Блокатор гистаминовых Н1-рецепторов (длительного действия). Является первичным активным метаболитом лоратадина. Ингибирует высвобождение гистамина и лейкотриена С4из тучных клеток. Предупреждает развитие и облегчает течение аллергических реакций. Обладает противоаллергическим, противозудным и противоэкссудативным действием. Уменьшает проницаемость капилляров, предупреждает развитие отека тканей, снимает спазм гладкой мускулатуры. Практически не обладает седативным эффектом и при приеме в дозе 7.5 мг не влияет на скорость психомоторных реакций. В сравнительных исследованиях дезлоратадина и лоратадина качественных или количественных различий токсичности двух препаратов в сопоставимых дозах (с учетом концентрации дезлоратадина) не выявлено.
Фармакокинетика
После приема внутрь начинает определяться в плазме через 30 мин. Пища не оказывает влияния на распределение. Биодоступность пропорциональна дозе в диапазоне от 5 мг до 20 мг. Связывание с белками плазмы составляет 83-87%. После однократного приема в дозе 5 мг или 7.5 мг Cmax достигается через 2-6 ч (в среднем через 3 ч). Не проникает через ГЭБ. Интенсивно метаболизируется в печени путем гидроксилирования с образованием 3-ОН-дезлоратадина, соединенного с глюкуронидом, лишь небольшая часть принятой внутрь дозы выводится почками (<2%) и с калом (<7%). T1/2 – 20-30 ч (в среднем - 27 ч). При применении дезлоратадина в дозе от 5 мг до 20 мг 1 раз/сут в течение 14 дней признаков клинически значимой кумуляции не выявлено.
Взаимодействие с другими лекарственными средствами
Изучение взаимодействия с кетоконазолом и эритромицином клинически значимых изменений не выявило.
Не влияет на эффекты этанола.
Особые указания
С осторожностью назначают дезлоратадин при тяжелой почечной недостаточности.
Влияние на способность управлять автомобилем и движущимися механизмами
Неблагоприятного воздействия на управление автомобилем или сложными техническими устройствами не отмечалось.
Форма выпуска
Сироп.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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При применении дезлоратадина в дозе от 5 мг до 20 мг 1 раз/сут в течение 14 дней признаков клинически значимой кумуляции не выявлено.\n\n"}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Сезонный аллергический ринит, хроническая идиопатическая крапивница."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Фенилкетонурия, беременность, лактация, детский возраст до 1 года, повышенная чувствительность к дезлоратадину."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Дезлоратадин противопоказан к применению при беременности и в период лактации (грудного вскармливания)."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Взрослым и подросткам в возрасте 12 лет и старше назначают внутрь, независимо от приема пищи, в дозе 5 мг/сут."}},{"type":"paragraph","data":{"text":"Детям в возрасте от 1 года до 5 лет - 1.25 мг 1 раз/сут, в возрасте от 6 до 11 лет - 2.5 мг 1 раз/сут."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны нервной системы:\u003c/i\u003e головная боль, галлюцинации, психомоторная гиперреактивность, судороги."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны пищеварительной системы:\u003c/i\u003e сухость во рту, гепатит."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПрочие: \u003c/i\u003eфотосенсибилизация, миалгия, одышка, чувство усталости."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Изучение взаимодействия с кетоконазолом и эритромицином клинически значимых изменений не выявило."}},{"type":"paragraph","data":{"text":"Не влияет на эффекты этанола."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"С осторожностью назначают дезлоратадин при тяжелой почечной недостаточности."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Неблагоприятного воздействия на управление автомобилем или сложными техническими устройствами не отмечалось."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Сироп."}}]}],"source":null},"description_toggle":false,"short_description":"Блокатор гистаминовых Н1-рецепторов (длительного действия). 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