Новокаин Раствор, 10 шт, 10 мл, 0.5 %

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Для уменьшения всасывания и удлинения действия при местной анестезии дополнительно вводят 0,1% раствор эпинефрина - по 1 капле на 2-5-10 мл раствора прокаина."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПри паранефральной блокаде (по А.В. Вишневскому)\u003c/i\u003e в околопочечную клетчатку вводят 50-80 мл раствора 5 мг/мл или 100-150 мл раствора 2,5 мг/мл."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПри вагосимпатической блокаде\u003c/i\u003e вводят 30-100 мл раствора 2,5 мг/мл."}},{"type":"paragraph","data":{"text":"\u003ci\u003eДля циркулярной или паравертебральной блокады \u003c/i\u003eвнутрикожно вводят раствор 2,5 мг/мл или 5 мг/мл."}},{"type":"paragraph","data":{"text":"Высшие дозы для инфильтрационной анестезии для взрослых: первая разовая доза в начале операции - не более 500 мл раствора 2,5 мг/мл или 150 мл раствора 5 мг/мл. Максимальная доза для применения у детей старше 12 лет - 15 мг/кг."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПорядок работы с полимерной ампулой:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"1. Взять ампулу и встряхнуть ее, удерживая за горлышко."}},{"type":"paragraph","data":{"text":"2. Сдавить ампулу рукой, при этом не должно происходить выделение препарата, и вращающими движениями повернуть и отделить клапан."}},{"type":"paragraph","data":{"text":"3. Через образовавшееся отверстие немедленно соединить шприц с ампулой."}},{"type":"paragraph","data":{"text":"4. Перевернуть ампулу и медленно набрать в шприц ее содержимое."}},{"type":"paragraph","data":{"text":"5. Надеть иглу на шприц."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Головная боль, головокружение, сонливость, слабость, повышение или снижение артериального давления, коллапс, периферическая вазодилатация, брадикардия, аритмия, боль в грудной клетке, тризм, тремор, нарушения зрения и слуха, нистагм, стойкая анестезия, гипотермия, метгемоглобинемия, аллергические реакции (вплоть до анафилактического шока)."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы:\u003c/i\u003e бледность кожных покровов и слизистых оболочек, головокружение, тошнота, рвота, \"холодный\" пот, учащение дыхания, тахикардия, снижение артериального давления, вплоть до коллапса, апноэ, метгемоглобинемия. Действие на центральную нервную систему проявляется чувством страха, галлюцинациями, судорогами, двигательным возбуждением."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение: \u003c/i\u003eподдержание адекватной легочной вентиляции, дезинтоксикационная и симптоматическая терапия."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Усиливает угнетающее действие на центральную нервную систему средств для общей анестезии, снотворных и седативных препаратов, наркотических анальгетиков и транквилизаторов."}},{"type":"paragraph","data":{"text":"Антикоагулянты (ардепарин натрия, далтепарин натрия, данапароид натрия, эноксапарин натрия, гепарин натрия, варфарин) повышают риск развития кровотечений."}},{"type":"paragraph","data":{"text":"При обработке места инъекции местного анестетика дезинфицирующими растворами, содержащими тяжелые металлы, повышается риск развития местной реакции в виде болезненности и отека."}},{"type":"paragraph","data":{"text":"При одновременном применении с местноанестезирующими лекарственными средствами для эпидуральной анестезии с гуанадрелом, гуанетидином, мекамиламином, триметафана камзилатом повышается риск развития резкого снижения артериального давления и брадикардии."}},{"type":"paragraph","data":{"text":"Одновременное применение с ингибиторами моноаминоксидазы (фуразолидон, прокарбазин, селегилин) повышает риск развития выраженного снижения артериального давления."}},{"type":"paragraph","data":{"text":"Усиливает и удлиняет действие миорелаксантов."}},{"type":"paragraph","data":{"text":"При одновременном применении прокаина совместно с наркотическими анальгетиками отмечается аддитивный эффект, при этом усиливается угнетение дыхания. Вазоконстрикторы (эпинефрин, метоксамин, фенилэфрин) удлиняют местноанестезирующее действие."}},{"type":"paragraph","data":{"text":"Прокаин снижает действие антимиастенических лекарственных средств, особенно при использовании его в высоких дозах, что требует дополнительной коррекции лечения миастении."}},{"type":"paragraph","data":{"text":"Ингибиторы холинэстеразы (антимиастенические лекарственные средства, циклофосфамид, демекария бромид, экотиопата йодид, тиотепа) снижают метаболизм прокаина."}},{"type":"paragraph","data":{"text":"Метаболит прокаина (парааминобензойная кислота) является антагонистом сульфаниламидов."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения необходим контроль функций сердечно-сосудистой, дыхательной и центральной нервной систем."}},{"type":"paragraph","data":{"text":"Необходимо отменить ингибиторы моноаминоксидазы за 10 дней до введения прокаина."}},{"type":"paragraph","data":{"text":"Перед применением рекомендуется обязательное проведение проб на индивидуальную чувствительность к препарату. Необходимо учитывать, что при проведении местной анестезии при использовании одной и той же общей дозы, токсичность прокаина тем выше, чем более концентрированный раствор используется."}},{"type":"paragraph","data":{"text":"Регионарная и местная анестезия должна проводиться опытными специалистами в соответствующем образом оборудованном помещении при доступности готового к немедленному использованию оборудования и препаратов, необходимых для проведения мониторинга сердечной деятельности и реанимационных мероприятий. Персонал, выполняющий анестезию, должен быть квалифицированным и обучен технике выполнения анестезии, должен быть знаком с диагностикой и лечением системных токсических реакций, нежелательных явлений и реакций и других осложнений."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения необходимо воздержаться от вождения автотранспорта и занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для инъекций, 5 мг/мл."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года."}},{"type":"paragraph","data":{"text":"Не использовать по истечении срока годности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ООО \"Славянская аптека\", 601125, Владимирская обл., Петушинский район, п. Вольгинский, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО \"Славянская аптека\""}}]}],"source":null},"description_toggle":false,"short_description":"Местноанестезирующее средство с умеренной анестезирующей активностью и большой широтой терапевтического действия. Являясь слабым основанием, блокирует натриевые каналы, препятствует генерации импульсов в окончаниях чувствительных нервов и проведению импульсов по нервным волокнам. Изменяет потенциал действия в мембранах нервных клеток без выраженного влияния на потенциал покоя. Подавляет проведение не только болевых, но и импульсов другой модальности. При всасывании и непосредственном сосудистом введении в ток крови снижает возбудимость периферических холинергических систем, уменьшает образование и высвобождение ацетилхолина из преганглионарных окончаний (обладает некоторым ганглиоблокирующим действием), устраняет спазм гладкой мускулатуры, уменьшает возбудимость миокарда и моторных зон коры головного мозга. Устраняет нисходящие тормозные влияния ретикулярной формации ствола мозга. Угнетает полисинаптические рефлексы. В больших дозах может вызывать судороги. Обладает короткой анестезирующей активностью (продолжительность инфильтрационной анестезии составляет 0,5-1 ч). Подвергается полной системной абсорбции. Степень абсорбции зависит от места и пути введения (особенно от васкуляризации и скорости кровотока в области введения) и итоговой дозы (количества и концентрации). Быстро гидролизуется эстеразами плазмы и печени с образованием двух основных фармакологически активных метаболитов: диэтиламиноэтанола (обладает умеренным сосудорасширяющим действием) и парааминобензойной кислоты (является конкурентным антагонистом сульфаниламидных химиотерапевтических препаратов и может ослабить их противомикробное действие). Период полувыведения 30-50 с, в неонатальном периоде - 54-114 с. 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