жиров и углеводов, что приводит к их полной абсорбции в тонкой кишке. Креон® 10000 содержит свиной панкреатин в форме минимикросфер, покрытых кишечнорастворимой (кислотоустойчивой) оболочкой, в желатиновых капсулах. Капсулы быстро растворяются в желудке, высвобождая сотни минимикросфер. Данный принцип разработан с целью тщательного перемешивания минимикросфер с кишечным содержимым, и, в конечном счете, лучшего распределения ферментов после их высвобождения внутри содержимого кишечника. Когда минимикросферы достигают тонкой кишки, кишечнорастворимая оболочка быстро разрушается (при pH > 5,5), происходит высвобождение ферментов с липолитической, амилолитической и протеолитической активностью, что приводит к расщеплению жиров, углеводов и белков. Полученные в результате расщепления вещества затем либо абсорбируются напрямую, либо подвергаются дальнейшему гидролизу кишечными ферментами.Побочные действияНарушения со стороны желудочно-кишечного трактаОчень часто (≥1/10): боль в области живота. Часто (≥1/100, меньше 1/10): тошнота, рвота, запор, вздутие живота, диарея. Частота неизвестна: стриктуры подвздошной, слепой и толстой кишки (фиброзирующая колонопатия). Желудочно-кишечные расстройства связаны главным образом с основным заболеванием. Частота возникновения таких нежелательных реакций, как боль в области живота и диарея, была ниже или схожей с таковой при применении плацебо. Стриктуры подвздошной, слепой и толстой кишки (фиброзирующая колонопатия) наблюдались у пациентов с муковисцидозом, получавших высокие дозы препаратов панкреатина.Нарушения со стороны кожи и подкожных тканей: Нечасто (≥1/1000, меньше 1/100): сыпь. Частота неизвестна: зуд, крапивница.Нарушения со стороны иммунной системы: Частота неизвестна: гиперчувствительность (анафилактические реакции). Аллергические реакции наблюдались преимущественно со стороны кожных покровов, но отмечались также и другие проявления аллергии. Сообщения о данных побочных эффектах были получены в период постмаркетингового применения и носили спонтанный характер. Для точной оценки частоты случаев имеющихся данных недостаточно. При применении у детей не было отмечено каких-либо специфических нежелательных реакций. Частота, тип и степень тяжести нежелательных реакций у детей с муковисцидозом были сходны с таковыми у взрослых.Лекарственное взаимодействиеИсследований по взаимодействию препарата Креон® 10 000 с другими лекарственными средствами не проводилось.ПередозировкаСимптомы: гиперурикозурия и гиперурикемия.Лечение: отмена препарата, симптоматическая терапия.Условия храненияХранить при температуре не выше 25 ºС в плотно закрытой упаковке. Хранить в недоступном для детей месте!Фармакокинетика:В исследованиях на животных было продемонстрировано отсутствие абсорбции интактных (нерасщепленных) ферментов, вследствие чего классические фармакокинетические исследования не проводились. Препаратам, содержащим ферменты поджелудочной железы, не требуется абсорбция для проявления своих эффектов. Наоборот, терапевтическая активность указанных препаратов в полной мере реализуется в просвете желудочно-кишечного тракта. По своей химической структуре они являются белками и, в связи с этим, при прохождении через желудочно-кишечный тракт подвергаются протеолитическому расщеплению до тех пор, пока они не абсорбируются в виде пептидов и аминокислот.ПоказанияЗаместительная терапия недостаточности экзокринной функции поджелудочной железы у детей и взрослых, обусловленной разнообразными заболеваниями желудочно-кишечного тракта и наиболее часто встречающейся при:муковисцидозехроническом панкреатитепосле операции на поджелудочной железепосле гастрэктомиираке поджелудочной железычастичной резекции желудка (например, Бильрот II)обструкции протоков поджелудочной железы или общего желчного протока (например, вследствие новообразования)синдроме Швахмана–Даймондасостоянии после приступа острого панкреатита и возобновлении питанияВо избежание осложнений применять только после консультации с врачом.Противопоказания Гиперчувствительность (в т.ч. непереносимость свинины), острый панкреатит, обострение хронического панкреатита.
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Панкреатические ферменты, входящие в состав препарата, облегчают расщепление белков, жиров и углеводов, что приводит к их полной абсорбции в тонкой кишке. Креон® 10000 содержит свиной панкреатин в форме минимикросфер, покрытых кишечнорастворимой (кислотоустойчивой) оболочкой, в желатиновых капсулах. Капсулы быстро растворяются в желудке, высвобождая сотни минимикросфер. Данный принцип разработан с целью тщательного перемешивания минимикросфер с кишечным содержимым, и, в конечном счете, лучшего распределения ферментов после их высвобождения внутри содержимого кишечника. Когда минимикросферы достигают тонкой кишки, кишечнорастворимая оболочка быстро разрушается (при pH \u003e 5,5), происходит высвобождение ферментов с липолитической, амилолитической и протеолитической активностью, что приводит к расщеплению жиров, углеводов и белков. Полученные в результате расщепления вещества затем либо абсорбируются напрямую, либо подвергаются дальнейшему гидролизу кишечными ферментами.Побочные действияНарушения со стороны желудочно-кишечного трактаОчень часто (≥1/10): боль в области живота. Часто (≥1/100, меньше 1/10): тошнота, рвота, запор, вздутие живота, диарея. Частота неизвестна: стриктуры подвздошной, слепой и толстой кишки (фиброзирующая колонопатия). Желудочно-кишечные расстройства связаны главным образом с основным заболеванием. Частота возникновения таких нежелательных реакций, как боль в области живота и диарея, была ниже или схожей с таковой при применении плацебо. Стриктуры подвздошной, слепой и толстой кишки (фиброзирующая колонопатия) наблюдались у пациентов с муковисцидозом, получавших высокие дозы препаратов панкреатина.Нарушения со стороны кожи и подкожных тканей: Нечасто (≥1/1000, меньше 1/100): сыпь. Частота неизвестна: зуд, крапивница.Нарушения со стороны иммунной системы: Частота неизвестна: гиперчувствительность (анафилактические реакции). Аллергические реакции наблюдались преимущественно со стороны кожных покровов, но отмечались также и другие проявления аллергии. Сообщения о данных побочных эффектах были получены в период постмаркетингового применения и носили спонтанный характер. Для точной оценки частоты случаев имеющихся данных недостаточно. При применении у детей не было отмечено каких-либо специфических нежелательных реакций. Частота, тип и степень тяжести нежелательных реакций у детей с муковисцидозом были сходны с таковыми у взрослых.Лекарственное взаимодействиеИсследований по взаимодействию препарата Креон® 10 000 с другими лекарственными средствами не проводилось.ПередозировкаСимптомы: гиперурикозурия и гиперурикемия.Лечение: отмена препарата, симптоматическая терапия.Условия храненияХранить при температуре не выше 25 ºС в плотно закрытой упаковке. Хранить в недоступном для детей месте!Фармакокинетика:В исследованиях на животных было продемонстрировано отсутствие абсорбции интактных (нерасщепленных) ферментов, вследствие чего классические фармакокинетические исследования не проводились. Препаратам, содержащим ферменты поджелудочной железы, не требуется абсорбция для проявления своих эффектов. Наоборот, терапевтическая активность указанных препаратов в полной мере реализуется в просвете желудочно-кишечного тракта. По своей химической структуре они являются белками и, в связи с этим, при прохождении через желудочно-кишечный тракт подвергаются протеолитическому расщеплению до тех пор, пока они не абсорбируются в виде пептидов и аминокислот.ПоказанияЗаместительная терапия недостаточности экзокринной функции поджелудочной железы у детей и взрослых, обусловленной разнообразными заболеваниями желудочно-кишечного тракта и наиболее часто встречающейся при:муковисцидозехроническом панкреатитепосле операции на поджелудочной железепосле гастрэктомиираке поджелудочной железычастичной резекции желудка (например, Бильрот II)обструкции протоков поджелудочной железы или общего желчного протока (например, вследствие новообразования)синдроме Швахмана–Даймондасостоянии после приступа острого панкреатита и возобновлении питанияВо избежание осложнений применять только после консультации с врачом.Противопоказания Гиперчувствительность (в т.ч. непереносимость свинины), острый панкреатит, обострение хронического панкреатита."}}]}],"source":{"title":"('Эркафарм/Столетов',)","url":"https://stoletov.ru/"}},"description_toggle":false,"short_description":"Фармакологическое действиеКреон - ферментный препарат, улучшающий процессы пищеварения. Панкреатические ферменты, входящие в состав препарата, облегчают расщепление белков, жиров и углеводов, что приводит к их полной абсорбции в тонкой кишке. Креон® 10000 содержит свиной панкреатин в форме минимикросфер, покрытых кишечнорастворимой (кислотоустойчивой) оболочкой, в желатиновых капсулах. Капсулы быстро растворяются в желудке, высвобождая сотни минимикросфер. Данный принцип разработан с целью тщательного перемешивания минимикросфер с кишечным содержимым, и, в конечном счете, лучшего распределения ферментов после их высвобождения внутри содержимого кишечника. Когда минимикросферы достигают тонкой кишки, кишечнорастворимая оболочка быстро разрушается (при pH \u003e 5,5), происходит высвобождение ферментов с липолитической, амилолитической и протеолитической активностью, что приводит к расщеплению жиров, углеводов и белков. Полученные в результате расщепления вещества затем либо абсорбируются напрямую, либо подвергаются дальнейшему гидролизу кишечными ферментами.Побочные действияНарушения со стороны желудочно-кишечного трактаОчень часто (≥1/10): боль в области живота. Часто (≥1/100, меньше 1/10): тошнота, рвота, запор, вздутие живота, диарея. Частота неизвестна: стриктуры подвздошной, слепой и толстой кишки (фиброзирующая колонопатия). Желудочно-кишечные расстройства связаны главным образом с основным заболеванием. Частота возникновения таких нежелательных реакций, как боль в области живота и диарея, была ниже или схожей с таковой при применении плацебо. Стриктуры подвздошной, слепой и толстой кишки (фиброзирующая колонопатия) наблюдались у пациентов с муковисцидозом, получавших высокие дозы препаратов панкреатина.Нарушения со стороны кожи и подкожных тканей: Нечасто (≥1/1000, меньше 1/100): сыпь. Частота неизвестна: зуд, крапивница.Нарушения со стороны иммунной системы: Частота неизвестна: гиперчувствительность (анафилактические реакции). Аллергические реакции наблюдались преимущественно со стороны кожных покровов, но отмечались также и другие проявления аллергии. Сообщения о данных побочных эффектах были получены в период постмаркетингового применения и носили спонтанный характер. Для точной оценки частоты случаев имеющихся данных недостаточно. При применении у детей не было отмечено каких-либо специфических нежелательных реакций. Частота, тип и степень тяжести нежелательных реакций у детей с муковисцидозом были сходны с таковыми у взрослых.Лекарственное взаимодействиеИсследований по взаимодействию препарата Креон® 10 000 с другими лекарственными средствами не проводилось.ПередозировкаСимптомы: гиперурикозурия и гиперурикемия.Лечение: отмена препарата, симптоматическая терапия.Условия храненияХранить при температуре не выше 25 ºС в плотно закрытой упаковке. Хранить в недоступном для детей месте!Фармакокинетика:В исследованиях на животных было продемонстрировано отсутствие абсорбции интактных (нерасщепленных) ферментов, вследствие чего классические фармакокинетические исследования не проводились. Препаратам, содержащим ферменты поджелудочной железы, не требуется абсорбция для проявления своих эффектов. Наоборот, терапевтическая активность указанных препаратов в полной мере реализуется в просвете желудочно-кишечного тракта. 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