симптомы простуды и гриппа (повышенная температура, головная боль, озноб, ощущение заложенности носа, боль в горле при глотании).
Фармакологическое действие
Комбинированный препарат, действие которого обусловлено входящими в его состав компонентами (НПВП парацетамол, альфа-адреномиметик фенилэфрин и витамин С). Оказывает жаропонижающее, анальгезирующее (обезболивающее), сосудосуживающее действие, устраняет симптомы простуды. Суживает сосуды носа, устраняет отек слизистой оболочки полости носа и носоглотки, восполняет дефицит витамина С при простудных заболеваниях. Начало действия - 20-30 мин после приема, длительность - 4-4.5 ч.
Лекарственное взаимодействие
Стимуляторы микросомального окисления в печени (фенитоин, этанол, барбитураты, рифампицин, фенилбутазон, трициклические антидепрессанты) увеличивают продукцию гидроксилированных активных метаболитов парацетамола, что обусловливает возможность развития тяжелых интоксикаций при небольших передозировках. Ингибиторы микросомального окисления (циметидин) снижают риск гепатотоксического действия препарата. Парацетамол усиливает эффекты ингибиторов МАО, седативных лекарственных средств, этанола. Этанол способствовует развитию острого панкреатита. Антидепрессанты, противопаркинсонические, антипсихотические лекарственные средства, производные фенотиазина увеличивают риск задержки мочи, сухости во рту, запора. ГКС увеличивают риск развития глаукомы. Фенилэфрин снижает гипотензивный эффект гуанетидина. Гуанетидин усиливает альфа-адреностимулирующий эффект, а трициклические антидепрессанты – симпатомиметический эффекты фенилэфрина. Препарат снижает эффективность урикозурических лекарственных средств. При замедлении опорожнения желудка (пропантелин) может иметь место замедленное наступление действия препарата. При ускорении опорожнения желудка (метоклопрамид) препарат начинает действовать быстрее. Препарат может усиливать действие непрямых антикоагулянтов.
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