Комбинированный препарат. Парацетамол обладает анальгетическ... Инструкция
Показания к применению
Инфекционно-воспалительные заболевания (ОРВИ, грипп), сопровожда-ющиеся повышенной температурой, ознобом, головной болью, болями в суставах и мышцах, заложенностью носа и болями в горле и пазухах носа.
Противопоказания
Повышенная чувствительность к парацетамолу, аскорбиновой кислоте, хлорфенамину или любому другому компоненту препарата.
Эрозивно-язвенные поражения желудочно-кишечного тракта (в фазе обострения).
Порошок медово-лимонный: порошок разной степени грануляции, состоящий из частиц от белого до серовато-бежевого цвета, со специфическим запахом. Допускаются вкрапления темно-бурого цвета.
Средство для устранения симптомов ОРЗ и «простуды» (анальгезирующее ненаркотическое средство + витамин + Н1-гистаминовых рецепторов блокатор).
Фармакологические свойства
Комбинированный препарат.
Парацетамол обладает анальгетическим и жаропонижающим действием; устраняет головную и другие виды боли, снижает повышенную температуру.
Аскорбиновая кислота (витамин С) участвует в регулировании окислительно-восстановительных процессов, углеводного обмена, повышает сопротивляемость организма.
Хлорфенамин – блокатор Н1-гистаминовых рецепторов, обладает противоаллергическим действием, облегчает дыхание через нос, снижает чувство заложенности носа, чихание, слезотечение, зуд и покраснение глаз.
Показания к применению
Инфекционно-воспалительные заболевания (ОРВИ, грипп), сопровожда-ющиеся повышенной температурой, ознобом, головной болью, болями в суставах и мышцах, заложенностью носа и болями в горле и пазухах носа.
Противопоказания
Повышенная чувствительность к парацетамолу, аскорбиновой кислоте, хлорфенамину или любому другому компоненту препарата.
Эрозивно-язвенные поражения желудочно-кишечного тракта (в фазе обострения).
Применение при беременности и в период грудного вскармливания
Противопоказано во время беременности и в период лактации.
Способ применения и дозы
Внутрь. Взрослым и детям старше 15 лет по 1 пакетику 2-3 раза в сутки. Содержимое пакетика следует полностью растворить в стакане (200 мл) теплой воды (50-60С) и полученный раствор сразу выпить. Лучше принимать препарат между приемами пищи. Максимальная суточная доза – 3 пакетика. Интервал между приемами препарата должен быть не менее 4 часов.
У пациентов с нарушениями функции печени или почек и у пожилых больных интервал между приемами препарата должен составлять не менее 8 часов.
Продолжительность приема без консультации с врачом не более 5 дней при назначении в качестве обезболивающего средства и 3-х дней в качестве жаропонижающего средства.
Побочное действие
Препарат хорошо переносится в рекомендованных дозах.
В единичных случаях встречаются:
со стороны ЦНС: головная боль, чувство усталости;
со стороны ЖКТ: тошнота, боль в эпигастральной области;
со стороны эндокринной системы: гипогликемия (вплоть до развития комы);
со стороны органов кроветворения: анемия, гемолитическая анемия (особенно для пациентов с дефицитом глюкозо-6-фосфатдегидрогеназы); крайне редко – тромбоцитопения;
аллергические реакции: кожная сыпь, зуд, крапивница, отек Квинке, анафилактоидные реакции (в т.ч. анафилактический шок), мультиформная экссудативная эритема (в т.ч. синдром Стивенса-Джонсона), токсический эпидермальный некролиз (синдром Лайелла);
прочие: гипервитаминоз С, нарушение обмена веществ, ощущение жара, сухость во рту, парез аккомодации, задержка мочи, сонливость.
Обо всех побочных эффектах препарата следует сообщать врачу.
Передозировка
Симптомы передозировки препаратом обусловлены входящими в его состав веществами. Клиническая картина острой интоксикации парацетамолом развивается в течение 6-14 часов после его приема. Симптомы хронической интоксикации проявляются через 2-4 суток после передозировки.
Симптомы острой интоксикации парацетамолом: диарея, снижение аппетита, тошнота и рвота, дискомфорт в брюшной полости и/или абдоминальная боль, повышение потоотделения.
Симптомы интоксикации хлорфенамином: головокружение, возбуждение, нарушения сна, депрессия, судороги.
Лечение: симптоматическое.
Взаимодействие с другими лекарственными средствами
Аскорбиновая кислота:
- повышает концентрацию в крови бензилпенициллина и тетрациклинов;
- улучшает всасывание в кишечнике препаратов железа (переводит трехвалентное железо в двухвалентное); может повышать выведение железа при одновременном применении с дефероксамином;
- увеличивает риск развития кристаллурии при лечении салицилатами и сульфаниламидами короткого действия, замедляет выведение почками кислот, повышает выведение ЛС, имеющих щелочную реакцию (в т.ч. алкалоидов), снижает концентрацию в крови пероральных контрацептивов;
- повышает общий клиренс этанола;
- при одновременном применении уменьшает хронотропное действие изопреналина.
Может как повышать, так и снижать эффект антикоагулянтных препаратов.
Уменьшает терапевтическое действие антипсихотических препаратов (нейролептиков) – производных фенотиазина, канальцевую реабсорбцию амфетамина и трициклических антидепрессантов.
Одновременный прием барбитуратов повышает выведение аскорбиновой кислоты с мочой.
Хлорфенамина малеат:
Хлорфенамина малеат усиливает действие снотворных лекарственных средств.
Антидепрессанты, противопаркинсонические средства, антипсихотические средства (производные фенотиазина) – повышают риск развития побочных эффектов (задержка мочи, сухость во рту, запоры).
Глюкокортикостероиды – увеличивают риск развития глаукомы.
Этанол усиливает седативное действие хлорфенамина малеата.
Парацетамол:
При взаимодействии парацетамола и индукторов микросомального окисления в печени (фенитоин, этанол, барбитураты, рифампицин, фенилбутазон, трициклические антидепрессанты) увеличивается продукция гидроксилированных активных метаболитов, что обусловливает возможность развития тяжелых интоксикаций при небольших передозировках.
На фоне приема парацетамола этанол способствует развитию острого панкреатита.
Ингибиторы микросомального окисления (в т.ч. циметидин) снижают риск гепатотоксического действия.
Одновременный прием дифлунисала и парацетамола повышает концентрацию в плазме крови последнего на 50%, повышая гепатотоксичность. Одновременный прием барбитуратов снижает эффективность парацетамола.
При приеме метоклопрамида, домперидона или колестирамина также необходимо проконсультироваться с врачом.
При длительном применении в дозах, значительно превышающих рекомендованные, повышается вероятность нарушения функции печени и почек, необходим контроль периферической картины крови.
Парацетамол и аскорбиновая кислота могут искажать показатели лабораторных исследований (количественное определение содержания глюкозы и мочевой кислоты в плазме крови, билирубина, активности «печеночных» трансаминаз, ЛДГ).
Во избежание токсического поражения печени парацетамол не следует сочетать с приемом алкогольных напитков, а также принимать лицам, склонным к хроническому потреблению алкоголя. Риск развития повреждений печени возрастает у больных с алкогольным гепатозом.
Назначение аскорбиновой кислоты пациентам с быстро пролиферирующими и интенсивно метастазирующими опухолями может усугубить течение процесса. У пациентов с повышенным содержанием железа в организме следует применять аскорбиновую кислоту в минимальных дозах.
В одном пакетике медово-лимонном содержится 1,793 г сахара, что соответствует 0,15 ХЕ.
В одном пакетике ромашковом содержится 2,058 г сахара, что соответствует 0,17 ХЕ.
Форма выпуска
По 5,0 г порошка в пакетике из бумаги/Al/полиэтилена. По 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 15, 16, 20, 30 пакетиков в картонной пачке с инструкцией по применению.
Условия хранения
Хранить при температуре не выше 10C-30С
Срок годности
3 года. Не применять по истечении срока годности.
Условия отпуска
Без рецепта.
Производитель
NATUR PRODUKT PHARMA. Страна производства: Польша.
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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Допускаются вкрапления темно-бурого цвета. "}}]},{"id":1,"name":"Состав","slug":"ingredients","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"СОСТАВ НА ОДИН ПАКЕТИК:"}},{"type":"paragraph","data":{"text":"Активные вещества:"}},{"type":"paragraph","data":{"text":"парацетамол…………………………………………………………………………..500,00 мг"}},{"type":"paragraph","data":{"text":"хлорфенамина малеат………………………………………………………………….10,00 мг"}},{"type":"paragraph","data":{"text":"аскорбиновая кислота………………………………………………………………...200,00 мг"}},{"type":"paragraph","data":{"text":"Вспомогательные вещества: "}},{"type":"paragraph","data":{"text":"Медово-лимонный: натрия гидрокарбонат 644,00 мг; лимонная кислота 1328,00 мг; сорбитол 317,00 мг; повидон 16,00 мг; сахароза 1793,00 мг; натрия цикламат 42,00 мг; аспартам 20,00 мг; ацесульфам калия 15,00 мг; ароматизатор лимонный 55,00 мг; краситель карамельный 15,00 мг; ароматизатор медовый 45,00 мг. "}}]},{"name":"Фармакотерапевтическая группа","slug":"","id":13,"body":[{"type":"paragraph","data":{"text":"Средство для устранения симптомов ОРЗ и «простуды» (анальгезирующее ненаркотическое средство + витамин + Н1-гистаминовых рецепторов блокатор)."}}]},{"id":2,"name":"Фармакологические свойства","slug":"pharmacologic_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Комбинированный препарат. "}},{"type":"paragraph","data":{"text":"Парацетамол обладает анальгетическим и жаропонижающим действием; устраняет головную и другие виды боли, снижает повышенную температуру."}},{"type":"paragraph","data":{"text":"Аскорбиновая кислота (витамин С) участвует в регулировании окислительно-восстановительных процессов, углеводного обмена, повышает сопротивляемость организма."}},{"type":"paragraph","data":{"text":"Хлорфенамин – блокатор Н1-гистаминовых рецепторов, обладает противоаллергическим действием, облегчает дыхание через нос, снижает чувство заложенности носа, чихание, слезотечение, зуд и покраснение глаз."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Инфекционно-воспалительные заболевания (ОРВИ, грипп), сопровожда-ющиеся повышенной температурой, ознобом, головной болью, болями в суставах и мышцах, заложенностью носа и болями в горле и пазухах носа."}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к парацетамолу, аскорбиновой кислоте, хлорфенамину или любому другому компоненту препарата. "}},{"type":"paragraph","data":{"text":"Эрозивно-язвенные поражения желудочно-кишечного тракта (в фазе обострения). "}},{"type":"paragraph","data":{"text":"Выраженная почечная и/или печеночная недостаточность."}},{"type":"paragraph","data":{"text":"Алкоголизм."}},{"type":"paragraph","data":{"text":"Закрытоугольная глаукома."}},{"type":"paragraph","data":{"text":"Фенилкетонурия."}},{"type":"paragraph","data":{"text":"Гиперплазия предстательной железы."}},{"type":"paragraph","data":{"text":"Детский возраст (до 15 лет)."}},{"type":"paragraph","data":{"text":"Беременность и период лактации."}}]},{"name":"С осторожностью","slug":"cautions","id":14,"body":[{"type":"paragraph","data":{"text":"Почечная и/или печеночная недостаточность, дефицит глюкозо-6-фосфатдегидрогеназы, врожденные гипербилирубинемии (синдромы Жильбера, Дубина-Джонсона и Ротора), вирусный гепатит, алкогольный гепатит, пожилой возраст."}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Противопоказано во время беременности и в период лактации."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Внутрь. Взрослым и детям старше 15 лет по 1 пакетику 2-3 раза в сутки. Содержимое пакетика следует полностью растворить в стакане (200 мл) теплой воды (50-60С) и полученный раствор сразу выпить. Лучше принимать препарат между приемами пищи. Максимальная суточная доза – 3 пакетика. Интервал между приемами препарата должен быть не менее 4 часов."}},{"type":"paragraph","data":{"text":"У пациентов с нарушениями функции печени или почек и у пожилых больных интервал между приемами препарата должен составлять не менее 8 часов."}},{"type":"paragraph","data":{"text":"Продолжительность приема без консультации с врачом не более 5 дней при назначении в качестве обезболивающего средства и 3-х дней в качестве жаропонижающего средства."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Препарат хорошо переносится в рекомендованных дозах."}},{"type":"paragraph","data":{"text":"В единичных случаях встречаются:"}},{"type":"paragraph","data":{"text":"со стороны ЦНС: головная боль, чувство усталости;"}},{"type":"paragraph","data":{"text":"со стороны ЖКТ: тошнота, боль в эпигастральной области;"}},{"type":"paragraph","data":{"text":"со стороны эндокринной системы: гипогликемия (вплоть до развития комы);"}},{"type":"paragraph","data":{"text":"со стороны органов кроветворения: анемия, гемолитическая анемия (особенно для пациентов с дефицитом глюкозо-6-фосфатдегидрогеназы); крайне редко – тромбоцитопения;"}},{"type":"paragraph","data":{"text":"аллергические реакции: кожная сыпь, зуд, крапивница, отек Квинке, анафилактоидные реакции (в т.ч. анафилактический шок), мультиформная экссудативная эритема (в т.ч. синдром Стивенса-Джонсона), токсический эпидермальный некролиз (синдром Лайелла);"}},{"type":"paragraph","data":{"text":"прочие: гипервитаминоз С, нарушение обмена веществ, ощущение жара, сухость во рту, парез аккомодации, задержка мочи, сонливость."}},{"type":"paragraph","data":{"text":"Обо всех побочных эффектах препарата следует сообщать врачу."}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Симптомы передозировки препаратом обусловлены входящими в его состав веществами. Клиническая картина острой интоксикации парацетамолом развивается в течение 6-14 часов после его приема. Симптомы хронической интоксикации проявляются через 2-4 суток после передозировки."}},{"type":"paragraph","data":{"text":"Симптомы острой интоксикации парацетамолом: диарея, снижение аппетита, тошнота и рвота, дискомфорт в брюшной полости и/или абдоминальная боль, повышение потоотделения."}},{"type":"paragraph","data":{"text":"Симптомы интоксикации хлорфенамином: головокружение, возбуждение, нарушения сна, депрессия, судороги."}},{"type":"paragraph","data":{"text":"Лечение: симптоматическое."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Аскорбиновая кислота:"}},{"type":"paragraph","data":{"text":"- повышает концентрацию в крови бензилпенициллина и тетрациклинов;"}},{"type":"paragraph","data":{"text":"- улучшает всасывание в кишечнике препаратов железа (переводит трехвалентное железо в двухвалентное); может повышать выведение железа при одновременном применении с дефероксамином;"}},{"type":"paragraph","data":{"text":" - увеличивает риск развития кристаллурии при лечении салицилатами и сульфаниламидами короткого действия, замедляет выведение почками кислот, повышает выведение ЛС, имеющих щелочную реакцию (в т.ч. алкалоидов), снижает концентрацию в крови пероральных контрацептивов;"}},{"type":"paragraph","data":{"text":"- повышает общий клиренс этанола;"}},{"type":"paragraph","data":{"text":"- при одновременном применении уменьшает хронотропное действие изопреналина."}},{"type":"paragraph","data":{"text":"Может как повышать, так и снижать эффект антикоагулянтных препаратов."}},{"type":"paragraph","data":{"text":"Уменьшает терапевтическое действие антипсихотических препаратов (нейролептиков) – производных фенотиазина, канальцевую реабсорбцию амфетамина и трициклических антидепрессантов."}},{"type":"paragraph","data":{"text":"Одновременный прием барбитуратов повышает выведение аскорбиновой кислоты с мочой."}},{"type":"paragraph","data":{"text":"Хлорфенамина малеат:"}},{"type":"paragraph","data":{"text":"Хлорфенамина малеат усиливает действие снотворных лекарственных средств."}},{"type":"paragraph","data":{"text":"Антидепрессанты, противопаркинсонические средства, антипсихотические средства (производные фенотиазина) – повышают риск развития побочных эффектов (задержка мочи, сухость во рту, запоры). "}},{"type":"paragraph","data":{"text":"Глюкокортикостероиды – увеличивают риск развития глаукомы. "}},{"type":"paragraph","data":{"text":"Этанол усиливает седативное действие хлорфенамина малеата."}},{"type":"paragraph","data":{"text":"Парацетамол:"}},{"type":"paragraph","data":{"text":"При взаимодействии парацетамола и индукторов микросомального окисления в печени (фенитоин, этанол, барбитураты, рифампицин, фенилбутазон, трициклические антидепрессанты) увеличивается продукция гидроксилированных активных метаболитов, что обусловливает возможность развития тяжелых интоксикаций при небольших передозировках. "}},{"type":"paragraph","data":{"text":"На фоне приема парацетамола этанол способствует развитию острого панкреатита. "}},{"type":"paragraph","data":{"text":"Ингибиторы микросомального окисления (в т.ч. циметидин) снижают риск гепатотоксического действия."}},{"type":"paragraph","data":{"text":"Одновременный прием дифлунисала и парацетамола повышает концентрацию в плазме крови последнего на 50%, повышая гепатотоксичность. Одновременный прием барбитуратов снижает эффективность парацетамола."}},{"type":"paragraph","data":{"text":"Парацетамол снижает эффективность урикозурических препаратов."}}]},{"id":9,"name":"Особые указания","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"При приеме метоклопрамида, домперидона или колестирамина также необходимо проконсультироваться с врачом."}},{"type":"paragraph","data":{"text":"При длительном применении в дозах, значительно превышающих рекомендованные, повышается вероятность нарушения функции печени и почек, необходим контроль периферической картины крови. "}},{"type":"paragraph","data":{"text":"Парацетамол и аскорбиновая кислота могут искажать показатели лабораторных исследований (количественное определение содержания глюкозы и мочевой кислоты в плазме крови, билирубина, активности «печеночных» трансаминаз, ЛДГ)."}},{"type":"paragraph","data":{"text":"Во избежание токсического поражения печени парацетамол не следует сочетать с приемом алкогольных напитков, а также принимать лицам, склонным к хроническому потреблению алкоголя. Риск развития повреждений печени возрастает у больных с алкогольным гепатозом. "}},{"type":"paragraph","data":{"text":"Назначение аскорбиновой кислоты пациентам с быстро пролиферирующими и интенсивно метастазирующими опухолями может усугубить течение процесса. У пациентов с повышенным содержанием железа в организме следует применять аскорбиновую кислоту в минимальных дозах."}},{"type":"paragraph","data":{"text":"В одном пакетике медово-лимонном содержится 1,793 г сахара, что соответствует 0,15 ХЕ."}},{"type":"paragraph","data":{"text":"В одном пакетике ромашковом содержится 2,058 г сахара, что соответствует 0,17 ХЕ."}}],"slug":""},{"name":"Форма выпуска","slug":"","id":17,"body":[{"type":"paragraph","data":{"text":"По 5,0 г порошка в пакетике из бумаги/Al/полиэтилена. По 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 15, 16, 20, 30 пакетиков в картонной пачке с инструкцией по применению."}}]},{"name":"Условия хранения","slug":"storage","id":18,"body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 10C-30С"}}]},{"name":"Срок годности","slug":"expiry_date","id":19,"body":[{"type":"paragraph","data":{"text":"3 года. 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