Лоратадин - активное вещество лекарственного препарата Лорат... Инструкция
Показания к применению
- Сезонный (поллиноз) и круглогодичный аллергические риниты и аллергический конъюнктивит - устранение симптомов связанных с этими заболеваниями - чихания зуда слизистой оболочки носа ринореи ощущения жжения и зуда в глазах слезотечения;
- хроническая идиопатическая крапивница;
- кожные заболевания аллергического происхождения.
Противопоказания
- Повышенная чувствительность к лоратадину или любому другому компоненту препарата;
Круглые плоскоцилиндрические таблетки белого или почти белого цвета с фаской.
Фармакотерапевтическая группа
Противоаллергическое средство - H1-гистаминовых рецепторов блокатор
Фармакологические свойства
Фармакодинамика:
Лоратадин - активное вещество лекарственного препарата Лоратадин - представляет собой трициклическое соединение с выраженным антигистаминным действием и является селективным блокатором периферических H1-гистаминовых рецепторов. Обладает быстрым и длительным противоаллергическим действием.
Антигистаминный эффект развивается через 30 минут после приема внутрь достигает максимума через 8-12 ч от начала действия и длится более 24 ч.
Лоратадин не оказывает воздействия на центральную нервную систему не оказывает клинически значимого антихолинергического и седативного действия то есть не вызывает сонливости и не влияет на скорость психомоторных реакций при применении в рекомендованных дозах.
При длительном лечении не наблюдалось клинически значимых изменений показателей жизненно важных функций данных физикального осмотра результатов лабораторных исследований или электрокардиографии. Прием лоратадина не приводит к удлинению интервала QT на электрокардиограмме (ЭКГ).
Лоратадин не обладает значимой селективностью но отношению к Н2-гистаминовым рецепторам. Не ингибирует обратный захват норэпинефрина и практически не оказывает влияния на сердечно-сосудистую систему или функцию водителя ритма.
Фармакокинетика:
Всасывание
Быстро и полностью всасывается в желудочно-кишечном тракте. Время достижения максимальной концентрации (Tmax)лоратадина в плазме крови - 1-15 ч а его активного метаболита дезлоратадина - 15-37 ч. Прием пищи увеличивает Тmах лоратадина и дезлоратадина приблизительно на 1 ч но не оказывает влияния на эффективность лекарственного препарата. Максимальная концентрация (Сmах) лоратадина и дезлоратадина не зависит от приема пищи. Сmах лоратадина возрастает у пожилых пациентов пациентов с хронической почечной недостаточностью или алкогольным поражением печени.
Распределение
Биодоступность лоратадина и его активного метаболита имеет дозозависимый характер. Лоратадин имеет высокую степень (97-99%) а его активный метаболит - умеренную степень (73-76 %) связывания с белками плазмы крови. Равновесные концентрации лоратадина и метаболита в плазме крови достигаются на пятые сутки введения. Не проникает через гематоэнцефалический барьер.
Метаболизм
Метаболизируется в печени с образованием активного метаболита дезлоратадина (дескарбоэтоксилоратадина) при участии изоферментов цитохрома Р450 CYP3A4 и в меньшей степени изофермента цитохрома Р450 CYP2D6.
Выведение
Выводится через почки (приблизительно 40 % принятой внутрь дозы) и через кишечник (приблизительно 42% принятой внутрь дозы) в течение более чем 10 дней преимущественно в виде конъюгированных метаболитов. Приблизительно 27 % принятой внутрь дозы выводится через почки в течение 24 часов после приема препарата. Менее 1 % активного вещества выводится через почки в неизмененном виде в течение 24 часов после приема препарата. Период полувыведения (Т1/2) лоратадина составляет от 3 до 20 ч (в среднем 84 ч) а дезлоратадина - от 88 до 92 ч (в среднем 28 ч).
Фармакокинетика у особых групп пациентов
Пожилой возраст
Фармакокинетические профили лоратадина и его активного метаболита у взрослых и пожилых здоровых добровольцев были сопоставимы.
Т1/2лоратадина у пожилых пациентов составляет от 67 до 37 ч (в среднем 182 ч) а дезлоратадина - от 11 до 39 ч (в среднем 175 ч).
Пациенты с нарушением функции печени
У пациентов с алкогольным поражением печени Сmах и площадь под кривой "концентрация - время" (AUC) лоратадина и его активного метаболита увеличиваются в дна раза по сравнению с данными показателями у пациентов с нормальной функцией печени. При этом Т1/2 лоратадина и Т1/2 его активного метаболита возрастают с увеличением тяжести заболевания.
Пациенты с нарушением функции почек
У пациентов с хроническими заболеваниями почек Сmax и AUC лоратадина и его активного метаболита увеличиваются по сравнению с данными показателями у пациентов с нормальной функцией почек. При этом Т1/2 лоратадина и Т1/2 его активного метаболита не отличаются от таковых у здоровых пациентов.
Проведение гемодиализа у пациентов с хронической почечной недостаточностью не оказывает влияния на фармакокинетику лоратадина и его активного метаболита.
Показания к применению
- Сезонный (поллиноз) и круглогодичный аллергические риниты и аллергический конъюнктивит - устранение симптомов связанных с этими заболеваниями - чихания зуда слизистой оболочки носа ринореи ощущения жжения и зуда в глазах слезотечения;
- хроническая идиопатическая крапивница;
- кожные заболевания аллергического происхождения.
Противопоказания
- Повышенная чувствительность к лоратадину или любому другому компоненту препарата;
Применение при беременности и в период грудного вскармливания
Безопасность применения лоратадина во время беременности не установлена.
Применять препарат в период беременности следует только тогда когда ожидаемый терапевтический эффект для будущей матери превышает потенциальный риск для плода. Лоратадин и его активный метаболит выделяются в грудное молоко поэтому при назначении препарата в период грудного вскармливания следует решить вопрос о прекращении грудного вскармливания.
Способ применения и дозы
Принимают внутрь не разжевывая запивая достаточным количеством воды независимо от приема пищи.
Взрослым в том числе пожилым и детям от б лет (с массой тела более 30 кг) - по 10 мг таблетка) 1 раз в день.
Пациентам с тяжелым нарушением функции печени необходимо назначить уменьшенную дозу препарата: 10 мг (1 таблетка) через день.
При применении препарата у пожилых пациентов и у пациентов с наличием хронической почечной недостаточности коррекция дозы не требуется.
Побочное действие
В клинических исследованиях с участием детей в возрасте от 2 до 12 лет принимавших лоратадин более часто чем в группе плацебо наблюдались головная боль (27 %) нервозность (23 %) утомляемость (1 %).
В клинических исследованиях с участием взрослых нежелательные явления наблюдавшиеся чаще чем при применении плацебо ("пустышки") встречались у 2 % пациентов принимавших лоратадин.
У взрослых при применении лоратадина более часто чем в группе плацебо отмечались головная боль (06 %) сонливость (12 %) повышение аппетита (05 %) и бессонница (01 %). Кроме того в пострегистрационном периоде имелись очень редкие сообщения (< 1/10000) о головокружении утомляемости сухости во рту желудочно-кишечных расстройствах (тошнота гастрит) аллергических реакциях в виде сыпи анафилаксии включая ангионевротический отек алопеции нарушении функции печени ощущении сердцебиения тахикардии и судорогах.
Если любые из указанных в инструкции побочных эффектов усугубляются или Вы заметили любые другие побочные эффекты не указанные в инструкции сообщите об этом врачу.
Передозировка
Симптомы
Сонливость тахикардия головная боль. В случае передозировки следует незамедлительно обратиться к врачу.
Взаимодействие с другими лекарственными средствами
Прием пищи не оказывает влияния на эффективность препарата Лоратадин.
Лоратадин не усиливает действие алкоголя на центральную нервную систему.
При совместном приеме лоратадина с кетоконазолом эритромицином или циметидином отмечается повышение концентрации лоратадина и его метаболита в плазме крови но это повышение не является клинически значимым в том числе по данным ЭКГ.
Особые указания
Препарат Лоратадин следует отменить не менее чем за 48 часов до проведения кожных аллергических проб так как лоратадин может оказывать влияние на их результаты.
Влияние на способность управлять автомобилем и движущимися механизмами
В период лечения следует соблюдать осторожность при управлении транспортными средствами и занятии другими потенциально опасными видами деятельности требующими повышенной концентрации внимания и быстроты психомоторных реакций и из-за риска возникновения сонливости.
Форма выпуска
Таблетки 10 мг.
Условия хранения
защищенном от света месте при температуре не выше 25 °С.
Хранить в недоступном для детей месте.
Срок годности
3 года.
Не применять по истечении срока годности.
Условия отпуска
Без рецепта
Для описания товара использована информация от партнера 36.6
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мг","volume":"","spf":"","size":""},"image":{"isTouch":{"retina":"https://vseapteki.ru/img/drugs/png/46.png","default":"https://vseapteki.ru/img/drugs/png/46.png"},"isFromTablet":{"retina":"https://vseapteki.ru/img/drugs/png/46.png","default":"https://vseapteki.ru/img/drugs/png/46.png"}},"image_thumb":{"isTouch":{"retina":"https://vseapteki.ru/img/drugs/png/46.png","default":"https://vseapteki.ru/img/drugs/png/46.png"},"isFromTablet":{"retina":"https://vseapteki.ru/img/drugs/png/46.png","default":"https://vseapteki.ru/img/drugs/png/46.png"}},"available":false,"price":{"min":null,"max":null},"counters":null,"description":{"data":[{"id":1,"name":"Регистрационный номер","slug":"","body":[{"type":"paragraph","data":{"text":"ЛС-000534 от 07.06.10"}}]},{"id":2,"name":"Торговое название препарата","slug":"","body":[{"type":"paragraph","data":{"text":"Лоратадин"}}]},{"id":3,"name":"Лекарственная форма","slug":"","body":[{"type":"paragraph","data":{"text":"таблетки"}}]},{"id":4,"name":"Состав","slug":"ingredients","body":[{"type":"paragraph","data":{"text":"Одна таблетка содержит:"}},{"type":"paragraph","data":{"text":"действующее вещество: лоратадин - 10,0 мг;"}},{"type":"paragraph","data":{"text":"вспомогательные вещества: лактозы моногидрат - 97,6 мг; целлюлоза микрокристаллическая - 28,0 мг; карбоксиметилкрахмал натрия (натрия крахмал гликолят, тип А) - 3,0 мг; кальция стеарат - 1,4 мг."}}]},{"id":5,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"Круглые плоскоцилиндрические таблетки белого или почти белого цвета с фаской."}}]},{"id":6,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"Противоаллергическое средство - H1-гистаминовых рецепторов блокатор"}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"header","data":{"text":"Фармакодинамика:","level":3}},{"type":"paragraph","data":{"text":"Лоратадин - активное вещество лекарственного препарата Лоратадин - представляет собой трициклическое соединение с выраженным антигистаминным действием и является селективным блокатором периферических H\u003csub\u003e1\u003c/sub\u003e-гистаминовых рецепторов. Обладает быстрым и длительным противоаллергическим действием."}},{"type":"paragraph","data":{"text":"Антигистаминный эффект развивается через 30 минут после приема внутрь достигает максимума через 8-12 ч от начала действия и длится более 24 ч."}},{"type":"paragraph","data":{"text":"Лоратадин не оказывает воздействия на центральную нервную систему не оказывает клинически значимого антихолинергического и седативного действия то есть не вызывает сонливости и не влияет на скорость психомоторных реакций при применении в рекомендованных дозах."}},{"type":"paragraph","data":{"text":"При длительном лечении не наблюдалось клинически значимых изменений показателей жизненно важных функций данных физикального осмотра результатов лабораторных исследований или электрокардиографии. Прием лоратадина не приводит к удлинению интервала QT на электрокардиограмме (ЭКГ)."}},{"type":"paragraph","data":{"text":"Лоратадин не обладает значимой селективностью но отношению к Н\u003csub\u003e2\u003c/sub\u003e-гистаминовым рецепторам. Не ингибирует обратный захват норэпинефрина и практически не оказывает влияния на сердечно-сосудистую систему или функцию водителя ритма."}},{"type":"header","data":{"text":"Фармакокинетика:","level":3}},{"type":"paragraph","data":{"text":"Всасывание"}},{"type":"paragraph","data":{"text":"Быстро и полностью всасывается в желудочно-кишечном тракте. Время достижения максимальной концентрации (T\u003csub\u003emax\u003c/sub\u003e)лоратадина в плазме крови - 1-15 ч а его активного метаболита дезлоратадина - 15-37 ч. Прием пищи увеличивает Т\u003csub\u003em\u003c/sub\u003e\u003csub\u003eах\u003c/sub\u003e лоратадина и дезлоратадина приблизительно на 1 ч но не оказывает влияния на эффективность лекарственного препарата. Максимальная концентрация (С\u003csub\u003em\u003c/sub\u003e\u003csub\u003eах\u003c/sub\u003e) лоратадина и дезлоратадина не зависит от приема пищи. С\u003csub\u003em\u003c/sub\u003e\u003csub\u003eах\u003c/sub\u003e лоратадина возрастает у пожилых пациентов пациентов с хронической почечной недостаточностью или алкогольным поражением печени."}},{"type":"paragraph","data":{"text":"Распределение"}},{"type":"paragraph","data":{"text":"Биодоступность лоратадина и его активного метаболита имеет дозозависимый характер. Лоратадин имеет высокую степень (97-99%) а его активный метаболит - умеренную степень (73-76 %) связывания с белками плазмы крови. Равновесные концентрации лоратадина и метаболита в плазме крови достигаются на пятые сутки введения. Не проникает через гематоэнцефалический барьер."}},{"type":"paragraph","data":{"text":"Метаболизм"}},{"type":"paragraph","data":{"text":"Метаболизируется в печени с образованием активного метаболита дезлоратадина (дескарбоэтоксилоратадина) при участии изоферментов цитохрома Р450 CYP3A4 и в меньшей степени изофермента цитохрома Р450 CYP2D6."}},{"type":"paragraph","data":{"text":"Выведение"}},{"type":"paragraph","data":{"text":"Выводится через почки (приблизительно 40 % принятой внутрь дозы) и через кишечник (приблизительно 42% принятой внутрь дозы) в течение более чем 10 дней преимущественно в виде конъюгированных метаболитов. Приблизительно 27 % принятой внутрь дозы выводится через почки в течение 24 часов после приема препарата. Менее 1 % активного вещества выводится через почки в неизмененном виде в течение 24 часов после приема препарата. Период полувыведения (Т\u003csub\u003e1/2\u003c/sub\u003e) лоратадина составляет от 3 до 20 ч (в среднем 84 ч) а дезлоратадина - от 88 до 92 ч (в среднем 28 ч)."}},{"type":"paragraph","data":{"text":"Фармакокинетика у особых групп пациентов"}},{"type":"paragraph","data":{"text":"Пожилой возраст"}},{"type":"paragraph","data":{"text":"Фармакокинетические профили лоратадина и его активного метаболита у взрослых и пожилых здоровых добровольцев были сопоставимы."}},{"type":"paragraph","data":{"text":"Т\u003csub\u003e1/2\u003c/sub\u003eлоратадина у пожилых пациентов составляет от 67 до 37 ч (в среднем 182 ч) а дезлоратадина - от 11 до 39 ч (в среднем 175 ч)."}},{"type":"paragraph","data":{"text":"Пациенты с нарушением функции печени"}},{"type":"paragraph","data":{"text":"У пациентов с алкогольным поражением печени С\u003csub\u003em\u003c/sub\u003e\u003csub\u003eах\u003c/sub\u003e и площадь под кривой \"концентрация - время\" (AUC) лоратадина и его активного метаболита увеличиваются в дна раза по сравнению с данными показателями у пациентов с нормальной функцией печени. При этом Т\u003csub\u003e1/2\u003c/sub\u003e лоратадина и Т\u003csub\u003e1/2\u003c/sub\u003e его активного метаболита возрастают с увеличением тяжести заболевания."}},{"type":"paragraph","data":{"text":"Пациенты с нарушением функции почек"}},{"type":"paragraph","data":{"text":"У пациентов с хроническими заболеваниями почек С\u003csub\u003emax\u003c/sub\u003e и AUC лоратадина и его активного метаболита увеличиваются по сравнению с данными показателями у пациентов с нормальной функцией почек. При этом Т\u003csub\u003e1/2\u003c/sub\u003e лоратадина и Т\u003csub\u003e1/2\u003c/sub\u003e его активного метаболита не отличаются от таковых у здоровых пациентов."}},{"type":"paragraph","data":{"text":"Проведение гемодиализа у пациентов с хронической почечной недостаточностью не оказывает влияния на фармакокинетику лоратадина и его активного метаболита."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"- Сезонный (поллиноз) и круглогодичный аллергические риниты и аллергический конъюнктивит - устранение симптомов связанных с этими заболеваниями - чихания зуда слизистой оболочки носа ринореи ощущения жжения и зуда в глазах слезотечения;"}},{"type":"paragraph","data":{"text":"- хроническая идиопатическая крапивница;"}},{"type":"paragraph","data":{"text":"- кожные заболевания аллергического происхождения."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"- Повышенная чувствительность к лоратадину или любому другому компоненту препарата;"}},{"type":"paragraph","data":{"text":"- период грудного вскармливания;"}},{"type":"paragraph","data":{"text":"- возраст до 6 лет;"}},{"type":"paragraph","data":{"text":"- дефицит лактазы непереносимость лактозы глюкозо-галактозная мальабсорбция."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"- Тяжелые нарушения функции печени;"}},{"type":"paragraph","data":{"text":"- беременность"}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Безопасность применения лоратадина во время беременности не установлена."}},{"type":"paragraph","data":{"text":"Применять препарат в период беременности следует только тогда когда ожидаемый терапевтический эффект для будущей матери превышает потенциальный риск для плода. Лоратадин и его активный метаболит выделяются в грудное молоко поэтому при назначении препарата в период грудного вскармливания следует решить вопрос о прекращении грудного вскармливания."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Принимают внутрь не разжевывая запивая достаточным количеством воды независимо от приема пищи."}},{"type":"paragraph","data":{"text":"Взрослым в том числе пожилым и детям от б лет (с массой тела более 30 кг) - по 10 мг таблетка) 1 раз в день."}},{"type":"paragraph","data":{"text":"Пациентам с тяжелым нарушением функции печени необходимо назначить уменьшенную дозу препарата: 10 мг (1 таблетка) через день."}},{"type":"paragraph","data":{"text":"При применении препарата у пожилых пациентов и у пациентов с наличием хронической почечной недостаточности коррекция дозы не требуется."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"В клинических исследованиях с участием детей в возрасте от 2 до 12 лет принимавших лоратадин более часто чем в группе плацебо наблюдались головная боль (27 %) нервозность (23 %) утомляемость (1 %)."}},{"type":"paragraph","data":{"text":"В клинических исследованиях с участием взрослых нежелательные явления наблюдавшиеся чаще чем при применении плацебо (\"пустышки\") встречались у 2 % пациентов принимавших лоратадин."}},{"type":"paragraph","data":{"text":"У взрослых при применении лоратадина более часто чем в группе плацебо отмечались головная боль (06 %) сонливость (12 %) повышение аппетита (05 %) и бессонница (01 %). Кроме того в пострегистрационном периоде имелись очень редкие сообщения (< 1/10000) о головокружении утомляемости сухости во рту желудочно-кишечных расстройствах (тошнота гастрит) аллергических реакциях в виде сыпи анафилаксии включая ангионевротический отек алопеции нарушении функции печени ощущении сердцебиения тахикардии и судорогах."}},{"type":"paragraph","data":{"text":"Если любые из указанных в инструкции побочных эффектов усугубляются или Вы заметили любые другие побочные эффекты не указанные в инструкции сообщите об этом врачу."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы"}},{"type":"paragraph","data":{"text":"Сонливость тахикардия головная боль. В случае передозировки следует незамедлительно обратиться к врачу."}},{"type":"paragraph","data":{"text":"Лечение"}},{"type":"paragraph","data":{"text":"Симптоматическое промывание желудка (предпочтительно 09% раствором натрия хлорида) прием адсорбентов (измельченного активированного угля с водой)."}},{"type":"paragraph","data":{"text":"Лоратадин не выводится с помощью гемодиализа."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Прием пищи не оказывает влияния на эффективность препарата Лоратадин."}},{"type":"paragraph","data":{"text":"Лоратадин не усиливает действие алкоголя на центральную нервную систему."}},{"type":"paragraph","data":{"text":"При совместном приеме лоратадина с кетоконазолом эритромицином или циметидином отмечается повышение концентрации лоратадина и его метаболита в плазме крови но это повышение не является клинически значимым в том числе по данным ЭКГ."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Препарат Лоратадин следует отменить не менее чем за 48 часов до проведения кожных аллергических проб так как лоратадин может оказывать влияние на их результаты."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения следует соблюдать осторожность при управлении транспортными средствами и занятии другими потенциально опасными видами деятельности требующими повышенной концентрации внимания и быстроты психомоторных реакций и из-за риска возникновения сонливости."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки 10 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":" защищенном от света месте при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта"}}]}],"source":null},"description_toggle":false,"short_description":"Лоратадин - активное вещество лекарственного препарата Лоратадин - представляет собой трициклическое соединение с выраженным антигистаминным действием и является селективным блокатором периферических H1-гистаминовых рецепторов. Обладает быстрым и длительным противоаллергическим действием. Антигистаминный эффект развивается через 30 минут после приема внутрь достигает максимума через 8-12 ч от начала действия и длится более 24 ч. Лоратадин не оказывает воздействия на центральную нервную систему не оказывает клинически значимого антихолинергического и седативного действия то есть не вызывает сонливости и не влияет на скорость психомоторных реакций при применении в рекомендованных дозах. При длительном лечении не наблюдалось клинически значимых изменений показателей жизненно важных функций данных физикального осмотра результатов лабораторных исследований или электрокардиографии. Прием лоратадина не приводит к удлинению интервала QT на электрокардиограмме (ЭКГ). Лоратадин не обладает значимой селективностью но отношению к Н2-гистаминовым рецепторам. Не ингибирует обратный захват норэпинефрина и практически не оказывает влияния на сердечно-сосудистую систему или функцию водителя ритма. Всасывание Быстро и полностью всасывается в желудочно-кишечном тракте. Время достижения максимальной концентрации (Tmax)лоратадина в плазме крови - 1-15 ч а его активного метаболита дезлоратадина - 15-37 ч. Прием пищи увеличивает Тmахлоратадина и дезлоратадина приблизительно на 1 ч но не оказывает влияния на эффективность лекарственного препарата. Максимальная концентрация (Сmах) лоратадина и дезлоратадина не зависит от приема пищи. Сmахлоратадина возрастает у пожилых пациентов пациентов с хронической почечной недостаточностью или алкогольным поражением печени. Распределение Биодоступность лоратадина и его активного метаболита имеет дозозависимый характер. Лоратадин имеет высокую степень (97-99%) а его активный метаболит - умеренную степень (73-76 %) связывания с белками плазмы крови. Равновесные концентрации лоратадина и метаболита в плазме крови достигаются на пятые сутки введения. Не проникает через гематоэнцефалический барьер. Метаболизм Метаболизируется в печени с образованием активного метаболита дезлоратадина (дескарбоэтоксилоратадина) при участии изоферментов цитохрома Р450 CYP3A4 и в меньшей степени изофермента цитохрома Р450 CYP2D6. Выведение Выводится через почки (приблизительно 40 % принятой внутрь дозы) и через кишечник (приблизительно 42% принятой внутрь дозы) в течение более чем 10 дней преимущественно в виде конъюгированных метаболитов. Приблизительно 27 % принятой внутрь дозы выводится через почки в течение 24 часов после приема препарата. Менее 1 % активного вещества выводится через почки в неизмененном виде в течение 24 часов после приема препарата. Период полувыведения (Т1/2) лоратадина составляет от 3 до 20 ч (в среднем 84 ч) а дезлоратадина - от 88 до 92 ч (в среднем 28 ч). Фармакокинетика у особых групп пациентов Пожилой возраст Фармакокинетические профили лоратадина и его активного метаболита у взрослых и пожилых здоровых добровольцев были сопоставимы. Т1/2лоратадина у пожилых пациентов составляет от 67 до 37 ч (в среднем 182 ч) а дезлоратадина - от 11 до 39 ч (в среднем 175 ч). Пациенты с нарушением функции печени У пациентов с алкогольным поражением печени Сmахи площадь под кривой \"концентрация - время\" (AUC) лоратадина и его активного метаболита увеличиваются в дна раза по сравнению с данными показателями у пациентов с нормальной функцией печени. При этом Т1/2лоратадина и Т1/2его активного метаболита возрастают с увеличением тяжести заболевания. Пациенты с нарушением функции почек У пациентов с хроническими заболеваниями почек Сmaxи AUC лоратадина и его активного метаболита увеличиваются по сравнению с данными показателями у пациентов с нормальной функцией почек. При этом Т1/2лоратадина и Т1/2его активного метаболита не отличаются от таковых у здоровых пациентов. Проведение гемодиализа у пациентов с хронической почечной недостаточностью не оказывает влияния на фармакокинетику лоратадина и его активного метаболита.","substance":[{"id":96,"title":"Лоратадин","title_latin":"Loratadinum","slug":"loratadin_96"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"Лоратадин - фото упаковки","image_share":{"isTouch":{"default":null},"isFromTablet":{"default":null}},"diseases":[],"other_packages":[{"id":107586,"title":"Лоратадин","subtitle":{"full":"Таблетки, 10 шт, 10 мг, для приема внутрь","short":"Таблетки, 10 шт, 10 мг","package":"10 шт, 10 мг"},"prescription":false,"catalog_section_id":100276,"manufacturer":{"id":375,"title":"Озон","slug":"ozon_375","logo":{"isTouch":{"retina":null,"default":null},"isFromTablet":{"retina":null,"default":null}}},"is_advert":false,"product_form":"Таблетки","slug":"107586-loratadin_ozon","attributes":{"count":"10 шт","dose":"10 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