Гормональное средство полипептидный аналог гормона задней до... Инструкция
Показания к применению
Для возбуждения и стимуляции родовой деятельности (первичная и вторичная слабость родовой деятельности необходимость досрочного родоразрешения в связи с гестозом резус-конфликтом внутриутробной гибелью плода; переношенная беременность преждевременное отхождение околоплодных вод ведение родов в тазовом предлежании).
Гиперчувствительность; узкий таз (анатомический и клинический) поперечное и косое положение плода лицевое предлежание плода преждевременные роды угрожающий разрыв матки рубцы на матке (после перенесенного ранее кесарева сечения операции на матке) чрезмерное растяжение матки матка после многократных родов частичное предлежание плаценты маточный сепсис ...
раствор для внутривенного и внутримышечного введения
Состав
1 мл препарата (1 ампула) содержит
действующее вещество: окситоцин - 5 ME;
вспомогательные вещества: хлоробутанолгидрат - 5 мг, 1 М раствор кислоты уксусной - до pH 3,0-4,5, вода для инъекций - до 1 мл.
Описание
Прозрачная, бесцветная жидкость с характерным запахом.
Фармакотерапевтическая группа
родовой деятельности стимулятор - препарат окситоцина
Фармакологические свойства
Фармакодинамика:
Гормональное средство полипептидный аналог гормона задней доли гипофиза. Обладает утеротонизирующим стимулирующим родовую деятельность и лактотропным действием. Оказывает стимулирующее действие на гладкую мускулатуру матки повышает сократительную активность миометрия и в меньшей степени тонус (особенно в конце беременности в течение родовой деятельности и непосредственно во время родоразрешения). Под влиянием окситоцина увеличивается проницаемость клеточных мембран для ионов кальция (Са2+) снижается потенциал покоя и повышается их возбудимость (уменьшение мембранного потенциала приводит к повышению частоты интенсивности и продолжительности сокращений).
Стимулирует секрецию грудного молока усиливая выработку пролактина передней долей гипофиза. Сокращает миоэпителиальные клетки вокруг альвеол молочной железы стимулирует поступление молока в крупные протоки или синусы способствуя усилению отделения молока. Практически лишен вазоконстрикторного и антидиуретического действия (проявляет их только в высоких дозах) не вызывает сокращения мышц мочевого пузыря и кишечника. Эффект наступает через 1-2 мин при внутримышечном введении длится 20-30 мин; при внутривенном - через 05-1 мин.
Фармакокинетика:
Период полувыведения - 1-6 мин (уменьшается на поздних сроках беременности и в период лактации). Связь с белками плазмы - низкая (30%). Метаболизируется в печени и почках. В период беременности в плазме органах-мишенях плаценте увеличивается содержание окситоциназы инактивирующей эндогенный и экзогенный окситоцин. Выведение в основном почками в неизмененном виде.
Показания к применению
Для возбуждения и стимуляции родовой деятельности (первичная и вторичная слабость родовой деятельности необходимость досрочного родоразрешения в связи с гестозом резус-конфликтом внутриутробной гибелью плода; переношенная беременность преждевременное отхождение околоплодных вод ведение родов в тазовом предлежании).
Для профилактики и лечения гипотонических маточных кровотечений после аборта (в том числе при больших сроках беременности) в раннем послеродовом периоде и для ускорения послеродовой инволюции матки; для усиления сократительной способности матки при кесаревом сечении (после удаления последа).
Гиполактация в послеродовом периоде.
Противопоказания
Гиперчувствительность; узкий таз (анатомический и клинический) поперечное и косое положение плода лицевое предлежание плода преждевременные роды угрожающий разрыв матки рубцы на матке (после перенесенного ранее кесарева сечения операции на матке) чрезмерное растяжение матки матка после многократных родов частичное предлежание плаценты маточный сепсис инвазивная карцинома шейки матки; гипертонус матки (возникший не в ходе родов) сдавление плода артериальная гипертензия хроническая почечная недостаточность.
Применение при беременности и в период грудного вскармливания
В первом триместре беременности окситоцин применяют только при спонтанном или индуцированном абортах. Многочисленные данные по применению окситоцина его химическая структура и фармакологические свойства указывают на то что при соблюдении предписаний по применению окситоцин не влияет на формирование пороков развития плода.
В небольших количествах проникает в грудное молоко. При применении препарата для остановки маточного кровотечения к кормлению грудью можно приступать только по завершении курса лечения окситоцином.
Способ применения и дозы
Внутривенно внутримышечно в стенку матки.
Для возбуждения родов: внутримышечно по 05-2 ME; при необходимости повторяют инъекции каждые 30-60 мин.
Индукция родов: внутривенно капельно 10 ME окситоцина на 1 л 5% раствора декстрозы при развитии чрезмерных сокращений матки замедление инфузии быстро приводит к снижению активности миометрия. Введение начинают с 5-8 кап/мин с последующим увеличением скорости в зависимости от характера родовой деятельности но не более 40 кап/мин. В ходе инфузии необходим постоянный контроль маточной активности и частоты сердечных сокращений плода.
Лечение неизбежного или незавершенного аборта: внутривенно капельно 10 ME окситоцина на 500 мл 5% раствора декстрозы со скоростью 20-40 кап/мин.
Для профилактики гипотонических маточных кровотечений окситоцин вводят внутримышечно по 3-5 ME 2-3 раза в сутки ежедневно в течение 2-3 дней допустимо внутримышечное введение 10 ME сразу после отделения плаценты. Для лечения гипотонических маточных кровотечений вводят 5-8 ME 2-3 раза в день в течение 3 суток. При необходимости вводят внутривенно капельно по 10-40 ME окситоцина растворенного в 100 мл донорской крови.
Усиление отделения молока (для предотвращения мастита из-за застоя молока): внутримышечно 2 ME.
Для стимуляции лактации в послеродовом периоде: внутримышечно 05 ME за 5 мин до кормления.
При родах в тазовом предлежании: 2-5 ME.
При операции кесарева сечения (после удаления последа) вводят в стенку матки в дозе 3-5 ME.
Побочное действие
Брадикардия (у матери и плода) снижение артериального давления шок или повышение артериального давления и субарахноидальное кровотечение нарушение ритма сердца (в том числе у плода) бронхоспазм тошнота рвота задержка воды неонатальная желтуха снижение концентрации фибриногена у плода аллергические реакции.
Лечение:отмена препарата уменьшение введения жидкости форсированный диурез гипертонический раствор натрия хлорида нормализация электролитного баланса барбитураты (с осторожностью) тщательное наблюдение.
Взаимодействие с другими лекарственными средствами
Окситоцин усиливает прессорный эффект симптоматических аминов.
В сочетании с ингибиторами моноаминоксидазы возрастает риск повышения артериального давления.
Галотан и циклопропан усиливают риск развития артериальной гипотензии.
Особые указания
Применять только под наблюдением врача в условиях стационара под контролем сократительной деятельности матки состояния плода артериального давления и общего состояния женщины.
Влияние на способность управлять автомобилем и движущимися механизмами
Не применимо учитывая показания к применению.
Форма выпуска
Раствор для внутривенного и внутримышечного введения 5 МЕ\мл.
Условия хранения
В защищенном от света месте при температуре от 8 до 20 °С.
Хранить в недоступном для детей месте.
Срок годности
3 года.
Не использовать препарат после истечения срока годности указанного на упаковке.
Условия отпуска
По рецепту
Производитель
ЗАО "Брынцалов-А", 117105, г. Москва, ул. Нагатинская, д. 1, Россия
Организация, принимающая претензии потребителей
ЗАО "Брынцалов-А"
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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внутримышечного введения"}}]},{"id":4,"name":"Состав","slug":"ingredients","body":[{"type":"paragraph","data":{"text":"1 мл препарата (1 ампула) содержит"}},{"type":"paragraph","data":{"text":"действующее вещество: окситоцин - 5 ME;"}},{"type":"paragraph","data":{"text":"вспомогательные вещества: хлоробутанолгидрат - 5 мг, 1 М раствор кислоты уксусной - до pH 3,0-4,5, вода для инъекций - до 1 мл."}}]},{"id":5,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"Прозрачная, бесцветная жидкость с характерным запахом."}}]},{"id":6,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"родовой деятельности стимулятор - препарат окситоцина"}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"header","data":{"text":"Фармакодинамика:","level":3}},{"type":"paragraph","data":{"text":"Гормональное средство полипептидный аналог гормона задней доли гипофиза. Обладает утеротонизирующим стимулирующим родовую деятельность и лактотропным действием. Оказывает стимулирующее действие на гладкую мускулатуру матки повышает сократительную активность миометрия и в меньшей степени тонус (особенно в конце беременности в течение родовой деятельности и непосредственно во время родоразрешения). Под влиянием окситоцина увеличивается проницаемость клеточных мембран для ионов кальция (Са\u003csup\u003e2+\u003c/sup\u003e) снижается потенциал покоя и повышается их возбудимость (уменьшение мембранного потенциала приводит к повышению частоты интенсивности и продолжительности сокращений)."}},{"type":"paragraph","data":{"text":"Стимулирует секрецию грудного молока усиливая выработку пролактина передней долей гипофиза. Сокращает миоэпителиальные клетки вокруг альвеол молочной железы стимулирует поступление молока в крупные протоки или синусы способствуя усилению отделения молока. Практически лишен вазоконстрикторного и антидиуретического действия (проявляет их только в высоких дозах) не вызывает сокращения мышц мочевого пузыря и кишечника. Эффект наступает через 1-2 мин при внутримышечном введении длится 20-30 мин; при внутривенном - через 05-1 мин."}},{"type":"header","data":{"text":"Фармакокинетика:","level":3}},{"type":"paragraph","data":{"text":"Период полувыведения - 1-6 мин (уменьшается на поздних сроках беременности и в период лактации). Связь с белками плазмы - низкая (30%). Метаболизируется в печени и почках. В период беременности в плазме органах-мишенях плаценте увеличивается содержание окситоциназы инактивирующей эндогенный и экзогенный окситоцин. Выведение в основном почками в неизмененном виде."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Для возбуждения и стимуляции родовой деятельности (первичная и вторичная слабость родовой деятельности необходимость досрочного родоразрешения в связи с гестозом резус-конфликтом внутриутробной гибелью плода; переношенная беременность преждевременное отхождение околоплодных вод ведение родов в тазовом предлежании)."}},{"type":"paragraph","data":{"text":"Для профилактики и лечения гипотонических маточных кровотечений после аборта (в том числе при больших сроках беременности) в раннем послеродовом периоде и для ускорения послеродовой инволюции матки; для усиления сократительной способности матки при кесаревом сечении (после удаления последа)."}},{"type":"paragraph","data":{"text":"Гиполактация в послеродовом периоде."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Гиперчувствительность; узкий таз (анатомический и клинический) поперечное и косое положение плода лицевое предлежание плода преждевременные роды угрожающий разрыв матки рубцы на матке (после перенесенного ранее кесарева сечения операции на матке) чрезмерное растяжение матки матка после многократных родов частичное предлежание плаценты маточный сепсис инвазивная карцинома шейки матки; гипертонус матки (возникший не в ходе родов) сдавление плода артериальная гипертензия хроническая почечная недостаточность."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"В первом триместре беременности окситоцин применяют только при спонтанном или индуцированном абортах. Многочисленные данные по применению окситоцина его химическая структура и фармакологические свойства указывают на то что при соблюдении предписаний по применению окситоцин не влияет на формирование пороков развития плода."}},{"type":"paragraph","data":{"text":"В небольших количествах проникает в грудное молоко. При применении препарата для остановки маточного кровотечения к кормлению грудью можно приступать только по завершении курса лечения окситоцином."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутривенно внутримышечно в стенку матки."}},{"type":"paragraph","data":{"text":"Для возбуждения родов: внутримышечно по 05-2 ME; при необходимости повторяют инъекции каждые 30-60 мин."}},{"type":"paragraph","data":{"text":"Индукция родов: внутривенно капельно 10 ME окситоцина на 1 л 5% раствора декстрозы при развитии чрезмерных сокращений матки замедление инфузии быстро приводит к снижению активности миометрия. Введение начинают с 5-8 кап/мин с последующим увеличением скорости в зависимости от характера родовой деятельности но не более 40 кап/мин. В ходе инфузии необходим постоянный контроль маточной активности и частоты сердечных сокращений плода."}},{"type":"paragraph","data":{"text":"Лечение неизбежного или незавершенного аборта: внутривенно капельно 10 ME окситоцина на 500 мл 5% раствора декстрозы со скоростью 20-40 кап/мин."}},{"type":"paragraph","data":{"text":"Для профилактики гипотонических маточных кровотечений окситоцин вводят внутримышечно по 3-5 ME 2-3 раза в сутки ежедневно в течение 2-3 дней допустимо внутримышечное введение 10 ME сразу после отделения плаценты. Для лечения гипотонических маточных кровотечений вводят 5-8 ME 2-3 раза в день в течение 3 суток. При необходимости вводят внутривенно капельно по 10-40 ME окситоцина растворенного в 100 мл донорской крови."}},{"type":"paragraph","data":{"text":"Усиление отделения молока (для предотвращения мастита из-за застоя молока): внутримышечно 2 ME."}},{"type":"paragraph","data":{"text":"Для стимуляции лактации в послеродовом периоде: внутримышечно 05 ME за 5 мин до кормления."}},{"type":"paragraph","data":{"text":"При родах в тазовом предлежании: 2-5 ME."}},{"type":"paragraph","data":{"text":"При операции кесарева сечения (после удаления последа) вводят в стенку матки в дозе 3-5 ME."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Брадикардия (у матери и плода) снижение артериального давления шок или повышение артериального давления и субарахноидальное кровотечение нарушение ритма сердца (в том числе у плода) бронхоспазм тошнота рвота задержка воды неонатальная желтуха снижение концентрации фибриногена у плода аллергические реакции."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: сдавление плода асфиксия плода брадикардия плода"}},{"type":"paragraph","data":{"text":"послеродовое кровотечение тетанус матки разрыв матки маточно-плацентарная гипоперфузия гипоксия гиперкапния гибель плода родовые травмы плода водная интоксикация судороги."}},{"type":"paragraph","data":{"text":"Лечение:отмена препарата уменьшение введения жидкости форсированный диурез гипертонический раствор натрия хлорида нормализация электролитного баланса барбитураты (с осторожностью) тщательное наблюдение."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Окситоцин усиливает прессорный эффект симптоматических аминов."}},{"type":"paragraph","data":{"text":"В сочетании с ингибиторами моноаминоксидазы возрастает риск повышения артериального давления."}},{"type":"paragraph","data":{"text":"Галотан и циклопропан усиливают риск развития артериальной гипотензии."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Применять только под наблюдением врача в условиях стационара под контролем сократительной деятельности матки состояния плода артериального давления и общего состояния женщины."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Не применимо учитывая показания к применению."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для внутривенного и внутримышечного введения 5 МЕ\\мл."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при температуре от 8 до 20 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не использовать препарат после истечения срока годности указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ЗАО \"Брынцалов-А\", 117105, г. 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Сокращает миоэпителиальные клетки вокруг альвеол молочной железы стимулирует поступление молока в крупные протоки или синусы способствуя усилению отделения молока. Практически лишен вазоконстрикторного и антидиуретического действия (проявляет их только в высоких дозах) не вызывает сокращения мышц мочевого пузыря и кишечника. Эффект наступает через 1-2 мин при внутримышечном введении длится 20-30 мин; при внутривенном - через 05-1 мин. Период полувыведения - 1-6 мин (уменьшается на поздних сроках беременности и в период лактации). Связь с белками плазмы - низкая (30%). Метаболизируется в печени и почках. В период беременности в плазме органах-мишенях плаценте увеличивается содержание окситоциназы инактивирующей эндогенный и экзогенный окситоцин. 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