Фамотидин Лиофилизат, флакон, 5 шт, 20 мг, для приготовления раствора, для взрослых

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Контролируемых исследований у человека не проводилось."}},{"type":"paragraph","data":{"text":"Препарат Фамотидин не рекомендуется применять при беременности."}},{"type":"paragraph","data":{"text":"Период грудного вскармливания"}},{"type":"paragraph","data":{"text":"Фамотидин проникает в грудное молоко в связи с этим грудное вскармливание во время применения препарата Фамотидин лиофилизат для приготовления раствора для внутривенного введения следует прекратить."}},{"type":"paragraph","data":{"text":"Фертильность"}},{"type":"paragraph","data":{"text":"Исследования на животных с применением фамотидина внутрь в дозах до 2000 и 500 мг/кг массы тела в день не показали какого-либо влияния препарата на фертильность."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Препарат Фамотидин лиофилизат для приготовления раствора для внутривенного введения предназначен только для внутривенного введения. Препарат Фамотидин лиофилизат для приготовления раствора для внутривенного введения рекомендован к применению у стационарных пациентов которые не имеют возможности принимать препарат внутрь. Препарат Фамотидин лиофилизат для приготовления раствора для внутривенного введения может применяться до тех пор пока проведение пероральной терапии не станет возможным."}},{"type":"paragraph","data":{"text":"При язве двенадцатиперстной кишки язве желудка без малигнизации гастроэзофагеальной рефлюксной болезни:"}},{"type":"paragraph","data":{"text":"Рекомендованная доза составляет 20 мг внутривенно два раза в день (каждые 12 часов)."}},{"type":"paragraph","data":{"text":"При синдроме Золлингера-Эллисона:"}},{"type":"paragraph","data":{"text":"Начальная доза составляет 20 мг внутривенно каждые 6 часов."}},{"type":"paragraph","data":{"text":"Далее: доза препарата зависит от объема секреции и клинического состояния пациента."}},{"type":"paragraph","data":{"text":"При общей анестезии для предотвращения аспирации кислого содержимого желудка:"}},{"type":"paragraph","data":{"text":"Фамотидин применяется в дозе 20 мг утром в день операции или по меньшей мере за 2 часа до ее начала операции."}},{"type":"paragraph","data":{"text":"Разовая доза для внутривенного введения не может превышать 20 мг. Для проведения внутривенной инъекции содержимое флакона следует растворить в 5-10 мл 09% раствора натрия хлорида (ампула растворителя) а затем медленно ввести (в течение не менее 2 минут). Готовый раствор для инъекции можно хранить в течение 8 часов при комнатной температуре."}},{"type":"paragraph","data":{"text":"Если препарат вводится инфузионно то продолжительность инфузии должна составлять 15-30 минут. Растворы следует готовить непосредственно перед введением. Для разведения рекомендуется применять следующие совместимые растворы:"}},{"type":"paragraph","data":{"text":"- раствор глюкозы 5% (годен в течение 5 часов);"}},{"type":"paragraph","data":{"text":"- раствор Рингера (годен в течение 8 часов);"}},{"type":"paragraph","data":{"text":"- раствор Рингера лактата (годен в течение 8 часов);"}},{"type":"paragraph","data":{"text":"- раствор натрия хлорида 09% годен в течение 8 часов."}},{"type":"paragraph","data":{"text":"Использовать можно только прозрачные бесцветные растворы."}},{"type":"paragraph","data":{"text":"Применение при почечной недостаточности:"}},{"type":"paragraph","data":{"text":"Поскольку фамотидин экскретируется преимущественно почками у пациентов с тяжелой почечной недостаточностью необходимо соблюдать меры предосторожности. Если клиренс креатинина составляет менее 30 мл/мин а сывороточная концентрация креатинина превышает 3 мг/100 мл то суточную дозу необходимо снизить до 20 мг или увеличить интервалы между введениями до 36-48 часов."}},{"type":"paragraph","data":{"text":"Применение у детей и подростков до 18 лет:"}},{"type":"paragraph","data":{"text":"Безопасность и эффективность препарата у детей и подростков до 18 лет не установлены."}},{"type":"paragraph","data":{"text":"Применение у пациентов пожилого возраста (старше 65 лет):"}},{"type":"paragraph","data":{"text":"Коррекция дозы в зависимости от возраста не требуется."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны пищеварительной системы:\u003c/i\u003e возможны отсутствие аппетита, сухость во рту, расстройства вкусовых ощущений, тошнота, рвота, вздутие живота, диарея или запор; в отдельных случаях - развитие холестатической желтухи, повышение уровня трансаминаз в плазме крови."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны ЦНС:\u003c/i\u003e возможны головная боль, повышенная утомляемость, шум в ушах, преходящие психические нарушения."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны сердечно-сосудистой системы:\u003c/i\u003e редко - аритмии."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны системы кроветворения:\u003c/i\u003e очень редко - агранулоцитоз, панцитопения, лейкопения, тромбоцитопения."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны костно-мышечной системы:\u003c/i\u003e возможны мышечные боли, боли в суставах."}},{"type":"paragraph","data":{"text":"\u003ci\u003eАллергические реакции:\u003c/i\u003e возможны кожный зуд, бронхоспазм, лихорадка."}},{"type":"paragraph","data":{"text":"\u003ci\u003eДерматологические реакции:\u003c/i\u003e возможны алопеция, обыкновенные угри, сухость кожи."}},{"type":"paragraph","data":{"text":"\u003ci\u003eМестные реакции:\u003c/i\u003e раздражение в месте инъекции."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"У пациентов с синдромом патологической гиперсекреции применялись дозы до 800 мг в сутки на протяжении периода свыше одного года что не сопровождалось возникновением серьезных нежелательных явлений."}},{"type":"paragraph","data":{"text":"Лечение передозировки: симптоматическая и поддерживающая терапия; мониторинг состояния пациента."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Фамотидин не оказывает влияния на систему цитохрома печени Р450. В связи с повышением pH желудочного сока может снижать степень всасывания кетоконазола при одновременном применении."}},{"type":"paragraph","data":{"text":"При совместном применении фамотидина и лекарственных средств угнетающих костный мозг увеличивается риск развития нейтропении. Фамотидин увеличивает всасывание амоксициллина и клавулановой кислоты."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"До внутривенного введения фамотидина или если такой возможности нет перед переходом на терапию пероральными формами необходимо исключить наличие злокачественного новообразования желудка."}},{"type":"paragraph","data":{"text":"При печеночной недостаточности препарат Фамотидин следует назначать с осторожностью в сниженной дозе."}},{"type":"paragraph","data":{"text":"Поскольку в случае использования блокаторов Н2-гистаминовых рецепторов была описана перекрестная гиперчувствительность применение препарата Фамотидин у пациентов имеющих в анамнезе гиперчувствительность к другим блокаторам Н2-гистаминовых рецепторов требует осторожности. Подобно всем блокаторам Н2-рецепторов при резком прекращении лечения фамотидин может вызывать синдром отмены поэтому лечение прекращают постепенно снижая его дозу."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Пациентам следует соблюдать осторожность при управлении транспортными средствами и работе с механизмами поскольку во время лечения может возникать головокружение и наблюдаться повышенная утомляемость."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Лиофилизат для приготовления раствора для внутривенного введения 20 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при температуре не более 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года."}},{"type":"paragraph","data":{"text":"Не применять препарат после истечения срока годности указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Федеральное казенное предприятие \"Курская биофабрика - фирма БИОК\", 305004, г. Курск, ул. Разина, д. 5, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"Общество с ограниченной ответственностью \"Б-ФАРМ\""}}]}],"source":null},"description_toggle":false,"short_description":"Фамотидин является мощным конкурентным ингибитором Н2-гистаминовых рецепторов. Основным клинически значимым фармакологическим действием фамотидина является ингибирование желудочной секреции. Фамотидин снижает как концентрацию соляной кислоты так и объем желудочной секреции в то время как изменения секреции пепсина происходят пропорционально секретируемому объему. У здоровых добровольцев и пациентов с гиперсекрецией фамотидин ингибирует базальную и ночную секрецию соляной кислоты и пепсиногена а также секрецию стимулируемую введением пентагастрина бетазола кофеина инсулина и физиологическим рефлексом блуждающего нерва. Продолжительность ингибирования секреции при применении доз 20 мг и 40 мг как после внутривенного введения так и после перорального приема составляет от 10 до 12 часов при этом однократное вечернее применение препарата ингибирует базальную и ночную секрецию соляной кислоты. Фамотидин практически не оказывает влияния на концентрацию гастрина в сыворотке натощак или после приема пищи. Фамотидин не оказывает влияния на опорожнение желудка экзокринную функцию поджелудочной железы кровоток в печени и портальной системе. Фамотидин не оказывает влияния на ферментную систему цитохрома Р450 в печени. Антиандрогенного влияния препарата не отмечено. Уровень гормонов в сыворотке крови после лечения фамотидином не изменялся. Кинетика фамотидина носит линейный характер. Всасывание. Препарат предназначен только для внутривенного введения. Распределение Связывание с белками плазмы выражено относительно слабо (15-20%). Период полу выведения составляет 23 - 35 часа. У пациентов с тяжелой почечной недостаточностью время полувыведения фамотидина может превышать 20 часов. Метаболизм Метаболизм фамотидина происходит в печени. Единственным метаболитом обнаруженным у человека является сульфоксид. Выведение Фамотидин выводится почками (65-70%) и путем метаболизма (30-35%). Почечный клиренс составляет 250-450 мл/мин что указывает на некоторую степень канальцевой экскреции. 65 - 70% внутривенно введенной дозы обнаруживается в моче в неизмененном виде. 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