Лоратадин Таблетки, пачка, 10 шт, 10 мг, для приема внутрь

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Обладает быстрым и длительным противоаллергическим действием."}},{"type":"paragraph","data":{"text":"Антигистаминный эффект развивается через 30 минут после приема внутрь достигает максимума через 8-12 ч от начала действия и длится более 24 ч."}},{"type":"paragraph","data":{"text":"Лоратадин не оказывает воздействия на центральную нервную систему не оказывает клинически значимого антихолинергического и седативного действия то есть не вызывает сонливости и не влияет на скорость психомоторных реакций при применении в рекомендованных дозах."}},{"type":"paragraph","data":{"text":"При длительном лечении не наблюдалось клинически значимых изменений показателей жизненно важных функций данных физикального осмотра результатов лабораторных исследований или электрокардиографии. Прием лоратадина не приводит к удлинению интервала QT на электрокардиограмме (ЭКГ)."}},{"type":"paragraph","data":{"text":"Лоратадин не обладает значимой селективностью но отношению к Н\u003csub\u003e2\u003c/sub\u003e-гистаминовым рецепторам. Не ингибирует обратный захват норэпинефрина и практически не оказывает влияния на сердечно-сосудистую систему или функцию водителя ритма."}},{"type":"header","data":{"text":"Фармакокинетика:","level":3}},{"type":"paragraph","data":{"text":"Всасывание"}},{"type":"paragraph","data":{"text":"Быстро и полностью всасывается в желудочно-кишечном тракте. Время достижения максимальной концентрации (T\u003csub\u003emax\u003c/sub\u003e)лоратадина в плазме крови - 1-15 ч а его активного метаболита дезлоратадина - 15-37 ч. Прием пищи увеличивает Т\u003csub\u003em\u003c/sub\u003e\u003csub\u003eах\u003c/sub\u003e лоратадина и дезлоратадина приблизительно на 1 ч но не оказывает влияния на эффективность лекарственного препарата. Максимальная концентрация (С\u003csub\u003em\u003c/sub\u003e\u003csub\u003eах\u003c/sub\u003e) лоратадина и дезлоратадина не зависит от приема пищи. С\u003csub\u003em\u003c/sub\u003e\u003csub\u003eах\u003c/sub\u003e лоратадина возрастает у пожилых пациентов пациентов с хронической почечной недостаточностью или алкогольным поражением печени."}},{"type":"paragraph","data":{"text":"Распределение"}},{"type":"paragraph","data":{"text":"Биодоступность лоратадина и его активного метаболита имеет дозозависимый характер. Лоратадин имеет высокую степень (97-99%) а его активный метаболит - умеренную степень (73-76 %) связывания с белками плазмы крови. Равновесные концентрации лоратадина и метаболита в плазме крови достигаются на пятые сутки введения. Не проникает через гематоэнцефалический барьер."}},{"type":"paragraph","data":{"text":"Метаболизм"}},{"type":"paragraph","data":{"text":"Метаболизируется в печени с образованием активного метаболита дезлоратадина (дескарбоэтоксилоратадина) при участии изоферментов цитохрома Р450 CYP3A4 и в меньшей степени изофермента цитохрома Р450 CYP2D6."}},{"type":"paragraph","data":{"text":"Выведение"}},{"type":"paragraph","data":{"text":"Выводится через почки (приблизительно 40 % принятой внутрь дозы) и через кишечник (приблизительно 42% принятой внутрь дозы) в течение более чем 10 дней преимущественно в виде конъюгированных метаболитов. Приблизительно 27 % принятой внутрь дозы выводится через почки в течение 24 часов после приема препарата. Менее 1 % активного вещества выводится через почки в неизмененном виде в течение 24 часов после приема препарата. Период полувыведения (Т\u003csub\u003e1/2\u003c/sub\u003e) лоратадина составляет от 3 до 20 ч (в среднем 84 ч) а дезлоратадина - от 88 до 92 ч (в среднем 28 ч)."}},{"type":"paragraph","data":{"text":"Фармакокинетика у особых групп пациентов"}},{"type":"paragraph","data":{"text":"Пожилой возраст"}},{"type":"paragraph","data":{"text":"Фармакокинетические профили лоратадина и его активного метаболита у взрослых и пожилых здоровых добровольцев были сопоставимы."}},{"type":"paragraph","data":{"text":"Т\u003csub\u003e1/2\u003c/sub\u003eлоратадина у пожилых пациентов составляет от 67 до 37 ч (в среднем 182 ч) а дезлоратадина - от 11 до 39 ч (в среднем 175 ч)."}},{"type":"paragraph","data":{"text":"Пациенты с нарушением функции печени"}},{"type":"paragraph","data":{"text":"У пациентов с алкогольным поражением печени С\u003csub\u003em\u003c/sub\u003e\u003csub\u003eах\u003c/sub\u003e и площадь под кривой \"концентрация - время\" (AUC) лоратадина и его активного метаболита увеличиваются в дна раза по сравнению с данными показателями у пациентов с нормальной функцией печени. При этом Т\u003csub\u003e1/2\u003c/sub\u003e лоратадина и Т\u003csub\u003e1/2\u003c/sub\u003e его активного метаболита возрастают с увеличением тяжести заболевания."}},{"type":"paragraph","data":{"text":"Пациенты с нарушением функции почек"}},{"type":"paragraph","data":{"text":"У пациентов с хроническими заболеваниями почек С\u003csub\u003emax\u003c/sub\u003e и AUC лоратадина и его активного метаболита увеличиваются по сравнению с данными показателями у пациентов с нормальной функцией почек. При этом Т\u003csub\u003e1/2\u003c/sub\u003e лоратадина и Т\u003csub\u003e1/2\u003c/sub\u003e его активного метаболита не отличаются от таковых у здоровых пациентов."}},{"type":"paragraph","data":{"text":"Проведение гемодиализа у пациентов с хронической почечной недостаточностью не оказывает влияния на фармакокинетику лоратадина и его активного метаболита."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"- Сезонный (поллиноз) и круглогодичный аллергические риниты и аллергический конъюнктивит - устранение симптомов связанных с этими заболеваниями - чихания зуда слизистой оболочки носа ринореи ощущения жжения и зуда в глазах слезотечения;"}},{"type":"paragraph","data":{"text":"- хроническая идиопатическая крапивница;"}},{"type":"paragraph","data":{"text":"- кожные заболевания аллергического происхождения."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"- Повышенная чувствительность к лоратадину или любому другому компоненту препарата;"}},{"type":"paragraph","data":{"text":"- период грудного вскармливания;"}},{"type":"paragraph","data":{"text":"- возраст до 6 лет;"}},{"type":"paragraph","data":{"text":"- дефицит лактазы непереносимость лактозы глюкозо-галактозная мальабсорбция."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"- Тяжелые нарушения функции печени;"}},{"type":"paragraph","data":{"text":"- беременность"}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Безопасность применения лоратадина во время беременности не установлена."}},{"type":"paragraph","data":{"text":"Применять препарат в период беременности следует только тогда когда ожидаемый терапевтический эффект для будущей матери превышает потенциальный риск для плода. Лоратадин и его активный метаболит выделяются в грудное молоко поэтому при назначении препарата в период грудного вскармливания следует решить вопрос о прекращении грудного вскармливания."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Принимают внутрь не разжевывая запивая достаточным количеством воды независимо от приема пищи."}},{"type":"paragraph","data":{"text":"Взрослым в том числе пожилым и детям от б лет (с массой тела более 30 кг) - по 10 мг таблетка) 1 раз в день."}},{"type":"paragraph","data":{"text":"Пациентам с тяжелым нарушением функции печени необходимо назначить уменьшенную дозу препарата: 10 мг (1 таблетка) через день."}},{"type":"paragraph","data":{"text":"При применении препарата у пожилых пациентов и у пациентов с наличием хронической почечной недостаточности коррекция дозы не требуется."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"В клинических исследованиях с участием детей в возрасте от 2 до 12 лет принимавших лоратадин более часто чем в группе плацебо наблюдались головная боль (27 %) нервозность (23 %) утомляемость (1 %)."}},{"type":"paragraph","data":{"text":"В клинических исследованиях с участием взрослых нежелательные явления наблюдавшиеся чаще чем при применении плацебо (\"пустышки\") встречались у 2 % пациентов принимавших лоратадин."}},{"type":"paragraph","data":{"text":"У взрослых при применении лоратадина более часто чем в группе плацебо отмечались головная боль (06 %) сонливость (12 %) повышение аппетита (05 %) и бессонница (01 %). Кроме того в пострегистрационном периоде имелись очень редкие сообщения (< 1/10000) о головокружении утомляемости сухости во рту желудочно-кишечных расстройствах (тошнота гастрит) аллергических реакциях в виде сыпи анафилаксии включая ангионевротический отек алопеции нарушении функции печени ощущении сердцебиения тахикардии и судорогах."}},{"type":"paragraph","data":{"text":"Если любые из указанных в инструкции побочных эффектов усугубляются или Вы заметили любые другие побочные эффекты не указанные в инструкции сообщите об этом врачу."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы"}},{"type":"paragraph","data":{"text":"Сонливость тахикардия головная боль. В случае передозировки следует незамедлительно обратиться к врачу."}},{"type":"paragraph","data":{"text":"Лечение"}},{"type":"paragraph","data":{"text":"Симптоматическое промывание желудка (предпочтительно 09% раствором натрия хлорида) прием адсорбентов (измельченного активированного угля с водой)."}},{"type":"paragraph","data":{"text":"Лоратадин не выводится с помощью гемодиализа."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Прием пищи не оказывает влияния на эффективность препарата Лоратадин."}},{"type":"paragraph","data":{"text":"Лоратадин не усиливает действие алкоголя на центральную нервную систему."}},{"type":"paragraph","data":{"text":"При совместном приеме лоратадина с кетоконазолом эритромицином или циметидином отмечается повышение концентрации лоратадина и его метаболита в плазме крови но это повышение не является клинически значимым в том числе по данным ЭКГ."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Препарат Лоратадин следует отменить не менее чем за 48 часов до проведения кожных аллергических проб так как лоратадин может оказывать влияние на их результаты."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения следует соблюдать осторожность при управлении транспортными средствами и занятии другими потенциально опасными видами деятельности требующими повышенной концентрации внимания и быстроты психомоторных реакций и из-за риска возникновения сонливости."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки 10 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":" защищенном от света месте при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта"}}]}],"source":null},"description_toggle":false,"short_description":"Лоратадин - активное вещество лекарственного препарата Лоратадин - представляет собой трициклическое соединение с выраженным антигистаминным действием и является селективным блокатором периферических H1-гистаминовых рецепторов. Обладает быстрым и длительным противоаллергическим действием. Антигистаминный эффект развивается через 30 минут после приема внутрь достигает максимума через 8-12 ч от начала действия и длится более 24 ч. Лоратадин не оказывает воздействия на центральную нервную систему не оказывает клинически значимого антихолинергического и седативного действия то есть не вызывает сонливости и не влияет на скорость психомоторных реакций при применении в рекомендованных дозах. При длительном лечении не наблюдалось клинически значимых изменений показателей жизненно важных функций данных физикального осмотра результатов лабораторных исследований или электрокардиографии. Прием лоратадина не приводит к удлинению интервала QT на электрокардиограмме (ЭКГ). Лоратадин не обладает значимой селективностью но отношению к Н2-гистаминовым рецепторам. Не ингибирует обратный захват норэпинефрина и практически не оказывает влияния на сердечно-сосудистую систему или функцию водителя ритма. Всасывание Быстро и полностью всасывается в желудочно-кишечном тракте. Время достижения максимальной концентрации (Tmax)лоратадина в плазме крови - 1-15 ч а его активного метаболита дезлоратадина - 15-37 ч. Прием пищи увеличивает Тmахлоратадина и дезлоратадина приблизительно на 1 ч но не оказывает влияния на эффективность лекарственного препарата. Максимальная концентрация (Сmах) лоратадина и дезлоратадина не зависит от приема пищи. Сmахлоратадина возрастает у пожилых пациентов пациентов с хронической почечной недостаточностью или алкогольным поражением печени. Распределение Биодоступность лоратадина и его активного метаболита имеет дозозависимый характер. Лоратадин имеет высокую степень (97-99%) а его активный метаболит - умеренную степень (73-76 %) связывания с белками плазмы крови. Равновесные концентрации лоратадина и метаболита в плазме крови достигаются на пятые сутки введения. Не проникает через гематоэнцефалический барьер. Метаболизм Метаболизируется в печени с образованием активного метаболита дезлоратадина (дескарбоэтоксилоратадина) при участии изоферментов цитохрома Р450 CYP3A4 и в меньшей степени изофермента цитохрома Р450 CYP2D6. Выведение Выводится через почки (приблизительно 40 % принятой внутрь дозы) и через кишечник (приблизительно 42% принятой внутрь дозы) в течение более чем 10 дней преимущественно в виде конъюгированных метаболитов. Приблизительно 27 % принятой внутрь дозы выводится через почки в течение 24 часов после приема препарата. Менее 1 % активного вещества выводится через почки в неизмененном виде в течение 24 часов после приема препарата. Период полувыведения (Т1/2) лоратадина составляет от 3 до 20 ч (в среднем 84 ч) а дезлоратадина - от 88 до 92 ч (в среднем 28 ч). Фармакокинетика у особых групп пациентов Пожилой возраст Фармакокинетические профили лоратадина и его активного метаболита у взрослых и пожилых здоровых добровольцев были сопоставимы. Т1/2лоратадина у пожилых пациентов составляет от 67 до 37 ч (в среднем 182 ч) а дезлоратадина - от 11 до 39 ч (в среднем 175 ч). Пациенты с нарушением функции печени У пациентов с алкогольным поражением печени Сmахи площадь под кривой \"концентрация - время\" (AUC) лоратадина и его активного метаболита увеличиваются в дна раза по сравнению с данными показателями у пациентов с нормальной функцией печени. При этом Т1/2лоратадина и Т1/2его активного метаболита возрастают с увеличением тяжести заболевания. Пациенты с нарушением функции почек У пациентов с хроническими заболеваниями почек Сmaxи AUC лоратадина и его активного метаболита увеличиваются по сравнению с данными показателями у пациентов с нормальной функцией почек. При этом Т1/2лоратадина и Т1/2его активного метаболита не отличаются от таковых у здоровых пациентов. Проведение гемодиализа у пациентов с хронической почечной недостаточностью не оказывает влияния на фармакокинетику лоратадина и его активного метаболита.","substance":[{"id":96,"title":"Лоратадин","title_latin":"Loratadinum","slug":"loratadin_96"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":true,"comments":null,"image_alt":"Лоратадин - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/224958/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/224958/share_default/"}},"diseases":[],"other_packages":[{"id":107586,"title":"Лоратадин","subtitle":{"full":"Таблетки, 10 шт, 10 мг, для приема внутрь","short":"Таблетки, 10 шт, 10 мг","package":"10 шт, 10 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