Диосмин Таблетки, 60 шт, 600 мг, в пленочной оболочке

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Было показано что диосмин снижает содержание в плазме крови ферментов ответственных за метаболизм мукополисахаридов в венозной стенке."}},{"type":"paragraph","data":{"text":"В клинических исследованиях диосмин уменьшал емкость венозного русла и объем венозного застоя (по данным плетизмографии) снижал среднее давление в глубоких и поверхностных венах ног (по данным ультразвуковой допплерографии) и повышал систолическое и диастолическое артериальное давление у пациентов с послеоперационной ортостатической гипотензией."}},{"type":"paragraph","data":{"text":"Фармакокинетика:"}},{"type":"paragraph","data":{"text":"Всасывание"}},{"type":"paragraph","data":{"text":"Быстро всасывается из желудочно-кишечного тракта обнаруживается в плазме крови через 2 часа после приема. Биодоступность диосмина после приема внутрь составляет примерно 40-579 %. В кишечнике диосмин трансформируется кишечной микрофлорой в диосметин гиппуровую и бензойную кислоту."}},{"type":"paragraph","data":{"text":"Распределение"}},{"type":"paragraph","data":{"text":"Максимальная концентрация в плазме крови достигается через 5 часов после приема. Диосмин равномерно распределяется и накапливается во всех слоях стенки полых вен и подкожных вен нижних конечностей в меньшей степени - в почках печени легких и других тканях. Объем распределения составляет 621 л. Избирательное накопление диосмина и/или его метаболитов в венозных сосудах достигает максимума к девятому часу после приема и сохраняется в течение 96 часов."}},{"type":"paragraph","data":{"text":"Метаболизм"}},{"type":"paragraph","data":{"text":"Диосмин метаболизируется в печени. Основной метаболит - гидроксифенилпропионовая кислота. 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После приема диосмина меченого радиоактивным изотопом примерно 86 % выводится почками и кишечником в течение 48 часов."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"В составе комплексной терапии:"}},{"type":"paragraph","data":{"text":"- для устранения симптомов варикозного расширения вен нижних конечностей;"}},{"type":"paragraph","data":{"text":"- для устранения симптомов хронической лимфовенозной недостаточности нижних конечностей: ощущение тяжести или усталости в ногах боль;"}},{"type":"paragraph","data":{"text":"- при нарушении микроциркуляции;"}},{"type":"paragraph","data":{"text":"- для устранения симптомов острого геморроя."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"- Повышенная чувствительность к компонентам препарата;"}},{"type":"paragraph","data":{"text":"- 1 триместр беременности и период грудного вскармливания (опыт применения ограничен);"}},{"type":"paragraph","data":{"text":"- возраст до 18 лет."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Беременность"}},{"type":"paragraph","data":{"text":"До сих пор в клинической практике не было сообщений о каких-либо побочных эффектах при применении препарата у беременных. Тем не менее по соображениям безопасности не рекомендуется применять препарат в I триместре беременности. Применение в период беременности во II и III триместрах возможно только по назначению врача в тех случаях когда ожидаемая польза для матери превышает потенциальный риск для плода."}},{"type":"paragraph","data":{"text":"В экспериментальных исследованиях не было выявлено тератогенного действия диосмина на плод."}},{"type":"paragraph","data":{"text":"Период грудного вскармливания"}},{"type":"paragraph","data":{"text":"Во время грудного вскармливания не рекомендуется прием препарата так как отсутствуют данные о проникновении диосмина в грудное молоко."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Препарат предназначен для приема внутрь Лимфовенозная недостаточность вен нижних конечностей При хронической лимфовенозной недостаточности назначают по 1 таблетке в сутки утром желательно до еды. Обычно курс приема составляет 2 месяца. Острый геморрой и обострение хронического геморроя При остром геморрое и обострении хронического геморроя препарат назначают первые четыре дня по 1 таблетке 3 раза в сутки во время еды; в последующие три дня по 1 таблетке 2 раза в сутки во время еды. В случае повторного возникновения симптомов курс лечения может быть повторен по рекомендации врача. Хронический геморрой После купирования острых явлений рекомендуется продолжить прием препарата по 1 таблетке 1 раз в сутки в течение 1-2 месяцев. Если пропущен один или несколько приемов препарата, необходимо продолжать применение препарата в обычном режиме и в обычной дозе. Перед применением препарата следует проконсультироваться с врачом."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Классификация частоты развития побочных эффектов согласно рекомендациям Всемирной организации здравоохранения (ВОЗ):"}},{"type":"paragraph","data":{"text":"очень часто ≥ 1/10;"}},{"type":"paragraph","data":{"text":"часто от ≥ 1/100 до < 1/10;"}},{"type":"paragraph","data":{"text":"нечасто от ≥ 1/1000 до < 1/100;"}},{"type":"paragraph","data":{"text":"редко от ≥ 1/10000 до < 1/1000;"}},{"type":"paragraph","data":{"text":"очень редко < 1/10000 включая отдельные сообщения;"}},{"type":"paragraph","data":{"text":"частота неизвестна - по имеющимся данным установить частоту возникновения не представляется возможным."}},{"type":"paragraph","data":{"text":"Со стороны желудочно-кишечного тракта:"}},{"type":"paragraph","data":{"text":"часто - тошнота рвота диарея диспептические расстройства изжога запор; нечасто - колит."}},{"type":"paragraph","data":{"text":"Со стороны центральной нервной системы:"}},{"type":"paragraph","data":{"text":"редко - головная боль недомогание головокружение."}},{"type":"paragraph","data":{"text":"Со стороны кожи и подкожной жировой клетчатки:"}},{"type":"paragraph","data":{"text":"редко - кожные высыпания кожный зуд."}},{"type":"paragraph","data":{"text":"Аллергические реакции:"}},{"type":"paragraph","data":{"text":"редко - крапивница;"}},{"type":"paragraph","data":{"text":"частота неизвестна - изолированный отек лица губ век; в исключительных случаях - ангионевротический отек (отек Квинке)."}},{"type":"paragraph","data":{"text":"Если любые из указанных в инструкции побочных эффектов усугубляются или Вы заметили любые другие побочные эффекты не указанные в инструкции сообщите об этом врачу."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы"}},{"type":"paragraph","data":{"text":"Симптомы передозировки не описаны. Учитывая широкий терапевтический диапазон диосмина риск интоксикации при передозировке представляется незначительным."}},{"type":"paragraph","data":{"text":"Лечение"}},{"type":"paragraph","data":{"text":"Специфический антидот неизвестен."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Клинически значимых эффектов взаимодействия диосмина с другими лекарственными средствами не описано."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Лечение острого геморроя проводят в комплексе с другими препаратами. При отсутствии быстрого клинического эффекта необходимо провести дополнительное обследование и скорректировать проводимую терапию."}},{"type":"paragraph","data":{"text":"При нарушении венозного кровообращения (варикозное расширение вен нижних конечностей хроническая лимфовенозная недостаточность нижних конечностей) максимальный эффект лечения обеспечивается сочетанием терапии с изменениями образа жизни: желательно избегать длительного пребывания в вертикальном положении уменьшить избыточную массу тела. В некоторых случаях улучшению циркуляции крови способствует ношение специальных чулок (компрессионного трикотажа)."}},{"type":"paragraph","data":{"text":"В случае отсутствия уменьшения или при утяжелении симптомов заболевания обратитесь к врачу."}},{"type":"paragraph","data":{"text":"Не превышайте максимальные сроки и рекомендованные дозы препарата без консультации врача."}},{"type":"paragraph","data":{"text":"Влияние на способность управлять трансп. ср. и мех.:"}},{"type":"paragraph","data":{"text":"Нет данных об отрицательном влиянии препарата на способность управлять транспортными средствами и другими механизмами."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить в защищенном от света месте при температуре не выше 25 °С. Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}}]}],"source":null},"description_toggle":false,"short_description":"Диосмин является производным бензпирона. Относится к группе биофлавоноидов. Обладает флеботонизирующим действием (уменьшает растяжимость вен повышает тонус вен (дозозависимый эффект) уменьшает венозный застой) улучшает лимфатический дренаж (повышает тонус и частоту сокращения лимфатических капилляров увеличивает их функциональную плотность снижает лимфатическое давление) улучшает микроциркуляцию (повышает резистентность капилляров (дозозависимый эффект) уменьшает их проницаемость) уменьшает адгезию лейкоцитов к венозной стенке и их миграцию в паравенозные ткани улучшает диффузию кислорода и перфузию в кожной ткани обладает противовоспалительным действием. Усиливает сосудосуживающее действие адреналина норадреналина блокирует выработку свободных радикалов синтез простагландинов и тромбоксана. Было показано что диосмин снижает содержание в плазме крови ферментов ответственных за метаболизм мукополисахаридов в венозной стенке. В клинических исследованиях диосмин уменьшал емкость венозного русла и объем венозного застоя (по данным плетизмографии) снижал среднее давление в глубоких и поверхностных венах ног (по данным ультразвуковой допплерографии) и повышал систолическое и диастолическое артериальное давление у пациентов с послеоперационной ортостатической гипотензией. Фармакокинетика: Всасывание Быстро всасывается из желудочно-кишечного тракта обнаруживается в плазме крови через 2 часа после приема. Биодоступность диосмина после приема внутрь составляет примерно 40-579 %. В кишечнике диосмин трансформируется кишечной микрофлорой в диосметин гиппуровую и бензойную кислоту. Распределение Максимальная концентрация в плазме крови достигается через 5 часов после приема. Диосмин равномерно распределяется и накапливается во всех слоях стенки полых вен и подкожных вен нижних конечностей в меньшей степени - в почках печени легких и других тканях. Объем распределения составляет 621 л. Избирательное накопление диосмина и/или его метаболитов в венозных сосудах достигает максимума к девятому часу после приема и сохраняется в течение 96 часов. Метаболизм Диосмин метаболизируется в печени. Основной метаболит - гидроксифенилпропионовая кислота. Метаболиты диосмина выводятся преимущественно почками в форме конъюгатов с глюкуроновой кислотой. Выведение 79 % принятого диосмина выводится почками через кишечник - 11 % с желчью - 24 %. Отмечается энтерогепатическая циркуляция диосмина. После приема диосмина меченого радиоактивным изотопом примерно 86 % выводится почками и кишечником в течение 48 часов.","substance":[{"id":260,"title":"Диосмин","title_latin":"Diosminum","slug":"diosmin_260"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":true,"comments":null,"image_alt":"Диосмин - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/224836/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/224836/share_default/"}},"diseases":[],"other_packages":[{"id":160018,"title":"Диосмин","subtitle":{"full":"Таблетки, коробка, 30 шт, 600 мг, для приема внутрь, покрытые оболочкой","short":"Таблетки, 30 шт, 600 мг","package":"30 шт, 600 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