Нарушение периферического кровообращения (в т.ч. облитерирующий эндартериит, диабетическая ангиопатия, болезнь Рейно); атеросклеротическая и дисциркуляторная ангиопатия, ангионейропатия; трофические нарушения тканей (в т.ч. варикозное расширение вен, трофические язвы голени, гангрена, обморожение, посттромботический синдром); нарушение мозгового кровообращения ...
Нарушение периферического кровообращения (в т.ч. облитерирующий эндартериит, диабетическая ангиопатия, болезнь Рейно); атеросклеротическая и дисциркуляторная ангиопатия, ангионейропатия; трофические нарушения тканей (в т.ч. варикозное расширение вен, трофические язвы голени, гангрена, обморожение, посттромботический синдром); нарушение мозгового кровообращения (последствия церебрального атеросклероза, например снижение концентрации внимания, головокружение, ухудшение памяти), ишемические и постинсультные состояния; нарушение кровообращения в сетчатке и сосудистой оболочке глаза; отосклероз, дегенеративные изменения на фоне патологии сосудов внутреннего уха и снижение слуха.
Противопоказания
Гиперчувствительность, в т.ч. к другим производным метилксантина (кофеин, теофиллин, теобромин), геморрагический инсульт, массивное кровотечение, обширное кровоизлияние в сетчатку глаза, острый инфаркт миокарда, беременность, кормление грудью.Для в/в введения (дополнительно): аритмия, выраженный атеросклероз коронарных или мозговых артерий, неконтролируемая артериальная гипотензия.
Применение при беременности и в период грудного вскармливания
Противопоказано при беременности.Категория действия на плод по FDA— C.На время лечения следует прекратить грудное вскармливание (проникает в грудное молоко).
Побочное действие
Со стороны нервной системы и органов чувств: головная боль, головокружение, тревожность, нарушение сна, судороги, расстройства зрения, скотома; очень редко— асептический менингит.Со стороны сердечно-сосудистой системы и крови (кроветворение, гемостаз): тахикардия, кардиалгия, аритмия, прогрессирование стенокардии, понижение АД, лейкопения, панцитопения, тромбоцитопения, гипофибриногенемия.Со стороны органов ЖКТ: сухость во рту, снижение аппетита, атония кишечника, обострение холецистита, холестатический гепатит, повышение активности печеночных ферментов (АСТ, АЛТ, ЩФ, ЛДГ).Со стороны кожных покровов и подкожно-жировой клетчатки: гиперемия кожи лица, приливы крови к лицу и верхней части грудной клетки, отеки, повышенная ломкость ногтей.Аллергические реакции: зуд, гиперемия кожи лица, крапивница, ангионевротический отек, анафилактический шок.Для таблеток дополнительно: чувство давления и переполнения в области желудка, тошнота, рвота, диарея.
Особые указания
Лечение следует проводить под контролем АД.У больных сахарным диабетом, принимающих гипогликемические средства, назначение больших доз может вызвать выраженную гипогликемию (требуется коррекция дозы).При назначении одновременно с антикоагулянтами необходимо тщательно следить за показателями свертывающей системы крови.У пациентов, недавно перенесших оперативное вмешательство, необходим систематический контроль уровня гемоглобина и гематокрита.Вводимая доза должна быть уменьшена у больных с низким и нестабильным АД.У пожилых людей может потребоваться уменьшение дозы (повышение биодоступности и снижение скорости выведения).Курение может снижать терапевтическую эффективность препарата.Совместимость раствора пентоксифиллина с инфузионным раствором следует проверять в каждом конкретном случае. При проведении в/в инфузий больной должен находиться в положении лежа.
Условия хранения
В сухом, защищенном от света месте, при температуре не выше 25°C. Хранить в недоступном для детей месте.
Срок годности
3 года. Не применять по истечении срока годности, указанного на упаковке.2000-2017. Регистр лекарственных средств России
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