Ультоп Лиофилизат, флакон, 1 шт, 40 мг, для раствора для инфузий

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Рекомендуется вводить инфузионный раствор сразу же после его приготовления."}},{"type":"paragraph","data":{"text":"Пациенты с нарушенной функцией почек - нет необходимости проводить коррекцию дозы."}},{"type":"paragraph","data":{"text":"Пациенты с нарушенной функцией печени - период полувыведения омепразола более продолжителен, рекомендуется уменьшение суточной дозы до 10-20 мг."}},{"type":"paragraph","data":{"text":"Пациентам пожилого возраста корректировки дозы не требуется."}},{"type":"paragraph","data":{"text":"Приготовление инфузионного раствора Ультопа."}},{"type":"paragraph","data":{"text":"Растворяют лиофилизированный порошок омепразола в 100 мл 5 % инфузионного раствора декстрозы (глюкозы) или в 100 мл инфузионного физиологического раствора. Инфузионный раствор на 5 % декстрозе должен быть использован в течение 6 часов. Инфузионный раствор на физиологическом растворе должен быть использован в течение 12 часов.\n\n"}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\n\nСо стороны органов пищеварения: диарея или запор, тошнота, рвота, метеоризм, боль в животе, сухость во рту, нарушения вкуса, стоматит, транзиторное повышение активности «печеночных» ферментов в плазме; у больных с предшествующим тяжелым заболеванием печени - гепатит (в т. ч. с желтухой), нарушение функции печени."}},{"type":"paragraph","data":{"text":"Со стороны нервной системы: головная боль, головокружение, возбуждение, сонливость, бессонница, парестезии, депрессия, галлюцинации; у больных с тяжелыми сопутствующими соматическими заболеваниями, больных с предшествующим тяжелым заболеванием печени - энцефалопатия."}},{"type":"paragraph","data":{"text":"Со стороны опорно-двигательного аппарата: мышечная слабость, миалгия, артралгия."}},{"type":"paragraph","data":{"text":"Со стороны системы кроветворения: лейкопения, тромбоцитопения; в отдельных случаях - агранулоцитоз, панцитопения."}},{"type":"paragraph","data":{"text":"Со стороны кожных покровов: зуд, кожная сыпь; в отдельных случаях - фотосенсибилизация, мультиформная экссудативная эритема, алопеция."}},{"type":"paragraph","data":{"text":"Аллергические реакции: крапивница, ангионевротический отек, бронхоспазм, интерстициальный нефрит, анафилактический шок, лихорадка."}},{"type":"paragraph","data":{"text":"Прочие: нарушение зрения, периферические отеки, усиление потоотделения, гинекомастия; редко - образование желудочных гландулярных кист во время длительного лечения (следствие ингибирования секреции соляной кислоты, носит доброкачественный, обратимый характер)."}},{"type":"paragraph","data":{"text":"Если Ультоп применяют в течение короткого периода времени, побочное действие отмечается редко и имеет слабый и преходящий характер. Чаще всего побочное действие отмечается в начале лечения. В течение продолжительного лечения частота побочных явлений снижается. Побочные действия тяжелой степени отмечаются очень редко. Если они развиваются, лечение следует прервать. Частота случаев развития побочных эффектов у пациентов старше 65 лет такая же, как и у более молодых пациентов.\n\n"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: боль в абдоминальной области, сонливость, головная боль, головокружение, повышенное потоотделение, сухость во рту, сердцебиение, нарушение зрения. Возможны судороги, затрудненное дыхание и понижение температура тела. Специфического антидота не существует. Лечение симптоматическое. Гемодиализ недостаточно эффективен."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"\n\nВзаимодействие омепразола с другими лекарственными препаратами отмечается редко. Существует вероятность взаимодействия с препаратами, которые метаболизируются в печени с участием энзима системы цитохрома Р450. Концентрации в плазме крови диазепама, фенитоина, нифедипина, варфарина, аминопирина, антипирина и дисульфирама могут увеличиться. Как правило, это повышение клинически незначимо для обычных доз омепразола. Тем не менее, рекомендуется проводить мониторинг пациентов при начале или отмене лечения Ультопом, а также при необходимости корректировать дозы фенитоина, диазепама, варфарина и дисульфирама."}},{"type":"paragraph","data":{"text":"При одновременном назначении кларитромицина концентрации кларитромицина и омепразола в сыворотке крови увеличиваются."}},{"type":"paragraph","data":{"text":"Увеличение уровня рН желудочного сока может привести к снижению биодоступности ампициллина, кетоконазола, итраконазола и препаратов железа."}},{"type":"paragraph","data":{"text":"Одновременное назначение омепразола и дигоксина здоровым людям увеличивает биодоступность дигоксина на 10% из-за повышенного уровня рН в желудке."}},{"type":"paragraph","data":{"text":"Эффективность преднизолона и циклоспорина может быть снижена. Поэтому иногда требуется корректировать дозу циклоспорина."}},{"type":"paragraph","data":{"text":"При одновременном назначении антацидов, амоксициллина, дигоксина, теофиллина, лидокаина, хинидина, метопролола или пропранолола клинически значимого взаимодействия не было установлено.\n\n"}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nПеред началом терапии необходимо исключить наличие злокачественного процесса (особенно при язве желудка), т. к. лечение, маскируя симптоматику, может отсрочить постановку правильного диагноза."}},{"type":"paragraph","data":{"text":"Для пациентов пожилого возраста корректировка дозы препарата не требуется. Биодоступность омепразола увеличивается у пациентов с циррозом печени, однако увеличение токсичности не отмечалось. Суточная доза не должна превышать 20 мг."}},{"type":"paragraph","data":{"text":"Для пациентов с заболеваниями почек корректировка дозы не требуется. Проведение диализа у пациентов с хроническими заболеваниями почек не оказывает воздействия на фармакокинетические свойства омепразола."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В обычных дозировках препарат не оказывает влияния на скорость психомоторных реакций и концентрацию внимания."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Лиофилизат для приготовления раствора для инфузий во флаконе из бесцветного стекла, содержащий 40 мг омепразола, укупоренный резиновой пробкой, алюминиевым колпачком и пластиковой защитной крышкой. По 1 флакону вместе с инструкцией по применению помещают в картонную пачку."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"\n\nХранить при температуре не выше 25°С, в защищенном от света месте. ."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте\n\n"}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"\n\n2 года."}},{"type":"paragraph","data":{"text":"Не использовать препарат после истечения срока годности.\n\n"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Софаримекс-Индустрия Кимика эФармасуэтика Лда, Португалия. Владелец регистрационного удостоверения - КРКА, д.д., Ново место, Шмарьешка цеста 6, 8501 Ново место, Словения."}},{"type":"paragraph","data":{"text":"По всем вопросам обращаться по адресу Представительства в РФ:"}},{"type":"paragraph","data":{"text":"123022, Москва, ул. 2-я Звенигородская, д. 13, стр. 41."}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"  ООО \"КРКА-РУС\", 143500, Россия, Московская обл., г. Истра, ул. Московская, д. 50"}}]}],"source":null},"description_toggle":false,"short_description":"Фармакодинамика. Ингибирует фермент Н+К+АТФ-азу («протонный насос») в париетальных клетках желудка и блокирует тем самым заключительную стадию синтеза соляной кислоты. Это приводит к снижению уровня базальной и стимулированной секреции, независимо от природы раздражителя. После однократного введения препарата фармакологический эффект сохраняется в течение 24 часов. Фармакокинетика. Связь с белками плазмы - 95%. Омепразол практически полностью метаболизируется в печени. Является ингибитором ферментной системы CYP2C19. Период полувыведения после внутривенного введения составляет 40 минут и не изменяется при длительном лечении. Выведение почками (70-80%) и с желчью (20-30%). При хронической почечной недостаточности выведение снижается пропорционально снижению клиренса креатинина.","substance":[{"id":137,"title":"Омепразол","title_latin":"Omeprazolum","slug":"omeprazol_137"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"Ультоп - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/189083/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/189083/share_default/"}},"diseases":[],"other_packages":[],"other_product_forms":[{"id":103282,"title":"Ультоп","subtitle":{"full":"Капсулы, 14 шт, 20 мг","short":"Капсулы, 14 шт, 20 мг","package":"14 шт, 20 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