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Предотвращает снижение внутриклеточного содержания АТФ, обеспечивает нормальное функционирование мембранных ионных каналов, трансмембранный перенос ионов калия и натрия и сохранение клеточного гомеостаза."}},{"type":"paragraph","data":{"text":"Триметазидин замедляет окисление жирных кислот за счет селективного ингибирования длинноцепочечной 3-кетоацетил-КоА тиолазы, что приводит к повышению окисления глюкозы и к восстановлению сопряжения между гликолизом и окислительным декарбоксилированием и, как было показано, обеспечивает защиту миокарда от ишемии. 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Рекомендуемая доза - 40-70 мг/сут, кратность приема 2-3 раза/сут. Продолжительность терапии устанавливают индивидуально, в зависимости от клинической ситуации."}}]},{"id":14,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны пищеварительной системы: \u003c/i\u003eчасто - боль в животе, диарея, диспепсия, тошнота, рвота; частота неизвестна - запор."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны нервной системы: \u003c/i\u003eчасто - головокружение, головная боль; частота неизвестна - симптомы паркинсонизма (тремор, акинезия, повышение тонуса), неустойчивость в позе Ромберга и неустойчивость походки, синдром \"беспокойных ног\" (обычно обратимые после прекращения терапии), бессонница, сонливость."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны органа слуха и лабиринтные нарушения: \u003c/i\u003eчастота неизвестна - вертиго."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны кожи и подкожных тканей: \u003c/i\u003eчасто - кожная сыпь, зуд, крапивница; частота неизвестна - острый генерализованный экзантематозный пустулез, отек Квинке."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны сердечно-сосудистой системы: \u003c/i\u003eредко - ощущение сердцебиения, экстрасистолия, тахикардия, выраженное снижение АД, ортостатическая гипотензия (может сопровождаться общей слабостью, головокружением или потерей равновесия, особенно при одновременном приеме гипотензивных препаратов), \"приливы\" крови к коже лица."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны системы кроветворения: \u003c/i\u003eчастота неизвестна - агранулоцитоз, тромбоцитопения, тромбоцитопеническая пурпура."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны печени и желчевыводящих путей: \u003c/i\u003eчастота неизвестна - гепатит."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПрочие: \u003c/i\u003eчасто - астения."}}]},{"id":17,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Не предназначен для купирования приступов стенокардии и не показан для начального курса терапии нестабильной стенокардии или инфаркта миокарда на догоспитальном этапе или в первые дни госпитализации."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВлияние на способность к управлению транспортными средствами и механизмами\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"В период применения триметазидина пациентам следует соблюдать осторожность при управлении транспортными средствами и механизмами, а также при занятиях другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]}],"source":{"title":"('Эркафарм/Столетов',)","url":"https://stoletov.ru/"}},"description_toggle":false,"short_description":"Средство, нормализующее энергетический метаболизм клеток, подвергшихся гипоксии или ишемии. 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