При наружном применении Адвантан® подавляет воспалительные и аллергические кожные реакции, также как и реакции, связанные с усиленной пролиферацией, что приводит к уменьшению объективных симптомов воспаления (в т.ч. эритема, отек, мокнутие и т. д.) и субъективных ощущений (в т.ч. зуд, раздражение, боль и т. д.).
При применении метилпреднизолона ацепоната наружно в рекомендуемой дозе системное действие выражено минимально как у человека, так и у животных. После многократного нанесения Адвантана на большие поверхности (40-60% поверхности кожи), а также при применении под окклюзионную повязку не отмечается нарушений функций надпочечников: уровень кортизола в плазме крови и его циркадный ритм остаются в пределах нормы, снижения уровня кортизола в суточной моче не происходит.
В ходе клинических исследований при применении Адвантана до 12 недель у взрослых и до 4 недель у детей (в т.ч. раннего возраста) не было выявлено развития атрофии кожи, телеангиэктазий, стрий и угреподобных высыпаний.
Метилпреднизолона ацепонат (особенно его основной метаболит – 6α-метилпреднизолон-17-пропионат) связывается с внутриклеточными глюкокортикоидными рецепторами. Стероид-рецепторный комплекс связывается с определенными участками ДНК клеток иммунного ответа, таким образом, вызывая серию биологических эффектов.
В частности, связывание стероид-рецепторного комплекса с ДНК клеток иммунного ответа приводит к индукции синтеза макрокортина. Макрокортин ингибирует высвобождение арахидоновой кислоты и, тем самым, образование медиаторов воспаления типа простагландинов и лейкотриенов.
Ингибирование ГКС синтеза вазодилатирующих простагландинов и потенцирование сосудосуживающего действия адреналина приводит к вазоконстрикторному эффекту.
Показания к применению
Воспалительные заболевания кожи, чувствительные к терапии топическими ГКС:
туберкулезный или сифилитический процессы в области нанесения препарата;
вирусные заболевания в области нанесения препарата (например, при ветряной оспе, опоясывающем лишае);
розацеа, периоральный дерматит в области нанесения препарата;
участки кожи с прявлениями реакции на вакцинацию;
детский возраст до 4 месяцев;
гиперчувствительность к компонентам препарата.
Применение при беременности и в период грудного вскармливания
При необходимости применения препарата Адвантан® при беременности и в период лактации следует тщательно взвесить потенциальный риск для плода и ожидаемую пользу терапии для матери. В эти периоды не рекомендуется длительное применение препарата на обширных поверхностях кожи.
Кормящим матерям не следует наносить препарат на молочные железы.
Способ применения и дозы
Наружно.
Взрослым и детям с 4 месяцев препарат наносят 1 раз/сут тонким слоем на пораженные участки кожи.
Непрерывное ежедневное применение Адвантана в форме крема, мази или жирной мази не должно превышать для взрослых 12 недель, для детей – 4 недель. Курс лечения Адвантаном в форме эмульсии обычно не должен превышать 2 недель.
Крем представляет собой лекарственную форму с небольшим содержанием жира и высоким содержанием воды, поэтому рекомендуется при подостром и остром воспалении без выраженного мокнутия. Крем обеспечивает устранение воспалительного процесса как на гладкой коже, так и на волосистой части головы, в т.ч. на коже, склонной к жирности.
Мазь представляет собой лекарственную форму с уравновешенным соотношением жира и воды, поэтому рекомендуется при подостром или хроническом течении воспалительных заболеваний кожи, не сопровождающихся мокнутием. Мазь оказывает лечебное действие, способствуя также устранению сухости кожи и восстановлению ее нормальной жирности.
Жирная мазь представляет собой безводную лекарственную форму, поэтому рекомендуется для лечения длительных хронических воспалительных кожных процессов при очень сухой коже. Окклюзионный эффект жирной мази обеспечивает выраженное лечебное воздействие даже при значительной лихенификации и инфильтрации.
Эмульсию наносят тонким слоем на пораженные участки кожи, слегка втирая. При солнечных ожогах эмульсию применяют 1-2 раза/сут. Если кожные покровы чрезмерно сохнут при применении эмульсии, необходимо перейти к лекарственной форме препарата Адвантан® с более высоким содержанием жира (мазь или жирная мазь).
Побочное действие
Обычно препарат хорошо переносится.
Очень редко (менее чем в 0.01% случаев) могут наблюдаться местные реакции, такие как зуд, жжение, эритема, образование везикулезной сыпи. Если препарат применяют более 4 недель и/или на площади 10% и более поверхности тела, могут возникнуть следующие реакции: атрофия кожи, телеангиэктазии, стрии, акнеформные изменения кожи, системные эффекты, обусловленные абсорбцией кортикостероида. В ходе клинических исследований ни один из вышеперечисленных побочных эффектов не был отмечен при применении препарата Адвантан® до 12 недель у взрослых и до 4 недель у детей.
В редких случаях (0.01-0.1%) может наблюдаться фолликулит, гипертрихоз, периоральный дерматит, депигментация кожи, аллергические реакции на один из компонентов препарата.
Особые указания
При наличии бактериальных осложнений и/или дерматомикозов в дополнение к терапии препаратом Адвантан® необходимо проводить специфическое антибактериальное или противогрибковое лечение.
Следует избегать попадания препарата в глаза.
Как и в случае применения системных кортикостероидов, после наружного применения ГКС может развиться глаукома (например, при применении больших доз или очень длительном применении окклюзионных повязок или нанесения на кожу вокруг глаз).
Влияние на способность к управлению транспортными средствами и механизмами
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объективных симптомов воспаления (в т.ч. эритема, отек, мокнутие и т. д.) и субъективных ощущений (в т.ч. зуд, раздражение, боль и т. д.)."}},{"type":"paragraph","data":{"text":"При применении метилпреднизолона ацепоната наружно в рекомендуемой дозе системное действие выражено минимально как у человека, так и у животных. После многократного нанесения Адвантана на большие поверхности (40-60% поверхности кожи), а также при применении под окклюзионную повязку не отмечается нарушений функций надпочечников: уровень кортизола в плазме крови и его циркадный ритм остаются в пределах нормы, снижения уровня кортизола в суточной моче не происходит."}},{"type":"paragraph","data":{"text":"В ходе клинических исследований при применении Адвантана до 12 недель у взрослых и до 4 недель у детей (в т.ч. раннего возраста) не было выявлено развития атрофии кожи, телеангиэктазий, стрий и угреподобных высыпаний."}},{"type":"paragraph","data":{"text":"Метилпреднизолона ацепонат (особенно его основной метаболит – 6α-метилпреднизолон-17-пропионат) связывается с внутриклеточными глюкокортикоидными рецепторами. Стероид-рецепторный комплекс связывается с определенными участками ДНК клеток иммунного ответа, таким образом, вызывая серию биологических эффектов."}},{"type":"paragraph","data":{"text":"В частности, связывание стероид-рецепторного комплекса с ДНК клеток иммунного ответа приводит к индукции синтеза макрокортина. Макрокортин ингибирует высвобождение арахидоновой кислоты и, тем самым, образование медиаторов воспаления типа простагландинов и лейкотриенов."}},{"type":"paragraph","data":{"text":"Ингибирование ГКС синтеза вазодилатирующих простагландинов и потенцирование сосудосуживающего действия адреналина приводит к вазоконстрикторному эффекту."}}]},{"id":11,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Воспалительные заболевания кожи, чувствительные к терапии топическими ГКС:"}},{"type":"list","data":{"style":"ordered","items":["атопический дерматит, нейродермит, детская экзема;","истинная экзема;","микробная экзема;","профессиональная экзема;","дисгидротическая экзема;","простой контактный дерматит;","аллергический (контактный) дерматит."]}}]},{"id":12,"name":"Противопоказания","slug":"contraindications","body":[{"type":"list","data":{"style":"ordered","items":["туберкулезный или сифилитический процессы в области нанесения препарата;","вирусные заболевания в области нанесения препарата (например, при ветряной оспе, опоясывающем лишае);","розацеа, периоральный дерматит в области нанесения препарата;","участки кожи с прявлениями реакции на вакцинацию;","детский возраст до 4 месяцев;","гиперчувствительность к компонентам препарата."]}}]},{"id":14,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"При необходимости применения препарата Адвантан\u003csup\u003e®\u003c/sup\u003e при беременности и в период лактации следует тщательно взвесить потенциальный риск для плода и ожидаемую пользу терапии для матери. В эти периоды не рекомендуется длительное применение препарата на обширных поверхностях кожи."}},{"type":"paragraph","data":{"text":"Кормящим матерям не следует наносить препарат на молочные железы."}}]},{"id":15,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Наружно."}},{"type":"paragraph","data":{"text":"\u003cb\u003eВзрослым и детям с 4 месяцев \u003c/b\u003eпрепарат наносят 1 раз/сут тонким слоем на пораженные участки кожи."}},{"type":"paragraph","data":{"text":"Непрерывное ежедневное применение Адвантана в форме крема, мази или жирной мази не должно превышать для \u003cb\u003eвзрослых\u003c/b\u003e 12 недель, для \u003cb\u003eдетей\u003c/b\u003e – 4 недель. Курс лечения Адвантаном в форме эмульсии обычно не должен превышать 2 недель."}},{"type":"paragraph","data":{"text":"\u003cb\u003eКрем \u003c/b\u003eпредставляет собой лекарственную форму с небольшим содержанием жира и высоким содержанием воды, поэтому рекомендуется при \u003ci\u003eподостром и остром воспалении без выраженного мокнутия. \u003c/i\u003eКрем обеспечивает устранение воспалительного процесса как на гладкой коже, так и на волосистой части головы, в т.ч. на коже, склонной к жирности."}},{"type":"paragraph","data":{"text":"\u003cb\u003eМазь \u003c/b\u003eпредставляет собой лекарственную форму с уравновешенным соотношением жира и воды, поэтому рекомендуется при \u003ci\u003eподостром или хроническом течении воспалительных заболеваний кожи, не сопровождающихся мокнутием. \u003c/i\u003eМазь оказывает лечебное действие, способствуя также устранению сухости кожи и восстановлению ее нормальной жирности."}},{"type":"paragraph","data":{"text":"\u003cb\u003eЖирная мазь\u003c/b\u003e представляет собой безводную лекарственную форму, поэтому рекомендуется для \u003ci\u003eлечения длительных хронических воспалительных кожных процессов при очень сухой коже\u003c/i\u003e. Окклюзионный эффект жирной мази обеспечивает выраженное лечебное воздействие даже при значительной лихенификации и инфильтрации."}},{"type":"paragraph","data":{"text":"\u003cb\u003eЭмульсию \u003c/b\u003eнаносят тонким слоем на пораженные участки кожи, слегка втирая. При солнечных ожогах эмульсию применяют 1-2 раза/сут. Если кожные покровы чрезмерно сохнут при применении эмульсии, необходимо перейти к лекарственной форме препарата Адвантан\u003csup\u003e®\u003c/sup\u003e с более высоким содержанием жира (мазь или жирная мазь)."}}]},{"id":16,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Обычно препарат хорошо переносится."}},{"type":"paragraph","data":{"text":"\u003ci\u003eОчень редко\u003c/i\u003e (менее чем в 0.01% случаев) могут наблюдаться местные реакции, такие как зуд, жжение, эритема, образование везикулезной сыпи. Если препарат применяют более 4 недель и/или на площади 10% и более поверхности тела, могут возникнуть следующие реакции: атрофия кожи, телеангиэктазии, стрии, акнеформные изменения кожи, системные эффекты, обусловленные абсорбцией кортикостероида. В ходе клинических исследований ни один из вышеперечисленных побочных эффектов не был отмечен при применении препарата Адвантан\u003csup\u003e®\u003c/sup\u003e до 12 недель у взрослых и до 4 недель у детей."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВ редких случаях\u003c/i\u003e (0.01-0.1%) может наблюдаться фолликулит, гипертрихоз, периоральный дерматит, депигментация кожи, аллергические реакции на один из компонентов препарата."}}]},{"id":19,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"При наличии бактериальных осложнений и/или дерматомикозов в дополнение к терапии препаратом Адвантан\u003csup\u003e®\u003c/sup\u003e необходимо проводить специфическое антибактериальное или противогрибковое лечение."}},{"type":"paragraph","data":{"text":"Следует избегать попадания препарата в глаза."}},{"type":"paragraph","data":{"text":"Как и в случае применения системных кортикостероидов, после наружного применения ГКС может развиться глаукома (например, при применении больших доз или очень длительном применении окклюзионных повязок или нанесения на кожу вокруг глаз)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВлияние на способность к управлению транспортными средствами и механизмами\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Не выявлено."}}]}],"source":{"title":"('Эркафарм/Столетов',)","url":"https://stoletov.ru/"}},"description_toggle":false,"short_description":"При наружном применении Адвантан®подавляет воспалительные и аллергические кожные реакции, также как и реакции, связанные с усиленной пролиферацией, что приводит к уменьшению объективных симптомов воспаления (в т.ч. эритема, отек, мокнутие и т. д.) и субъективных ощущений (в т.ч. зуд, раздражение, боль и т. д.). 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