Базисная терапия ревматоидного артрита с целью уменьшения симптомов заболевания и задержки развития структурных повреждений суставов. Активная форма псориатического артрита.
Фармакологическое действие
Средство с антипролиферативным, иммуномодулирующим (иммуносупрессивным) и противовоспалительным действием. Активный метаболит лефлуномида А771726 ингибирует фермент дегидрооротат дегидрогеназу и оказывает антипролиферативное действие. А771726 in vitro тормозит вызванную митогенами пролиферацию и синтез ДНК Т-лимфоцитов. Терапевтическое действие лефлуномида было показано на нескольких экспериментальных моделях аутоиммунных заболеваний, включая ревматоидный артрит.
Лекарственное взаимодействие
Усиление побочных реакций может иметь место в случае недавнего или сопутствующего применения гепатотоксичных или гематотоксичных препаратов или когда прием этих препаратов начинают после лечения лефлуномидом без процедуры "отмывания". Исследования in vitro показали, что метаболит лефлуномида А771726 угнетает активность изофермента CYP2С9. При одновременном применении с препаратами, метаболизирующимися данной ферментной системой (фенитоин, варфарин, толбутамид), нельзя исключить развития нежелательных эффектов лекарственного взаимодействия.
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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