Цетиризин-АКОС Таблетки, 20 шт, 10 мг, для приема внутрь, в пленочной оболочке

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У детей после приема цетиризина в дозе 5 мг максимальная концентрация (Сmах) в плазме крови достигается через 1 час и составляет 275 нг/мл."}},{"type":"paragraph","data":{"text":"При приеме цетиризина в форме капель максимальные концентрации в плазме крови достигаются с более высокой скоростью."}},{"type":"paragraph","data":{"text":"\u003ci\u003eРаспределение \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Распределение после приема 10 мг составляет 35 литров у взрослых, а связывание с белками плазмы крови – 93 %. У детей объем распределения после приема 5 мг составляет примерно 17 литров."}},{"type":"paragraph","data":{"text":"Незначительное количество цетиризина выделяется в грудное молоко."}},{"type":"paragraph","data":{"text":"\u003ci\u003eМетаболизм \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"У взрослых 60 % дозы выводится из организма в неизмененном виде почками."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВыведение \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"После приема 10 мг у взрослых общий клиренс цетиризина составляет 0,60 мл/мин/кг; период полувыведения (Т1/2) составляет примерно 10 часов. "}},{"type":"paragraph","data":{"text":"Прием нескольких доз не изменяет фармакокинетические параметры. При приеме препарата в суточной дозе 10 мг в течение 10 дней кумуляции цетиризина не наблюдалось."}},{"type":"paragraph","data":{"text":"После окончания лечения уровень цетиризина в плазме крови быстро падает ниже определяемых пределов. Повторные аллергологические тесты можно возобновить через   3 дня."}},{"type":"paragraph","data":{"text":"\u003ci\u003eОтдельные группы пациентов \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eПожилые пациенты \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"У 16 пожилых лиц при однократном приеме препарата в дозе 10 мг Т1/2 был выше на 50 %, а скорость выведения была ниже на 40 % по сравнению с контрольной группой."}},{"type":"paragraph","data":{"text":"Снижение клиренса цетиризина у пожилых пациентов вероятно связано с уменьшением функции почек у этой категории пациентов."}},{"type":"paragraph","data":{"text":"\u003ci\u003eДети \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"У детей от 6 до 12 лет 70 % дозы выводится из организма в неизмененном виде почками."}},{"type":"paragraph","data":{"text":"После приема 5 мг у детей общий клиренс цетиризина составляет 0,93 мл/мин/кг."}},{"type":"paragraph","data":{"text":"Т1/2 у детей от 6 до 12 лет составляет 6 часов, от 2 до 6 лет - 5 часов."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПациенты с почечной недостаточностью \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"У пациентов с почечной недостаточностью легкой степени тяжести (клиренс креатинина (КК) > 50 мл/мин) фармакокинетические параметры аналогичны таковым у здоровых добровольцев с нормальной функцией почек."}},{"type":"paragraph","data":{"text":"У пациентов с почечной недостаточностью средней степени тяжести (КК 30 - 49 мл/мин) Т1/2 удлиняется в 3 раза, а общий клиренс снижается на 70 % относительно здоровых добровольцев с нормальной функцией почек."}},{"type":"paragraph","data":{"text":"У пациентов, находящихся на гемодиализе (КК < 7 мл/мин), при приеме препарата внутрь в дозе 10 мг, общий клиренс снижается приблизительно на 70 % относительно здоровых добровольцев с нормальной функцией почек, а Т1/2 удлиняется в 3 раза."}},{"type":"paragraph","data":{"text":"Менее 10 % цетиризина удаляется в ходе стандартной процедуры гемодиализа. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eПациенты с печеночной недостаточностью\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"У пациентов с хроническими заболеваниями печени (гепатоцеллюлярным, холестатическим и билиарным циррозом) при однократном приеме препарата в дозе 10 или 20 мг Т1/2 увеличивается примерно на 50 %, а клиренс снижается на 40 % по сравнению со здоровыми субъектами."}},{"type":"paragraph","data":{"text":"Коррекция дозы необходима только в случае, если у пациента с печеночной недостаточностью имеется также сопутствующая почечная недостаточность.\n\n"}}]},{"id":7,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"\n\nПрименение препарата показано у взрослых и детей с 6 лет для облегчения:"}},{"type":"paragraph","data":{"text":"- назальных и глазных симптомов круглогодичного (персистирующего) и сезонного (интермиттирующего) аллергического ринита и аллергического конъюнктивита: зуда, чиханья, заложенности носа, ринореи, слезотечения, гиперемии конъюнктивы.\n\n"}}]},{"id":8,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"\n\n- повышенная чувствительность к цетиризину, гидроксизину или другим производным пиперазина, а также к любому другому компоненту препарата; "}},{"type":"paragraph","data":{"text":"- средняя, тяжелая и терминальная стадия почечной недостаточности с клиренсом креатинина < 49 мл/мин (для данной дозировки); "}},{"type":"paragraph","data":{"text":"- детский возраст до 6 лет (для данной лекарственной формы); "}},{"type":"paragraph","data":{"text":"- наследственная непереносимость галактозы, недостаток лактазы или синдром глюкозо-галактозной мальабсорбции.\n\n"}}]},{"id":9,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"\n\n- хроническая почечная недостаточность (при клиренсе креатинина 50-79 мл/мин требуется коррекция режима дозирования); "}},{"type":"paragraph","data":{"text":"- пациенты пожилого возраста (при возрастном снижении клубочковой фильтрации); "}},{"type":"paragraph","data":{"text":"- эпилепсия и пациенты с повышенной судорожной готовностью; "}},{"type":"paragraph","data":{"text":"- пациенты с предрасполагающими факторами к задержке мочи (см. раздел «Особые указания»); "}},{"type":"paragraph","data":{"text":"- при одновременном употреблении с алкоголем (см. раздел «Взаимодействие с другими лекарственными средствами»); "}},{"type":"paragraph","data":{"text":"- период грудного вскармливания; "}},{"type":"paragraph","data":{"text":"- беременность.\n\n"}}]},{"id":10,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eБеременность \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Данные по применению цетиризина во время беременности ограничены (300- 1000 исходов беременности). Однако не выявлено случаев формирования пороков развития, эмбриональной и неонатальной токсичности с четкой причинно-следственной связью."}},{"type":"paragraph","data":{"text":"Экспериментальные исследования на животных не выявили каких-либо прямых или косвенных неблагоприятных эффектов цетиризина на развивающийся плод (в том числе в постнатальном периоде), течение беременности и родов."}},{"type":"paragraph","data":{"text":"При беременности назначение цетиризина возможно после консультации с врачом, в случае если предполагаемая польза для матери превышает потенциальный риск для плода."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПериод грудного вскармливания \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Не следует применять цетиризин во время грудного вскармливания, т.к. цетиризин экскретируется с грудным молоком. Цетиризин выделяется в грудное молоко в количестве 25-90 % от концентрации в плазме крови, в зависимости от времени отбора проб после приема препарата."}},{"type":"paragraph","data":{"text":"Нежелательные реакции, связанные с цетиризином, могут наблюдаться у грудных детей."}},{"type":"paragraph","data":{"text":"В период грудного вскармливания применяют после консультации с врачом, если предполагаемая польза для матери превышает потенциальный риск для ребенка."}},{"type":"paragraph","data":{"text":"\u003ci\u003eФертильность \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Доступные данные о влиянии на фертильность человека ограничены, однако отрицательного влияния на фертильность в исследованиях на животных не выявлено."}},{"type":"paragraph","data":{"text":"Перед применением препарата, если Вы беременны, или предполагаете, что Вы могли бы быть беременной, или планируете беременность, необходимо проконсультироваться с врачом.\n\n"}}]},{"id":11,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"\n\nВнутрь."}},{"type":"paragraph","data":{"text":"Принимать препарат следует вечером, т.к. симптомы становятся более выраженными вечером."}},{"type":"paragraph","data":{"text":"Препарат Цетиризин-АКОС следует применять не разжевывая, рекомендуется запивать водой."}},{"type":"paragraph","data":{"text":"Препарат Цетиризин-АКОС можно принимать независимо от приема пищи."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВзрослые \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"10 мг (1 таблетка) 1 раз в день."}},{"type":"paragraph","data":{"text":"Дети "}},{"type":"paragraph","data":{"text":"\u003ci\u003eДети от 6 до 12 лет: \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"10 мг (1 таблетка) 1 раз в день."}},{"type":"paragraph","data":{"text":"Продолжительность лечения не должна превышать 4-х недель."}},{"type":"paragraph","data":{"text":"\u003ci\u003eДети старше 12 лет: \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"10 мг (1 таблетка) 1 раз в день."}},{"type":"paragraph","data":{"text":"Детям с почечной недостаточностью дозу корректируют с учетом КК и массы тела. Для удобства коррекции дозы рекомендуется использовать другие лекарственные формы."}},{"type":"paragraph","data":{"text":"\u003ci\u003eОтдельные группы пациентов \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eПациенты пожилого возраста\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Из-за возможного снижения функции почек режим дозирования препарата следует корректировать (см. подраздел «Пациенты с почечной недостаточностью» раздела «Способ применения и дозы»). "}},{"type":"paragraph","data":{"text":"\u003ci\u003eПациенты с почечной недостаточностью \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Поскольку препарат Цетиризин-АКОС выводится из организма в основном почками (см. подраздел «Фармакокинетика»), при невозможности альтернативного лечения пациентам с почечной недостаточностью режим дозирования препарата следует корректировать в зависимости от функции почек (величины клиренса креатинина КК).\n\n"}},{"type":"paragraph","data":{"text":"\n\nУ пациентов с нарушением только функции печени коррекции режима дозирования не требуется."}},{"type":"paragraph","data":{"text":"У пациентов с нарушением и функции печени, и функции почек, рекомендуется коррекция дозирования (см. таблицу выше)."}},{"type":"paragraph","data":{"text":"Если после лечения улучшения не наступает или появляются новые симптомы, необходимо проконсультироваться с врачом."}},{"type":"paragraph","data":{"text":"Применяйте препарат только согласно тому способу применения и в тех дозах, которые указаны в инструкции.\n\n"}}]},{"id":12,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eДанные, полученные в клинических исследованиях\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Обзор"}},{"type":"paragraph","data":{"text":"Результаты клинических исследований продемонстрировали, что применение цетиризина в рекомендованных дозах приводит к развитию незначительных нежелательных эффектов на ЦНС, включая сонливость, утомляемость, головокружение и головную боль. В некоторых случаях была зарегистрирована парадоксальная стимуляция ЦНС."}},{"type":"paragraph","data":{"text":"Несмотря на то, что цетиризин является селективным блокатором периферических Н1-рецепторов и практически не оказывает антихолинергического действия, сообщалось о единичных случаях затруднения мочеиспускания, нарушениях аккомодации и сухости во рту."}},{"type":"paragraph","data":{"text":"Сообщалось о нарушениях функции печени, сопровождающихся повышением уровня печеночных ферментов и билирубина. В большинстве случаев нежелательные явления разрешались после прекращения приема цетиризина."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПеречень нежелательных побочных реакций\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Имеются данные, полученные в ходе двойных слепых контролируемых клинических исследований, направленных на сравнение цетиризина и плацебо или других антигистаминных препаратов, применяемых в рекомендованных дозах (10 мг один раз в сутки для цетиризина) более чем у 3200 пациентов, на основании которых можно провести достоверный анализ данных по безопасности.\n\n"}}]},{"id":13,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\n\nСимптомы, наблюдаемые после явной передозировки препарата, влияли на центральную нервную систему или были связаны с возможным антихолинергическим эффектом. Симптомы, которые наблюдались после приема по меньшей мере пятикратного количества рекомендуемой суточной дозы, включали следующее: спутанность сознания, диарея, утомляемость, головная боль, недомогание, мидриаз, зуд, беспокойство, седативный эффект, сонливость, ступор, тахикардия, тремор, задержка мочи."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение: \u003c/i\u003eспецифического антидота нет."}},{"type":"paragraph","data":{"text":"В случае передозировки рекомендуется симптоматическое или поддерживающее лечение. Промывание желудка и/или прием активированного угля может быть эффективным, если передозировка произошла недавно. Цетиризин частично выводится при диализе.\n\n"}}]},{"id":14,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"\n\nОдновременное применение с азитромицином, циметидином, эритромицином, кетоконазолом или псевдоэфедрином не влияет на фармакокинетические параметры цетиризина. Фармакокинетических взаимодействий не наблюдалось. Согласно испытаниям in vitro, цетиризин не влияет на эффект связывания белка варфарина."}},{"type":"paragraph","data":{"text":"Одновременный прием азитромицина, эритромицина, кетоконазола, теофиллина и псевдоэфедрина не выявил существенных изменений в клинических лабораторных показателях, жизненно важных функциях и ЭКГ. В исследовании с одновременным приемом теофиллина (400 мг в день) и цетиризина (20 мг в день) было обнаружено незначительное, но статистически достоверное повышение 24-часовой AUC (площади под кривой) на 19 % для цетиризина и на 11 % для теофиллина. Кроме того, максимальные уровни в плазме крови увеличились до 7,7 % и 6,4 % соответственно для цетиризина и теофиллина. Одновременно клиренс цетиризина уменьшился на -16 %, а также на -10 % в случае теофиллина, когда цетиризин принимали пациенты, которые ранее получали лечение теофиллином. Тем не менее, предварительное лечение цетиризином не оказало существенного влияния на фармакокинетические параметры теофиллина."}},{"type":"paragraph","data":{"text":"После однократного приема цетиризина в дозе 10 мг эффект алкоголя (0,8 %о) значительно не усиливался; статистически значимое взаимодействие с 5 мг диазепама было доказано в одном из 16 психометрических тестов. Одновременный прием 10 мг цетиризина в день с глипизидом привел к незначительному снижению показателей глюкозы. Этот эффект не имеет клинического значения. Тем не менее, рекомендуется раздельный прием - глипизид утром и цетиризин вечером."}},{"type":"paragraph","data":{"text":"Степень всасывания цетиризина не снижается при одновременном приеме пищи, хотя всасывание замедляется на 1 час."}},{"type":"paragraph","data":{"text":"В исследовании с многократным приемом ритонавира (600 мг два раза в день) и цетиризина (10 мг в день) степень экспозиции цетиризина была увеличена примерно на 40 %, в то время как экспозиция ритонавира незначительно изменилась (-11 %) вследствие сопутствующего приема цетиризина."}},{"type":"paragraph","data":{"text":"Если Вы применяете вышеперечисленные или другие лекарственные препараты (в том числе безрецептурные) перед применением препарата Цетиризин-АКОС проконсультируйтесь с врачом.\n\n"}}]},{"id":15,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nУ пациентов с повреждением спинного мозга, гиперплазией предстательной железы, а также при наличии других предрасполагающих факторов к задержке мочи, требуется соблюдение осторожности, так как цетиризин может увеличивать риск задержки мочи."}},{"type":"paragraph","data":{"text":"У пациентов с почечной недостаточностью режим дозирования препарата следует корректировать (см. раздел «Способ применения и дозы»)."}},{"type":"paragraph","data":{"text":"Из-за возможного снижения функции почек у пациентов пожилого возраста режим дозирования препарата следует корректировать (см. раздел «Способ применения и дозы»)."}},{"type":"paragraph","data":{"text":"Рекомендовано соблюдать осторожность при применении цетиризина одновременно с алкоголем, так как цетиризин может привести к повышенной сонливости."}},{"type":"paragraph","data":{"text":"Осторожность следует соблюдать у пациентов с эпилепсией и повышенной судорожной готовностью."}},{"type":"paragraph","data":{"text":"Перед назначением аллергологических проб рекомендован трехдневный «отмывочный» период ввиду того, что блокаторы H1-гистаминовых рецепторов ингибируют развитие кожных аллергических реакций."}},{"type":"paragraph","data":{"text":"Цетиризин в таблетках, покрытых пленочной оболочкой, не должен назначаться пациентам с наследственной непереносимостью галактозы, недостатке лактазы или синдроме глюкозо-галактозной мальабсорбции."}},{"type":"paragraph","data":{"text":"После прекращения применения цетиризина может появиться зуд и/или крапивница, даже если эти симптомы отсутствовали в начале лечения. В некоторых случаях симптомы могут быть интенсивными и требовать возобновления приема цетиризина. Симптомы исчезают при возобновлении приема цетиризина."}},{"type":"paragraph","data":{"text":"\u003ci\u003eДети \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Цетиризин в таблетках, покрытых пленочной оболочкой, противопоказан детям до 6 лет, поскольку данная лекарственная форма не позволяет использовать подходящую дозировку для этой возрастной группы. Рекомендуется использовать педиатрическую лекарственную форму (капли для приема внутрь)."}},{"type":"paragraph","data":{"text":"Внимательно прочтите инструкцию перед тем, как начать применение препарата. Сохраните инструкцию, она может понадобиться вновь. Если у Вас возникли вопросы, обратитесь к врачу. Лекарственное средство, которым Вы лечитесь предназначено лично Вам, и его не следует передавать другим лицам, поскольку оно может причинить им вред даже при наличии тех же симптомов, что и у Вас.\n\n"}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"При объективной оценке способности к вождению автотранспорта и управлению механизмами достоверно не выявлено каких-либо нежелательных явлений при приеме препарата в рекомендуемой дозе. Однако пациентам с проявлениями сонливости на фоне приема препарата целесообразно воздерживаться от управления автомобилем, занятиями потенциально опасными видами деятельности или управлением механизмами, требующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"\n\nПри температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в местах, недоступных для детей.\n\n"}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}}]}],"source":{"title":"('Эркафарм/Столетов',)","url":"https://stoletov.ru/"}},"description_toggle":false,"short_description":"Фармакодинамические свойстваМеханизм действияЦетиризин является метаболитом гидроксизина, обладает антигистаминным эффектом с противоаллергическим действием. Цетиризин относится к группе конкурентных антагонистов гистамина и блокирует H1-гистаминовые рецепторы с небольшим воздействием на другие рецепторы и практически не оказывает антихолинергического и антисеротонинового действия. Цетиризин оказывает влияние на гистаминзависимую стадию аллергических реакций немедленного действия, а также уменьшает миграцию эозинофилов и ограничивает высвобождение медиаторов при аллергических реакциях замедленного типа. Практически не проходит через гематоэнцефалический барьер и, следовательно, почти не способен достичь центральных рецепторов H1.ФармакодинамикаВ исследованиях влияния гистамина на кожу действие цетиризина в дозе 10 мг начиналось через 1 час, достигало максимума со 2-го по 12-ый час и все еще наблюдалось на статистически значимых уровнях через 24 часа. В дополнении к антигистаминному эффекту цетиризин также обладает противовоспалительным эффектом и тем самым оказывает влияние на позднюю фазу аллергической реакции: - при дозе 10 мг один или два раза в день, ингибирует позднюю фазу агрегации эозинофилов в коже; - при дозе 30 мг в день, ингибирует выведение эозинофилов в бронхиальную альвеолярную жидкость после вызванного аллергеном бронхиального сужения; - ингибирует вызванную калликреином позднюю воспалительную реакцию; - подавляет экспрессию маркеров воспаления, таких как ICAM-1 или VCAM-1; - ингибирует действие гистаминолибераторов, таких как PAF или субстанция Р.ФармакокинетикаВсасываниеПосле приема внутрь препарат быстро абсорбируется из желудочно-кишечного тракта. Фармакокинетические параметры цетиризина при его применении в дозах от 5 до 60 мг изменяются линейно. Равновесная концентрация достигается через 3 дня. Фармакокинетический профиль цетиризина аналогичен у взрослых и детей. У детей после приема цетиризина в дозе 5 мг концентрация активной субстанции в организме такая же, как и у взрослых после приема 10 мг. У взрослых после приема цетиризина в дозе 10 мг максимальная концентрация (Сmах) в плазме крови достигается через 1-2 часа и составляет 350 нг/мл. У детей после приема цетиризина в дозе 5 мг максимальная концентрация (Сmах) в плазме крови достигается через 1 час и составляет 275 нг/мл. При приеме цетиризина в форме капель максимальные концентрации в плазме крови достигаются с более высокой скоростью.РаспределениеРаспределение после приема 10 мг составляет 35 литров у взрослых, а связывание с белками плазмы крови – 93 %. У детей объем распределения после приема 5 мг составляет примерно 17 литров. Незначительное количество цетиризина выделяется в грудное молоко.МетаболизмУ взрослых 60 % дозы выводится из организма в неизмененном виде почками.ВыведениеПосле приема 10 мг у взрослых общий клиренс цетиризина составляет 0,60 мл/мин/кг; период полувыведения (Т1/2) составляет примерно 10 часов. Прием нескольких доз не изменяет фармакокинетические параметры. При приеме препарата в суточной дозе 10 мг в течение 10 дней кумуляции цетиризина не наблюдалось. После окончания лечения уровень цетиризина в плазме крови быстро падает ниже определяемых пределов. Повторные аллергологические тесты можно возобновить через 3 дня.Отдельные группы пациентовПожилые пациентыУ 16 пожилых лиц при однократном приеме препарата в дозе 10 мг Т1/2 был выше на 50 %, а скорость выведения была ниже на 40 % по сравнению с контрольной группой. Снижение клиренса цетиризина у пожилых пациентов вероятно связано с уменьшением функции почек у этой категории пациентов.ДетиУ детей от 6 до 12 лет 70 % дозы выводится из организма в неизмененном виде почками. После приема 5 мг у детей общий клиренс цетиризина составляет 0,93 мл/мин/кг. Т1/2 у детей от 6 до 12 лет составляет 6 часов, от 2 до 6 лет - 5 часов.Пациенты с почечной недостаточностьюУ пациентов с почечной недостаточностью легкой степени тяжести (клиренс креатинина (КК) \u003e 50 мл/мин) фармакокинетические параметры аналогичны таковым у здоровых добровольцев с нормальной функцией почек. У пациентов с почечной недостаточностью средней степени тяжести (КК 30 - 49 мл/мин) Т1/2 удлиняется в 3 раза, а общий клиренс снижается на 70 % относительно здоровых добровольцев с нормальной функцией почек. У пациентов, находящихся на гемодиализе (КК\u003c7 мл/мин), при приеме препарата внутрь в дозе 10 мг, общий клиренс снижается приблизительно на 70 % относительно здоровых добровольцев с нормальной функцией почек, а Т1/2 удлиняется в 3 раза. Менее 10 % цетиризина удаляется в ходе стандартной процедуры гемодиализа.Пациенты с печеночной недостаточностьюУ пациентов с хроническими заболеваниями печени (гепатоцеллюлярным, холестатическим и билиарным циррозом) при однократном приеме препарата в дозе 10 или 20 мг Т1/2 увеличивается примерно на 50 %, а клиренс снижается на 40 % по сравнению со здоровыми субъектами. Коррекция дозы необходима только в случае, если у пациента с печеночной недостаточностью имеется также сопутствующая почечная недостаточность.","substance":[{"id":197,"title":"Цетиризин","title_latin":"Cetirizinum","slug":"tsetirizin_197"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":true,"comments":null,"image_alt":"Цетиризин-АКОС - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/203634/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/203634/share_default/"}},"diseases":[],"other_packages":[{"id":201398,"title":"Цетиризин-АКОС","subtitle":{"full":"Таблетки, 30 шт, 10 мг, для приема внутрь, в пленочной оболочке","short":"Таблетки, 30 шт, 10 мг","package":"30 шт, 10 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