Комбинированный препарат, оказывает бронхорасширяющее и спазмолитическое действие.
Бронхорасширяющее действие препарата обусловлено комбинацией производных метилксантина (теофиллина, кофеина) с симпатомиметиком эфедрином и м-холинолитиком атропином, являющимся основным действующим началом экстракта красавки.
Фенобарбитал устраняет возбуждение ЦНС.
Препарат увеличивает просвет бронхов, расширяет сосуды легких и понижает давление в малом круге кровообращения, стимулирует дыхательный центр, расширяет коронарные сосуды и повышает частоту и силу сердечных сокращений, увеличивает почечный кровоток и оказывает умеренный диуретический эффект. За счет присутствия в составе препарата парацетамола Теофедрин-Н® обладает жаропонижающим и анальгезирующим действием.
Фармакокинетика
После приема внутрь парацетамол хорошо всасывается из ЖКТ. Cmax в плазме крови достигается в течение 1 ч. Метаболиты парацетамола выводятся в течение 1-4 ч, главным образом, с мочой. T1/2 неизмененного препарата из плазмы крови около 3 ч. При недостаточности функции печени и/или почек, а также при передозировке этот показатель увеличивается.
Cmaxтеофиллина в крови достигается через 2.5 ч после приема таблетки. T1/2 теофиллина 11 ч, терапевтическая концентрация теофиллина в крови 20 мкг/мл.
Атропин после приема внутрь на 18 % связывается с белками крови, 50% выводится с мочой почками в неизмененном виде.
Эфедрин хорошо всасывается из ЖКТ, создавая и поддерживая необходимый терапевтический уровень в плазме крови. Метаболизируется в печени, выделяется, главным образом, с мочой.
Показания к применению
В качестве вспомогательного средства при заболеваниях органов дыхания, сопровождающихся бронхоспазмом, в т.ч.:
бронхиальная астма;
хронический обструктивный бронхит;
эмфизема легких.
Противопоказания
хроническая сердечная недостаточность;
стенокардия;
нарушение коронарного кровообращения;
нарушения ритма сердца;
закрытоугольная глаукома;
гиперплазия предстательной железы;
гипертиреоз;
артериальная гипертензия;
эпилепсия и другие судорожные состояния;
беременность;
период лактации;
детский возраст до 18 лет;
повышенная чувствительность к входящим в препарат компонентам.
С осторожностью
С осторожностью применяют препарат при почечной или печеночной недостаточности, сахарном диабете, нарушениях мочеиспускания, склонности к развитию лекарственной зависимости.
Применение при беременности и в период грудного вскармливания
Противопоказано применение препарата при беременности и в период лактации.
Способ применения и дозы
Препарат принимают внутрь.
Для купирования приступов бронхиальной астмы как вспомогательное средство принимают однократно по 2 таб. Теофедрина-Н. При необходимости препарат применяют 2-3 раза/сут. Максимальная суточная доза - 3 таб.
В целях профилактики Теофедрин-Н® принимают внутрь по 1/2-1 таб. 1 раз/сут после еды.
Во избежание нарушения ночного сна препарат принимают утром или днем. Длительность применения препарата зависит от характера, особенностей течения заболевания и оказываемого терапевтического эффекта.
Побочное действие
Со стороны сердечно-сосудистой системы: в единичных случаях - тахикардия, нарушения сердечного ритма.
Со стороны ЦНС: в единичных случаях - психическое возбуждение, тремор, головная боль, нарушение сна, бессонница.
Со стороны пищеварительной системы: в единичных случаях - снижение аппетита, изжога, тошнота, рвота.
Прочие: в единичных случаях - сухость во рту, повышенное потоотделение, задержка мочи, аллергические реакции.
Передозировка
Симптомы острого отравления: тошнота, рвота, боли в желудке, бессонница, эпилептоидные припадки, нарушение зрения.
Эфедрин, применяемый в высоких дозах, приводит к повышению уровня глюкозы в крови. Летальная пероральная доза эфедрина составляет 1 г.
Передозировка, обусловленная парацетамолом (с развитием гепатонекроза, повышением активности печеночных трансаминаз и увеличением протромбинового времени) проявляется после приема свыше 10-15 г последнего и вряд ли возможна из-за наличия в составе препарата других активных компонентов.
Взаимодействие с другими лекарственными средствами
Бета-адреноблокаторы (пропранолол), непрямые антикоагулянты (аценокумарол, фениндион), карбамазепин, фуросемид, циметидин, верапамил, антибиотики (линкомицин, макролиды), фторхинолоны (ципрофлоксацин, норфлоксацин), ингибиторы МАО, гормональные контрацептивы, ГКС повышают концентрацию теофиллина в крови и поэтому могут усиливать риск развития его побочных эффектов.
Экстракт красавки ослабляет действие м-холиномиметиков и антихолинэстеразных средств.
Парацетамол усиливает действие антикоагулянтов. Риск развития гепатотоксического действия парацетамола повышается при одновременном назначении барбитуратов, фенитоина, карбамазепина, рифампицина, зидовудина и других индукторов микросомальных ферментов печени.
При комбинированном применении эфедрина с ингибиторами МАО могут наступить тяжелые гипертензивные кризы из-за подавления метаболизма этих вазопрессорных субстанций. Эфедрин ослабляет действие опиоидных анальгетиков и других средств, угнетающих ЦНС. При одновременном применении с неселективными бета-адреноблокаторами уменьшается бронхолитическое действие препарата.
Особые указания
Во избежание нарушения ночного сна препарат не следует принимать вечером.
Во избежание токсического поражения печени препарат не следует сочетать с приемом алкогольных напитков, также принимать лицам, склонным к регулярному употреблению алкоголя.
Не рекомендуется назначать препарат больным с сахарным диабетом, поскольку эфедрин, применяемый в дозах, превышающих терапевтические, повышает обмен веществ, приводя, таким образом, к повышению уровня глюкозы в крови.
Влияние на способность к управлению транспортными средствами и механизмами
В период лечения необходимо соблюдать осторожность при вождении автотранспорта и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций. Препарат содержит сильнодействующие компоненты.
Условия хранения
Список сильнодействующих веществ.
Препарат следует хранить в недоступном для детей, сухом, защищенном от света месте при температуре не выше 25°С.
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За счет присутствия в составе препарата парацетамола Теофедрин-Н\u003csup\u003e®\u003c/sup\u003e обладает жаропонижающим и анальгезирующим действием."}},{"type":"header","data":{"text":"Фармакокинетика","level":4}},{"type":"paragraph","data":{"text":"После приема внутрь \u003ci\u003eпарацетамол\u003c/i\u003e хорошо всасывается из ЖКТ. C\u003csub\u003emax\u003c/sub\u003e в плазме крови достигается в течение 1 ч. Метаболиты парацетамола выводятся в течение 1-4 ч, главным образом, с мочой. T\u003csub\u003e1/2\u003c/sub\u003e неизмененного препарата из плазмы крови около 3 ч. При недостаточности функции печени и/или почек, а также при передозировке этот показатель увеличивается."}},{"type":"paragraph","data":{"text":"C\u003csub\u003emax\u003c/sub\u003e \u003ci\u003eтеофиллина\u003c/i\u003e в крови достигается через 2.5 ч после приема таблетки. T\u003csub\u003e1/2\u003c/sub\u003e теофиллина 11 ч, терапевтическая концентрация теофиллина в крови 20 мкг/мл."}},{"type":"paragraph","data":{"text":"\u003ci\u003eАтропин\u003c/i\u003e после приема внутрь на 18 % связывается с белками крови, 50% выводится с мочой почками в неизмененном виде."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЭфедрин\u003c/i\u003e хорошо всасывается из ЖКТ, создавая и поддерживая необходимый терапевтический уровень в плазме крови. Метаболизируется в печени, выделяется, главным образом, с мочой."}}]},{"id":10,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"В качестве вспомогательного средства при заболеваниях органов дыхания, сопровождающихся бронхоспазмом, в т.ч.:"}},{"type":"list","data":{"style":"ordered","items":["бронхиальная астма;","хронический обструктивный бронхит;","эмфизема легких."]}}]},{"id":11,"name":"Противопоказания","slug":"contraindications","body":[{"type":"list","data":{"style":"ordered","items":["хроническая сердечная недостаточность;","стенокардия;","нарушение коронарного кровообращения;","нарушения ритма сердца;","закрытоугольная глаукома;","гиперплазия предстательной железы;","гипертиреоз;","артериальная гипертензия;","эпилепсия и другие судорожные состояния;","беременность;","период лактации;","детский возраст до 18 лет;","повышенная чувствительность к входящим в препарат компонентам."]}}]},{"id":12,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eС осторожностью\u003c/i\u003e применяют препарат при почечной или печеночной недостаточности, сахарном диабете, нарушениях мочеиспускания, склонности к развитию лекарственной зависимости."}}]},{"id":13,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Противопоказано применение препарата при беременности и в период лактации."}}]},{"id":14,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Препарат принимают внутрь."}},{"type":"paragraph","data":{"text":"Для \u003ci\u003eкупирования приступов бронхиальной астмы\u003c/i\u003e как вспомогательное средство принимают однократно по 2 таб. Теофедрина-Н. При необходимости препарат применяют 2-3 раза/сут. Максимальная суточная доза - 3 таб."}},{"type":"paragraph","data":{"text":"В \u003ci\u003eцелях профилактики\u003c/i\u003e Теофедрин-Н\u003csup\u003e®\u003c/sup\u003e принимают внутрь по 1/2-1 таб. 1 раз/сут после еды."}},{"type":"paragraph","data":{"text":"Во избежание нарушения ночного сна препарат принимают утром или днем. Длительность применения препарата зависит от характера, особенностей течения заболевания и оказываемого терапевтического эффекта."}}]},{"id":15,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны сердечно-сосудистой системы:\u003c/i\u003e в единичных случаях - тахикардия, нарушения сердечного ритма."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны ЦНС:\u003c/i\u003e в единичных случаях - психическое возбуждение, тремор, головная боль, нарушение сна, бессонница."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны пищеварительной системы:\u003c/i\u003e в единичных случаях - снижение аппетита, изжога, тошнота, рвота."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПрочие:\u003c/i\u003e в единичных случаях - сухость во рту, повышенное потоотделение, задержка мочи, аллергические реакции."}}]},{"id":16,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы острого отравления:\u003c/i\u003e тошнота, рвота, боли в желудке, бессонница, эпилептоидные припадки, нарушение зрения."}},{"type":"paragraph","data":{"text":"Эфедрин, применяемый в высоких дозах, приводит к повышению уровня глюкозы в крови. Летальная пероральная доза эфедрина составляет 1 г."}},{"type":"paragraph","data":{"text":"Передозировка, обусловленная парацетамолом (с развитием гепатонекроза, повышением активности печеночных трансаминаз и увеличением протромбинового времени) проявляется после приема свыше 10-15 г последнего и вряд ли возможна из-за наличия в составе препарата других активных компонентов."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение:\u003c/i\u003e промывание желудка, искусственная рвота, симптоматическая терапия."}}]},{"id":17,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Бета-адреноблокаторы (пропранолол), непрямые антикоагулянты (аценокумарол, фениндион), карбамазепин, фуросемид, циметидин, верапамил, антибиотики (линкомицин, макролиды), фторхинолоны (ципрофлоксацин, норфлоксацин), ингибиторы МАО, гормональные контрацептивы, ГКС повышают концентрацию теофиллина в крови и поэтому могут усиливать риск развития его побочных эффектов."}},{"type":"paragraph","data":{"text":"Экстракт красавки ослабляет действие м-холиномиметиков и антихолинэстеразных средств."}},{"type":"paragraph","data":{"text":"Парацетамол усиливает действие антикоагулянтов. Риск развития гепатотоксического действия парацетамола повышается при одновременном назначении барбитуратов, фенитоина, карбамазепина, рифампицина, зидовудина и других индукторов микросомальных ферментов печени."}},{"type":"paragraph","data":{"text":"При комбинированном применении эфедрина с ингибиторами МАО могут наступить тяжелые гипертензивные кризы из-за подавления метаболизма этих вазопрессорных субстанций. Эфедрин ослабляет действие опиоидных анальгетиков и других средств, угнетающих ЦНС. При одновременном применении с неселективными бета-адреноблокаторами уменьшается бронхолитическое действие препарата."}}]},{"id":18,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Во избежание нарушения ночного сна препарат не следует принимать вечером."}},{"type":"paragraph","data":{"text":"Во избежание токсического поражения печени препарат не следует сочетать с приемом алкогольных напитков, также принимать лицам, склонным к регулярному употреблению алкоголя."}},{"type":"paragraph","data":{"text":"Не рекомендуется назначать препарат больным с сахарным диабетом, поскольку эфедрин, применяемый в дозах, превышающих терапевтические, повышает обмен веществ, приводя, таким образом, к повышению уровня глюкозы в крови."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВлияние на способность к управлению транспортными средствами и механизмами\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"В период лечения необходимо соблюдать осторожность при вождении автотранспорта и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций. Препарат содержит сильнодействующие компоненты."}}]},{"id":21,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Список сильнодействующих веществ."}},{"type":"paragraph","data":{"text":"Препарат следует хранить в недоступном для детей, сухом, защищенном от света месте при температуре не выше 25°С."}}]},{"id":22,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":" 2 года."}}]},{"id":23,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Препарат отпускается по рецепту."}}]},{"id":24,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.vidal.ru/drugs/company/783\"\u003eМОСХИМФАРМПРЕПАРАТЫ ИМ. Н.А.СЕМАШКО ОАО\u003c/a\u003e (Россия). "}}]}],"source":{"title":"('Эркафарм/Столетов',)","url":"https://stoletov.ru/"}},"description_toggle":false,"short_description":"Комбинированный препарат, оказывает бронхорасширяющее и спазмолитическое действие. Бронхорасширяющее действие препарата обусловлено комбинацией производных метилксантина (теофиллина, кофеина) с симпатомиметиком эфедрином и м-холинолитиком атропином, являющимся основным действующим началом экстракта красавки. Фенобарбитал устраняет возбуждение ЦНС. Препарат увеличивает просвет бронхов, расширяет сосуды легких и понижает давление в малом круге кровообращения, стимулирует дыхательный центр, расширяет коронарные сосуды и повышает частоту и силу сердечных сокращений, увеличивает почечный кровоток и оказывает умеренный диуретический эффект. За счет присутствия в составе препарата парацетамола Теофедрин-Н®обладает жаропонижающим и анальгезирующим действием. После приема внутрьпарацетамолхорошо всасывается из ЖКТ. Cmaxв плазме крови достигается в течение 1 ч. Метаболиты парацетамола выводятся в течение 1-4 ч, главным образом, с мочой. T1/2неизмененного препарата из плазмы крови около 3 ч. При недостаточности функции печени и/или почек, а также при передозировке этот показатель увеличивается. Cmaxтеофиллинав крови достигается через 2.5 ч после приема таблетки. T1/2теофиллина 11 ч, терапевтическая концентрация теофиллина в крови 20 мкг/мл.Атропинпосле приема внутрь на 18 % связывается с белками крови, 50% выводится с мочой почками в неизмененном виде.Эфедринхорошо всасывается из ЖКТ, создавая и поддерживая необходимый терапевтический уровень в плазме крови. 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