Антигипертензивное действие лекарственных препаратов заключа... Инструкция
Показания к применению
Артериальная гипертензия; хроническая сердечная недостаточность. Профилактика повторного инсульта (комбинированная терапия с индапамидом) у пациентов, перенесших инсульт или транзиторное нарушение мозгового кровообращения по ишемическому типу.
Противопоказания
Повышенная чувствительность к периндоприлу и другим компонентам препарата, а также к лекарственным препаратам данной группы в анамнезе; ангионевротический отек в анамнезе; беременность; период грудного вскармливания. С осторожностью: снижение ОЦК (прием диуретиков, бессолевая диета, рвота, диарея, гемодиализ), гипонатриемия, цереброваскулярные заболевания, ...
Антигипертензивное действие лекарственных препаратов заключается в нормализации повышенного уровня артериального давления. Сосудорасширяющее (вазодилатирующее) действие препаратов заключается в снижении тонуса сосудистой стенки, в результате чего просвет сосуда увеличивается.
Показания к применению
Артериальная гипертензия; хроническая сердечная недостаточность. Профилактика повторного инсульта (комбинированная терапия с индапамидом) у пациентов, перенесших инсульт или транзиторное нарушение мозгового кровообращения по ишемическому типу.
Противопоказания
Повышенная чувствительность к периндоприлу и другим компонентам препарата, а также к лекарственным препаратам данной группы в анамнезе; ангионевротический отек в анамнезе; беременность; период грудного вскармливания. С осторожностью: снижение ОЦК (прием диуретиков, бессолевая диета, рвота, диарея, гемодиализ), гипонатриемия, цереброваскулярные заболевания, стенокардия - риск резкого снижения артериального давления; реноваскулярная гипертензия; двусторонний стеноз почечных артерий или наличие только одной функционирующей почки - риск развития тяжелой артериальной гипотензии и почечной недостаточности; хроническая почечная и сердечная недостаточность (риск гипокалиемии); системные заболевания соединительной ткани (системная красная волчанка, склеродермия) и терапия иммунодепрессантами (в т.ч. при трансплантации почки) - риск развития агранулоцитоза и нейтропении; гиперкалиемия; стеноз аортального клапана, гипертрофическая обструктивная кардиомиопатия; терапия гипогликемическими средствами у больных сахарным диабетом - риск развития гипогликемии; процедура гемодиализа с использованием высокопроточных полиакрилонитриловых мембран, проведение десенсибилизирующей терапии аллергенами - риск аллергических реакций; хирургическое вмешательство/общая анестезия - возможность развития артериальной гипотензии; наличие лактазной недостаточности, галактоземии или синдрома глюкозной/галактозной мальабсорбции; пожилой возраст (лечение следует начинать с низких доз); возраст до 18 лет (эффективность и безопасность применения не исследованы).
С осторожностью
С осторожностью следует проводить комбинированную терапию препаратом с препаратами лития, противодиабетическими средствами, анестетиками, наркотическими анальгетиками, антипсихотическими, антигипертензивными средствами, аллопуринолом, цитостатическими средствами, иммунодепрессантами, системными кортикостероидами, прокаинамидом. Не рекомендуется комбинированное назначение с солями калия и такими калийсберегающими диуретиками, как спиронолактон, триамтерен и амилорид.
Побочное действие
Со стороны сердечно-сосудистой системы: чрезмерное снижение АД и связанные с этим симптомы; аритмия, стенокардия, инфаркт миокарда, инсульт. Со стороны мочевыделительной системы: снижение функции почек, острая почечная недостаточность. Со стороны органов дыхания: сухой кашель, затруднение дыхания; бронхоспазм, ринорея. Со стороны пищеварительной системы: тошнота, рвота, боль в животе, диарея, запор, нарушение вкуса; сухость во рту; холестатическая желтуха, панкреатит. Со стороны нервной системы: головная боль, астения, головокружение, звон в ушах, нарушение зрения, мышечные судороги, парестезии; снижение настроения, нарушение сна; спутанность сознания. Аллергические реакции: кожные высыпания, зуд; крапивница, ангионевротический отек; мультиформная эритема. Прочие: потливость, нарушение сексуальной функции. Лабораторные показатели: на фоне приема препарата возможно незначительное увеличение концентрации креатинина в моче и плазме крови, обратимое после отмены препарата - наиболее вероятно при стенозе почечных артерий, лечении артериальной гипертензии с помощью диуретических препаратов, наличии почечной недостаточности. Повышение концентрации ионов калия, обычно временное. Применение ингибиторов АПФ у больных с клубочковой нефропатией может привести к развитию протеинурии. У некоторых больных (после трансплантации почки, гемодиализа) на фоне приема ингибиторов АПФ может развиться анемия. Тромбоцитопения, снижение гемоглобина, гематокрита. Агранулоцитоз, панцитопения, повышение активности печеночных трансаминаз, гипербилирубинемия. Возможность развития гемолитической анемии на фоне дефицита глюкозо-6-фосфатдегидрогеназы. В случае развития удушья и отечности лица или языка следует незамедлительно обратиться к врачу и прекратить прием препарата.
Передозировка
При передозировке препарата следует немедленно обратиться к врачу. Симптомы - выраженное снижение АД, шок, ступор, брадикардия, нарушения электролитного баланса, почечная недостаточность.
Особые указания
Больные с артериальной гипертензией, уже получающие терапию диуретиками, а также соблюдающие бессолевую диету, должны предупредить об этом своего лечащего врача. При возникновении сухого кашля следует проконсультироваться со своим лечащим врачом о дальнейшем продолжении лечения данным препаратом. Имеется риск развития аллергических реакций и ангионевротического отека. Во избежание нежелательного лекарственного взаимодействия следует сообщить лечащему врачу о всех принимаемых ЛС. В состав вспомогательных веществ препарата входит лактозы моногидрат. Вследствие этого данный препарат не рекомендуется назначать лицам с лактазной недостаточностью, галактоземией или синдромом глюкозной/галактозной мальабсорбции.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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