У взрослых: вирусный гепатит А В С герпетическая и цитомегаловирусная инфекция комплексная терапия: инфекционно-аллергические и вирусные энцефаломиелиты (рассеянный склероз лейкоэнцефалит увеоэнцефалит) хламидийные инфекции урогенитального и респираторного тракта; профилактика гриппа и др.
Острая респираторная вирусная инфекция.
Противопоказания
Гиперчувствительность беременность период лактации детский возраст (до 7 лет).
Инструкция
Торговое название препарата
Тилорон
Лекарственная форма
капсулы
Состав
На одну капсулу:
активное вещество: тилорон (в пересчете на 100% вещество) - 125 мг;
Капсулы желатиновые твердые №1 оранжевого цвета. Содержимое капсул - гранулят, содержащий гранулы и порошок оранжевого цвета, допускаются вкрапления от светло-оранжевого до темно-оранжевого цвета.
Фармакотерапевтическая группа
Противовирусное и иммуностимулирующее средство
Код АТХ
L03AX
Фармакологические свойства
Низкомолекулярный синтетический индуктор интерферона стимулирующий образование в организме интерферонов альфа бета и гамма. Основными продуцентами интерферона в ответ на введение тилорона являются клетки эпителия кишечника гепатоциты Т-лимфоциты нейтрофилы и гранулоциты.
После приема внутрь максимум продукции интерферона определяется в последовательности кишечник - печень - кровь через 4-24 ч. В лейкоцитах человека индуцирует синтез интерферона.
Стимулирует стволовые клетки костного мозга в зависимости от дозы усиливает антителообразование уменьшает степень иммунодепрессии восстанавливает соотношения Т-супрессоров и Т-хелперов.
Механизм противовирусного действия связан с ингибированием трансляции вирус-специфических белков в инфицированных клетках в результате чего подавляется репродукция вирусов. Эффективен в отношении возбудителей вирусного гепатита герпесвирусов (в т.ч. цитомегаловирусов).
Фармакокинетика:
После приема внутрь быстро всасывается из желудочно-кишечного тракта биодоступность 60%. Около 80% препарата связывается с белками плазмы. Выводится препарат практически в неизмененном виде с фекалиями (70%) и с мочой (9%). Т1/2 - 48 ч. Препарат не подвергается метаболизму и не кумулирует.
Показания к применению
У взрослых: вирусный гепатит А В С герпетическая и цитомегаловирусная инфекция комплексная терапия: инфекционно-аллергические и вирусные энцефаломиелиты (рассеянный склероз лейкоэнцефалит увеоэнцефалит) хламидийные инфекции урогенитального и респираторного тракта; профилактика гриппа и др.
Острая респираторная вирусная инфекция.
Противопоказания
Гиперчувствительность беременность период лактации детский возраст (до 7 лет).
С осторожностью
Не рекомендуется применять тилорон в дозах, превышающих рекомендуемые, во избежание возможного кратковременного истощения иммунокомпетентных клеток. В составе комплексной терапии нейровирусных инфекций тилорон применяют под наблюдением врача.
Применение при беременности и в период грудного вскармливания
Тилорон противопоказан к применению при беременности и в период лактации (грудного вскармливания).
Применение у детей
Противопоказан в детском возрасте до 7 лет.
Способ применения и дозы
Внутрь после еды с профилактической целью - по 125 мг 1 раз в неделю в течение 4-6 нед с лечебной - по 125-250 мг/сут в течение 1-2 дней зачем по 125 мг через 48 ч.
Курс лечения:
грипп и другие острые респираторные вирусные инфекции у взрослых - 1 нед;
гепатит А - 2-3 нед;
гепатит В - 3-4 нед:
герпетические цитомегаловирусные и хламидийные инфекции и их сочетания - 4 нед.
Хронические вирусные гепатиты В и С гепатиты-микст - по 250 мг 2 раза в неделю курс лечения - 2-4 нед.
Вторичные иммунодефицит и нарушения интерферонового статуса по 125 мг 2 раза к неделю. Курс лечения - 2-4 нед.
Рассеянный склероз - по 125 мг через 48 ч (всего 10 капсул).
Побочное действие
Аллергические реакции.
Диспептические явления кратковременный озноб.
Передозировка
Случаи передозировки препарата не известны
Взаимодействие с другими лекарственными средствами
Совместим с антибиотиками лекарственными средствами для лечения вирусных и бактериальных заболеваний.
Влияние на способность управлять автомобилем и движущимися механизмами
Влияние лекарственного препарата для медицинского применения на способность управлять транспортными средствами, механизмами
Препарат не оказывает отрицательного влияния на способность управлять транспортными средствами и занятиями другими потенциально опасными видами деятельности,
повышенной концентрации внимания и быстроты психомоторных реакций.
Форма выпуска
Капсулы 125 мг.
6 или 10 капсул в контурную ячейковую упаковку из пленки ПВХ и фольги.
1 контурную ячейковую упаковку вместе с инструкцией по применению в пачку из картона.
Условия хранения
В сухом защищенном от света месте при температуре не выше 25 °С.
Хранить в недоступном для детей месте.
Срок годности
2 года.
Не использовать по истечении срока годности указанного на упаковке.
Условия отпуска
Без рецепта
Производитель
Открытое акционерное общество "Московское производственное химико-фармацевтическое объединение им. Н.А. Семашко" (ОАО "Мосхимфармпрепараты" им.Н.А.Семашко"), 115172, г. Москва, ул. Большие Каменщики, д. 9, Россия
Организация, принимающая претензии потребителей
Центральная аптека Федеральной службы безопасности РФ ФГУ
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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