Нурофен экспресс Таблетки, 24 шт, 200 мг, покрытые пленочной оболочкой

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Наступление родов может быть задержано, а их продолжительность – увеличена; также у матери и у ребенка может усилиться склонность к кровотечениям."}},{"type":"paragraph","data":{"text":"Особенности влияния лекарственного средства на способность управлять транспортом и другими потенциально опасными механизмами."}},{"type":"paragraph","data":{"text":"Необходимо соблюдать осторожность учитывая возможные побочные эффекты."}},{"type":"paragraph","data":{"text":"При соблюдении рекомендованного режима дозирования и длительности применения, препарат не влияет на способность управлять транспортом и другими механизмами."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Препарат предназначен для кратковременного перорального применения."}},{"type":"paragraph","data":{"text":"Взрослые (в том числе и пожилые) и дети старше 12 лет: принимать внутрь по 1-2 таблетки, запивая водой, при необходимости - до трех раз в сутки."}},{"type":"paragraph","data":{"text":"Интервал между приемами препарата должен составлять не менее четырех часов. Принимать не более 6 таблеток в течение 24 часов."}},{"type":"paragraph","data":{"text":"Рекомендуется непродолжительный прием препарата в минимальной эффективной дозе, необходимой для устранения симптомов. Если при кратковременном приеме препарата симптомы сохраняются или усиливаются, необходимо обратиться к врачу."}},{"type":"paragraph","data":{"text":"При необходимости применения препарата более 7 дней, или при усилении выраженности симптомов, необходимо проконсультироваться с врачом."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"При применении препарата Нурофен Экспресс в течении 2–3 дней побочные действия практически не наблюдаются. В случае длительного применения возможно появление следующих побочных эффектов:"}},{"type":"paragraph","data":{"text":"Нечасто"}},{"type":"paragraph","data":{"text":"- реакции гиперчувствительности, проявляющиеся крапивницей, зудом, пурпурой"}},{"type":"paragraph","data":{"text":"- боль в животе, тошнота, диспепсия"}},{"type":"paragraph","data":{"text":"- головная боль"}},{"type":"paragraph","data":{"text":"- различные виды кожной сыпи"}},{"type":"paragraph","data":{"text":"Редко"}},{"type":"paragraph","data":{"text":"- диарея, повышенное газообразование, запор и рвота"}},{"type":"paragraph","data":{"text":"Очень редко"}},{"type":"paragraph","data":{"text":"- тяжелые реакции гиперчувствительности (отек лица, языка и гортани, одышку, тахикардию, гипотензию, анафилаксию, отек Квинке или тяжелый анафилактический шок)"}},{"type":"paragraph","data":{"text":"- ухудшение течения бронхиальной астмы и бронхоспазм"}},{"type":"paragraph","data":{"text":"- пептическая язва, перфорация или желудочно-кишечное кровотечение, мелена, кровавая рвота, в некоторых случаях со смертельным исходом, чаще у пациентов пожилого возраста"}},{"type":"paragraph","data":{"text":"- язвенный стоматит, гастрит"}},{"type":"paragraph","data":{"text":"- обострение неспецифического язвенного колита и болезни Крона"}},{"type":"paragraph","data":{"text":"- острая почечная недостаточность, полиурия, цистит, папиллонекроз, особенно при длительном применении, в сочетании с повышением уровня мочевины в сыворотке крови и появлением отеков"}},{"type":"paragraph","data":{"text":"- нарушения функции печени"}},{"type":"paragraph","data":{"text":"- нарушения кроветворения (анемия, лейкопения, тромбоцитопения, панцитопения, агранулоцитоз). Первыми признаками являются лихорадка, боль в горле, образование язв в полости рта, гриппоподобные симптомы, тяжелый упадок сил, беспричинное появление кровотечений и гематом"}},{"type":"paragraph","data":{"text":"- тяжелые формы кожных реакций, в частности, синдром Стивенса-Джонсона, мультиформная эритема и токсический эпидермальный некролиз"}},{"type":"paragraph","data":{"text":"- у пациентов с аутоиммунными нарушениями (системная красная волчанка, смешанное заболевание соединительной ткани) во время лечения ибупрофеном наблюдали единичные случаи возникновения симптомов асептического менингита, в частности, ригидность затылочных мышц, головная боль, тошнота, рвота, лихорадка или нарушение ориентации"}},{"type":"paragraph","data":{"text":"- имеются сообщения о возникновении отека, артериальной гипертензии и сердечной недостаточности"}},{"type":"paragraph","data":{"text":"Согласно данным клинических и эпидемиологических исследований и эпидемиологическим данным, длительное применение ибупрофена, особенно в высоких дозах (2400 мг в сутки), может быть связано с небольшим повышением риска развития тромботических осложнений или побочных эффектов (например, инфаркта миокарда или инсульта)."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"У детей симптомы могут возникать после приема дозы, превышающей 400 мг/кг массы тела. У взрослых дозозависимый эффект менее выражен. Период полувыведения препарата при передозировке составляет 1,5 - 3 часа."}},{"type":"paragraph","data":{"text":"Симптомы: у большинства пациентов, симптомы передозировки ограничиваются тошнотой, рвотой, болями в эпигастрии или, реже, диареей. Возможно возникновение таких симптомов, как шум в ушах, головная боль и желудочно-кишечное кровотечение. В более тяжелых случаях наблюдаются проявления токсичности со стороны центральной нервной системы, в частности, сонливость, изредка – возбуждение, а также дезориентация или кома. В редких случаях возникают судороги. В случаях тяжелого отравления может развиваться метаболический ацидоз и увеличение протромбинового времени, что, вероятно, является следствием ингибирования циркулирующих факторов свертывания крови. Может возникать острая почечная недостаточность и повреждение печени. У пациентов с бронхиальной астмой возможно обострение этого заболевания."}},{"type":"paragraph","data":{"text":"Лечение: симптоматическое и поддерживающее, контроль дыхания, мониторинг ЭКГ и основных показателей жизнедеятельности до нормализации состояния пациента. Показано промывание желудка, пероральное применение активированного угля в течение первых часов после приема препарата. Частые или продолжительные судороги следует купировать внутривенным введением диазепама или лоразепама. При бронхиальной астме рекомендуется применение бронходилататоров."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Следует избегать одновременного применения ибупрофена (и других НПВП) со следующими препаратами:"}},{"type":"paragraph","data":{"text":"Аспирин: за исключением низких доз аспирина (не более 75 мг в сутки), назначенных врачом, поскольку совместное применение может повысить риск возникновения побочных эффектов."}},{"type":"paragraph","data":{"text":"Экспериментальные данные позволяют предполагать, что ибупрофен может подавлять действие низких доз одновременно принимаемого аспирина на агрегацию тромбоцитов. Однако ограничения этих данных и неопределенность в отношении перенесения данных, полученных ex vivo, на клинические ситуации, означает невозможность определенного заключения в отношении постоянного приема ибупрофена. Подобный клинически значимый эффект при нерегулярном применении считается маловероятным."}},{"type":"paragraph","data":{"text":"Другие НПВП, в частности, селективные ингибиторы циклооксигеназы-2: следует избегать одновременного применения двух и более препаратов из группы НПВП из-за возможного увеличения риска возникновения побочных эффектов."}},{"type":"paragraph","data":{"text":"С осторожностью назначать одновременно со следующими препаратами:"}},{"type":"paragraph","data":{"text":"Антикоагулянты: НПВП могут усиливать эффект антикоагулянтов, в частности, варфарина."}},{"type":"paragraph","data":{"text":"Глюкокортикостероиды: из-за возможного увеличения риска возникновения язв или желудочно-кишечного кровотечения."}},{"type":"paragraph","data":{"text":"Гипотензивные препараты и диуретики: НПВП могут снизить эффективность препаратов этих групп. Одновременное применение с диуретиками может привести к повышению нефротоксичности НПВП."}},{"type":"paragraph","data":{"text":"Антиагреганты и селективные ингибиторы обратного захвата серотонина (СИОЗС): повышенный риск возникновения желудочно-кишечного кровотечения."}},{"type":"paragraph","data":{"text":"Сердечные гликозиды: одновременное назначение НПВП и сердечных гликозидов может привести к усугублению сердечной недостаточности, снижению скорости клубочковой фильтрации и увеличению концентрации сердечных гликозидов в плазме крови."}},{"type":"paragraph","data":{"text":"Препараты лития: существуют данные о вероятности увеличения концентрации лития в плазме крови на фоне применения НПВП."}},{"type":"paragraph","data":{"text":"Метотрексат: существуют данные о вероятности увеличения концентрации метотрексата в плазме крови на фоне применения НПВП."}},{"type":"paragraph","data":{"text":"Циклоспорин: увеличение риска нефротоксичности при одновременном назначении НПВП и циклоспорина."}},{"type":"paragraph","data":{"text":"Мифепристон: прием НПВП следует начать не ранее, чем через 8-12 дней после приема мифепристона, поскольку НПВП могут снижать эффективность мифепристона."}},{"type":"paragraph","data":{"text":"Такролимус: при одновременном назначении НПВП и такролимуса возможно увеличение риска нефротоксичности."}},{"type":"paragraph","data":{"text":"Зидовудин: одновременное применение НПВП и зидовудина может привести к повышению гематологической токсичности. Имеются данные о повышенном риске возникновения гемартроза и гематом у ВИЧ-положительных пациентов с гемофилией, получавших совместное лечение зидовудином и ибупрофеном."}},{"type":"paragraph","data":{"text":"Антибиотики хинолонового ряда: у пациентов, получающих совместное лечение НПВП и антибиотиками хинолонового ряда, возможно увеличение риска возникновения судорог."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Нежелательные эффекты можно свести к минимуму, если принимать препарат в течение непродолжительного промежутка времени, в минимальной эффективной дозе, необходимой для устранения симптомов."}},{"type":"paragraph","data":{"text":"У людей пожилого возраста наблюдается повышенная частота побочных реакций на фоне применения НПВП, особенно желудочно-кишечных кровотечений и перфораций, в некоторых случаях со смертельным исходом."}},{"type":"paragraph","data":{"text":"Влияние на органы дыхания: у пациентов с бронхиальной астмой или аллергическим заболеванием в стадии обострения, а также у пациентов с анамнезом бронхиальной астмы/аллергического заболевания препарат может спровоцировать бронхоспазм."}},{"type":"paragraph","data":{"text":"Совместное использование с другими НПВП: следует избегать одновременного применения ибупрофена с другими НПВП, в частности, селективными ингибиторами циклооксигеназы-2."}},{"type":"paragraph","data":{"text":"Системная красная волчанка и смешанное заболевание соединительной ткани: применение препарата у пациентов с системной красной волчанкой или смешанным заболеванием соединительной ткани связано с повышенным риском развития асептического менингита."}},{"type":"paragraph","data":{"text":"Влияние на почки: препарат может вызвать ухудшение функции почек с развитием почечной недостаточности."}},{"type":"paragraph","data":{"text":"Влияние на печень: препарат может вызывать нарушение функции печени."}},{"type":"paragraph","data":{"text":"Влияние на сердечно-сосудистую систему и мозговое кровообращение: рекомендуется с осторожностью применять препарат у пациентов с артериальной гипертензией и/или сердечной недостаточностью (перед применением следует проконсультироваться с врачом) из-за имеющихся сообщений о задержке жидкости, повышении артериального давления и появлении отеков на фоне применения НПВП."}},{"type":"paragraph","data":{"text":"Согласно данным клинических и эпидемиологических исследований и эпидемиологическим данным, длительное применение ибупрофена, особенно в высоких дозах (2400 мг в сутки), может быть связано с небольшим повышенным риском развития тромботических событий (например, инфаркта миокарда или инсульта). В целом же, эпидемиологические исследования не показывают зависимости между приемом низких доз аспирина (то есть, 1200 мг в сутки и менее) с повышенным риском развития инфаркта миокарда."}},{"type":"paragraph","data":{"text":"Влияние на желудочно-кишечный тракт: необходимо с осторожностью применять препарат у пациентов, имеющих в анамнезе заболевания желудочно-кишечного тракта (неспецифический язвенный колит, болезнь Крона), поскольку при использовании препаратов данной группы возможно обострение этих заболеваний."}},{"type":"paragraph","data":{"text":"Имеются сообщения о случаях возникновения желудочно-кишечного кровотечения, язв и перфорации в любой момент применения любых препаратов из группы НПВП, при наличии или отсутствии предупреждающих симптомов или предыдущего анамнеза подобных осложнений."}},{"type":"paragraph","data":{"text":"Повышенный риск желудочно-кишечного кровотечения или язвы/перфорации связан с использованием высоких доз НПВП, наличием в анамнезе пациента язвенной болезни, особенно, осложненной кровотечением или перфорацией, а также с применением препарата у людей пожилого возраста. У перечисленных категорий пациентов лечение следует начинать с наименьшей эффективной дозы препарата."}},{"type":"paragraph","data":{"text":"Пациенты с проявлением токсичности со стороны ЖКТ в анамнезе, особенно, больные пожилого возраста, должны сообщать о любых необычных симптомах со стороны желудочно-кишечного тракта (в частности, случаи желудочно-кишечного кровотечения), особенно, в начале лечения."}},{"type":"paragraph","data":{"text":"Рекомендуется с осторожностью применять препарат у пациентов, одновременно получающих лечение лекарственными средствами, которые могут увеличить риск возникновения язв или кровотечения, в частности, пероральные глюкокортикостероиды, антикоагулянты (варфарин), селективные ингибиторы обратного захвата серотонина или антиагреганты (аспирин)."}},{"type":"paragraph","data":{"text":"При возникновении желудочно-кишечного кровотечения или язвы у пациентов, получающих лечение ибупрофеном, прием препарата следует прекратить."}},{"type":"paragraph","data":{"text":"Влияние на кожу: в редких случаях при применении НПВП сообщалось о развитии тяжелых кожных реакций, в том числе, со смертельным исходом (эксфолиативный дерматит, синдром Стивенса-Джонсона и токсический эпидермальный некролиз). Повышенный риск возникновения подобных реакций наблюдается в начале лечения: в большинстве случаев реакция развивается в течение первого месяца приема препарата. При первых признаках высыпаний на коже, поражений слизистой оболочки или других проявлениях гиперчувствительности прием препарата следует прекратить."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить в сухом месте при температуре не выше 25°С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте!"}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}}]}],"source":null},"description_toggle":false,"short_description":"Нурофен Экспресс – нестероидное противовоспалительное средство, действующим веществом которого является ибупрофена лизинат, являющийся лизинатовой солью ибупрофена – производного пропионовой кислоты, обладающего обезболивающим, противовоспалительным и жаропонижающим действием. Механизм действия заключается в торможении активности циклооксигеназы арахидоновой кислоты, что приводит к подавлению синтеза простагландинов и препятствует высвобождению медиаторов воспаления. Нурофен Экспресс уменьшает обусловленные воспалением боль, отек и повышение температуры. Кроме того, ибупрофен обратимо ингибирует агрегацию тромбоцитов. Большинство данных фармакокинетики, полученных при назначении ибупрофена, также применимы к ибупрофена лизинату. Пиковые концентрации в плазме достигаются через 1-2 часа после приема ибупрофена. Однако ибупрофен быстрее всасывается из желудочно-кишечного тракта после приема в виде ибупрофена лизината. При приеме таблеток Нурофен® Экспресс натощак, пиковая концентрация ибупрофена в плазме достигается, приблизительно, через 35 минут. Период полувыведения – 2 часа. Ибупрофен в значительной степени связывается с белками плазмы. 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