Лоперамид Капсулы, 10 шт, 2 мг

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Ожидается, что фармакокинетика лоперамида и его взаимодействие с другими лекарственными препаратами будут аналогичны таковым у взрослых."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"- Симптоматическое лечение острой и хронической диареи различного генеза (в том числе аллергического, эмоционального, лекарственного, лучевого; при изменении режима питания и качественного состава пищи, при нарушении метаболизма и всасывания);"}},{"type":"paragraph","data":{"text":"- в качестве вспомогательного лекарственного средства при диарее инфекционного генеза;"}},{"type":"paragraph","data":{"text":"- регуляция стула у пациентов с илеостомой."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"- Повышенная чувствительность к лоперамиду и/или любому из компонентов препарата;"}},{"type":"paragraph","data":{"text":"- дефицит лактазы, непереносимость лактозы, глюкозо-галактозная мальабсорбция;"}},{"type":"paragraph","data":{"text":"- беременность (1 триместр);"}},{"type":"paragraph","data":{"text":"- период грудного вскармливания;"}},{"type":"paragraph","data":{"text":"- детский возраст до 6 лет;"}},{"type":"paragraph","data":{"text":"- острая дизентерия, характеризующаяся стулом с примесью крови и высокой температурой;"}},{"type":"paragraph","data":{"text":"- язвенный колит в стадии обострения;"}},{"type":"paragraph","data":{"text":"- бактериальный энтероколит, вызванный патогенными микроорганизмами, в том числе Salmonella, Shigella и Campylobacter;"}},{"type":"paragraph","data":{"text":"- псевдомембранозный колит, связанный с терапией антибиотиками широкого спектра действия;"}},{"type":"paragraph","data":{"text":"- кишечная непроходимость (в том числе в случаях, когда следует избегать подавления перистальтики кишечника в связи с риском развития тяжелых последствий, таких как, мегаколон или токсический мегаколон). Лоперамид необходимо немедленно отменить при появлении запора, вздутия живота или кишечной непроходимости."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Лоперамид следует применять с осторожностью у пациентов с нарушениями функции печени вследствие замедленного пресистемного метаболизма."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eБеременность\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Данные о том, что лоперамид обладает тератогенным или эмбриотоксическим действием, отсутствуют. В течение I триместра беременности прием препарата противопоказан. В период II-III триместров беременности применение препарата возможно, если предполагаемая польза терапии для матери превосходит потенциальный риск для плода."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПериод грудного вскармливания\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Небольшое количество лоперамида может проникать в грудное молоко, поэтому препарат не рекомендуется принимать в период грудного вскармливания."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь, запивая водой."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВзрослым:\u003c/i\u003e при острой и хронической диарее назначают в начальной дозе 2 капсулы (4 мг) в день, затем - по 1 капсуле (2 мг) после каждого акта дефекации (в случае жидкого стула); максимальная суточная доза - 8 капсул (16 мг)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eДети старше 6 лет:\u003c/i\u003e при острой и хронической диарее назначают в начальной дозе 1 капсулу (2 мг) в день, затем по 1 капсуле после каждого акта дефекации (в случае жидкого стула); максимальная суточная доза - 3 капсулы (6 мг)."}},{"type":"paragraph","data":{"text":"При нормализации стула или при отсутствии стула более 12 часов препарат отменяют. \u003ci\u003eПожилые пациенты:\u003c/i\u003e при лечении пожилых пациентов корректировка дозы не требуется."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПациенты с нарушениями функции почек:\u003c/i\u003e при лечении пациентов с нарушениями функции почек корректировка дозы не требуется."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПациенты с нарушениями функции печени:\u003c/i\u003e хотя фармакокинетические данные у пациентов с печеночной недостаточностью отсутствуют, у таких больных препарат Лоперамид следует применять с осторожностью вследствие замедленного пресистемного метаболизма (смотри раздел \"Особые указания\")."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Для оценки частоты нежелательных реакций (HP) использованы следующие критерии: \"часто\" (≥1/100, <1/10); \"нечасто\" (≥ 1/1000, < 1/100); \"редко\" (≥ 1/10000, < 1/1000); \"очень редко\" (< 1/10000). HP сгруппированы в соответствии с системно-органными классами медицинского словаря для нормативно-правовой деятельности MedDRA, а также рекомендаций Всемирной организации здравоохранения."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны иммунной системы:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Очень редко: реакции гиперчувствительности, анафилактические реакции, включая анафилактический шок, анафилактоидные реакции."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны нервной системы:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Часто: головная боль, головокружение."}},{"type":"paragraph","data":{"text":"Очень редко: нарушение координации, гипертонус, угнетение сознания, потеря сознания, сонливость, ступор."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны органа зрения:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Очень редко: миоз."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны желудочно-кишечного тракта:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Часто: запор, метеоризм, тошнота."}},{"type":"paragraph","data":{"text":"Нечасто: боль или ощущение дискомфорта в области живота, сухость во рту, рвота, расстройство пищеварения, диспепсия."}},{"type":"paragraph","data":{"text":"Очень редко: кишечная непроходимость (в том числе паралитическая кишечная непроходимость), мегаколон (в том числе токсический мегаколон), глоссалгия, вздутие живота."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны колеи и подкожных тканей:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Очень редко: ангионевротический отек, буллезная сыпь, включая синдром Стивенса-Джонсона, токсический эпидермальный некролиз и мультиформную эритему, кожный зуд, крапивница."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны почек и мочевыводящих путей:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Очень редко: задержка мочи."}},{"type":"paragraph","data":{"text":"\u003ci\u003eОбщие расстройства:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Очень редко: утомляемость."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВажно сообщать о развитии нежелательных реакций с целью обеспечения непрерывного мониторинга отношения пользы и риска лекарственного препарата. Если любые из указанных в инструкции побочных эффектов усугубляются, или Вы заметили любые другие побочные эффекты, не указанные в инструкции, сообщите об этом врачу. Медицинские работники сообщают о нежелательных реакциях лекарственного препарата через национальные системы сообщения о нежелательных реакциях.\u003c/i\u003e"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы:\u003c/i\u003e угнетение центральной нервной системы (ступор, нарушение координации, сонливость, миоз, мышечный гипертонус, угнетение дыхания), задержка мочи, кишечная непроходимость. Дети могут быть более чувствительны к влиянию лоперамида на центральную нервную систему, чем взрослые. У пациентов с передозировкой лоперамида гидрохлорида наблюдались сердечные осложнения, такие как удлинение интервала QT, развитие тахисистолической желудочковой аритмии типа \"пируэт\" (torsade de pointes), другие серьезные желудочковые аритмии, остановка сердца и обморок. Сообщалось также о летальных случаях."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение:\u003c/i\u003e антидот - налоксон; учитывая, что продолжительность действия лоперамида больше, чем у налоксона, возможно повторное введение налоксона."}},{"type":"paragraph","data":{"text":"Необходимо медицинское наблюдение, по крайней мере, в течение 48 часов."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"При одновременном применении лоперамида и \u003ci\u003eингибиторов Р-гликопротеина, CYP3A4 \u003c/i\u003eили \u003ci\u003eCYP2C8\u003c/i\u003e (хинидин, ритонавир, итраконазол, гемфиброзил, кетоконазол) возможно повышение концентрации лоперамида в плазме крови."}},{"type":"paragraph","data":{"text":"При одновременном приеме лоперамида и десмопрессина для перорального применения концентрация десмопрессина в плазме крови увеличивается."}},{"type":"paragraph","data":{"text":"Препараты, имеющие схожие фармакологические свойства, могут усиливать действие лоперамида; препараты, увеличивающие скорость прохождения пищи через желудочно-кишечный тракт, ослабляют действие лоперамида."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Лоперамид используется для симптоматического лечения диареи. В случае установления причины заболевания следует проводить соответствующую терапию."}},{"type":"paragraph","data":{"text":"У пациентов, страдающих диареей, в особенности у детей, возможны потеря жидкости и электролитов. В таких случаях крайне необходимы возмещение потери электролитов и регидратация. В случае отсутствия улучшения при острой диарее после использования препарата на протяжении 48 часов следует обратиться к врачу."}},{"type":"paragraph","data":{"text":"Если при лечении диареи у пациентов с синдромом приобретенного иммунодефицита (СПИД) развивается вздутие живота, препарат следует незамедлительно отменить. В очень редких случаях у пациентов с диагнозом СПИД, страдающих инфекционным колитом, возможен запор с риском токсического мегаколона."}},{"type":"paragraph","data":{"text":"Лоперамид следует применять с осторожностью при печеночной недостаточности во избежание токсического поражения центральной нервной системы."}},{"type":"paragraph","data":{"text":"Если при лечении развивается запор, вздутие живота или кишечная непроходимость препарат следует отменить."}},{"type":"paragraph","data":{"text":"\u003ci\u003eУказание для пациентов с сахарным диабетом:\u003c/i\u003e каждая таблетка соответствует 0,01 ХЕ.\n\n"}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Во время лечения следует соблюдать осторожность при управлении транспортными средствами и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Капсулы, 2 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В пачке при температуре не выше 30 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"В пачке при температуре не выше 30 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"АО \"Производственная фармацевтическая компания Обновление\" (АО \"ПФК Обновление\"), г. Новосибирск, ул. Станционная, д.80, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"АО \"ПФК Обновление\""}}]}],"source":null},"description_toggle":false,"short_description":"Связываясь с опиоидными рецепторами кишечной стенки, подавляет высвобождение ацетилхолина и простагландинов, снижая тем самым тонус и моторику гладкой мускулатуры кишечника. Замедляет перистальтику и увеличивает время прохождения кишечного содержимого. Повышает тонус анального сфинктера. Способствует удержанию каловых масс и урежению позывов к дефекации, уменьшает частоту актов дефекации. Действие наступает быстро и продолжается 4-6 часов. Большая часть лоперамида всасывается в кишечнике, но вследствие активного пресистемного метаболизма, системная биодоступность составляет примерно 0,3 %. Данные доклинических исследований свидетельствуют о том, что лоперамид является субстратом Р-гликопротеина. Связывание лоперамида с белками плазмы крови (преимущественно с альбумином) составляет 95 %. Лоперамид преимущественно метаболизируется в печени, конъюгируется и выделяется с желчью. Окислительное N-деметилирование является основным путем метаболизма лоперамида и осуществляется преимущественно при участии изоферментовCYP3A4иCYP2CS.Вследствие активного пресистемного метаболизма концентрация неизмененного лоперамида в плазме крови незначительна. У человека период полувыведения лоперамида составляет в среднем 1 1 часов, варьируя от 9 до 14 часов. Неизмененный лоперамид и его метаболиты выводятся преимущественно через кишечник. Фармакокинетические исследования у детей не проводились. Ожидается, что фармакокинетика лоперамида и его взаимодействие с другими лекарственными препаратами будут аналогичны таковым у взрослых.","substance":[{"id":613,"title":"Лоперамид","title_latin":"Loperamidum","slug":"loperamid_613"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":true,"comments":null,"image_alt":"Лоперамид - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/103098/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/103098/share_default/"}},"diseases":[],"other_packages":[{"id":142199,"title":"Лоперамид","subtitle":{"full":"Капсулы, 10 шт, 2 мг","short":"Капсулы, 10 шт, 2 мг","package":"10 шт, 2 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