Панангин Таблетки, 100 шт, 158 + 140 мг + мг, для приема внутрь, в пленочной оболочке

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В краткосрочной перспективе содержание калия в крови также регулируется током калия между внутриклеточным и внеклеточным пространством."}}]},{"id":10,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Для устранения дефицита калия и магния в составе комбинированной терапии при:"}},{"type":"list","data":{"style":"ordered","items":["различных проявлениях ишемической болезни сердца (включая острый инфаркт миокарда);","хронической сердечной недостаточности;","нарушениях ритма сердца (включая аритмии, вызванные передозировкой сердечных гликозидов)."]}}]},{"id":11,"name":"Противопоказания","slug":"contraindications","body":[{"type":"list","data":{"style":"ordered","items":["повышенная чувствительность к какому-либо из компонентов препарата;","острая и хроническая почечная недостаточность;","гиперкалиемия;","гипермагниемия;","болезнь Аддисона;","AV-блокада I-III степени;","шок, включая кардиогенный (АД менее 90 мм рт.ст.);","нарушение обмена аминокислот;","тяжелая миастения;","гемолиз;","острый метаболический ацидоз;","обезвоживание;","возраст до 18 лет (эффективность и безопасность не установлены)."]}}]},{"id":12,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"С осторожностью: беременность (особенно в I триместре) и период грудного вскармливания."}}]},{"id":13,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Применение возможно, если потенциальная польза для матери превышает возможный риск для плода."}},{"type":"paragraph","data":{"text":"Калия и магния аспарагинат проникают в грудное молоко. При необходимости приема препарата в период кормления грудью, грудное вскармливание необходимо прекратить."}}]},{"id":14,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Перед применением пациент должен проконсультироваться с врачом."}},{"type":"paragraph","data":{"text":"Внутрь, не разжевывая и запивая достаточным количеством воды. Препарат следует применять после еды, т.к. кислая среда желудка снижает его эффективность."}},{"type":"paragraph","data":{"text":"Обычная суточная доза - по 1-2 таб. 3 раза/сут. Максимальная суточная доза - по 2 таб. 3 раза/сут."}},{"type":"paragraph","data":{"text":"Длительность приема препарата и необходимость повторных курсов определяет врач."}},{"type":"paragraph","data":{"text":"Данные по безопасности и эффективности применения препарата Панангин\u003csup\u003e®\u003c/sup\u003e у детей и подростков отсутствуют."}}]},{"id":15,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы: возможны тошнота, рвота, диарея, неприятные ощущения или жжение в эпигастрии (у больных анацидным гастритом или холециститом)."}},{"type":"paragraph","data":{"text":"Со стороны сердечно-сосудистой системы: возможны AV-блокада, парадоксальная реакция (увеличение числа экстрасистол)."}},{"type":"paragraph","data":{"text":"Со стороны водно-электролитного баланса: возможны гиперкалиемия (тошнота, рвота, диарея, парестезии), гипермагниемия (покраснение лица, чувство жажды, снижение АД, гипорефлексия, угнетение дыхания, судороги)."}}]},{"id":16,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Возрастает риск возникновения симптомов гиперкалиемии и гипермагниемии."}},{"type":"paragraph","data":{"text":"Симптомы гиперкалиемии: повышенная утомляемость, миастения, парестезии, спутанность сознания, нарушение сердечного ритма (брадикардия, AV-блокада, аритмии, остановка сердца)."}},{"type":"paragraph","data":{"text":"Симптомы гипермагниемии: снижение нервно-мышечной возбудимости, тошнота, рвота, летаргия, снижение АД. При резком повышении содержания ионов магния в крови - угнетение глубоких сухожильных рефлексов, паралич дыхания, кома."}},{"type":"paragraph","data":{"text":"Лечение: симптоматическая терапия - в/в введение кальция хлорида в дозе 100 мг/мин, при необходимости - гемодиализ."}}]},{"id":17,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Фармакодинамическое взаимодействие"}},{"type":"paragraph","data":{"text":"Совместное применение с калийсберегающими диуретиками (триамтерен, спиронолактон), бета-адреноблокаторами, циклоспорином, гепарином, ингибиторами АПФ, НПВП повышает риск развития гиперкалиемии вплоть до развития аритмии и асистолии."}},{"type":"paragraph","data":{"text":"Одновременное применение препаратов калия с ГКС устраняет гипокалиемию, вызываемую последними."}},{"type":"paragraph","data":{"text":"Калий уменьшает нежелательные эффекты сердечных гликозидов."}},{"type":"paragraph","data":{"text":"Препарат Панангин\u003csup\u003e®\u003c/sup\u003e усиливает отрицательное дромо- и батмотропное действие антиаритмических лекарственных средств."}},{"type":"paragraph","data":{"text":"Магний снижает эффект неомицина, полимиксина В, тетрациклина и стрептомицина."}},{"type":"paragraph","data":{"text":"Анестетики увеличивают угнетающее действие препаратов магния на ЦНС; при одновременном применении с атракурием, декаметонием, сукцинилхлоридом и суксаметонием возможно усиление нервно-мышечной блокады; кальцитриол повышает содержание магния в плазме крови, препараты кальция снижают эффект препаратов магния."}},{"type":"paragraph","data":{"text":"Фармакокинетическое взаимодействие"}},{"type":"paragraph","data":{"text":"Лекарственные препараты, обладающие вяжущим и обволакивающим действием, уменьшают всасывание магния аспарагината и калия аспарагината в ЖКТ, поэтому необходимо соблюдать трехчасовой интервал между приемом внутрь препарата Панангин\u003csup\u003e®\u003c/sup\u003e с указанными выше лекарственными препаратами."}}]},{"id":18,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Особое внимание требуется пациентам с заболеваниями, сопровождающимися гиперкалиемией: необходим регулярный контроль содержания калия в плазме крови."}},{"type":"paragraph","data":{"text":"В каждой таблетке, покрытой пленочной оболочкой, препарата Панангин\u003csup\u003e®\u003c/sup\u003e содержится 36.2 мг калия. Это следует учитывать пациентам с нарушениями функции почек или пациентам, получающим препараты калия или калийсодержащие пищевые добавки."}},{"type":"paragraph","data":{"text":"Влияние на способность к управлению транспортными средствами и механизмами"}},{"type":"paragraph","data":{"text":"Исследования не проводились. Не ожидается влияния на способность управлять транспортными средствами и заниматься видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":21,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Препарат следует хранить в недоступном для детей месте при температуре не выше 25°C."}}]},{"id":22,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"Срок годности - 5 лет (при упаковке во флаконы), 3 года (при упаковке в блистеры). Не применять по истечении срока годности, указанного на упаковке."}}]},{"id":23,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Препарат отпускается без рецепта."}}]},{"id":24,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.vidal.ru/drugs/company/12\"\u003eГЕДЕОН РИХТЕР ОАО\u003c/a\u003e (Венгрия).  "}}]}],"source":{"title":"('Эркафарм/Столетов',)","url":"https://stoletov.ru/"}},"description_toggle":false,"short_description":"Важнейшие внутриклеточные катионы калий и магний играют ключевую роль в функционировании многих ферментов, в образовании связей между макромолекулами и внутриклеточными структурами и в механизме мышечной сократимости. Внутри- и внеклеточное соотношение ионов калия, магния, кальция и натрия оказывает влияние на сократимость миокарда. Эндогенный аспартат действует в качестве проводника ионов: обладает высоким сродством к клеткам, благодаря незначительной диссоциации его солей, ионы в виде комплексных соединений проникают внутрь клетки. Аспартаты магния и калия улучшают метаболизм миокарда. Недостаток ионов калия и/или магния предрасполагает к развитию артериальной гипертензии, атеросклероза коронарных артерий, аритмий и возникновению метаболических изменений в миокарде. Прием аспартатов магния и калия позволяет компенсировать недостаток этих электролитов в пище. Магний Общий запас магния в организме человека массой тела 70 кг составляет в среднем 24 г (1000 ммоль); более 60% магния приходится на костную ткань и около 40% на скелетные мышцы и другие ткани. Около 1% общего запаса магния в организме находится во внеклеточной жидкости, преимущественно в сыворотке крови. У здоровых взрослых людей содержание магния в сыворотке крови находится в диапазоне 0.7-1.10 ммоль/л. Магний всасывается из ЖКТ путем активного транспорта. Основным регулятором баланса магния в организме являются почки. 3-5% ионизированного магния выводится почками. Увеличение объема мочи (например, при терапии \"петлевыми\" диуретиками) приводит к увеличению экскреции ионизированного магния. Если абсорбция магния в тонком отделе кишечника снижается, последующая гипомагниемия приводит к уменьшению его экскреции (\u003c0.5 ммоль/сут). Калий Общий запас калия в организме человека массой тела 70 кг составляет в среднем 140 г (3570 ммоль). Общий запас калия несколько меньше у женщин, чем у мужчин, и незначительно снижается с возрастом. 2% общего запаса калия в организме находится вне клеток, а оставшиеся 98% - внутри клеток. Калий всасывается в ЖКТ. Оптимальная норма потребления калия с пищей составляет 3-4 г (75-100 ммоль)/сут. Основной путь выведения калия - почечный (около 90% калия выводится почками ежедневно). Оставшиеся 10% выводятся через ЖКТ. 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В краткосрочной перспективе содержание калия в крови также регулируется током калия между внутриклеточным и внеклеточным пространством.","substance":[{"id":1033,"title":"Калия и магния аспарагинат","title_latin":"Kalii asparaginas","slug":"kaliya_i_magniya_asparaginat_1033"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Панангин - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/101891/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/101891/share_default/"}},"diseases":[],"other_packages":[{"id":99190,"title":"Панангин","subtitle":{"full":"Таблетки, коробка, 50 шт, для приема внутрь","short":"Таблетки, 50 шт","package":"50 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