Натрия пикосульфат Капли, флакон, 1 шт, 15 мл, 7.5 мг / мл, для приема внутрь

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Как местное слабительное натрия пикосульфат после бактериального расщепления в толстом кишечнике оказывает стимулирующее действие на слизистую толстого кишечника, увеличивая перистальтику, способствует накоплению воды и электролитов в толстом кишечнике. Это приводит к стимуляции акта дефекации, уменьшению времени эвакуации и размягчению стула."}},{"type":"paragraph","data":{"text":"Натрия пикосульфат, являясь слабительным средством, действующим на уровне толстой кишки, стимулирует естественный процесс эвакуации содержимого из нижних отделов желудочно-кишечного тракта. Поэтому натрия пикосульфат не оказывает влияния на переваривание или всасывание калорийной пищи или незаменимых питательных веществ в тонком кишечнике."}},{"type":"paragraph","data":{"text":"Фармакокинетика"}},{"type":"paragraph","data":{"text":"Абсорбция: незначительная, препарат практически полностью метаболизируется в стенке кишечника и печени до неактивного глюкуронида."}},{"type":"paragraph","data":{"text":"После перорального приема натрия пикосульфат поступает в толстый кишечник; абсорбция препарата незначительна, что исключает его энтерогепатическую циркуляцию. В дистальном отделе толстого кишечника происходит расщепление натрия пикосульфата с образованием активного метаболита, бис-(п-гидроксифенил)-пиридил-2-метана. Время развития слабительного эффекта препарата определяется скоростью высвобождения активного метаболита и обычно составляет 6-12 часов после применения (в среднем 10 часов)."}},{"type":"paragraph","data":{"text":"В системный кровоток поступает незначительная часть препарата. Взаимосвязь между слабительным эффектом активного метаболита и его концентрацией в сыворотке крови отсутствует."}},{"type":"paragraph","data":{"text":"После приема 10 мг препарата внутрь около 10,4% от величины общей дозы выделяется с мочой в виде глюкуронида через 48 часов."}},{"type":"paragraph","data":{"text":"При применении более высоких доз препарата выделение его с мочой, в целом, уменьшается.\n\n"}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"В качестве слабительного средства в следующих случаях:"}},{"type":"list","data":{"style":"ordered","items":["запоры, обусловленные атонией и гипотонией толстой кишки (в том числе в пожилом возрасте, у лежачих больных, после операций, после родов и в период лактации),","запоры, вызванные приемом лекарственных средств,","для регулирования стула при геморрое, проктите, анальных трещинах (для размягчения консистенции кала),","заболевания желчного пузыря, синдром раздраженной кишки с преобладанием запоров,","запор, обусловленный дисбактериозом кишечника, нарушениями диеты."]}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"list","data":{"style":"ordered","items":["Кишечная непроходимость или обструктивные заболевания кишечника;","острые заболевания органов брюшной полости или сильная боль в животе, которые могут сопровождаться тошнотой, рвотой, повышением температуры тела, включая аппендицит;","острые воспалительные заболевания кишечника;","повышенная чувствительность к натрию пикосульфату или другим компонентам препарата;","тяжелая дегидратация;","непереносимость фруктозы."]}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"\n\nВо II и III триместрах беременности (как и при использовании других слабительных средств) прием препарата возможен только по назначению врача."}},{"type":"paragraph","data":{"text":"Активный метаболит и его глюкурониды не выделяются с грудным молоком. Таким образом, препарат может быть использован в период грудного вскармливания.\n\n"}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Данные о достоверных и хорошо контролируемых исследованиях у беременных женщин отсутствуют. Длительный опыт применения не выявил отрицательного влияния препарата на беременность. Прием препарата в I триместре беременности противопоказан. Исследования о влиянии препарата на фертильность не проводились. В ходе доклинических исследований тератогенных эффектов на репродуктивность выявлено не было."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"\n\nВнутрь."}},{"type":"paragraph","data":{"text":"Рекомендуется следующий режим дозирования:"}},{"type":"paragraph","data":{"text":"Взрослые и дети старше 10 лет: 10-20 капель (5-10 мг) в сутки."}},{"type":"paragraph","data":{"text":"Дети 4-10 лет: 5-10 капель (2,5-5 мг) в сутки."}},{"type":"paragraph","data":{"text":"Рекомендуется начинать с наименьшей дозы. Для того чтобы достичь регулярного стула, доза может повышаться до максимальной рекомендуемой. Не следует превышать максимальную рекомендуемую суточную дозу."}},{"type":"paragraph","data":{"text":"Рекомендуемая доза для детей младше 4 лет составляет 0,25 мг/кг массы тела в сутки."}},{"type":"paragraph","data":{"text":"Это соответствует 1 капле препарата (0,5 мг натрия пикосульфата) на 2 кг массы тела в сутки."}},{"type":"paragraph","data":{"text":"Для получения слабительного эффекта в утренние часы следует принимать препарат накануне на ночь. Препарат не обязательно растворять в жидкости.\n\n"}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\n\nСо стороны желудочно-кишечного тракта возможны дискомфорт, тошнота, рвота, спазмы и боли в области живота, диарея."}},{"type":"paragraph","data":{"text":"Со стороны нервной системы возможны головокружение и обморок. Головокружение и обморок, возникающие после приема препарата, могут быть связаны с вазовагальной реакцией (например, напряжением при дефекации, спазмами в области живота)."}},{"type":"paragraph","data":{"text":"Возможны реакции повышенной чувствительности со стороны иммунной системы, включая ангионевротический отек и кожные реакции.\n\n"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\n\nСимптомы"}},{"type":"paragraph","data":{"text":"При приеме высоких доз возможны: диарея, обезвоживание, снижение артериального давления, нарушение водно-электролитного баланса, гипокалиемия, судороги."}},{"type":"paragraph","data":{"text":"Кроме того, имеются сообщения о случаях ишемии мускулатуры толстого кишечника, связанных с приемом доз Натрия пикосульфат, значительно превышающих рекомендованные для обычного лечения запора."}},{"type":"paragraph","data":{"text":"Натрия пикосульфат как и другие слабительные, при хронической передозировке может привести к хронической диарее, болях в области живота, гипокалиемии, вторичному гиперальдостеронизму, мочекаменной болезни. В связи с хроническим злоупотреблением слабительными может развиться повреждение почечных канальцев, метаболический алкалоз и мышечная слабость, связанная с гипокалиемией."}},{"type":"paragraph","data":{"text":"Лечение"}},{"type":"paragraph","data":{"text":"Для уменьшения абсорбции препарата после приема внутрь можно вызвать рвоту или провести промывание желудка. Может потребоваться восполнение жидкости и коррекция баланса электролитов, а также назначение спазмолитических средств.\n\n"}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"\n\nДиуретики или глюкокортикостероиды увеличивают риск нарушения электролитного баланса (гипокалиемии) при приеме высоких доз Натрия пикосульфата."}},{"type":"paragraph","data":{"text":"Нарушение электролитного баланса может повышать чувствительность к сердечным гликозидам."}},{"type":"paragraph","data":{"text":"Совместное применение препарата и антибиотиков может снижать послабляющий эффект препарата.\n\n"}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nНе применять препарат ежедневно без консультации врача более 10 дней. Длительный прием высоких доз препарата может приводить к потере жидкости, нарушению баланса электролитов, гипокалиемии."}},{"type":"paragraph","data":{"text":"Головокружение и обмороки наблюдались у пациентов, принимавших препарат Натрия пикосульфат. Анализ показал, что эти случаи связаны с обмороком при дефекации (или обмороком, вызванным напряжением при дефекации), или с вазовагальной реакцией на боль в животе, которая может быть обусловлена запором, и не обязательно связана с приемом препарата."}},{"type":"paragraph","data":{"text":"В 1 мл капель содержится 0,45 г сорбитола. В максимальной рекомендованной суточной дозе для лечения взрослых и детей 4-10 лет содержится 0,6 г и 0,3 г сорбитола соответственно."}},{"type":"paragraph","data":{"text":"Препарат не обладает вкусовыми качествами, поэтому детям можно добавлять в пищу. Дети должны принимать препарат только по назначению врача.\n\n"}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Специальных клинических исследований влияния препарата на способность управлять автомобилем и механизмами не проводилось. Несмотря на это пациентам следует сообщать, что у них вследствие вазовагальной реакции (т.е., во время спазма кишечника) могут возникать головокружение и/или обморок. Если у пациентов возникает спазм кишечника, они должны избегать потенциально опасных видов деятельности, в том числе вождения автотранспорта или управления механизмами."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nКапли для приема внутрь 7,5 мг/мл."}},{"type":"paragraph","data":{"text":"По 10, 15, 20, 25, 30, 40, 50, 90, 100 мл препарата во флаконы-капельницы оранжевого стекла типа ФК с винтовой горловиной, укупоренные пробками полиэтиленовыми или пробками-капельницами полиэтиленовыми и навинчиваемыми пластмассовыми крышками или укупорочными изделиями."}},{"type":"paragraph","data":{"text":"По 10, 15, 20, 25, 30, 40, 50, 90 и 100 мл препарата во флаконы темного стекла, укупоренные пробками полиэтиленовыми или пробками капельницами и навинчиваемыми пластмассовыми крышками или укупоренные средствами укупорочными полиэтиленовыми или полимерными или укупорочными изделиями."}},{"type":"paragraph","data":{"text":"По 10, 15, 20, 25, 30, 40, 50, 90 и 100 мл препарата во флаконы, банки полимерные или флаконы капельницы в комплекте, укупоренные пробками полиэтиленовыми или пробками капельницами и навинчиваемыми пластмассовыми крышками или укупоренные средствами укупорочными полиэтиленовыми или полимерными или укупоренными изделиями."}},{"type":"paragraph","data":{"text":"По 10, 15, 20, 25, 30, 40, 50, 90 и 100 мл во флаконы из полиэтилентерефталата, укупоренные колпачками полимерными винтовыми."}},{"type":"paragraph","data":{"text":"На каждый флакон, банку, флакон-капельницу наклеивают этикетку из бумаги или самоклеющуюся этикетку."}},{"type":"paragraph","data":{"text":"Каждый флакон, банку, флакон-капельницу вместе с инструкцией по применению помещают в пачку из картона."}},{"type":"paragraph","data":{"text":"Допускается упаковка флаконов, банок, флаконов-капельниц без пачки от 9 до 200 штук с равным количеством инструкций по применению в групповую упаковку – ящик из гофрированного картона (для стационаров)."}},{"type":"paragraph","data":{"text":"По 9, 18 кг в канистры полиэтиленовые с крышкой из полиэтилена низкого давления (для стационаров)."}},{"type":"paragraph","data":{"text":"По 9; 18 кг в бутыли стеклянные, укупоренные пробками притертыми или крышками навинчиваемыми с прокладками (для стационаров)."}},{"type":"paragraph","data":{"text":"Каждую бутыль по 9; 18 кг с инструкцией по применению помещают в ящик из гофрированного картона (для стационаров)."}},{"type":"paragraph","data":{"text":"На каждую канистру, бутыль наклеивают этикетку из бумаги или самоклеющуюся этикетку и прикрепляют инструкцию по применению.\n\n"}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"\n\nПри температуре не выше 30 °С. Не замораживать."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте.\n\n"}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"\n\n3 года."}},{"type":"paragraph","data":{"text":"Не применять после истечения срока годности, указанного на упаковке.\n\n"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ООО «Тульская фармацевтическая фабрика», Россия"}}]}],"source":null},"description_toggle":false,"short_description":"Фармакодинамика Действующее вещество – натрия пикосульфат представляет собой слабительное триарилметановой группы. Как местное слабительное натрия пикосульфат после бактериального расщепления в толстом кишечнике оказывает стимулирующее действие на слизистую толстого кишечника, увеличивая перистальтику, способствует накоплению воды и электролитов в толстом кишечнике. Это приводит к стимуляции акта дефекации, уменьшению времени эвакуации и размягчению стула. Натрия пикосульфат, являясь слабительным средством, действующим на уровне толстой кишки, стимулирует естественный процесс эвакуации содержимого из нижних отделов желудочно-кишечного тракта. Поэтому натрия пикосульфат не оказывает влияния на переваривание или всасывание калорийной пищи или незаменимых питательных веществ в тонком кишечнике. Фармакокинетика Абсорбция: незначительная, препарат практически полностью метаболизируется в стенке кишечника и печени до неактивного глюкуронида. После перорального приема натрия пикосульфат поступает в толстый кишечник; абсорбция препарата незначительна, что исключает его энтерогепатическую циркуляцию. В дистальном отделе толстого кишечника происходит расщепление натрия пикосульфата с образованием активного метаболита, бис-(п-гидроксифенил)-пиридил-2-метана. Время развития слабительного эффекта препарата определяется скоростью высвобождения активного метаболита и обычно составляет 6-12 часов после применения (в среднем 10 часов). В системный кровоток поступает незначительная часть препарата. Взаимосвязь между слабительным эффектом активного метаболита и его концентрацией в сыворотке крови отсутствует. После приема 10 мг препарата внутрь около 10,4% от величины общей дозы выделяется с мочой в виде глюкуронида через 48 часов. При применении более высоких доз препарата выделение его с мочой, в целом, уменьшается.","substance":[{"id":470,"title":"Натрия пикосульфат","title_latin":"Natrii picosulfas","slug":"natriya_pikosulfat_470"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":true,"comments":null,"image_alt":"Натрия пикосульфат - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/100607/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/100607/share_default/"}},"diseases":[],"other_packages":[{"id":180648,"title":"Натрия пикосульфат","subtitle":{"full":"Капли, флакон, 1 шт, 30 мл, 7.5 мг / мл, для приема внутрь","short":"Капли, 1 шт, 30 мл, 7.5 мг / мл","package":"1 шт, 30 мл, 7.5 мг / мл"},"prescription":false,"catalog_section_id":142,"manufacturer":{"id":2814,"title":"Тульская 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